scholarly journals Changes in intracranial venous blood flow and pulsatility in Alzheimer’s disease: A 4D flow MRI study

2016 ◽  
Vol 37 (6) ◽  
pp. 2149-2158 ◽  
Author(s):  
Leonardo A Rivera-Rivera ◽  
Tilman Schubert ◽  
Patrick Turski ◽  
Kevin M Johnson ◽  
Sara E Berman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Peak Flow ◽  
Superior Sagittal Sinus ◽  
4D Flow ◽  
Sagittal Sinus ◽  
Flow Mri

Cerebral blood flow, arterial pulsation, and vasomotion may be important indicators of cerebrovascular health in aging and diseases of aging such as Alzheimer’s disease. Noninvasive markers that assess these characteristics may be helpful in the study of co-occurrence of these diseases and potential additive and interacting effects. In this study, 4D flow MRI was used to measure intra-cranial flow features with cardiac-gated phase contrast MRI in cranial arteries and veins. Mean blood flow and pulsatility index as well as the transit time of the peak flow from the middle cerebral artery to the superior sagittal sinus were measured in a total of 104 subjects comprising of four groups: (a) subjects with Alzheimer’s disease, (b) age-matched controls, (c) subjects with mild cognitive impairment, and (d) a group of late middle-aged with parental history of sporadic Alzheimer’s disease. The Alzheimer’s disease group exhibited: a significant decrease in mean blood flow in the superior sagittal sinus, transverse sinus, middle cerebral artery, and internal carotid arteries; a significant decrease of the peak and end diastolic blood flow in the middle cerebral artery and superior sagittal sinus; a faster transmission of peak flow from the middle cerebral artery to the superior sagittal sinus and increased pulsatility index along the carotid siphon.

scholarly journals 4D flow MRI for intracranial hemodynamics assessment in Alzheimer’s disease

2016 ◽  
Vol 36 (10) ◽  
pp. 1718-1730 ◽  
Author(s):  
Leonardo A Rivera-Rivera ◽  
Patrick Turski ◽  
Kevin M Johnson ◽  
Carson Hoffman ◽  
Sara E Berman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Pulsatility Index ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
4D Flow Mri ◽  
4D Flow ◽  
Cross Sectional ◽  
Flow Mri

Cerebral blood flow, arterial pulsation, and vasomotion play important roles in the transport of waste metabolites out of the brain. Impaired vasomotion results in reduced driving force for the perivascular/glymphatic clearance of beta-amyloid. Noninvasive cerebrovascular characteristic features that potentially assess these transport mechanisms are mean blood flow (MBF) and pulsatility index (PI). In this study, 4D flow MRI was used to measure intra-cranial flow features, particularly MBF, PI, resistive index (RI) and cross-sectional area in patients with Alzheimer’s disease (AD), mild cognitive impairment and in age matched and younger cognitively healthy controls. Three-hundred fourteen subjects participated in this study. Volumetric, time-resolved phase contrast (PC) MRI data were used to quantify hemodynamic parameters from 11 vessel segments. Anatomical variants of the Circle of Willis were also cataloged. The AD population reported a statistically significant decrease in MBF and cross-sectional area, and also an increase in PI and RI compared to age matched cognitively healthy control subjects. The 4D flow MRI technique used in this study provides quantitative measurements of intracranial vessel geometry and the velocity of flow. Cerebrovascular characteristics features of vascular health such as pulsatility index can be extracted from the 4D flow MRI data.

scholarly journals Arterial Spin Labeling Blood Flow MRI: Its Role in the Early Characterization of Alzheimer's Disease

2010 ◽  
Vol 20 (3) ◽  
pp. 871-880 ◽  
Author(s):  
David C. Alsop ◽  
Weiying Dai ◽  
Murray Grossman ◽  
John A. Detre
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Mri

scholarly journals Intracranial vascular flow oscillations in Alzheimer’s disease from 4D flow MRI

2020 ◽  
Vol 28 ◽  
pp. 102379
Author(s):  
Leonardo A. Rivera-Rivera ◽  
Karly A. Cody ◽  
David Rutkowski ◽  
Paul Cary ◽  
Laura Eisenmenger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
4D Flow Mri ◽  
4D Flow ◽  
Vascular Flow ◽  
Flow Mri ◽  
Flow Oscillations

scholarly journals Assessment of intracranial vascular flow oscillations in Alzheimer’s disease using real time 4D flow MRI

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Leonardo A Rivera ◽  
Laura Eisenmenger ◽  
Paul Cary ◽  
Sterling C. Johnson ◽  
Kevin M Johnson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Real Time ◽  
4D Flow Mri ◽  
4D Flow ◽  
Vascular Flow ◽  
Flow Mri ◽  
Flow Oscillations

Abstract WP168: Association of Stenosis, Proximal Flow and Distal Perfusion in Subjects With Middle Cerebral Artery Stenosis

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Xiaowei Song ◽  
Wenwen Chen ◽  
Yunduo Li ◽  
David S Liebeskind ◽  
Rui Li ◽  
...  
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Brain Tissue ◽  
Cerebral Artery ◽  
Tissue Perfusion ◽  
Artery Stenosis ◽  
Compensatory Mechanism ◽  
4D Flow ◽  
Distal Perfusion ◽  
Relative Flow

Introduction: Hemodynamic compromise caused by intracranial artery stenosis is one of the critical factors contributing to ischemic stroke. However, the association between flow and stenosis has not been well determined quantitatively, nor its correlation with distal perfusion. The purpose of this study was to investigate the association of blood flow in different grades of stenosis, as well as its association with distal brain tissue perfusion. Methods: Intracranial 4D flow and perfusion were obtained in 33 patients (mean 56 years old) with different grades of unilateral middle cerebral artery (MCA) stenosis. GTFlow was used to measure the flow at the proximal of stenosis and the symmetrical location of contralateral side (Fig 1a). Olea was accessed to calculate the perfusion parameters in MCA area. The average net flow at the proximal of stenosis was compared in patients with different grades(<30%,30-49%,50-69%, and ≥70%) of stenosis. Correlation between relative flow(stenosis/contralateral) and perfusion parameters were also compared in different pial collateral status. Results: Blood flow at the proximal of stenosis changes with the grades of stenosis increasing (Fig 1b, p =0.01). Subjects with <50% and ≥50% stenosis differ in MCA flow, rCBF and rTTP, but not in rCBV (Fig 1c).Spearman correlation analysis indicated that the relative flow was also associated with rTTP shown in distal brain tissue in subjects with poor collateral (Fig 1d, r=-0.69, p =0.02), but not in patients with good collateral. No association between relative flow and rCBF was detected in this group of population. Conclusion: In conclusion, decreased flow at the proximal of stenosis could result in the delay of perfusion in distal brain tissue in patients with poor collateral. Association of flow and stenosis, as well as its relationship with distal perfusion need further study, collateral status and potential compensatory mechanism should be considered in future study.

scholarly journals Associations in Alzheimer’s disease between intracranial vascular metrics from 4D‐flow MRI and β‐amyloid and tau PET

2021 ◽  
Vol 17 (S1) ◽  
Author(s):  
Leonardo A Rivera‐Rivera ◽  
Karly Alex Cody ◽  
Tobey J Betthauser ◽  
Robert V Cadman ◽  
Thomas Reher ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri ◽  
Β Amyloid ◽  
Tau Pet
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