Relating Hair Growth Theory and Experimental Evidence to Practical Hair Transplantation

1994 ◽  
Vol 11 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Bobby L. Limmer ◽  
Ronald Razmi ◽  
Thomas Davis ◽  
Charles Stevens
Keyword(s):  
Experimental Evidence ◽  
Hair Growth ◽  
Androgenetic Alopecia ◽  
Growth Theory ◽  
Follicular Growth ◽  
Hair Transplantation ◽  
Terminal Hair ◽  
Male Patients ◽  
Hair Shafts ◽  
Germinal Cells

Hair transplantation methods as generally practiced utilize grafting of full follicles. Recent experimental evidence suggests that germinal cells responsible for follicular growth and differentiation may reside in specific localized areas within the follicle. This study was performed to relate experimental evidence to practical hair transplantation and to discuss results obtained from implantation of ½ follicular grafts. The study was done on four male patients with androgenetic alopecia who underwent transplantation with follicular half autografts. A total of 697 grafts of the upper ½ follicles and 694 grafts of lower ½ follicles were implanted. The results demonstrated that 50 hair shafts were produced from 697 upper ½ grafts, and 152 hair shafts from 694 lower ½ grafts. The conclusion is that the low percentage of terminal hair growth from ½ follicular grafts preclude this technique as an alternative method for cosmetic hair transplantation.

scholarly journals Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Young Hye Cho ◽  
Sang Yeoup Lee ◽  
Dong Wook Jeong ◽  
Eun Jung Choi ◽  
Yun Jin Kim ◽  
...  
Keyword(s):  
Placebo Group ◽  
Hair Growth ◽  
Seed Oil ◽  
Scalp Hair ◽  
Treated Group ◽  
Androgenetic Alopecia ◽  
Double Blind ◽  
Pumpkin Seed ◽  
Male Patients ◽  
Pumpkin Seed Oil

Pumpkin seed oil (PSO) has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats. This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of PSO for treatment of hair growth in male patients with mild to moderate androgenetic alopecia (AGA). 76 male patients with AGA received 400 mg of PSO per day or a placebo for 24 weeks. Change over time in scalp hair growth was evaluated by four outcomes: assessment of standardized clinical photographs by a blinded investigator; patient self-assessment scores; scalp hair thickness; and scalp hair counts. Reports of adverse events were collected throughout the study. After 24 weeks of treatment, self-rated improvement score and self-rated satisfaction scores in the PSO-treated group were higher than in the placebo group (P = 0.013, 0.003). The PSO-treated group had more hair after treatment than at baseline, compared to the placebo group (P<0.001). Mean hair count increases of 40% were observed in PSO-treated men at 24 weeks, whereas increases of 10% were observed in placebo-treated men (P<0.001). Adverse effects were not different in the two groups.

scholarly journals Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia

2021 ◽  
Vol 8 ◽  
Author(s):  
Saranya Khunkhet ◽  
Kumutnart Chanprapaph ◽  
Suthinee Rutnin ◽  
Poonkiat Suchonwanit
Keyword(s):  
Donor Site ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Occipital Region ◽  
Terminal Hair ◽  
Male Patients ◽  
The Mean ◽  
Scalp Biopsy ◽  
Control Study ◽  
Histopathological Evidence

Background: The occipital region of the scalp is generally accepted as an unaffected area of androgenetic alopecia (AGA) for both genders. However, evidence of AGA involving the occipital scalp has been demonstrated in women; meanwhile, it is unclear whether occipital involvement also occurs in men.Objective: We aimed to determine if there is occipital involvement in men with AGA.Methods: This case-control study compared hair counts of scalp biopsy specimens from the occipital region of 82 men with Hamilton-Norwood III-VII and 82 unaffected men.Results: The mean ages of men with AGA and controls were 40.1 ± 8.9 and 38.6 ± 10.5 years, respectively (P = 0.291). A significant decrease in total hair follicles, terminal hair follicles, follicular units and terminal to vellus (T:V) ratio, along with a significant increase in follicular stelae was indicated in the AGA group compared to controls (all P &lt; 0.05). Subgroup analyses revealed that average counts of total hair follicles, terminal hair follicles and T:V ratios were also significantly lower in males with Hamilton-Norwood VI and VII than in controls (all P &lt; 0.05). There were no correlations between increasing age and hair count parameters, but a significant negative association was found between total follicle numbers and disease duration (r = −0.23, P = 0.02).Conclusions: AGA can involve the occipital area of male patients with advanced disease. Therefore, the occiput of particular cases should not be used to determine reference data for normal scalp hair, and preoperative measurements of miniaturized hairs in the donor site are strongly recommended in all persons undergoing hair transplantation.

scholarly journals Comparative study of follicular unit yield in elliptical versus trapezoid donor strip in hair transplantation

2021 ◽  
Vol 7 (3) ◽  
pp. 375
Author(s):  
Savitha A. Somaiah ◽  
Nirmal Balakrishnan ◽  
Sacchidanand Sarvajnamurthy
Keyword(s):  
Comparative Study ◽  
Hair Loss ◽  
Classical Method ◽  
The Other ◽  
Androgenetic Alopecia ◽  
Hair Transplantation ◽  
Strip Method ◽  
Donor Area ◽  
Male Patients ◽  
Unit Yield

<p class="abstract"><strong>Background:</strong> Hair transplantation is a surgical method of management of hair loss. The classical method involves harvesting an elliptical strip from the donor area and dissection follicular units, which are then implanted into the recipient area. A modification of elliptical strip is trapezoid strip, where the ends are tapered to a trapezoid to reduce the transection of follicles.</p><p class="abstract"><strong>Methods:</strong> 12 male patients with androgenetic alopecia undergoing hair transplantation by strip method were included in the study. One cm strip was harvested from the donor area in all the patients. One end of the strip was designed elliptical and the other end was trapezoid. The ends were dissected and follicular grafts were counted.</p><p class="abstract"><strong>Results:</strong> The trapezoid end of strip yielded more follicular units in 10 out of 12 cases (83.3%), one was equal and in one case the elliptical end had a greater yield.</p><p class="abstract"><strong>Conclusions:</strong> Transection of follicular units in the ends of donor strip can be minimized by 30-40% by harvesting a trapezoid strip. The grafts harvested were 28.3% more in the trapezoid end of the strip than the elliptical end.</p>

Androgenetic alopecia: Hair transplantation surgery update

2021 ◽  
Author(s):  
Baltazar Sanabria ◽  
Gabriel H. Fachini ◽  
Paulo M. Ramos
Keyword(s):  
Androgenetic Alopecia ◽  
Hair Transplantation ◽  
Transplantation Surgery

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

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