Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans

Background: Psilocybin is a serotonergic psychedelic with psychoactive effects mediated by serotonin 2A receptor (5-HT2AR) activation. It produces an acute psychedelic altered state of consciousness with a unique phenomenology that can be temporally characterized by three intensity phases: onset of psychoactive effect, a peak plateau and return to normal consciousness. Aims: We evaluated whether pre-drug brain 5-HT2AR binding predicted the three phases of psilocybin subjective drug intensity (SDI) and retrospective self-report of mystical type experiences in healthy individuals. Method: Sixteen participants completed a pre-drug [11C]Cimbi-36 positron emission tomography scan to assess 5-HT2AR binding. On a separate day, participants completed a single psilocybin session (oral dose range 0.2–0.3 mg/kg), during which SDI was assessed every 20 min. The Mystical Experience Questionnaire (MEQ) was completed at the end of the session. The three SDI phases were modelled using segmented linear regressions. We evaluated the associations between neocortex 5-HT2AR binding and SDI/MEQ outcomes using linear regression models. Results: Neocortex 5-HT2AR was statistically significantly negatively associated with peak plateau duration and positively with time to return to normal waking consciousness. It was also statistically significantly negatively associated with MEQ total score. Conclusion: This is the first study to investigate how individual brain 5-HT2AR binding predicts subjective effects of a single dose of psilocybin. Our findings reinforce the role of cerebral 5-HT2AR in shaping the temporal and mystical features of the psychedelic experience. Future studies should examine whether individual brain levels of 5-HT2AR have an impact on therapeutic outcomes in clinical studies.

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P.107 Common HTR2A variants and 5-HTTLPR are not associated with in-vivo serotonin 2A receptor binding in healthy humans

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2019.12.008 ◽

2020 ◽

Vol 31 ◽

pp. S6-S7

Author(s):

M. Spies ◽

A. Nasser ◽

B. Ozenne ◽

P.S. Jensen ◽

G.M. Knudsen ◽

...

Keyword(s):

Receptor Binding ◽

Serotonin 2A Receptor ◽

Healthy Humans ◽

Serotonin 2A

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Positive correlation between body mass index and in vivo serotonin 2A receptor binding in healthy humans

NeuroImage ◽

10.1016/j.neuroimage.2006.04.147 ◽

2006 ◽

Vol 31 ◽

pp. T164

Author(s):

David Erritzoe ◽

V.G. Frokjaer ◽

H. Arfan ◽

S. Haugbol ◽

L. Pinborg ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Receptor Binding ◽

Serotonin 2A Receptor ◽

Positive Correlation ◽

Healthy Humans ◽

Serotonin 2A

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The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation

Current Biology ◽

10.1016/j.cub.2016.12.030 ◽

2017 ◽

Vol 27 (3) ◽

pp. 451-457 ◽

Cited By ~ 118

Author(s):

Katrin H. Preller ◽

Marcus Herdener ◽

Thomas Pokorny ◽

Amanda Planzer ◽

Rainer Kraehenmann ◽

...

Keyword(s):

Subjective Effects ◽

Receptor Activation ◽

Serotonin 2A Receptor ◽

Serotonin 2A

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SEROTONIN 2A RECEPTOR POLYMORPHISMS AND DEPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUS - A PRELIMINARY STUDY

10.26226/morressier.56e174d4d462b8028d88a7e4 ◽

2016 ◽

Author(s):

Bárbara Leal

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Serotonin 2A Receptor ◽

Preliminary Study ◽

Serotonin 2A

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Camouflaging in non-autistic adults is associated with poorer mental health

10.31234/osf.io/myp4g ◽

2019 ◽

Author(s):

Mark Somerville ◽

Sarah E. MacPherson ◽

Sue Fletcher-Watson

Keyword(s):

Mental Health ◽

Executive Function ◽

Autistic Traits ◽

Self Report ◽

Linear Regression Models ◽

Mental Health Symptoms ◽

Health Symptoms ◽

Autistic People ◽

Autistic Adults ◽

The Relationship

Camouflaging is a frequently reported behaviour in autistic people, which entails the use of strategies to compensate for and mask autistic traits in social situations. Camouflaging is associated with poor mental health in autistic people. This study examined the manifestation of camouflaging in a non-autistic sample, examining the relationship between autistic traits, camouflaging, and mental health. In addition, the role of executive functions as a mechanism underpinning camouflaging was explored. Sixty-three non-autistic adults completed standardised self-report questionnaires which measured: autistic traits, mental health symptoms, and camouflaging behaviours. In addition, a subset (n=51) completed three tests of executive function measuring inhibition, working memory, and set-shifting. Multiple linear regression models were used to analyse data. Results indicated that autistic traits are not associated with mental health symptoms when controlling for camouflaging, and camouflaging predicted increased mental health symptoms. Camouflaging did not correlate with any measure of executive function. These findings have implications for understanding the relationship between autistic traits and mental health in non-autistic people and add to the growing development of theory and knowledge about the mechanism and effects of camouflaging.

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Location, Location, Location: The Role of Objective Neighborhood Characteristics for Perceptions of Control

Gerontology ◽

10.1159/000515634 ◽

2021 ◽

pp. 1-10

Author(s):

Johanna Drewelies ◽

Peter Eibich ◽

Sandra Düzel ◽

Simone Kühn ◽

Christian Krekel ◽

...

Keyword(s):

Internal Control ◽

Reference Model ◽

Self Report ◽

Control Beliefs ◽

External Control ◽

Neighborhood Characteristics ◽

Linear Regression Models ◽

Residential Areas ◽

Age Related ◽

Self Report Data

Introduction: Control beliefs can protect against age-related declines in functioning. It is unclear whether neighborhood characteristics shape how much control people perceive over their life. This article studies associations of neighborhood characteristics with control beliefs of residents of a diverse metropolitan area (Berlin, Germany). Methods: We combine self-report data about perceptions of control obtained from participants in the Berlin Aging Study II (N = 507, 60–87 years, 51% women) with multisource geo-referenced indicators of neighborhood characteristics using linear regression models. Results: Findings indicate that objective neighborhood characteristics (i.e., unemployment rate) are indeed tied to perceptions of control, in particular, how much control participants feel others have over their lives. Including neighborhood characteristics in part doubled the amount of explained variance compared with a reference model covarying for demographic characteristics only (from R2 = 0.017 to R2 = 0.030 for internal control beliefs; R2 = 0.056 to R2 = 0.102 for external control beliefs in chance; R2 = 0.006 to R2 = 0.030 for external control beliefs in powerful others). Discussion/Conclusion: Findings highlight the importance of access to neighborhood resources for control beliefs across old age and can inform interventions to build up neighborhood characteristics which might be especially helpful in residential areas with high unemployment.

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Supporting Employee Health at Work: How Perceptions Differ Across Wage Category

American Journal of Health Promotion ◽

10.1177/08901171211024416 ◽

2021 ◽

pp. 089011712110244

Author(s):

Kristi Rahrig Jenkins ◽

Emily Stiehl ◽

Bruce W. Sherman ◽

Susan L. Bales

Keyword(s):

Organizational Support ◽

Supervisor Support ◽

Well Being ◽

Perceived Support ◽

Linear Regression Models ◽

Job Responsibilities ◽

Loved One ◽

Negatively Associated ◽

Workplace Stressors ◽

Health And Well Being

Purpose: This study examines the association between sources of stress and perceptions of organizational and supervisor support for health and well-being. Design: Retrospective, cross-sectional analysis. Setting: Large university in the mid-western United States. Sample: This study focused on university employees with complete data for all variables (organizational support/N = 19,536; supervisor support/N = 20,287). Measures: 2019 socioeconomic and demographic characteristics, count of chronic conditions, sources of stress and perceptions of organizational and supervisor support. Analysis: For the multivariate analyzes, linear regression models were analyzed separately by wage bands (low ≤$46,100; middle >$46,100-$62,800; high >$62,800). Results: For all employees, workplace stressors, including problematic relationships at work and heavy job responsibilities, were negatively associated with perceptions of supervisor and organizational support. In comparison, the most salient home-based stressors were negatively associated with perceptions of supervisor support for the lowest-wage band (the death of a loved one, b = −0.13) and middle-wage band (personal illness or injury, b = −0.09), while the one for the highest-wage band (illness or injury of a loved one, b = 0.07) was positively associated with perceptions of supervisor support. Conclusion: Stressful job responsibilities and work relationships are associated with lower perceptions of supervisor and organizational support for health and well-being across all wage bands. Favorable perceived support for personal stressors only among high wage earning employees may suggest a need for improved equity of perceived support for these stressors among lower wage workers.

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