Lymphography and Abdominal Computed Tomography in the Staging of Non-Hodgkin Lymphoma

1987 ◽  
Vol 28 (3) ◽  
pp. 263-269 ◽  
Author(s):  
S. P. Strijk
Keyword(s):  
Computed Tomography ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Ct Scan ◽  
Hodgkin Lymphoma ◽  
Lymph Node Involvement ◽  
Initial Examination ◽  
Additional Information ◽  
Non Hodgkin Lymphoma ◽  
Ct Lymphography

Ninety-one patients with non-Hodgkin lymphoma (NHL) were subjected to computed tomography (CT) and lymphography. Both examinations agreed in 74 patients (81%) with regard to the infradiaphragmatic lymph nodes. In patients undergoing CT prior to lymphography, the concordance amounted to 75 per cent. When lymphography was the initial examination, the concordance amounted to 86 per cent. Lymphography was abnormal in 30 per cent of the patients with a normal CT scan and in 93 per cent of those with an abnormal CT scan as the first examination. CT was abnormal in 4 per cent of patients with a normal lymphogram and in 84 per cent of those with an abnormal lymphogram as the first examination. CT did not detect mesenteric or retrocrural lymph node enlargement in the absence of retroperitoneal lymph node involvement. Eleven patients had extranodal manifestations of the disease (excluding liver and spleen), and 3 were detected primarily with CT. Lymphography is the most complete examination for the infradiaphragmatic lymph nodes for staging purposes. Although CT outlined the disease better, it changed the ***lymphographic diagnosis in only 2 per cent of the patients. Lymphography modified the CT stage in 15 per cent of the patients. When abdominal CT is performed first, in staging patients with NHL, lymphography will only yield additional information when CT is normal or equivocal.

scholarly journals Determination of Hodgkin and non-Hodgkin lymphoma stage with combined positron-emission and computed tomography

2011 ◽  
Vol 10 (6) ◽  
pp. 100-108
Author(s):  
I. V. Boikov ◽  
G. Ye. Trufanov ◽  
V. V. Ipatov
Keyword(s):  
Computed Tomography ◽  
Lymph Node ◽  
Hodgkin Lymphoma ◽  
Lung Lesion ◽  
Histological Diagnosis ◽  
Non Hodgkin Lymphoma ◽  
Positron Emission ◽  
Ann Arbor

126 patients with histological diagnosis of Hodgkin and non-Hodgkin lymphoma were examined using combined positronemission and computed tomography with radiotracer 18F-deoxyglucose. For staging Ann Arbor classification (1971) with Costwolds modification (1989) was used. The combined positron-emission and computed tomography pattern of Hodgkin and non-Hodgkin lymphoma was established. Morphofunctional characteristics of lymphoma were determined in cases of lymph node, spleen, liver, kidneys, bones and lung lesion. Using combined positron-emission and computed tomography it can provide more accuracy in staging of Hodgkin and non-Hodgkin lymphoma.

scholarly journals Lymphoscintigraphy in Detection of the Regional Lymph Node Involvement in Gastric Cancer

2006 ◽  
Vol 88 (7) ◽  
pp. 632-638 ◽  
Author(s):  
M Mahir Ozmen ◽  
Baris Zulfikaroglu ◽  
N Ozlem Kucuk ◽  
Necdet Ozalp ◽  
Gulseren Aras ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Computed Tomography ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Regional Lymph Node ◽  
Lymph Node Involvement ◽  
Regional Lymph Nodes ◽  
Abdominal Ultrasonography ◽  
Regional Lymph Node Involvement ◽  
Node Involvement

INTRODUCTION Involvement of regional lymph node is a critical sign in prognosis of gastric cancer. Radiological techniques are commonly used to evaluate the extension of gastric cancer. But their sensitivity and specificity are low especially in the early stage. Our aim was to assess the value of gastric lymphoscintigraphy in identifying regional lymph node involvement in patients with gastric cancer, as compared to the abdominal ultrasonography, computed tomography and postoperative histopathological evaluation. PATIENTS AND METHODS 50 patients (12 females) with a median age of 61 years (range, 35–73 years) were included in the study. Pre-operative staging in all cases included upper gastrointestinal endoscopy and biopsy, followed by ultrasound, computed tomography and lymphoscintigraphy. 148 MBq Technetium-99m lymphoscint was injected around the tumour during endoscopy and immediately after injection, anterior, lateral and posterior images were taken in 5-min intervals using a gamma camera. Findings were compared to the findings of other tests. The sensitivity, specificity, positive predictive value, and negative predictive value of each test were calculated and compared. RESULTS Histologically, 68% of cases (34/50) had metastasis in regional lymph nodes and all cases were accurately diagnosed by lymphoscintigraphy. Lymphoscintigraphy was significantly more sensitive for detecting lymph node involvement (P < 0.01). Both abdominal ultrasonography and CT had very low sensitivity in identifying lymph nodes. CONCLUSIONS Lymphoscintigraphy is a promising test in the identification of regional lymph nodes pre-operatively in patients with gastric cancer. It might help the surgeon to plan the extent of dissection before surgery which may decrease postoperative complications related to unnecessary extensive lymph node dissection.

scholarly journals Computed tomography–based distribution of involved lymph nodes in patients with upper esophageal cancer

2015 ◽  
Vol 22 (3) ◽  
pp. 178 ◽  
Author(s):  
M. Li ◽  
Y. Liu ◽  
L. Xu ◽  
Y. Huang ◽  
W. Li ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Regional Lymph Node ◽  
Metastatic Lymph Node ◽  
Radiation Therapy Oncology Group ◽  
Lymph Node Involvement ◽  
Specific Distribution ◽  
Node Involvement ◽  
Upper Thoracic

BackgroundDelineating the nodal clinical target volume (ctvn) remains a challenging task in patients with cervical or upper thoracic esophageal carcinoma (ec). In particular, the extent of the lymph area that should be included in the irradiation field remains controversial. In the present study, the extent of the ctvn was determined based on the incidence of lymph node involvement mapped by computed tomography (ct) imaging.Methods Our study included 468 patients who were diagnosed with cervical and upper thoracic ec and who received staging information between June 2005 and April 2011. The anatomic distribution of metastatic regional lymph nodes was mapped using ct images and grouped using the levels established by the Radiation Therapy Oncology Group. The probability of the various groups being involved was examined. If a lymph node group had a probability of 10% or more of being involved, it was considered at high risk for metastasis, and elective treatment as part of the ctvn was recommended.Results Lymph node involvement was mapped by ct in 256 patients (54.7%). Not all lymph node groups should be included in the ctvn. For cervical lesions, the involved lymph nodes were located mainly between the hyoid bone and the arcus aortae; the recommended ctvn should consist of the neck lymph nodes at levels iii and iv (supraclavicular group) and thoracic groups 2 and 3P. In upper thoracic ec patients, most of the involved lymph nodes were distributed between the cricoid cartilage and the subcarinal area; the ctvn should cover the supraclavicular group and thoracic nodal groups 2, 3P, 4, 5, and 7.Conclusions Our ct-based study indicates a specific distribution and incidence of metastatic lymph node groups in patients with cervical and upper thoracic ec. The results suggest that regional lymph node groups should be electively included in the ctvn for precise radiation administration.

scholarly journals Evaluation of Active Disease in a Patient of non-Hodgkin Lymphoma by PET-CT scan over non Significant CT, MRI Findings: a case report

2019 ◽  
Vol 21 (2) ◽  
pp. 125-128
Author(s):  
Abu Bakker Siddique ◽  
Mohammad Simoon Salekin ◽  
Fatima Begum ◽  
Shamim MF Begum
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Hodgkin Lymphoma ◽  
Hybrid Imaging ◽  
Imaging Modality ◽  
Diagnostic Tools ◽  
Non Hodgkin Lymphoma ◽  
Pet Ct ◽  
Pet Ct Scan ◽  
Active Disease

Imaging modalities like computed tomography (CT) and MRI (magnetic resonance imaging) have been used as diagnostic tools for decades for screening as well as staging for any malignancies but these scans provide anatomical information only. After introduction of 18 Flurodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) hybrid imaging modality as molecular imaging technique by measuring glucose metabolism has revolutionized the detection capability of tumor. PET-CT scan has been used in localization and staging of lymphoma for two decades worldwide. Here, a case of 52 years male, diagnosed case of non-Hodgkin lymphoma (NHL) and received chemotherapy. At the end of therapy results of conventional imaging by CT, MRI suggested complete response of the disease. However, simultaneous PET-CT scan showed extensive active disease. PET-CT hybrid imaging provides additive information about location and extent of the active tumor over CT & MRI, which have limitation to define functional lesion. Bangladesh J. Nuclear Med. 21(2): 125-128, July 2018 

Incidental Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia in Pelvic Lymph Nodes Excised at Radical Prostatectomy

2003 ◽  
Vol 127 (5) ◽  
pp. 567-572 ◽  
Author(s):  
Edward G. Weir ◽  
Jonathan I. Epstein
Keyword(s):  
Lymph Node ◽  
Radical Prostatectomy ◽  
Lymph Nodes ◽  
Diagnostic Accuracy ◽  
Hodgkin Lymphoma ◽  
Pelvic Lymph Node ◽  
Cell Phenotype ◽  
Small Lymphocytic Lymphoma ◽  
Pelvic Lymph Nodes ◽  
Non Hodgkin Lymphoma

Abstract Context.—Incidental non-Hodgkin lymphoma is often unrecognized at the time of radical prostatectomy in patients with prostate cancer because of nonspecific symptoms and an inconspicuous pathology. The early identification of lymphoma allows optimal long-term management and prevention of significant morbidity. Objective.—To show the subtlety of pathologic findings in cases of non-Hodgkin lymphoma in pelvic lymph nodes and the need for scrupulous attention to detail for diagnostic accuracy. Design.—Histologic and immunohistochemical profiles of 18 consecutive cases of small lymphocytic lymphoma (SLL) incidentally identified in pelvic lymph node dissections were reviewed and compared with 22 cases of benign pelvic lymph node dissections. Results.—Malignant nodes were grossly enlarged and averaged 3.2 cm in their greatest dimension. Histologically, 16 of the SLL cases were characterized by diffuse architectural effacement with obliterated sinuses and rare cortical follicles. Twelve of these cases showed evidence of pseudofollicles. Two cases showed an interfollicular growth pattern with occasional small pseudofollicles. In contrast, benign pelvic lymph nodes averaged 1.7 cm in their greatest dimension. Although most were architecturally distorted by fibrosis, all benign nodes were notable for patent sinuses. Immunohistochemistry was diagnostically helpful in several cases with equivocal morphology. All malignant cases had a B-cell phenotype with aberrant coexpression of T-cell–related antigens typical of SLL. Conclusion.—Incidental low-grade non-Hodgkin lymphoma identified at radical prostatectomy is often overlooked by both the urologist and the pathologist. Although malignant pelvic lymph node dissections frequently lack overt manifestations of lymphoma, attention to subtle morphologic features coupled with lymph node size and immunohistochemical findings should permit diagnostic accuracy.

STUDY OF HISTOPATHOLOGY IN PATIENTS WITH HODGKIN AND NON - HODGKIN LYMPHOMA

2016 ◽  
pp. 59-65 ◽  
Author(s):  
Van Mao Nguyen
Keyword(s):  
Lymph Node ◽  
Hodgkin Lymphoma ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Histopathological Classification ◽  
Non Hodgkin Lymphoma ◽  
Key Words Lymphoma ◽  
Malignant Grade

Background: Lymphoma is one of the most ten common cancers in the world as well as in Vietnam which has been ever increasing. It was divided into 2 main groups Hodgkin and non – Hodgkin lymphoma in which non-Hodgkin lymphoma appeared more frequency, worse prognosis and different therapy. Objectives: - To describe some common characteristics in patients with non – Hodgkin lymphoma; - To determine the proportion between Hodgkin and non- Hodgkin lymphoma, histopathological classification of classical Hodgkin by modified Rye 1966 and non-Hodgkin lymphoma by Working Formulation (WF) of US national oncology institute 1982. Materials and Method: This cross-sectional study was conducted on 65 patients with Hodgkin and non- Hodgkin lymphoma diagnosed definitely by histopathology at Hue Central Hospital and Hue University Hospital. Results:. The ratio of male/female for the non-Hodgkin lymphoma was 1.14/1, the most frequent range of age was 51-60 accounting for 35%, not common under 40 years. Non - Hodgkin lymphoma appeared at lymph node was the most common (51.7%), at the extranodal site was rather high 48.3%. The non - Hodgkin lymphoma proportion was predominant 92.3% comparing to the Hodgkin lymphoma only 7.7%; The most WF type was WF7 (53.3%), following the WF6 18,3% and WF5 11,7%; The intermediate malignancy grade of non- Hodgkin lymphoma was the highest proportion accouting for 85%, then the low and the high one 8.3% and 6.7% respectively. Conclusion: The histopathological classification and the malignant grade of lymphoma for Hodgkin and non - Hodgkin lymphoma played a practical role for the prognosis and the treatment orientation, also a fundamental one for the modern classification of non - Hodgkin lymphoma nowadays. Key words: lymphoma, Hodgkin lymphoma, non-Hodgkin lymphoma, classication, grade, histopathology, lymph node

Assessment of cervical lymph node metastases using indirect computed tomography lymphography with iopamidol in a tongue VX2 carcinoma model

2011 ◽  
Vol 125 (8) ◽  
pp. 820-828 ◽  
Author(s):  
Y Shu ◽  
X Xu ◽  
Z Wang ◽  
W Dai ◽  
Y Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Cervical Lymph Node ◽  
Cervical Lymph Nodes ◽  
Cervical Lymph Node Metastases ◽  
Computed Tomography Images ◽  
Vx2 Carcinoma ◽  
Node Metastases

AbstractObjective:To investigate the performance of indirect computed tomography lymphography with iopamidol for detecting cervical lymph node metastases in a tongue VX2 carcinoma model.Materials and methods:A metastatic cervical lymph node model was created by implanting VX2 carcinoma suspension into the tongue submucosa of 21 rabbits. Computed tomography images were obtained 1, 3, 5, 10, 15 and 20 minutes after iopamidol injection, on days 11, 14, 21 (six rabbits each) and 28 (three rabbits) after carcinoma transplantation. Computed tomography lymphography was performed, and lymph node filling defects and enhancement characteristics evaluated.Results:Indirect computed tomography lymphography revealed bilateral enhancement of cervical lymph nodes in all animals, except for one animal imaged on day 28. There was significantly slower evacuation of contrast in metastatic than non-metastatic nodes. A total of 41 enhanced lymph nodes displayed an oval or round shape, or local filling defects. One lymph node with an oval shape was metastatic (one of 11, 9.1 per cent), while 21 nodes with filling defects were metastatic (21/30, 70 per cent). The sensitivity, specificity, accuracy, and positive and negative predictive values when using a filling defect diameter of 1.5 mm as a diagnostic criterion were 86.4, 78.9, 82.9, 82.6 and 83.3 per cent, respectively.Conclusion:When using indirect computed tomography lymphography to detect metastatic lymph nodes, filling defects and slow evacuation of contrast agent are important diagnostic features.

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