scholarly journals Well-Differentiated Lymphocytic Leukemia in a Dog: Long-Term Survival Without Therapy

1981 ◽  
Vol 18 (1) ◽  
pp. 37-47 ◽  
Author(s):  
J. W. Harvey ◽  
T. G. Terrell ◽  
D. M. Hyde ◽  
R. I. Jackson
Keyword(s):  
Lymphocytic Leukemia ◽  
Surface Markers ◽  
Cell Surface Markers ◽  
Total White Blood Cell ◽  
Blood Cell Count ◽  
Term Survival ◽  
Mitogen Stimulation ◽  
Well Differentiated ◽  
Hematologic Examination

Well-differentiated lymphocytic leukemia was found during routine hematologic examination of a 12-year-old female poodle with signs of anxiousness, panting and pica. The total white blood cell count was 106,900/μ1 and at least 90% of the leukocytes were small, normal-appearing lymphocytes. The dog was examined several times during a 23-month period before it was killed at the owner's request for conditions unrelated to the leukemia. The hematologic picture of the leukemia was essentially unchanged during this time. A deep nuclear cleft was seen in most lymphocytes examined by electron microscopy. Cell surface markers showed most blood lymphocytes to be B-cells. These cells responded poorly to mitogen stimulation.

scholarly journals Case Report: Long-Term Survival of a Dog With Chronic Lymphocytic Leukemia Treated With Chlorambucil, Prednisolone, and Imatinib

2022 ◽  
Vol 8 ◽  
Author(s):  
Ga-Won Lee ◽  
Min-Hee Kang ◽  
Jin-Ha Jeon ◽  
Doo-Won Song ◽  
Woong-Bin Ro ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Chronic Lymphocytic Leukemia ◽  
Bone Marrow Aspirate ◽  
Peripheral Blood Smear ◽  
Additional Treatment ◽  
Lymphocytic Leukemia ◽  
Term Survival ◽  
Neoplastic Lymphocytes ◽  
Well Differentiated

A 7-year-old castrated male Poodle dog presented with chronic progressive lymphocytosis. Hematologic and peripheral blood smear findings included remarkable lymphocytosis with well-differentiated small lymphocytes. Cytology of bone marrow aspirate showed hypercellular integrity with infiltration of small mature lymphocytes, accounting for 45% of all nucleated cells. Flow cytometry of blood and marrow samples revealed neoplastic lymphocytes predominantly expressing the CD21 molecule. B-cell chronic lymphocytic leukemia (CLL) was diagnosed on an immunophenotypic analysis. Administrations of prednisolone and chlorambucil were initiated and the response was unremarkable. Therefore, additional treatment with imatinib was provided, which resolved the hematologic abnormalities associated with CLL. Flow cytometry after ~1 year of treatment showed normalization of the count of lymphocytes positive for CD21 and resolved hematologic lymphocytosis. The dog was followed-up for 2 years, and there were no severe adverse effects. This case indicates that imatinib may be a good option as an adjunctive therapy with prednisolone and chlorambucil treatment for CLL in dogs without treatment response.

scholarly journals No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy

Haematologica ◽  
2017 ◽  
Vol 103 (4) ◽  
pp. e158-e161 ◽  
Author(s):  
Panagiotis Baliakas ◽  
Mattias Mattsson ◽  
Anastasia Hadzidimitriou ◽  
Eva Minga ◽  
Andreas Agathangelidis ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Term Survival ◽  
Long Term Survival ◽  
Over Time

scholarly journals Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers

2020 ◽  
Vol 481-482 ◽  
pp. 112792
Author(s):  
Mariana Hugo Silva ◽  
Rico Lepzien ◽  
Sebastian Ols ◽  
Benita Dahlberg ◽  
Johan Grunewald ◽  
...  
Keyword(s):  
Cell Surface ◽  
Surface Markers ◽  
Cell Surface Markers ◽  
Long Term Storage ◽  
Term Storage

Well-differentiated hepatocellular carcinoma associated with long-term survival

1991 ◽  
Vol 418 (6) ◽  
pp. 551-556 ◽  
Author(s):  
M. Loda ◽  
A. E. Mendoza ◽  
C. O'Hara ◽  
J. M. Crawford ◽  
M. Federman ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Well Differentiated

scholarly journals A Case of Intraosseous Well-differentiated Osteosarcoma of the Rib With Long-term Survival

Haigan ◽  
2003 ◽  
Vol 43 (1) ◽  
pp. 23-27
Author(s):  
Hiroyuki Oura ◽  
Mikihito Ishiki ◽  
Masahide Hirose ◽  
Nobukazu Tomichi ◽  
Kazuo Takayama ◽  
...  
Keyword(s):  
Term Survival ◽  
Long Term Survival ◽  
Well Differentiated

scholarly journals Long-term survival after fludarabine, cyclophosphamide, and rituximab treatment in previously untreated chronic lymphocytic leukemia patients

2021 ◽  
Vol 10 (2) ◽  
pp. 139
Author(s):  
ShokhanMohammad Mustafa ◽  
AhmedKhudair Yassin ◽  
NawsherwanS Mohammed ◽  
RawandP Shamoon ◽  
MarwaN Karam ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Term Survival ◽  
Long Term Survival
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