Determination of plasma concentrations of organochlorine pesticides and polychlorinated biphenyls in pet cats and dogs

2018 ◽  
Vol 34 (8) ◽  
pp. 541-553 ◽  
Author(s):  
Oguzhan Yavuz ◽  
Handan Hilal Arslan ◽  
Cagatay Esin ◽  
Yavuz Kursad Das ◽  
Abdurrahman Aksoy
Keyword(s):  
Polychlorinated Biphenyls ◽  
Organochlorine Pesticides ◽  
Plasma Concentrations ◽  
Plasma Samples ◽  
Domestic Cats ◽  
Potential Health ◽  
High Prevalence ◽  
Lipid Weight ◽  
First Time

The aim of this study was the determination of plasma concentrations of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in cats and dogs and evaluation of their prevalence and possible effects. The concentrations of nine OCPs, such as α-hexachlorocyclohexane (HCH), β-HCH, γ-HCH, hexachlorobenzene (HCB), aldrin, 2,4′-dichlorodiphenyltrichloroethane (2,4′-DDT), 4,4′-DDT, 2,4′-dichlorodiphenyldichloroethylene (2,4′-DDE) and 4,4′-DDE and 16 PCBs (PCB-28, -52, -70, -74, -81, -99, -101, -118, -138, -153, -156, -170, -180, -183, -187 and -208) were evaluated in the plasma samples of pet cats ( n = 15) and dogs ( n = 21). The concentrations of OCPs ranged from 1.12 ng g−1 lipid weight (lw) to 7.65 ng g−1 lw in cats and from 1.25 ng g−1 lw to 6.79 ng g−1 lw in dogs. In addition, mean PCB levels were 0.58–5.66 and 0.52–6.62 ng g−1 lw in cats and dogs, respectively. β-HCH, γ-HCH and PCB-138 levels were significantly higher in dogs ( p < 0.05). As far as could be determined, OCPs and PCBs were detected in the plasma samples of domestic cats and dogs in Turkey for the first time. Their concentrations were similar to those reported in earlier studies abroad. However, in contrast to other research, the levels of some OCPs were higher in dogs than in cats. It is concluded that, because of their high prevalence and potential health effects in animals and humans, OCP and PCB levels should be monitored systematically in domestic cats and dogs.

Development of an HPLC-UV Method for Quantification of Stattic

2019 ◽  
Vol 15 (6) ◽  
pp. 568-573
Author(s):  
Soheil Sedaghat ◽  
Ommoleila Molavi ◽  
Akram Faridi ◽  
Ali Shayanfar ◽  
Mohammad Reza Rashidi
Keyword(s):  
High Performance ◽  
Accurate Method ◽  
Plasma Samples ◽  
Promising Target ◽  
Relative Standard ◽  
Dimerization Inhibitor ◽  
Oncogenic Protein ◽  
First Time ◽  
Transcription 3

Background: Signal transducer and activator of transcription 3 (STAT3), an oncogenic protein found constitutively active in many types of human malignancies, is considered to be a promising target for cancer therapy. Objective: In this study for the first time, a simple and accurate method has been developed for the determination of a STAT3 dimerization inhibitor called stattic in aqueous and plasma samples. Methods: A reverse-phase high-performance liquid chromatography (RP-HPLC) composed of C18 column as stationary phase, and the mixture of acetonitrile (60%) and water (40%) as mobile phase with a UV detection at 215 nm were applied for quantification of stattic. The developed method was validated by Food and Drug Administration (FDA) guideline. Results: The method provided a linear range between 1-40 and 2.5-40 µg mL-1 for aqueous and plasma samples, respectively, with a correlation coefficient of 0.999. The accuracy (as recovery) of the developed method was found to be between 95-105% for aqueous medium and 85-115% for plasma samples. The precision (as relative standard deviation) for aqueous and plasma samples was less than 6% and 15%, respectively. The sensitivity of the developed method based on FDA guideline was 1 µg mL-1 for aqueous and 2.5 µg mL-1 for plasma samples. Conclusion: These results show that the established method is a fast and accurate quantification for stattic in aqueous and plasma samples.

High throughput method for the determination of organochlorine pesticides and polychlorinated biphenyls in human serum

2007 ◽  
Vol 852 (1-2) ◽  
pp. 15-21 ◽  
Author(s):  
Fernando Goñi ◽  
Raul López ◽  
Arsenio Etxeandia ◽  
Esmeralda Millán ◽  
Pilar Amiano
Keyword(s):  
Polychlorinated Biphenyls ◽  
Human Serum ◽  
Organochlorine Pesticides ◽  
High Throughput ◽  
High Throughput Method

Determination of Selected Organochlorine Pesticides and Polychlorinated Biphenyls in Human Serum*

1990 ◽  
Vol 14 (3) ◽  
pp. 137-142 ◽  
Author(s):  
Virlyn W. Burse ◽  
Susan L. Head ◽  
Margaret P. Korver ◽  
Patricia C. McClure ◽  
John F. Donahue ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Human Serum ◽  
Organochlorine Pesticides

Determination of polychlorinated biphenyls and organochlorine pesticides in Chinese mitten crabs (Eriocheir sinensis) using modified QuEChERS followed by GC-MS

2020 ◽  
Vol 12 (18) ◽  
pp. 2398-2406
Author(s):  
Ting Liu ◽  
Jianguang Zhou ◽  
Li He ◽  
Jinhua Gan
Keyword(s):  
Polychlorinated Biphenyls ◽  
Organochlorine Pesticides ◽  
Eriocheir Sinensis ◽  
Simultaneous Analysis ◽  
Quechers Method ◽  
Modified Quechers ◽  
Mitten Crabs

A new QuEChERS method followed by GC-MS was developed for the simultaneous analysis of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in Chinese mitten crabs.

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