Increase in P50 with the use of Bicarbonate Hemodialysis

1987 ◽  
Vol 10 (6) ◽  
pp. 361-366
Author(s):  
G. Ramirez ◽  
G.L. Collice ◽  
S. James ◽  
C.C. Johns ◽  
W.P. Nelson
Keyword(s):  
Cell Volume ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Similar Amount ◽  
Red Cell ◽  
Dialysis Patients ◽  
Corpuscular Hemoglobin ◽  
Red Cell Volume ◽  
Blood Ph ◽  
The Mean

We studied the effect of bicarbonate and acetate on oxygenation during dialysis in ten male chronic dialysis patients. The dialysis delivery system and dialysate constituents were identical except for the use of either bicarbonate or acetate. We found no hemodynamic differences between the two kinds of dialysis. Blood PO2 fell by a similar amount, but blood PCO2 was higher during bicarbonate dialysis. The blood pH became alkalotic by the second hour of bicarbonate dialysis and remained so throughout the dialysis, whereas blood pH became alkalotic only at the end of acetate dialysis. The P50 increased significantly only during bicarbonate dialysis, but 2.3 DPG concentration did not change. Red cell volume, assessed by the mean corpuscular hemoglobin concentration, was unchanged. Without changes in the red cell volume we cannot explain the observed changes in P50 in the absence of concomitant changes in 2.3 DPG concentration.

scholarly journals HEMATOLOGICAL CHARACTERIZATION OF BETA-THALASSEMIA IN SUDANESE PATIENTS

2020 ◽  
pp. 5-7
Author(s):  
RABAB HASSAN ELSHAIKH ◽  
SANAA ELFATIH HUSSEIN
Keyword(s):  
Iron Deficiency ◽  
Hemoglobin Concentration ◽  
Mean Value ◽  
Beta Thalassemia ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Significant Difference ◽  
Hematological Analysis ◽  
The Mean

Thalassemia is common inherited disorder among humans, and they represent a major public health problem in many areas of the world. The study aimed to the measurement of hematological characterization of beta-thalassemia in Sudanese patients. Blood samples from 61 beta-thalassemic patients were collected after written consent form obtained from all participants. The frequency of adults (>18 years) was 45 (73.8%) and children’s (<18 years) was 16 (26.2%); the frequency of male was 27 (44.3%) and 34 were female (55.7%). Hemoglobin estimation and red cell indices were carried out using the automatic blood cell counter Sysmex K × 21N. The results showed that Hb and RBCs indices were varied between mild to moderate and severe decreasing, hemoglobin concentration (Hb) with the mean value of 9.6 g/dL, with minimum value of 6.1 g/dl and maximum of 11.9 g/dl, while RBCs were increased in all patients, mean value 5.2 c/l, mean corpuscular volume mean was 58.9 fl, hematocrit was 30.4, mean corpuscular hemoglobin (MCH) 18.8 pg, mean corpuscular hemoglobin concentration (MCHC) was 31.7pg, and RDW was 18.8%. The method used for hemoglobin electrophoresis was capillary electrophoresis, Hb pattern shows increased HbA2 and HbF, the mean of HbA is 78.3%, HbF is 2.3%, and HbA2 is 6.5% with the min. value of 3.6% and max. of 12.2%. While the mean of serum iron was 82.75 μg/dl, 7 patients showed low level, 19 high level, and 35 were normal level. Comparison of hematological analysis (HbA2) in thalassemic patients coexisted with iron deficiency and without result was insignificant difference (p=0.645), this result disagrees with references that say iron deficiency masking HbA2. Nevertheless, the association between HbA2 and HbF revealed a statistically significant difference (p<0.013) and HbA2 with Hb was insignificant (p=0.260).

scholarly journals Blood Donation in Nigeria: Standard of the Donated Blood

2012 ◽  
Vol 4 (02) ◽  
pp. 094-097 ◽  
Author(s):  
Nwogoh Benedict ◽  
Awodu Omolade Augustina ◽  
Bazuaye Godwin Nosakhare
Keyword(s):  
Blood Donation ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Mean Cell Volume ◽  
Benin City ◽  
Cell Counts ◽  
Significant Difference ◽  
The Mean

ABSTRACT Objective: The objective was to determine the basic hematological parameters of remunerated blood donors in Benin City and to compare them with those of voluntary donors. Materials and Methods: This is a prospective study conducted in a tertiary health facility in Benin City. Pretransfusion samples were obtained from blood bags after gentle mixing and analyzed for hematological parameters. Samples were analyzed using the hematology autoanalyzer MODEL SYSMEX KN21. Result: A total of 215 samples were obtained comprising 160 remunerated (paid) and 55 voluntary donor samples. In the paid donors, the mean hemoglobin concentration (Hb) and hematocrit (HCT) 7.7±2.9 and 28.8±8.5 respectively. This was significantly lower than those of voluntary donors who had 13.9±1.2 and 42.2±3.3 with P < 0.001. The mean values of the red cell counts (RBC), white cell counts (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly lower in paid donors as P-values were <0.001. MCV was significantly low but not compared to the other parameters as P=0.04. There was no significant difference in the platelet count. Conclusion: Paid donors in Benin City have significantly lower hematological parameters than controls.

scholarly journals Marked interference of hyperglycemia in measurements of mean (red) cell volume by Technicon H analyzers

1996 ◽  
Vol 42 (1) ◽  
pp. 76-80 ◽  
Author(s):  
H L van Duijnhoven ◽  
M Treskes
Keyword(s):  
Sodium Dodecyl Sulfate ◽  
Cell Volume ◽  
Sodium Dodecyl ◽  
Hemoglobin Concentration ◽  
Red Cell ◽  
Erythrocyte Volume ◽  
Red Cell Volume ◽  
Erythrocyte Indices ◽  
Dodecyl Sulfate ◽  
Mean Cell Hemoglobin

Abstract Severe hyperglycemia can result in falsely high results for mean cell (erythrocyte) volume (MCV), which will also cause false results for erythrocyte indices calculated on the basis of MCV. Falsely high MCV results were obtained with the Technicon H1 and H2 analyzers and (to a lesser extent) with the Coulter T660. The H analyzers were more susceptible to this interference than was the Coulter T660. This difference in sensitivity of MCV to hyperglycemia can be explained by the use of sodium dodecyl sulfate in the Technicon erythrocyte diluent and by differences in incubation times. In severe hyperglycemia, results for MCV, mean cell hemoglobin concentration, and hematocrit obtained from electronic cell counters, especially Technicon H systems, are unreliable.

scholarly journals Markers of Anemia in Children with Type 1 Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Ewa Rusak ◽  
Anna Rotarska-Mizera ◽  
Piotr Adamczyk ◽  
Bogdan Mazur ◽  
Joanna Polanska ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Vitamin B12 ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Cell Distribution ◽  
Corpuscular Hemoglobin ◽  
Distribution Width

Aim. The aim of the study was to assess markers of anemia in type 1 diabetes (T1D) children, compare them to results obtained in the control group, and estimate their relation to BMI SDS. Methods. 94 (59% ♀) T1D children without other autoimmune disorders, aged 12.5 ± 4.1 years, T1D duration: 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol). Sex- and age-matched controls (43 children). In all children, anthropometric measurements, the blood count, iron turnover parameters, and vitamin B12 concentration were taken. Results. T1DM children had significantly higher red cell distribution width (RDW) (13.6 versus 12.6%; p<0.001), hepcidin (0.25 versus 0.12 ng/ml; p<0.001), and vitamin B12 concentrations (459 versus 397 pg/ml; p<0.01) and lower TIBC (59.09 versus 68.15 μmol/l; p<0.001) than in the control group. Logistic regression revealed that RDW, TIBC (both p<0.001), and hepcidin (p<0.05) significantly differentiated both groups. In T1DM children, BMI SDS negatively correlated with vitamin B12 (p<0.01) concentration and mean corpuscular hemoglobin concentration (p<0.05) and positively with TIBC (p<0.01) and HbA1c (p<0.001). Conclusions. Patients and controls differed especially in terms of RDW and TIBC. In studied T1DM children, BMI SDS was associated to iron metabolism parameters and vitamin B12 concentration.

scholarly journals Hematological parameters of Hoplias malabaricus (Characiformes: Erythrinidae) parasitized by Monogenea in lagoons in Pirassununga, Brazil

2013 ◽  
Vol 22 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Lincoln Lima Corrêa ◽  
Letícia Cucolo Karling ◽  
Ricardo Massato Takemoto ◽  
Paulo Sérgio Ceccarelli ◽  
Marlene Tiduko Ueta
Keyword(s):  
Condition Factor ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Good Health ◽  
Blood Parameters ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Hoplias Malabaricus ◽  
Relative Condition Factor ◽  
The Mean

Hematology is an important pathological and diagnostic tool. This paper describes the hematological parameters of 76 specimens of Hoplias malabaricus infested with monogenean parasites, which were collected from two lagoons. The hematological parameters included: erythrocyte count (Er), microhematocrit (Hct), hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). The blood parameters showed no significant changes associated with the infestation. Water temperature was found to be negatively correlated with MCV and Hct, with values of rs= −0.52, p<0.0001 and rs= −0.48, p<0.0001, respectively. The mean Relative Condition Factor was Kn=1.01, indicating good health conditions of the fish in these lagoons. No correlation was found between the monogenean infestation and the blood parameters, or between the environmental factors and the monogeneans.

scholarly journals The mean red cell volume in diabetes mellitus

Diabetologia ◽  
1981 ◽  
Vol 20 (5) ◽  
Author(s):  
R.J.L. Davidson ◽  
L.A. Evan-Wong ◽  
J.M. Stowers
Keyword(s):  
Diabetes Mellitus ◽  
Cell Volume ◽  
Red Cell ◽  
Red Cell Volume ◽  
The Mean

Hematological studies in the normal adult Indian camel (Camelus dromedarius)

1962 ◽  
Vol 203 (6) ◽  
pp. 1185-1187 ◽  
Author(s):  
Sachchidananda Banerjee ◽  
Ramesh Chandra Bhattacharjee ◽  
Tej Inder Singh
Keyword(s):  
Electrophoretic Mobility ◽  
Minor Component ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Corpuscular Hemoglobin ◽  
Blood Picture ◽  
Blood Indices ◽  
Camelus Bactrianus ◽  
The One

The normal blood picture, different blood indices, and electrophoretic mobility of hemoglobin were determined in the Indian camel with one hump ( Camelus dromidarius). The different values were as follows: erythrocytes, 7.24 million/mm3; hematocrit, 27%; size of red cell, 7.7 µ x 4.2 µ; hemoglobin, 13.1 g/100 ml; mean corpuscular volume, 37.9 µ3; mean corpuscular hemoglobin, 17.4 µµg; mean corpuscular hemoglobin concentration, 47%; red cell sedimentation rate, 1.1 mm/hr; leukocytes, 18,000/mm3; neutrophils, 51%; eosinophils, 6%; basophils, 0.05%; lymphocytes, 40%; and monocytes, 3%. The electrophoretic mobility of camel hemoglobin was less than the mobility of human and monkey hemoglobin and the hemoglobinogram showed only one minor component. In the one-humped Indian camel, the number of red cells was less, the size bigger, and the hematocrit value lower than the values reported for the two-humped camel ( Camelus bactrianus).

scholarly journals Quantitative aspects of bilirubin metabolism for hematologists

Blood ◽  
1981 ◽  
Vol 57 (6) ◽  
pp. 983-999 ◽  
Author(s):  
NI Berlin ◽  
PD Berk
Keyword(s):  
Hemoglobin Concentration ◽  
Unconjugated Bilirubin ◽  
Cell Physiology ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Bilirubin Concentration ◽  
Bilirubin Metabolism ◽  
Red Cell Survival ◽  
The Mean ◽  
Kinetics Of

Abstract Techniques now available for the study of plasma disappearance kinetics of isotopically labeled unconjugated bilirubin have led to new insights into the factors that determine the plasma unconjugated bilirubin concentration (BR). This variable can be shown to depend in turn on five other parameters: the total circulating red cell volume (TRVC), the mean corpuscular hemoglobin concentration (MCHC), the mean red cell lifespan (RBCLS), plasma volume (PV), and the hepatic extraction coefficient for unconjugated bilirubin (ke). Of these, three clearly relect varying aspects of erythrokinetics and red cell physiology, while only one is reflective of liver function. It is not surprising, therefore, that knowledgeable interpretations of measurements of the plasma unconjugated bilirubin concentration can provide substantial information of value to the clinical hematologist. In particular, such interpretations can increase the sensitivity of these measurements as a screening test for the presence of hemolysis and provide the earliest indication of changes in red cell survival, as may occur during the therapy of various acquired hemolytic anemias. Furthermore, an understanding of the physiology of bilirubin in plasma substantially enhances the ability of the physician to categorize individual cases of hyperbilirubinemia as being due to hepatic dysfunction, hemolysis, or some combination of both.

scholarly journals Is diabetes responsible for an increase of the mean red cell volume?

Diabetologia ◽  
1981 ◽  
Vol 21 (4) ◽  
Author(s):  
L. Papoz ◽  
J.M. Warnet ◽  
E. Eschwege
Keyword(s):  
Cell Volume ◽  
Red Cell ◽  
Red Cell Volume ◽  
The Mean

Roles of cell geometry and cellular viscosity in red cell passage through narrow pores

1985 ◽  
Vol 248 (5) ◽  
pp. C473-C479 ◽  
Author(s):  
W. H. Reinhart ◽  
S. Chien
Keyword(s):  
Pore Size ◽  
Hemoglobin Concentration ◽  
Red Cells ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Cell Passage ◽  
Cell Deformability ◽  
Red Cell Deformability ◽  
Narrow Channels ◽  
The Mean

The relative roles of two fundamental determinants of red cell deformability, namely cell size and cellular viscosity, in affecting red cell passage through narrow channels have been assessed by determining the filterability of red cells subjected to osmotic variations. Suspensions of red cells (10(6) cells/microliter) in eight different osmolalities ranging from 172 +/- 3 (mean +/- SD) to 665 +/- 28 mosmol/kg H2O were filtered through polycarbonate sieves with three different pore diameters (2.6 +/- 0.2, 4.5 +/- 0.6, and 6.9 +/- 0.8 micron). The mean corpuscular volume varied inversely with osmolality and ranged from 149 +/- 9 to 67 +/- 10 fl; the mean corpuscular hemoglobin concentration varied directly with osmolality and ranged from 23.7 +/- 0.8 to 55.9 +/- 3.9 g/dl. The filtration data were analyzed with a theoretical model to derive the parameter beta, which is the ratio of resistance in a pore bearing a red blood cell to that in a pore filled with the suspending medium alone. For each pore size, beta showed a V-shaped relationship with osmolality; the optimum osmolality for minimum beta varied inversely with the pore size. For the small 2.6-micron pores, the minimum beta was attained following hyperosmotic shrinkage of the red cells at 400 mosmol/kg H2O, whereas passage through the large 6.9-micron pores was facilitated by hypoosmotic swelling of the red cells in about 200 mosmol/kg H2O. Red cell filtration through small pores is more sensitive to alterations in cell volume, whereas that through large pores is primarily determined by changes in cellular viscosity.(ABSTRACT TRUNCATED AT 250 WORDS)

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