The Effects of Dexmedetomidine and Fentanyl on Emergence Characteristics after Adenoidectomy in Children

This randomised controlled study evaluated the effects of fentanyl and dexmedetomidine on emergence characteristics of children having adenoidectomy and anaesthetised with sevoflurane. Ninety children, two to seven years of age and ASA physical status I, were studied. Children were randomly assigned to one of three groups of 30 children, with the study intervention injection given intravenously after intubation. Children in Group F received fentanyl 2.5 μg.kg−1 children in Group D received dexmedetomidine 0.5 μg.kg−1 and children in Group C received saline solution. Anaesthesia was induced with 50% N2O and 8% sevoflurane in O2 by mask and atracurium 0.6 mg.kg−1 was administered for tracheal intubation. All children received paracetamol 40 mg/kg rectally one hour preoperatively and dexamethasone 0.5 mg.kg−1 intravenously. The time to extubation was shorter in Group D than Group F. The eye-opening time was longer in Group F (16.1∓5.3 minutes) than in Groups C (12.0∓4.2 minutes) and D (12.7∓3.2 minutes). The proportion of pain-free children in early recovery was significantly higher in Groups D (47%) and F (43%) than Group C (13%) (P <0.05). The proportion of children with agitation scores >3 was lower in Groups D 17% (5/30) and F 13% (4130) than in Group C 47% (14/30) (P <0.05). Fentanyl 2.5 μg.kg−1 and dexmedetomidine 0.5 μg.kg−1 had similar haemodynamic effects and emergence characteristics. Fentanyl has been safely used in children for many years. Further studies of dexmedetomidine safety and its interaction with other anaesthetic agents are required before recommending its routine use during general anaesthesia in children.

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Comparison of postoperative recovery from desflurane and sevoflurane anaesthesia using laryngeal mask airway: a prospective randomized comparative study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20180603 ◽

2018 ◽

Vol 6 (3) ◽

pp. 853

Author(s):

Supriya V. Jadhav ◽

Prerna Gomes ◽

Swati Daftary

Keyword(s):

Statistical Significance ◽

Postoperative Recovery ◽

Research Centre ◽

Early Recovery ◽

Anaesthetic Agents ◽

Recovery Profile ◽

Inhalational Anaesthetic ◽

Eye Opening ◽

Group D ◽

Mean Time

Background: Ambulatory surgeries necessitate safe anaesthesia and faster recovery. Sevoflurane and desflurane are proved as such effective inhalational anaesthetic agents. The aim of this study was to compare early postoperative recovery profile in patient undergoing elective ambulatory surgical operations and receiving anaesthesia with sevoflurane or desflurane using supreme LMA.Methods: This prospective study was conducted at Jaslok Hospital and Research Centre, Dr. G. Deshmukh Marg, Mumbai, from August 2014 to April 2015. Patients were randomized into two groups receiving desflurane (Group D- n=40) and sevoflurane (Group S- n=40) for maintenance of anaesthesia. Patients were monitored for recovery by using fast track criteria (FTC) score at different time intervals.Results: The demographic characteristics, hemodynamic parameters were comparable in both the groups and no statistical significance was seen among them (p>0.05). The mean time taken for postoperative recovery characteristics were significantly lower in in Group D than Group S (p=0.00). The FTC score was significantly higher in group D as compared to group S at all times (p<0.05) for thirty minutes. The prevalence of consuming additional analgesic was 12.5% in group D and 15% in group S (p=1.000). The additional antiemetic requirement was seen in 10% patients in both the groups (p=1.000).The incidence of coughing was seen in among 5% of Group D patients and in none among Group S (p=0.152).Conclusion: The study concludes that desflurane is superior to sevoflurane with respect to time of eye opening, response to verbal commands, orientation, ability to sit, early recovery profile and duration of stay in recovery room.

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Effect of anaesthetic agents on olfactory threshold and identification – A single blinded randomised controlled study

Indian Journal of Anaesthesia ◽

10.4103/ija.ija_245_18 ◽

2018 ◽

Vol 62 (8) ◽

pp. 592 ◽

Cited By ~ 2

Author(s):

Pankaj Kundra ◽

Balachandar Saravanan ◽

SandeepKumar Mishra ◽

Gopalakrishnan Surianarayanan ◽

PradiptaKumar Parida

Keyword(s):

Controlled Study ◽

Olfactory Threshold ◽

Anaesthetic Agents ◽

Randomised Controlled Study ◽

Randomised Controlled

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The efficacy of nasal cavity lavage with a physiological saline solution in prevention of recurrent acute otitis media: a pilot randomised controlled study

http://isrctn.org/> ◽

10.1186/isrctn50641733 ◽

2012 ◽

Author(s):

Annie Lapointe

Keyword(s):

Nasal Cavity ◽

Otitis Media ◽

Saline Solution ◽

Acute Otitis Media ◽

Physiological Saline ◽

Controlled Study ◽

Randomised Controlled Study ◽

Recurrent Acute Otitis Media ◽

Physiological Saline Solution ◽

Randomised Controlled

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Better timing of ultrasound-guided transversus abdominis plane block for early recovery after open inguinal herniorrhaphy: A prospective randomised controlled study

Asian Journal of Surgery ◽

10.1016/j.asjsur.2020.06.001 ◽

2021 ◽

Vol 44 (1) ◽

pp. 254-261 ◽

Cited By ~ 1

Author(s):

Jung-Woo Shim ◽

Jemin Ko ◽

Chul-Seung Lee ◽

Do-Sang Lee ◽

Jaesik Park ◽

...

Keyword(s):

Transversus Abdominis Plane Block ◽

Transversus Abdominis ◽

Controlled Study ◽

Transversus Abdominis Plane ◽

Ultrasound Guided ◽

Early Recovery ◽

Inguinal Herniorrhaphy ◽

Randomised Controlled Study ◽

Randomised Controlled ◽

Open Inguinal Herniorrhaphy

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Comparison of Efficacy of 4% Articaine and 0.5% Bupivacaine and 2% Lignocaine Anaesthetic agents in Orthodontic Extractions-A Prospective Randomised Controlled Study

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i41b32349 ◽

2021 ◽

pp. 108-116

Author(s):

Yandeti Srinivasulu ◽

Abdul Wahab ◽

P. Senthil Murugan

Keyword(s):

Controlled Study ◽

Onset Of Action ◽

Anaesthetic Agents ◽

Anesthetic Agents ◽

Pain Scores ◽

Randomised Controlled Study ◽

Maxillary Premolars ◽

Randomised Controlled ◽

Two Sides ◽

Fast Acting

Aim: Articaine, bupivacaine, lignocaine are amide type of local anesthetic agents, which are of almost equal potency. However, lidocaine is considered the gold standard and is the most widely used anesthetic agent because of its potency, safety, and efficiency. Articaine is fast acting and bupivacaine is long lasting local anaesthesia. The aim of this clinical study was to evaluate and compare the clinical anesthetic efficacy of 4% articaine and 0.5% bupivacaine and 2% lignocaine in therapeutic orthodontic extractions. Materials and Methods: A 150 healthy patients, requiring Maxillary premolars extraction for orthodontic reasons were included. Patients were categorized into three groups (4% articaine and 0.5% bupivacaine, 2% lignocaine) in a crossover manner. Subjective and objective observations recorded that include age, gender, and pain score using visual analog scale. At the first appointment, both upper premolars were extracted on one or two sides of the jaws. Each patient was evaluated using a visual analogue scale. Results: The results showed that 0.5% Bupivacaine had significantly faster onset of action and lower visual analogue scores when compared with articaine and lignocaine. However, the duration of analgesia and need of first rescue analgesic medication was longer in the bupivacaine group. Conclusion: Within the limitations of study we found that Bupivacaine has the best anaesthetic effect with low pain scores followed by Articaine and followed by Lignocaine. Bupivacaine is an alternative local anaesthetic drug for performing therapeutic orthodontic extractions.

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