Carcinogenic Hazards in Food

1968 ◽  
Vol 54 (1) ◽  
pp. 93-98
Author(s):  
Benedetto Terracini
Keyword(s):  
Natural Product ◽  
Experimental Tumors ◽  
Polycyclic Hydrocarbons ◽  
Derivatives Of

A review is presented of the circumstances in which chemicals known to produce experimental tumors have been found in the diet of humans or animals. At the present time the instances in which this occurrence is known to take place concern (a) the natural product, (b) toxins produced by fungi contaminating the natural product, (c) chemicals added to the natural product for its preservation at different stages of processing, (d) products of the reaction between an additive and the natural product and (e) derivatives of the natural product which are formed during cooking. Aflatoxins, nitrosamines and polycyclic hydrocarbons are among the most powerful carcinogens which can be found in food.

Synthetic derivatives of pulchrol: An antiparasitic natural product

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
P Terrazas ◽  
O Sterner
Keyword(s):  
Natural Product ◽  
Synthetic Derivatives ◽  
Derivatives Of

scholarly journals Semisynthesis and acaricidal activities of isoxazole and pyrazole derivatives of a natural product bisdemethoxycurcumin

2013 ◽  
Vol 38 (4) ◽  
pp. 214-219 ◽  
Author(s):  
Jinxiang Luo ◽  
Wei Ding ◽  
Yongqiang Zhang ◽  
Zhenguo Yang ◽  
Yang Li ◽  
...  
Keyword(s):  
Natural Product ◽  
Pyrazole Derivatives ◽  
Derivatives Of

scholarly journals Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz[a]anthracene 8,9-oxide and 10,11-dihydrobenz[a]anthracene 8,9-oxide and their metabolism by rat liver preparations

1971 ◽  
Vol 125 (1) ◽  
pp. 159-168 ◽  
Author(s):  
P. Sims
Keyword(s):  
Rat Liver ◽  
Reduced Glutathione ◽  
Mercapturic Acids ◽  
Polycyclic Hydrocarbons ◽  
Glutathione Conjugates ◽  
Liver Homogenates ◽  
Derivatives Of ◽  
Related Compounds

The syntheses of 10,11-dihydrobenz[a]anthracene 8,9-oxide, benz[a]anthracene 8,9-oxide and 9-hydroxybenz[a]anthracene are described, together with those of a number of related compounds. The epoxides react both chemically and enzymically with water to yield the corresponding dihydrodiols and with reduced glutathione to form glutathione conjugates, and they react chemically with N-acetylcysteine to yield the corresponding mercapturic acids. 8,9-Dihydro-8,9-dihydroxybenz[a]anthracene, formed enzymically from benz[a]anthracene 8,9-oxide, was identical with a dihydrodiol formed when benz[a]anthracene was metabolized by rat liver homogenates. Similarly 10,11-dihydrobenz[a]anthracene 8,9-oxide yielded a dihydrodiol identical with the product formed when 10,11-dihydrobenz[a]anthracene was metabolized.

scholarly journals Shushe Acids A-D from Ganoderma Applanatum

2017 ◽  
Vol 12 (3) ◽  
pp. 1934578X1701200
Author(s):  
Qi Luo ◽  
Yan-Jiao Zhang ◽  
Zhi-Qiang Shen ◽  
Peng Chen ◽  
Yong-Xian Cheng
Keyword(s):  
Succinic Acid ◽  
Natural Product ◽  
Gallic Acid ◽  
Spectroscopic Methods ◽  
Fruiting Bodies ◽  
Ganoderma Applanatum ◽  
Prevention And Treatment ◽  
New Compounds ◽  
Derivatives Of ◽  
Mcf 7

Ganoderma applanatum is a fungus used for the prevention and treatment of a variety of disorders in China. In the present study, four new compounds, named shushe acids A-D (1-4), were isolated from the fruiting bodies of this species. Their structures were identified on the basis of spectroscopic methods. Compounds 1-4 are all natural product hybrids composed of derivatives of gallic acid, glycerol and succinic acid. None of the four compounds showed activity against the MCF-7 cell line.

scholarly journals Antifeedant Activity of Spin-Labeled Derivatives of Deoxypodophyllotoxin against Brontispa longissima Larvae

2013 ◽  
Vol 8 (2) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Gang Feng ◽  
Jing Zhang ◽  
Liu Yang ◽  
Ying-Qian Liu ◽  
Zhi-Wei Zhang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Natural Product ◽  
Antifeedant Activity ◽  
Podophyllotoxin Derivatives ◽  
Derivatives Of ◽  
Third Instar Larvae

To continue our search for natural product-based compounds for the control of Brontispa longissima larvae, eight spin-labeled podophyllotoxin derivatives (4a-h) and the intermediates 2 and 3 were tested for their insect antifeedant activity against third-instar larvae of B. longissima. Among all the tested compounds, 4a, 4c, 2 and 3 showed pronounced antifeedant activities with AFC50 values of 0.16, 0.31, 0.15 and 0.28 mg/mL, respectively. The different antifeedant activity ranges of these compounds indicated that variation of the structures of L-amino acids in these compounds markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it.

scholarly journals Non-Ionic Deep Eutectic Liquids: Acetamide–Urea Derived Room Temperature Solvents

2019 ◽  
Vol 20 (12) ◽  
pp. 2857 ◽  
Author(s):  
Subramanian Suriyanarayanan ◽  
Gustaf D. Olsson ◽  
Subban Kathiravan ◽  
Natacha Ndizeye ◽  
Ian A. Nicholls
Keyword(s):  
Molecular Dynamics ◽  
Natural Product ◽  
Room Temperature ◽  
Polymer Synthesis ◽  
Physical Characteristics ◽  
Melting Points ◽  
Eutectic Mixtures ◽  
Alkyl Derivatives ◽  
Ideal Mixing ◽  
Derivatives Of

A family of non-ionic deep eutectic liquids has been developed based upon mixtures of solid N-alkyl derivatives of urea and acetamide that in some cases have melting points below room temperature. The eutectic behaviour and physical characteristics of a series of eleven eutectic mixtures are presented, along with a molecular dynamics study-supported hypothesis for the origin of the non-ideal mixing of these substances. Their use as solvents in applications ranging from natural product extraction to organic and polymer synthesis are demonstrated.

scholarly journals Antimalarial Properties of Dunnione Derivatives as NQO2 Substrates

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3697 ◽  
Author(s):  
Monivan Chhour ◽  
Agnès Aubouy ◽  
Sandra Bourgeade-Delmas ◽  
Pierre Pério ◽  
Hélène Ternet-Fontebasso ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Natural Product ◽  
Murine Model ◽  
Blood Cells ◽  
Oxygen Species ◽  
Ic50 Value ◽  
Quinone Reductases ◽  
Derivatives Of

Dunnione, a natural product isolated from the leaves of Streptocarpus dunnii (Gesneriaceae), acts as a substrate for quinone-reductases that may be associated with its antimalarial properties. Following our exploration of reactive oxygen species-producing compounds such as indolones, as possible new approaches for the research of new ways to treat this parasitosis, we explored derivatives of this natural product and their possible antiplasmodial and antimalarial properties, in vitro and in vivo, respectively. Apart from one compound, all the products tested had weak to moderate antiplasmodial activities, the best IC50 value being equal to 0.58 µM. In vivo activities in the murine model were moderate (at a dose of 50 mg/kg/mice, five times higher than the dose of chloroquine). These results encourage further pharmacomodulation steps to improve the targeting of the parasitized red blood cells and antimalarial activities.

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