Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

Hair Growth in a Patient with Alopecia Areata on Tocilizumab

2021 ◽  
pp. 1-5
Author(s):  
Chloe J. Walker ◽  
Kelly E. Flanagan ◽  
James T. Pathoulas ◽  
Isabel Pupo Wiss ◽  
Maryanne M. Senna
Keyword(s):  
Monoclonal Antibody ◽  
Autoimmune Disease ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Interleukin 6 ◽  
Hair Growth ◽  
Posterior Uveitis ◽  
Case Presentation ◽  
Antibody Targeting ◽  
Growth Changes

<b><i>Introduction:</i></b> Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ. <b><i>Case Presentation:</i></b> Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis. <b><i>Discussion:</i></b> Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

scholarly journals Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1808 ◽  
Author(s):  
Gennaro Riccio ◽  
Eduardo Sommella ◽  
Nadia Badolati ◽  
Emanuela Salviati ◽  
Sara Bottone ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Hair Loss ◽  
Hair Growth ◽  
Treatment Options ◽  
Pentose Phosphate ◽  
Hair Follicles ◽  
Common Side Effect ◽  
Safe Alternative ◽  
Polyphenolic Extract

Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. Even months after the end of chemotherapy, many cancer patients complain of hair loss, a condition that is psychologically difficult to manage. CIA disturbs social and sexual interactions and causes anxiety and depression. Synthetic drugs protecting from CIA and endowed with hair growth stimulatory properties are prescribed with caution by oncologists. Hormones, growth factors, morphogens could unwontedly protect tumour cells or induce cancer cell proliferation and are thus considered incompatible with many chemotherapy regimens. Nutraceuticals, on the contrary, have been shown to be safe and effective treatment options for hair loss. We here show that polyphenols from Malus Pumila Miller cv Annurca are endowed with hair growth promoting activity and can be considered a safe alternative to avoid CIA. In vitro, Annurca Apple Polyphenolic Extract (AAE) protects murine Hair Follicles (HF) from taxanes induced dystrophy. Moreover, in virtue of its mechanism of action, AAE is herein proven to be compatible with chemotherapy regimens. AAE forces HFs to produce ATP using mitochondrial β-oxidation, reducing Pentose Phosphate Pathway (PPP) rate and nucleotides production. As consequence, DNA replication and mitosis are not stimulated, while a pool of free amino acids usually involved in catabolic reactions are spared for keratin production. Moreover, measuring the effect exerted on Poly Unsaturated Fatty Acid (PUFA) metabolism, we prove that AAE promotes hair-growth by increasing the intracellular levels of Prostaglandins F2α (PGF2α) and by hijacking PUFA catabolites toward β-oxidation.

scholarly journals Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss

2017 ◽  
Vol 4 (7) ◽  
pp. 58-58 ◽  
Author(s):  
Pietro Gentile ◽  
Maria G. Scioli ◽  
Alessandra Bielli ◽  
Augusto Orlandi ◽  
Valerio Cervelli
Keyword(s):  
Stem Cells ◽  
Hair Loss ◽  
Human Hair ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Clinical Use ◽  
Mechanical Isolation

scholarly journals Hair Growth Promotion by Extracts of Inula Helenium and Caesalpinia Sappan Bark in Patients with Androgenetic Alopecia: A Pre-clinical Study Using Phototrichogram Analysis

Cosmetics ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 66
Author(s):  
Hyoung Chul Choi ◽  
Gae Won Nam ◽  
Noh Hee Jeong ◽  
Bu Young Choi
Keyword(s):  
Clinical Study ◽  
Hair Loss ◽  
Hair Growth ◽  
Blood Circulation ◽  
Growth Promotion ◽  
Test Group ◽  
Androgenetic Alopecia ◽  
Hair Density ◽  
Caesalpinia Sappan ◽  
Inula Helenium

Inula helenium (IH) is known to possess antifungal, anti-bacterial, anti-helminthic, and anti-proliferation activities. Caesalpinia Sappan (CS) is known to reduce inflammation and improve blood circulation. Based on their folkloric use, these plants are expected to be promising candidates for promoting hair growth and preventing hair loss. Moreover, these plants are rich sources of certain phytochemicals, which have been reported to promote hair growth. In this clinical trial, we investigate the efficacy of a scalp shampoo formulated by mixing extracts of IH and CS in preventing hair loss and promoting hair growth in patients with androgenetic alopecia. Using a phototrichogram (Folliscope 2.8, LeadM, Korea), we compared the hair density and total hair counts in patients receiving the scalp shampoo at baseline, and at 8, 16, and 24 weeks after use of the shampoo. We found a statistically significant increase in the total hair count in the test group (n = 23) after 16 and 24 weeks of using the scalp shampoo (2.17 n/cm2 ± 5.72, p < 0.05; and 4.30 n/cm2 ± 6.37, p < 0.01, respectively) as compared to the control subjects. Based on the results of this clinical study, we conclude that the IH and CS extract complex is a promising remedy for preventing hair loss and promoting hair growth.

scholarly journals Plants as potential active components in treatment of androgenetic alopecia

2014 ◽  
Vol 60 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Renata Dawid-Pać ◽  
Maria Urbańska ◽  
Ilona Dębosz ◽  
Gerard Nowak
Keyword(s):  
Sex Hormones ◽  
Growth Phase ◽  
Hair Growth ◽  
Raw Materials ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Active Components ◽  
Plant Raw Materials ◽  
Reductase Inhibitors ◽  
Hereditary Factors

Summary Androgenetic alopecia is caused by the influence of sex hormones on hair follicles and by hereditary factors. Characteristic for that type of alopecia is shortening of the hair growth phase and elongation of the rest phase caused by disturbance of the process of transformation of testosterone into dihydrotestosterone. Treatment of that type of alopecia involves 5α-reductase inhibitors, antagonists of the androgenic receptor or stimulating proliferation of cells to induce the hair growth. A number of plant raw materials work that way, thus they can be used in treatment of this type of alopecia.

HOW WIGS AND WOMEN’S BEAUTY SUPPLY PRODUCTS MOVE THROUGHOUT THE SUPPLY CHAIN

2018 ◽  
Vol 3 (10) ◽  
Author(s):  
Alexa Green ◽  
Felicia Jefferson
Keyword(s):  
Supply Chain ◽  
Epithelial Cells ◽  
Literature Review ◽  
Hair Loss ◽  
Outer Layer ◽  
Hair Growth ◽  
Review Paper ◽  
Hair Follicles ◽  
Key Factors ◽  
Sebaceous Glands

Everyone wants shine, softness, and hair strength, all key factors in having healthy hair. The purpose of this literature review is to provide information about healthy hair growth. Research states that the hair grows from follicles within the skin. Hair follicles are sacs where hair grows and where the sebaceous glands open. The follicles lined by cells derived from the epidermal. Keratin protects epithelial cells from damage and it makes up the outer layer of human skin. Even though there are many ways you can grow your hair, there are many ways you can lose your hair as well. This review paper also explains disorders that can cause hair loss.

scholarly journals Hair Follicles from Alopecia Areata Patients Exhibit Alterations in Immune Privilege-Associated Gene Expression in Advance of Hair Loss

2010 ◽  
Vol 130 (11) ◽  
pp. 2677-2680 ◽  
Author(s):  
Hoon Kang ◽  
Wen-Yu Wu ◽  
Blanche K.K. Lo ◽  
Mei Yu ◽  
Gigi Leung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Follicles ◽  
Immune Privilege

scholarly journals Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata - part II

2012 ◽  
Vol 87 (6) ◽  
pp. 884-890 ◽  
Author(s):  
Betina Werner ◽  
Fabiane Mulinari-Brenner
Keyword(s):  
Differential Diagnosis ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Diagnostic Approach ◽  
Androgenetic Alopecia

Diffuse alopecia is mainly caused by telogen effluvium, diffuse androgenetic alopecia (femalepattern hair loss) and diffuse alopecia areata. Differential diagnosis between the three disorders may be difficult in several occasions. In this second part of our study, chronic telogen effluvium and diffuse alopecia areata are discussed in detail, including clinical, dermoscopic and histological aspects. A flowchart presents a practical and objective differential diagnostic approach to diffuse alopecia.

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