scholarly journals Stimulating meditation: a pre-registered randomised controlled experiment combining a single dose of the cognitive enhancer, modafinil, with brief mindfulness training

2021 ◽  
pp. 026988112199183
Author(s):  
Emily M Thomas ◽  
Tom P Freeman ◽  
Patrick Poplutz ◽  
Kane Howden ◽  
Chandni Hindocha ◽  
...  
Keyword(s):  
Single Dose ◽  
Sustained Attention ◽  
Attention Deficit Disorder ◽  
Well Being ◽  
Mind Wandering ◽  
Mindfulness Training ◽  
Autonomic Activity ◽  
Cognitive Enhancer ◽  
State Mindfulness

Background: Mindfulness-meditation has a variety of benefits on well-being. However, individuals with primary attentional impairments (e.g. attention deficit disorder) or attentional symptoms secondary to anxiety, depression or addiction, may be less likely to benefit, and require additional mindfulness-augmenting strategies. Aims: To determine whether a single dose of the cognitive enhancer, modafinil, acutely increases subjective and behavioural indices of mindfulness, and augments brief mindfulness training. Methods: A randomised, double-blind, placebo-controlled, 2 (drug: placebo, modafinil) × 2 (strategy: mindfulness, relaxation control) experiment was conducted. Seventy-nine meditation-naïve participants were assigned to: placebo–relaxation, placebo–mindfulness, modafinil–relaxation or modafinil–mindfulness. Pre-drug, post-drug and post-strategy state mindfulness, affect and autonomic activity, along with post-strategy sustained attention and mind-wandering were assessed within a single lab session. After the session, participants were instructed to practice their assigned behavioural strategy daily for one week, with no further drug administration, after which, follow-up measures were taken. Results: As predicted, modafinil acutely increased state mindfulness and improved sustained attention. Differential acute strategy effects were found following mindfulness on autonomic activity but not state mindfulness. There were no strategy or drug effects on mind-wandering. However, exploratory analyses indicated that participants receiving modafinil engaged in more strategy practice across strategy conditions during follow-up. Conclusions: Modafinil acutely mimicked the effects of brief mindfulness training on state mindfulness but did not enhance the effects of this training. Limitations of the current study, and recommendations for future research examining modafinil as an adjunct to mindfulness- (or relaxation-) based treatments are discussed.

Healthy Mind Healthy You: An Online Study Comparing Standard Mindfulness-Based Cognitive Therapy with a Brief Mindfulness Program to Improve Well-Being (Preprint)

2021 ◽  
Author(s):  
Louisa G Sylvia ◽  
Mitchell R Lunn ◽  
Juno Obedin-Maliver ◽  
Robert N McBurney ◽  
W Benjamin Nowell ◽  
...  
Keyword(s):  
Cognitive Therapy ◽  
Well Being ◽  
Mindfulness Training ◽  
Mindfulness Practice ◽  
World Health ◽  
Present Moment ◽  
Intervention Period ◽  
Model Based ◽  
Health Organization

BACKGROUND Mindfulness can improve overall well-being by training individuals to focus on the present moment without judging their thoughts. However, it is unknown how much mindfulness practice and training are necessary to improve well-being. OBJECTIVE The purpose of this study was to compare standard with brief mindfulness training to improve overall well-being. METHODS Participants were recruited from 17 Patient-Powered Research Networks, online communities of stakeholders interested in a common area of research. Participants were randomized to either a standard 8-session mindfulness based cognitive therapy (MBCT) or a brief 3-session mindfulness training intervention accessed online. Participants were followed for 12 weeks. The primary outcome of the study was well-being as measured by the World Health Organization (WHO)-5 Index. We hypothesized that MBCT would be superior to brief mindfulness training. RESULTS We randomized 4,411 participants, 88% of whom were white and 80% female sex assigned at birth. Baseline WHO-5 score mean was 50.3 (SD = 20.7). Average self-reported well-being in each group increased over the intervention period (baseline to 8 weeks) (model-based slope [95% CI] for MBCT group: 0.78 [0.63, 0.93]; brief mindfulness group: 0.76 [0.60, 0.91]) as well as the full study period (i.e., intervention plus follow-up; baseline to 20 weeks) (model-based slope [95% CI] for MBCT group: 0.41 [0.34, 0.48]; brief mindfulness group: 0.33 [0.26, 0.40]). Change in self-reported well-being was not statistically significantly different between MBCT and brief mindfulness during the intervention period (model-based difference in slopes [95% CI]: -0.02 [-0.24, 0.19], P = .80) or during the intervention period plus 12-week follow-up (-0.08 [-0.18, 0.02], P = .10). During the intervention period, younger participants (P = .05) and participants who completed a higher percentage of intervention sessions (P = .005) experienced greater improvements in well-being across both interventions, effects that were stronger for participants in the MBCT condition. CONCLUSIONS Standard MBCT improved well-being but was not superior to a brief mindfulness intervention. Younger patients and those able to complete more training sessions improved the most. CLINICALTRIAL ClinicalTrials.gov, NCT03844321, https://clinicaltrials.gov/ct2/show/NCT03844321

scholarly journals Mindfulness Training as an Intervention for Fibromyalgia: Evidence of Postintervention and 3-Year Follow-Up Benefits in Well-Being

2007 ◽  
Vol 76 (4) ◽  
pp. 226-233 ◽  
Author(s):  
Paul Grossman ◽  
Ulrike Tiefenthaler-Gilmer ◽  
Annette Raysz ◽  
Ulrike Kesper
Keyword(s):  
Well Being ◽  
Mindfulness Training

Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer

2020 ◽  
Vol 34 (2) ◽  
pp. 155-166 ◽  
Author(s):  
Gabrielle I Agin-Liebes ◽  
Tara Malone ◽  
Matthew M Yalch ◽  
Sarah E Mennenga ◽  
K Linnae Ponté ◽  
...  
Keyword(s):  
Single Dose ◽  
Controlled Trial ◽  
Well Being ◽  
Psychiatric Distress ◽  
Existential Distress ◽  
Spiritual Well Being ◽  
Life Threatening ◽  
Clinically Significant

Background: A recently published randomized controlled trial compared single-dose psilocybin with single-dose niacin in conjunction with psychotherapy in participants with cancer-related psychiatric distress. Results suggested that psilocybin-assisted psychotherapy facilitated improvements in psychiatric and existential distress, quality of life, and spiritual well-being up to seven weeks prior to the crossover. At the 6.5-month follow-up, after the crossover, 60–80% of participants continued to meet criteria for clinically significant antidepressant or anxiolytic responses. Methods: The present study is a long-term within-subjects follow-up analysis of self-reported symptomatology involving a subset of participants that completed the parent trial. All 16 participants who were still alive were contacted, and 15 participants agreed to participate at an average of 3.2 and 4.5 years following psilocybin administration. Results: Reductions in anxiety, depression, hopelessness, demoralization, and death anxiety were sustained at the first and second follow-ups. Within-group effect sizes were large. At the second (4.5 year) follow-up approximately 60–80% of participants met criteria for clinically significant antidepressant or anxiolytic responses. Participants overwhelmingly (71–100%) attributed positive life changes to the psilocybin-assisted therapy experience and rated it among the most personally meaningful and spiritually significant experiences of their lives. Conclusion: These findings suggest that psilocybin-assisted psychotherapy holds promise in promoting long-term relief from cancer-related psychiatric distress. Limited conclusions, however, can be drawn regarding the efficacy of this therapy due to the crossover design of the parent study. Nonetheless, the present study adds to the emerging literature base suggesting that psilocybin-facilitated therapy may enhance the psychological, emotional, and spiritual well-being of patients with life-threatening cancer.

scholarly journals Mindfulness training and employee well-being

2016 ◽  
Vol 9 (2) ◽  
pp. 126-145 ◽  
Author(s):  
Nadine Joelle Mellor ◽  
Leanne Ingram ◽  
Marc Van Huizen ◽  
John Arnold ◽  
Anne-Helen Harding
Keyword(s):  
Satisfaction With Life ◽  
Psychological Intervention ◽  
Well Being ◽  
Mindfulness Training ◽  
Future Research ◽  
Control Group ◽  
Present Moment ◽  
Content Type ◽  
Mindfulness Skills

Purpose – The purpose of this paper is to assess the effects of mindfulness training (MT) on employee well-being. Mindfulness is the awareness of one’s thoughts, emotions, sensations, actions and surroundings in the present moment. Design/methodology/approach – The authors used pre-post training measures and a four-week follow-up on a sample of 23 employees from a UK-based organization. The MT group (n=12) received a weekly two-hour training over eight weeks whilst the control group (n=11) received no training. Qualitative interviews (n=36) were conducted with the MT group at three time points to further assess the subjective experiences of training participants. Findings – Compared to the control group, the MT group significantly increased their mindfulness skills including observing and acting with awareness. Scores on well-being, i.e. satisfaction with life, hope and anxiety also improved and were generally maintained at follow-up. Some improvements were seen in the control group too but there was a larger difference in change scores in the MT group on most variables. Qualitative data show additional benefits of MT such as improved concentration at work and better interpersonal relationships. More practice at home led to greater benefits suggesting a dose-response relationship between the amount of practice and substantial benefits. Research limitations/implications – Inviting participants to have a greater amount of practice between sessions may further increase the benefits of mindfulness. Future research should consider a longer follow-up period to further explore the sustainability of the training benefits. Originality/value – Employing a mixed-method approach, this study showed that MT is a viable psychological intervention for enhancing employee well-being.

Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Danica W. Y. Liu ◽  
A. Kate Fairweather-Schmidt ◽  
Richard Burns ◽  
Rachel M. Roberts ◽  
Kaarin J. Anstey
Keyword(s):  
Risk Factors ◽  
Well Being ◽  
Current Status ◽  
Psychological Resilience ◽  
Cross Sectional ◽  
Life Project ◽  
Resilience Factors ◽  
First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

Psychometric Properties of the Spontaneous and Deliberate Mind Wandering Scales

2019 ◽  
Vol 35 (6) ◽  
pp. 878-890 ◽  
Author(s):  
David Marcusson-Clavertz ◽  
Oscar N. E. Kjell
Keyword(s):  
Anxiety Disorder ◽  
Psychometric Properties ◽  
Generalized Anxiety Disorder ◽  
Social Desirability ◽  
Cognitive Task ◽  
Experience Sampling ◽  
Well Being ◽  
Mind Wandering ◽  
Generalized Anxiety ◽  
Psychological Variables

Abstract. Thinking about task-unrelated matters (mind wandering) is related to cognition and well-being. However, the relations between mind wandering and other psychological variables may depend on whether the former commence spontaneously or deliberately. The current two studies investigated the psychometric properties of the Spontaneous and Deliberate Mind Wandering Scales (SDMWS; Carriere, Seli, & Smilek, 2013 ). Study 1 evaluated the stability of the scales over 2 weeks ( N = 284 at Time 1), whereas Study 2 ( N = 323) evaluated their relations to Generalized anxiety disorder symptoms, Openness, Social desirability, and experience-sampling reports of intentional and unintentional mind wandering during an online cognitive task. The results indicated that the SDMWS were better fitted with a two-factor than a one-factor solution, although the fit was improved with the exclusion of one item. The scales exhibited strong measurement invariance across gender and time, and moderately high test-retest reliability. Spontaneous mind wandering predicted Generalized anxiety disorder and experience-sampling reports of unintentional mind wandering, whereas Deliberate mind wandering predicted Openness and experience-sampling reports of intentional mind wandering. Furthermore, Spontaneous mind wandering showed a negative association with social desirability of weak-to-medium strength. In sum, the scales generally showed favorable psychometric properties.

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