Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

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Hair Growth Promotion by Extracts of Inula Helenium and Caesalpinia Sappan Bark in Patients with Androgenetic Alopecia: A Pre-clinical Study Using Phototrichogram Analysis

Cosmetics ◽

10.3390/cosmetics6040066 ◽

2019 ◽

Vol 6 (4) ◽

pp. 66

Author(s):

Hyoung Chul Choi ◽

Gae Won Nam ◽

Noh Hee Jeong ◽

Bu Young Choi

Keyword(s):

Clinical Study ◽

Hair Loss ◽

Hair Growth ◽

Blood Circulation ◽

Growth Promotion ◽

Test Group ◽

Androgenetic Alopecia ◽

Hair Density ◽

Caesalpinia Sappan ◽

Inula Helenium

Inula helenium (IH) is known to possess antifungal, anti-bacterial, anti-helminthic, and anti-proliferation activities. Caesalpinia Sappan (CS) is known to reduce inflammation and improve blood circulation. Based on their folkloric use, these plants are expected to be promising candidates for promoting hair growth and preventing hair loss. Moreover, these plants are rich sources of certain phytochemicals, which have been reported to promote hair growth. In this clinical trial, we investigate the efficacy of a scalp shampoo formulated by mixing extracts of IH and CS in preventing hair loss and promoting hair growth in patients with androgenetic alopecia. Using a phototrichogram (Folliscope 2.8, LeadM, Korea), we compared the hair density and total hair counts in patients receiving the scalp shampoo at baseline, and at 8, 16, and 24 weeks after use of the shampoo. We found a statistically significant increase in the total hair count in the test group (n = 23) after 16 and 24 weeks of using the scalp shampoo (2.17 n/cm2 ± 5.72, p < 0.05; and 4.30 n/cm2 ± 6.37, p < 0.01, respectively) as compared to the control subjects. Based on the results of this clinical study, we conclude that the IH and CS extract complex is a promising remedy for preventing hair loss and promoting hair growth.

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Plants as potential active components in treatment of androgenetic alopecia

Herba Polonica ◽

10.2478/hepo-2014-0005 ◽

2014 ◽

Vol 60 (1) ◽

pp. 49-56 ◽

Cited By ~ 2

Author(s):

Renata Dawid-Pać ◽

Maria Urbańska ◽

Ilona Dębosz ◽

Gerard Nowak

Keyword(s):

Sex Hormones ◽

Growth Phase ◽

Hair Growth ◽

Raw Materials ◽

Hair Follicles ◽

Androgenetic Alopecia ◽

Active Components ◽

Plant Raw Materials ◽

Reductase Inhibitors ◽

Hereditary Factors

Summary Androgenetic alopecia is caused by the influence of sex hormones on hair follicles and by hereditary factors. Characteristic for that type of alopecia is shortening of the hair growth phase and elongation of the rest phase caused by disturbance of the process of transformation of testosterone into dihydrotestosterone. Treatment of that type of alopecia involves 5α-reductase inhibitors, antagonists of the androgenic receptor or stimulating proliferation of cells to induce the hair growth. A number of plant raw materials work that way, thus they can be used in treatment of this type of alopecia.

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Autologous activated platelet‐rich plasma in hair growth: A pilot study in male androgenetic alopecia with in vitro bioactivity investigation

Journal of Cosmetic Dermatology ◽

10.1111/jocd.13709 ◽

2020 ◽

Author(s):

Yinghui Zhou ◽

Qingmei Liu ◽

Yanshuang Bai ◽

Kai Yang ◽

Yaqi Ye ◽

...

Keyword(s):

Pilot Study ◽

Hair Growth ◽

Platelet Rich Plasma ◽

Androgenetic Alopecia ◽

In Vitro Bioactivity

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Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/549721 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 16

Author(s):

Young Hye Cho ◽

Sang Yeoup Lee ◽

Dong Wook Jeong ◽

Eun Jung Choi ◽

Yun Jin Kim ◽

...

Keyword(s):

Placebo Group ◽

Hair Growth ◽

Seed Oil ◽

Scalp Hair ◽

Treated Group ◽

Androgenetic Alopecia ◽

Double Blind ◽

Pumpkin Seed ◽

Male Patients ◽

Pumpkin Seed Oil

Pumpkin seed oil (PSO) has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats. This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of PSO for treatment of hair growth in male patients with mild to moderate androgenetic alopecia (AGA). 76 male patients with AGA received 400 mg of PSO per day or a placebo for 24 weeks. Change over time in scalp hair growth was evaluated by four outcomes: assessment of standardized clinical photographs by a blinded investigator; patient self-assessment scores; scalp hair thickness; and scalp hair counts. Reports of adverse events were collected throughout the study. After 24 weeks of treatment, self-rated improvement score and self-rated satisfaction scores in the PSO-treated group were higher than in the placebo group (P = 0.013, 0.003). The PSO-treated group had more hair after treatment than at baseline, compared to the placebo group (P<0.001). Mean hair count increases of 40% were observed in PSO-treated men at 24 weeks, whereas increases of 10% were observed in placebo-treated men (P<0.001). Adverse effects were not different in the two groups.

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