scholarly journals Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping

2018 ◽  
Vol 39 (8) ◽  
pp. 1648-1658 ◽  
Author(s):  
Mari Miyata ◽  
Shingo Kakeda ◽  
Kohsuke Kudo ◽  
Shigeru Iwata ◽  
Yoshiya Tanaka ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Regression Analysis ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Oxygen Extraction Fraction ◽  
Systemic Lupus ◽  
Quantitative Susceptibility Mapping ◽  
Extraction Fraction

The purposes of this study are to assess the oxygen extraction fraction (OEF) changes on MRI-based quantitative susceptibility mapping (QSM) in systemic lupus erythematosus (SLE) patients and to determine whether QSM-OEF is associated with disease activity in SLE. We enrolled 42 SLE patients and 20 healthy subjects (HS) who had no pathologies on conventional brain MRI. Disease activity was assessed using SLE Disease Activity Index (SLEDAI). For the measurement of QSM-OEF, QSM data were analysed using the Perfusion Mismatch Analyzer software program. Spearman's or Pearson's correlation coefficients were calculated, and independent predictors were identified through a multiple linear regression analysis. QSM-OEF was significantly higher in SLE than that in HS (51.3 ± 10.1 vs. 40.5 ± 3.7, p < 0.001). QSM-OEF was positively correlated with SLEDAI and the presence of neuropsychiatric symptom (NPS) scores (ρ = 0.663, p < 0.001 and ρ = 0.340, p = 0.028). At multiple linear regression analysis, SLEDAI and NPS were independently associated with QSM-OEF (standardized β = 0.426, p = 0.016 and standardized β = 6.148, p = 0.029). In the SLE patients, QSM-OEF is associated with disease activity, which might predict an increased risk of stroke in SLE.

Plasma Platelet-derived Microparticles in Patients with Connective Tissue Diseases

2011 ◽  
Vol 38 (4) ◽  
pp. 680-684 ◽  
Author(s):  
CHINAMI OYABU ◽  
AKIO MORINOBU ◽  
DAISUKE SUGIYAMA ◽  
JUN SAEGUSA ◽  
SHINO TANAKA ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Regression Analysis ◽  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Clinical Characteristics ◽  
Linear Regression Analysis ◽  
Connective Tissue Diseases ◽  
Multiple Linear Regression Analysis ◽  
Systemic Lupus

Objective.To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD).Methods.Plasma levels of PDMP were measured by ELISA, and compared among patients with one of the 4 diseases. Association of PDMP levels with clinical characteristics and medication of the patients was also examined.Results.PDMP levels were higher in patients with MCTD and SSc than in controls. Multiple linear regression analysis revealed that patients with Raynaud’s phenomenon (RP) showed higher PDMP levels than those without. PDMP levels in individual patients did not fluctuate significantly over several months.Conclusion.PDMP level is associated with MCTD, SSc, and RP, and could be a novel marker for RP.

Prognostic nutritional index is correlated with disease activity in patients with systemic lupus erythematosus

Lupus ◽  
2018 ◽  
Vol 27 (10) ◽  
pp. 1697-1705 ◽  
Author(s):  
S S Ahn ◽  
S M Jung ◽  
J J Song ◽  
Y-B Park ◽  
S-W Lee
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Lymphocyte Count ◽  
Prognostic Nutritional Index ◽  
Systemic Lupus ◽  
Nutritional Index ◽  
Laboratory Variables

The prognostic nutritional index (PNI), which is calculated using serum albumin level and total lymphocyte count in the peripheral blood, is regarded as an index that reflects the immunonutritional status of patients. PNI was calculated in 217 systemic lupus erythematosus (SLE) patients according to the following formula: 10 × serum albumin value (g/dL) + 0.005 × peripheral lymphocyte count (/mm3). Pearson’s correlation analysis was used to elucidate the correlation between continuous variables. Linear and logistic regression analyses were performed to assess the correlation between laboratory variables and SLE Disease Activity Index-2000 (SLEDAI-2 K) and to differentiate between active and inactive SLE. Ninety-three patients were classified as active SLE (SLEDAI-2 K ≥ 5) and 124 as inactive SLE. Patients with active SLE exhibited lower median PNI than those with inactive SLE (39.0 vs. 49.1, p < 0.001). Multivariable logistic regression analysis revealed PNI as an independent predictor of active SLE. Multivariable linear regression analysis revealed that PNI was significantly correlated with laboratory variables of SLEDAI-2 K, erythrocyte sedimentation rate, C-reactive protein and SLEDAI-2 K. Furthermore, in patients who switched from active to inactive SLE after treatment ( n = 55), PNI increased as disease activity improved ( p < 0.001), which suggests that PNI may be useful for estimating SLE activity.

scholarly journals Trichoscopic Signs in Dermatomyositis, Systemic Lupus Erythematosus, and Systemic Sclerosis: A Comparative Study of 150 Patients

Dermatology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Kumutnart Chanprapaph ◽  
Preeyachat Limtong ◽  
Pintip Ngamjanyaporn ◽  
Poonkiat Suchonwanit
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Regression Analysis ◽  
Systemic Sclerosis ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Multinomial Logistic Regression ◽  
Connective Tissue Diseases ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Brown Pigmentation

<b><i>Background:</i></b> Hair and scalp involvement is prevalent in connective tissue diseases (CTDs). Trichoscopic features may provide a diagnostic implementation and enable differentiation among CTDs; however, a direct comparison of these signs among CTD patients is lacking. <b><i>Objectives:</i></b> To compare trichoscopic findings in dermatomyositis (DM), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc) as well as determine their distinctive features and associations with disease activity. <b><i>Methods:</i></b> Trichoscopic photographs were taken from DM, SLE, and SSc patients and further evaluated for hair shaft and scalp surface abnormalities. Data regarding patients’ clinical manifestations, laboratory results, and disease activity were analyzed. <b><i>Results:</i></b> One hundred fifty participants, consisting of 30 DM, 60 SLE, and 60 SSc patients, were included. Perifollicular red-brown pigmentation, brown scattered pigmentation, and white patches were exclusive findings in DM, SLE, and SSc, respectively (<i>p</i> &#x3c; 0.001). A multinomial logistic regression analysis revealed that DM demonstrated higher odds for having microaneurysmal blood vessels than SLE and SSc (odds ratio [OR] = 22.22, 95% confidence interval [CI] = 1.73–285.13, <i>p</i> = 0.017, and OR = 15.34, 95% CI = 1.36–177.59, <i>p</i> = 0.029, respectively). Polymorphic vessels forming a telangiectatic network suggested SSc over SLE (OR = 12.83, 95% CI = 1.35–121.98, <i>p</i> = 0.026), while avascular areas were more pronounced in SSc than DM and SLE (OR = 43.24, 95% CI = 5.17–361.67, <i>p</i> = 0.001, and OR = 0.03, 95% CI = 0.01–0.24, <i>p</i> = 0.001, respectively). In a quantile regression analysis, perifollicular red-brown pigmentation, reduction in hair diameter, and the absence of thin arborizing vessels were linked to higher disease activity in DM, SLE, and SSc, respectively (all <i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> Trichoscopy is a valuable tool possessing diagnostic and prognostic values for CTDs. Specific trichoscopic features allow adequate distinction between DM, SLE, and SSc and may help identify active disease.

Association between sRAGE and arterial stiffness in women with systemic lupus erythematosus

2020 ◽  
Vol 20 ◽  
Author(s):  
Hongru Wang ◽  
Yibin Zeng ◽  
Huan Zheng ◽  
Bin Liu
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Arterial Stiffness ◽  
Logistic Regression Analysis ◽  
Lupus Erythematosus ◽  
Pulse Wave ◽  
Linear Regression Analysis ◽  
Diabetic Patients ◽  
Systemic Lupus

Background: sRAGE (soluble receptor for advanced glycation end products) is identified as playing a protective role in chronic inflammatory diseases, and it has been found to be related to arterial stiffness in hypertensive or diabetic patients. This cross-sectional study was designed to study the potential association of sRAGE with arterial stiffness in systemic lupus erythematosus(SLE) patients. Methods: Ninety-four female SLE patients were enrolled. Brachial-ankle pulse wave velocity (baPWV) was measured by an automatic pulse wave analyzer. Those patients were divided into two groups according to baPWV values, those with values greater than 1400cm/s being defined as the high arterial stiffness group. Biochemical parameters were compared between the two groups. Linear and logistic regression analysis was used to observe the association between sRAGE and arterial stiffness in those patients. Results: Thirty-five patients were defined as being in the high arterial stiffness group in which sRAGE levels were lower (P<0.05). sRAGE levels were significantly related to baPWV(standardized β=1.18, P<0.01) by linear regression analysis. Multivariate logistic regression analysis showed that sRAGE, SLE duration, systolic blood pressure and low-density lipoprotein cholesterol were independent predictors of arterial stiffness in those patients. Conclusion: Our results revealed that sRAGE was negatively associated with arterial stiffness in Chinese female SLE patients.

Lupus Low Disease Activity State achievement is important for reducing adverse outcomes in pregnant patients with systemic lupus erythematosus

2020 ◽  
pp. jrheum.200802
Author(s):  
Ji-Won Kim ◽  
Ju-Yang Jung ◽  
Hyoun-Ah Kim ◽  
Jeong In Yang ◽  
Dong Wook Kwak ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Regression Analysis ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Systemic Lupus ◽  
Low Disease Activity ◽  
Adverse Pregnancy ◽  
Activity State

Objective This study aimed to examine the frequency and risk factors of complications during pregnancy in women with systemic lupus erythematosus (SLE). Methods The medical records of patients with SLE and age-matched controls at Ajou University Hospital were collected. Clinical features and pregnancy complications in women with SLE were compared to those in controls. Multivariate logistic regression analysis was performed to determine the predictors of adverse maternal and fetal outcomes. Results We analyzed 163 pregnancies in patients with SLE and 596 pregnancies in the general population; no significant differences regarding demographic characteristics were noted. Lupus patients experienced a higher rate of stillbirth (odds ratio [OR], 13.2), pre-eclampsia (OR, 4.3), preterm labor (OR, 2.6), intrauterine growth retardation (OR, 2.5), admission to neonatal intensive care unit (OR, 2.2) and emergency cesarean section (OR, 1.9) than control group. Multivariate regression analysis revealed that thrombocytopenia, low complement, high proteinuria, high SLE Disease Activity Index (SLEDAI), low Lupus Low Disease Activity State (LLDAS) achievement rate, and high corticosteroid dose were associated with adverse pregnancy outcomes. In the receiver operating characteristic curve analysis, the optimal cut-off value for the cumulative and mean corticosteroid doses were 3,500 mg and 6 mg, respectively. Conclusion Pregnant women with SLE have a higher risk of adverse pregnancy outcomes. Pregnancies are recommended to be delayed until achieving LLDAS and should be closely monitored with the lowest possible dose of corticosteroids.

Assessment of Quality of Life (QoL) in Systemic Lupus Erythematosus Patients at a Tertiary Care Hospital in Egypt

2019 ◽  
Vol 15 (4) ◽  
pp. 304-311
Author(s):  
Mervat E. Behiry ◽  
Sahar A. Ahmed ◽  
Eman H. Elsebaie
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Tertiary Care ◽  
Damage Index ◽  
Life Questionnaire ◽  
Care Hospital ◽  
Systemic Lupus

: Systemic Lupus Erythematosus (SLE) has a profound impact on quality of life. Objective: The objective of this study was to explore the quality of life among Egyptian SLE patients and to assess its relationships with demographic and clinical features. Methods: One hundred sixty-four SLE patients were recruited for this study. Demographic information; clinical parameters; disease activity, as evaluated by the systemic lupus erythematosus Disease Activity Index; and organ damage, as assessed by the systemic lupus international Collaborative Clinics/American College of Rheumatology Damage Index, were reported. Quality of life was assessed with a quality of life questionnaire specifically designed for patients with systemic lupus erythematosus; the questions are grouped in the following six domains: physical function, sociooccupational activities, symptoms, treatment, mood, and self-image. Higher values indicate poorer quality of life. Conclusion: Poor quality of life among Egyptian SLE patients and disease activity are strongly related to impaired lifestyles in these patients.

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