STUDY OF HISTOPATHOLOGY IN PATIENTS WITH HODGKIN AND NON - HODGKIN LYMPHOMA

2016 ◽  
pp. 59-65 ◽  
Author(s):  
Van Mao Nguyen
Keyword(s):  
Lymph Node ◽  
Hodgkin Lymphoma ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Histopathological Classification ◽  
Non Hodgkin Lymphoma ◽  
Key Words Lymphoma ◽  
Malignant Grade

Background: Lymphoma is one of the most ten common cancers in the world as well as in Vietnam which has been ever increasing. It was divided into 2 main groups Hodgkin and non – Hodgkin lymphoma in which non-Hodgkin lymphoma appeared more frequency, worse prognosis and different therapy. Objectives: - To describe some common characteristics in patients with non – Hodgkin lymphoma; - To determine the proportion between Hodgkin and non- Hodgkin lymphoma, histopathological classification of classical Hodgkin by modified Rye 1966 and non-Hodgkin lymphoma by Working Formulation (WF) of US national oncology institute 1982. Materials and Method: This cross-sectional study was conducted on 65 patients with Hodgkin and non- Hodgkin lymphoma diagnosed definitely by histopathology at Hue Central Hospital and Hue University Hospital. Results:. The ratio of male/female for the non-Hodgkin lymphoma was 1.14/1, the most frequent range of age was 51-60 accounting for 35%, not common under 40 years. Non - Hodgkin lymphoma appeared at lymph node was the most common (51.7%), at the extranodal site was rather high 48.3%. The non - Hodgkin lymphoma proportion was predominant 92.3% comparing to the Hodgkin lymphoma only 7.7%; The most WF type was WF7 (53.3%), following the WF6 18,3% and WF5 11,7%; The intermediate malignancy grade of non- Hodgkin lymphoma was the highest proportion accouting for 85%, then the low and the high one 8.3% and 6.7% respectively. Conclusion: The histopathological classification and the malignant grade of lymphoma for Hodgkin and non - Hodgkin lymphoma played a practical role for the prognosis and the treatment orientation, also a fundamental one for the modern classification of non - Hodgkin lymphoma nowadays. Key words: lymphoma, Hodgkin lymphoma, non-Hodgkin lymphoma, classication, grade, histopathology, lymph node

EXPRESSION OF SOME IMMUNOLOGIC MARKERS AND THE RELATION BETWEEN TUMOUR CELL LINEAGE WITH HISTOPATHOLOGY IN NON - HODGKIN LYMPHOMA

2016 ◽  
pp. 93-99
Author(s):  
Van Mao Nguyen ◽  
Sy Hoan Nguyen ◽  
Thi Minh Phuong Phan ◽  
Van Trung Ngo
Keyword(s):  
T Cell ◽  
Hodgkin Lymphoma ◽  
Tumour Cell ◽  
Cell Lineage ◽  
University Hospital ◽  
Low Grade ◽  
Cross Sectional ◽  
Non Hodgkin Lymphoma ◽  
Immunologic Markers ◽  
Malignant Grade

Background: Non - Hodgkin lymphoma is one of the two most common types of lymphoma, accounting for 85% and one of the most ten common cancers in the world as well as in Vietnam. The application of immunohistochemistry besides the histopathology for the tumours cell lineage diagnosis as well as the relation between the cell lineage with histopathology were very important for the prognosis and therapy orientation. Objectives: - To describe the gender, location and the malignant grade in patients with non – Hodgkin lymphôma; - To determine the expression of some immunologic markers, the relation between tumour cell lineage and histopathology in patients with non - Hodgkin lymphoma. Materials and method: This cross-sectional study was carried out on 60 patients with non- Hodgkin lymphoma diagnosed definitely by histopathology and classified as B, T cell by immunohistochemistry at Hue Central Hospital and Hue University Hospital. Results: The ratio of male/female for the non-Hodgkin lymphoma was 1.14/1, non - Hodgkin lymphoma appeared at lymph node was the most common (51.7%), at the extranodal site was relatively high 48.3%. The intermediate malignancy grade of non - Hodgkin lymphoma was the highest proportion accounting for 85%, then the low and the high ones 8.3% and 6.7% respectively. Immunophenotype by 5 markers including LCA, CD3, CD20, CD79a and CD45RO showed that: the B-cell non-Hodgkin lymphoma was predominant type (85%) and appeared more frequent as intermediate or low grade of malignancy, T - cell non – Hodgkin lymphoma was 13.3% and under the high orientation of malignant grade, unclassified type 1.7%; There were no relation between the tumours cell lineage and the gender or the original location of the tumours as well. Conclusion: The application of immunohistochemistry by 5 markers: LCA, CD3, CD20, CD79a and CD45RO was able to divide the tumour cell as the B or T cell of the non – Hodgkin lymphoma which was for for the prognosis and for the better treatment orientation as well. Key words: Lymphoma, non-Hodgkin lymphoma, grade, histopathology, immunohistochemistry, cell lineage

Role of MRI in the Diagnosis and Pre-Operative Classification of Perianal and Anal Fistulas - A Cross-Sectional Study, Southern Rajasthan

2021 ◽  
Vol 8 (33) ◽  
pp. 3156-3162
Author(s):  
Hari Ram Jat ◽  
Neel Patel ◽  
Sitaram Barath ◽  
Pooja Yadav
Keyword(s):  
Perianal Fistula ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Anal Fistulas ◽  
Chi Square ◽  
Cross Sectional ◽  
Perianal Fistulas ◽  
Operative Assessment

BACKGROUND Perianal fistulas account for a substantial discomfort and morbidity to the patient thus affecting productive man hours and quality of life. Accurate pre-operative assessment of course of the primary fistulous track and secondary extension or abscesses is required for successful surgical management of anal fistulas. The purpose of this study was to diagnose and classify pre-operative perianal fistulas. METHODS This is a cross-sectional study at Department of Radiodiagnosis in a tertiary level hospital of southern Rajasthan from November 2018 to November 2020. The study included a total of 50 patients referred to department of radiology for magnetic resonance imaging (MRI). Statistical analysis was done using chi square test and student t test. RESULTS Out of these patients, 56 % were having secondary tract on MRI, 12 % patients were having abscess and 4 % were having horseshoe abscess on MRI. The commonest type of ano-rectal fistula encountered in the study was Grade -II seen in 32 %. CONCLUSIONS MRI is a highly accurate, rapid and non-invasive tool in pre-operative evaluation of the perianal and anal fistulas. MRI evaluation and classification of perianal fistulae has a high degree of diagnostic accuracy. The use of MRI for the diagnosis and classification of perianal fistula can provide reliable information which has both pre-operative and prognostic value. St James University Hospital classification, which is an MR imaging-based grading system for perianal fistula is very useful for effective radiological-surgical communication thus contributing to improved patient care and reduced rate of recurrence. KEYWORDS MR Fistulogram, Perianal Fistula, Anal Fistula, Fistula Classification, Fistulography

scholarly journals Long‐term fatigue in survivors of non‐Hodgkin lymphoma: The Lymphoma Study Association SIMONAL cross‐sectional study

Cancer ◽  
2019 ◽  
Author(s):  
Nicolas Mounier ◽  
Sabine Anthony ◽  
Raphaël Busson ◽  
Catherine Thieblemont ◽  
Vincent Ribrag ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Hodgkin Lymphoma ◽  
Study Association

scholarly journals Comprehensive Geriatric Assessment in Elderly Patients with Aggressive Non-Hodgkin Lymphoma in Peru

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 2307-2307
Author(s):  
Brady E. Beltrán ◽  
Rodrigo Motta ◽  
María P. Gamarra ◽  
Roger Araujo ◽  
Jorge J. Castillo
Keyword(s):  
Hodgkin Lymphoma ◽  
Geriatric Assessment ◽  
Comprehensive Geriatric Assessment ◽  
Research Funding ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Geriatric Syndrome ◽  
Geriatric Syndromes ◽  
Cross Sectional ◽  
Non Hodgkin Lymphoma

Abstract Introduction: The incidence of Non-Hodgkin Lymphoma (NHL) is increasing, especially in people over 60 years of age. This population usually has a worse prognosis, probably due to comorbidities, functional deterioration and decreased tolerance to treatment. Therefore, a pre-therapeutic evaluation would be important to make decisions. The Comprehensive Geriatric Assessment (CGA) is the recommended tool for this evaluation, but it is a complex process that demands time and resources. We performed a study to evaluate the characteristics of the CGA in patients >64 years of age with NHL and to determine which domains can constitute a simplified model. Methods: This is a cross-sectional study with retrospective data collection of geriatric evaluations performed in >64 years with aggressive NHL (90% DLBCL, 10% PTCL) admitted to our institution between September 2015 and August 2017. Number of drugs, prescriptions in older adults was evaluated (STOPP), Lawton scale, Barthel scale, KATZ index, walking speed, Up and Go time (TUG), Mini-mental test, Yesavage scale, Gijón scale, Mini-nutritional, Geriatric syndromes (Incontinence, Falls, Pressure ulcers, Immobility, Sensory Deficits, Osteoporosis), and Accumulated Disease Scale in Geriatrics (CIRS-G). The CGA included 9 domains, and fragility was defined as deterioration in >2 domains. The different evaluations were compared with fragility. Multivariate models were constructed using logistic regression. Results: We included 253 patients with an average age of 76 years. 62% had >1 affected domain, and 40% were considered fragile (>2 affected domains). In the bivariate analysis, age >85 years, and all the geriatric scales except STOPP, were strongly associated with fragility. The final model had 6 variables: Use of >5 drugs ( OR 773.1, 95% CI,4.5-132134.4;p=0.011), Lawton scale <7 (OR 385.2,95%CI, 20.1-7363.5;p<0.001), TUG >20 (OR 124.6,95%CI, 6.2-2489.8;p=0.002), Mini-mental <23 (OR 53.5,95%CI, 3.7-778.8;p=0.004),Yesavage scale >5 (OR 118.7,95%CI, 11.2-1254.5;p<0.001), and presence of at least one geriatric syndrome (OR 235.6,95%CI, 13.3-4158.7;p<0.001). Removing the Mini-mental minimally affected the model, but suppressing two or more variables does weaken the model. Conclusions: In our cohort of patients older than 64 years with aggressive NHL, a model based on five measurements (i.e. number of drugs, TUG, Lawton scale, Yesavage scale and Geriatric Syndromes) could constitute an evaluation with an efficiency similar to a complete CGA. Disclosures Castillo: Pharmacyclics: Consultancy, Research Funding; Genentech: Consultancy; Millennium: Research Funding; Abbvie: Consultancy, Research Funding; Janssen: Consultancy, Research Funding; Beigene: Consultancy, Research Funding.

Economic burden in non‐Hodgkin lymphoma survivors: The French Lymphoma Study Association SIMONAL cross‐sectional study

Cancer ◽  
2021 ◽  
Author(s):  
Virginie Nerich ◽  
Christophe Guyeux ◽  
Michel Henry‐Amar ◽  
Raphaël Couturier ◽  
Catherine Thieblemont ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Economic Burden ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Hodgkin Lymphoma ◽  
Study Association ◽  
Lymphoma Survivors

scholarly journals Demand for Intensive Care beds and patient classification according to the priority criterion

2021 ◽  
Vol 29 ◽  
Author(s):  
Aline Nassiff ◽  
Mayra Gonçalves Menegueti ◽  
Thamiris Ricci de Araújo ◽  
Maria Auxiliadora-Martins ◽  
Ana Maria Laus
Keyword(s):  
Intensive Care ◽  
Lead Time ◽  
Electronic System ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Priority System ◽  
System Method ◽  
Priority Criterion

Objective: to assess the demand for Intensive Care Unit beds as well as the classification of the patients for admission, according to the priority system. Method: a retrospective and cross-sectional study, developed from January2014 to December2018 in two Intensive Care Units for adults of a university hospital. The sample consisted of the requests for vacancies according to the priority system(scale from 1 to 4, where 1 is the highest priority and 4 is no priority), registered in the institution’s electronic system. Results: a total of 8,483 vacancies were requested, of which 4,389(51.7%) were from unitB. The highest percentage in unitA was of Priority2 patients(32.6%); and Priority1 was prevalent in unitB(45.4%). The median lead time between request and admission to unitA presented a lower value for priority1 patients(2h57) and a higher value for priority4 patients(11h24); in unitB, priority4 patients presented shorter time(5h54) and priority3 had longer time(11h54). 40.5% of the requests made to unitA and 48.5% of those made to unitB were fulfilled, with 50.7% and 48.5% of these patients being discharged from the units, respectively. Conclusion: it is concluded that the demand for intensive care beds was greater than their availability. Most of the patients assisted were priorities1 and2, although a considerable percentage of those classified as priorities3 and4 is observed.

Cognitive decline in older long-term survivors from Non-Hodgkin Lymphoma: a multicenter cross-sectional study

2020 ◽  
Vol 11 (5) ◽  
pp. 790-795 ◽  
Author(s):  
Domenico La Carpia ◽  
Rosa Liperoti ◽  
Mauro Guglielmo ◽  
Beatrice Di Capua ◽  
Liliana Franca Devizzi ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Hodgkin Lymphoma ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Hodgkin Lymphoma ◽  
Long Term Survivors

Bone Marrow and Peripheral Blood Evaluation in Non-Hodgkin Lymphoma – A Cross Sectional Study of 78 Cases in a Tertiary Care Centre in Kerala

2021 ◽  
Vol 8 (32) ◽  
pp. 2943-2949
Author(s):  
Arya Puthukkat Muraleedharan ◽  
Prabhalakshmy Kuzhikkattil Krishnankutty
Keyword(s):  
Bone Marrow ◽  
Hodgkin Lymphoma ◽  
Peripheral Blood ◽  
Bone Marrow Aspirate ◽  
Peripheral Blood Smear ◽  
Cross Sectional Study ◽  
Lymphoid Cells ◽  
Cross Sectional ◽  
Non Hodgkin Lymphoma ◽  
Blood Smears

BACKGROUND In the evaluation of patients with non-Hodgkin lymphoma (NHL), determination of bone marrow involvement is an integral part of staging work up. Peripheral blood counts and examination of blood smears are also done in patients with lymphoma as part of pre-treatment investigations. METHODS A cross sectional study of 78 patients with a prior histopathological diagnosis of NHL was conducted. Peripheral blood counts were performed on an automated haematology analyser to look for various cytopenias. Peripheral blood smears and bone marrow aspirate (BMA) / imprint smears were examined in detail for atypical lymphoid cells. Bone marrow trephine biopsies of these patients were studied to assess the NHL involvement and the various patterns of involvement. Adjuvant immunohistochemistry (IHC) was performed in bone marrow biopsies with scant cellularity or crush artefact to discern the marrow involvement. RESULTS Bone marrow trephine biopsy showed involvement by lymphoma in 65.4 % cases. The incidence of involvement was higher in B-cell lymphomas, especially in low grade types. The predominant pattern of involvement was interstitial pattern (41.2 %). Discordant histology between bone marrow and the primary anatomic site was found in 7.8 % of the cases, which was seen more in diffuse large B-cell lymphomas. Majority of the patients with bone marrow infiltration by NHL had anaemia (84.3 %). Bicytopenia and pancytopenia were also observed. On peripheral blood smear examination atypical lymphoid cells were present in 23 % cases. CONCLUSIONS Bone marrow examination is an important aspect in the diagnosis of NHL, because of its both prognostic and therapeutic implications. Hence, the presence of atypical lymphoid cells and other changes in the peripheral blood should be detected in these patients. KEYWORDS Non-Hodgkin Lymphoma, Bone Marrow Biopsy, Bone Marrow Aspirate / Imprint, Peripheral Blood Smear, Atypical Lymphoid Cells

scholarly journals Performance of the rapid triage conducted by nurses at the emergency entrance

2020 ◽  
Vol 28 ◽  
Author(s):  
Bruna Roberta Siqueira Moura ◽  
Lilia de Souza Nogueira
Keyword(s):  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Observation Unit ◽  
Cross Sectional ◽  
Priority Level ◽  
Manchester Triage System ◽  
Priority Levels ◽  
Better Than

Objective: to compare the performance of the rapid triage conducted by nurses at the emergency entrance and of the Manchester Triage System (MTS) in identifying the priority level of care for patients with spontaneous demand and predicting variables related to hospitalization. Method: a cross-sectional study carried out in an Emergency Department (ED) of a university hospital in São Paulo. The priority levels established in the rapid triage performed by nurses were high priority (patients of spontaneous demand directed to the emergency room) or low priority (those referred to the institution’s usual flow). Diagnostic accuracy measures were calculated to assess the performance of the indexes. Results: of the 173 patients (52.0% female, with mean age of 60.4 ± 21.2 years old) evaluated, it was observed that rapid triage was more inclusive for high priority and had better sensitivity and worse specificity than the MTS. The probability of non-severe patients being admitted to the emergency observation unit was lower due to the rapid triage. For the prediction of the other variables, the systems presented unsatisfactory results. Conclusion: the nurses overestimated the classification of patients as high priority, and rapid triage performed better than MTS in predicting admission to the emergency observation unit.

Non-Hodgkin Lymphoma Diagnosis and Treatment in Kosovo, A Cross Sectional Study

2019 ◽  
Vol 19 ◽  
pp. S246
Author(s):  
Adriatik Berisha ◽  
Shemsedin Sadiku ◽  
Aferdita Ukimeraj ◽  
Shpat Rrusta ◽  
Edlira Gashi
Keyword(s):  
Hodgkin Lymphoma ◽  
Cross Sectional Study ◽  
Diagnosis And Treatment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Hodgkin Lymphoma
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