Age of Onset of Cannabis Use is Associated with Age of Onset of High-Risk Symptoms for Psychosis

AbstractAttention allows us to select relevant information from the background. Although several studies have described that cannabis use induces deleterious effects on attention, it remains unclear if cannabis dependence affects the attention network systems differently.Objectives:To evaluate whether customary consumption of cannabis or cannabis dependence impacts the alerting, orienting, and executive control systems in young adults; to find out whether it is related to tobacco or alcohol dependence and if cannabis use characteristics are associated with the attention network systems.Method:One-hundred and fifty-four healthy adults and 102 cannabis users performed the Attention Network Test (ANT) to evaluate the alerting, orienting, and executive control systems.Results:Cannabis use enhanced the alerting system but decreased the orienting system. Moreover, those effects seem to be associated with cannabis dependence. Out of all the cannabis-using variables, only the age of onset of cannabis use significantly predicted the efficiency of the orienting and executive control systems.Conclusion:Cannabis dependence favors tonic alertness but reduces selective attention ability; earlier use of cannabis worsens the efficiency of selective attention and resolution of conflicts.

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Effects of cannabis use on event related potentials in subjects at ultra high risk for psychosis and healthy controls

International Journal of Psychophysiology ◽

10.1016/j.ijpsycho.2013.03.012 ◽

2013 ◽

Vol 88 (2) ◽

pp. 149-156 ◽

Cited By ~ 10

Author(s):

Mirjam J. van Tricht ◽

Emma C. Harmsen ◽

Johannes H.T.M. Koelman ◽

Lo J. Bour ◽

Thérèse A. van Amelsvoort ◽

...

Keyword(s):

High Risk ◽

Event Related Potentials ◽

Cannabis Use ◽

Healthy Controls ◽

Ultra High Risk ◽

Related Potentials

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Poster #172 EFFECT OF CANNABIS USE ON AGE OF ONSET. FINDINGS FROM A SAMPLE OF ITALIAN FIRSTEPISODE PSYCHOTIC PATIENTS

Schizophrenia Research ◽

10.1016/s0920-9964(12)71004-6 ◽

2012 ◽

Vol 136 ◽

pp. S343

Author(s):

Maria Valentina Rumeo ◽

Lucia Sideli ◽

Alice Mule ◽

Marta Di Forti ◽

Daniele La Barbera ◽

...

Keyword(s):

Age Of Onset ◽

Cannabis Use

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The association between cannabis use and outcome in pharmacological treatment for opioid use disorder

Harm Reduction Journal ◽

10.1186/s12954-021-00468-6 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Tea Rosic ◽

Raveena Kapoor ◽

Balpreet Panesar ◽

Leen Naji ◽

Darren B. Chai ◽

...

Keyword(s):

Side Effects ◽

Pharmacological Treatment ◽

Addiction Treatment ◽

Age Of Onset ◽

Opioid Use Disorder ◽

Cannabis Use ◽

Self Report ◽

Opioid Use ◽

Differential Outcomes ◽

Urine Drug

Abstract Background With the ongoing opioid crisis and policy changes regarding legalization of cannabis occurring around the world, it is necessary to consider cannabis use in the context of opioid use disorder (OUD) and its treatment. We aimed to examine (1) past-month cannabis use in patients with OUD, (2) self-reported cannabis-related side effects and craving, and (3) the association between specific characteristics of cannabis use and opioid use during treatment in cannabis users. Methods Participants receiving pharmacological treatment for OUD (n = 2315) were recruited from community-based addiction treatment clinics in Ontario, Canada, and provided information on past-month cannabis use (self-report). Participants were followed for 3 months with routine urine drug screens in order to assess opioid use during treatment. We used logistic regression analysis to explore (1) the association between any cannabis use and opioid use during treatment, and (2) amongst cannabis-users, specific cannabis use characteristics associated with opioid use. Qualitative methods were used to examine responses to the question: “What effect does marijuana have on your treatment?”. Results Past-month cannabis use was reported by 51% of participants (n = 1178). Any cannabis use compared to non-use was not associated with opioid use (OR = 1.03, 95% CI 0.87–1.23, p = 0.703). Amongst cannabis users, nearly 70% reported daily use, and half reported experiencing cannabis-related side effects, with the most common side effects being slower thought process (26.2%) and lack of motivation (17.3%). For cannabis users, daily cannabis use was associated with lower odds of opioid use, when compared with occasional use (OR = 0.61, 95% CI 0.47–0.79, p < 0.001) as was older age of onset of cannabis use (OR = 0.97, 95% CI 0.94, 0.99, p = 0.032), and reporting cannabis-related side effects (OR = 0.67, 95% CI 0.51, 0.85, p = 0.001). Altogether, 75% of cannabis users perceived no impact of cannabis on their OUD treatment. Conclusion Past-month cannabis use was not associated with more or less opioid use during treatment. For patients who use cannabis, we identified specific characteristics of cannabis use associated with differential outcomes. Further examination of characteristics and patterns of cannabis use is warranted and may inform more tailored assessments and treatment recommendations.

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An Australian Twin Study of Cannabis and Other Illicit Drug Use and Misuse, and Other Psychopathology

Twin Research and Human Genetics ◽

10.1017/thg.2012.41 ◽

2012 ◽

Vol 15 (5) ◽

pp. 631-641 ◽

Cited By ~ 45

Author(s):

Michael T. Lynskey ◽

Arpana Agrawal ◽

Anjali Henders ◽

Elliot C. Nelson ◽

Pamela A. F. Madden ◽

...

Keyword(s):

Drug Use ◽

Large Scale ◽

Illicit Drugs ◽

Illicit Drug ◽

Age Of Onset ◽

Cannabis Use ◽

Drug Use Disorders ◽

Illicit Drug Abuse ◽

Highly Correlated ◽

Adult Twins

Cannabis is the most widely used illicit drug throughout the developed world and there is consistent evidence of heritable influences on multiple stages of cannabis involvement including initiation of use and abuse/dependence. In this paper, we describe the methodology and preliminary results of a large-scale interview study of 3,824 young adult twins (born 1972–1979) and their siblings. Cannabis use was common with 75.2% of males and 64.7% of females reporting some lifetime use of cannabis while 24.5% of males and 11.8% of females reported meeting criteria for DSM-IV cannabis abuse or dependence. Rates of other drug use disorders and common psychiatric conditions were highly correlated with extent of cannabis involvement and there was consistent evidence of heritable influences across a range of cannabis phenotypes including early (≤15 years) opportunity to use (h2 = 72%), early (≤16 years) onset use (h2 = 80%), using cannabis 11+ times lifetime (h2 = 76%), and DSM abuse/dependence (h2 = 72%). Early age of onset of cannabis use was strongly associated with increased rates of subsequent use of other illicit drugs and with illicit drug abuse/dependence; further analyses indicating that some component of this association may have been mediated by increasing exposure to and opportunity to use other illicit drugs.

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Effects of Cannabis Use in Those at Ultra-High Risk for Psychosis

The Complex Connection Between Cannabis and Schizophrenia ◽

10.1016/b978-0-12-804791-0.00007-0 ◽

2018 ◽

pp. 167-181 ◽

Cited By ~ 3

Author(s):

Brian O'Donoghue ◽

Meredith McHugh ◽

Barnaby Nelson ◽

Patrick McGorry

Keyword(s):

High Risk ◽

Cannabis Use ◽

Ultra High Risk

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Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use

Brain and Behavior ◽

10.1002/brb3.1120 ◽

2018 ◽

Vol 8 (9) ◽

pp. e01120

Author(s):

Rohit J. Lodhi ◽

Yabing Wang ◽

David Rossolatos ◽

Georgina MacIntyre ◽

Alexandra Bowker ◽

...

Keyword(s):

Age Of Onset ◽

Cannabis Use ◽

Comt Val158met

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Relationships between Problematic Cannabis Use and Risky Behaviors in Spanish Adolescents

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16173029 ◽

2019 ◽

Vol 16 (17) ◽

pp. 3029

Author(s):

Raquel Alarcó-Rosales ◽

Miriam Sánchez-SanSegundo ◽

Rosario Ferrer-Cascales ◽

Natalia Albaladejo-Blázquez ◽

Nicolás Ruiz-Robledillo ◽

...

Keyword(s):

High Risk ◽

Motor Vehicle ◽

Motor Vehicle Accident ◽

Risky Behaviors ◽

Cannabis Use ◽

Physical Assault ◽

Cannabis Abuse ◽

The Past ◽

Vehicle Accident ◽

Increased Risk

This study examined the relations between problematic cannabis use, physical assault, and getting involved in a motor vehicle accident under the influence of cannabis in a sample of adolescents randomly selected from 25 public and semiprivate high schools in Alicante (Spain). Participants (n = 648) completed The Spanish National Standardized Survey about drug use in high school adolescents (ESTUDES, 2017), which includes the cannabis abuse screening test (CAST). Prevalence of cannabis use across the life-span and within the past 30 days was 37.5% and 17.4%, respectively. CAST scores were associated with an increased risk of driving under the effects of cannabis, riding shotgun, and physical assault, but not with an increased risk of having a motor vehicle accident. There were no differences between boys and girls in the association of problematic cannabis use with risky behaviors. This result highlights the importance of comprehensive prevention and education strategies for adolescents at high risk of cannabis use.

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