Local Delivery of BMP-2 from Poly(lactic-co-glycolic acid) Microspheres Incorporated into Porous Nanofibrous Scaffold for Bone Tissue Regeneration

2017 ◽  
Vol 13 (11) ◽  
pp. 1446-1456 ◽  
Author(s):  
Weizhong Wang ◽  
Yingke Miao ◽  
Xiaojun Zhou ◽  
Wei Nie ◽  
Liang Chen ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Glycolic Acid ◽  
Local Delivery ◽  
Nanofibrous Scaffold ◽  
Bone Tissue Regeneration

Fibers Obtaining and Characterization Using Poly (Lactic-co-Glycolic Acid) and Poly (Isoprene) Containing Hydroxyapatite and α TCP Calcium Phosphate by Electrospinning Method

2014 ◽  
Vol 631 ◽  
pp. 173-178
Author(s):  
Fernanda Albrecht Vechietti ◽  
D. Marques ◽  
Nathália Oderich Muniz ◽  
Luis Alberto Santos
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Glycolic Acid ◽  
Bone Tissue Regeneration ◽  
Morphological Properties ◽  
Polymeric Fibers ◽  
Natural Bone ◽  
Electrospinning Method ◽  
Biological Apatite ◽  
The One

Natural bone is formed by a complex composite, essentially constituted of biological apatite and fibers of collagen. The combination of materials such as biopolymers and bioceramics may result in an interesting material for application in bone tissue regeneration. This work aims to obtain polymeric fibers containing Poly (Lactic-co-Glycolic Acid) and Poly (Isoprene), supplemented with hydroxyapatite (HA) and α-tricalcium phosphate (TCP). The thermal, mechanical and morphological properties of the fibers were evaluated . Even presenting a larger diameter, fibers with α-TCP presented lower elastic modulus than fibers with HA. Both fibers presented similar thermal behavior, with glass transition temperature in the same range that the one presented by raw PLGA and similar degradation temperatures. Is safe to say that the presence of ceramics in the fibers have a potential for further investigations aiming bone tissue regeneration.

Biological and mechanical evaluation of poly(lactic-co-glycolic acid)-based composites reinforced with 1D, 2D and 3D carbon biomaterials for bone tissue regeneration

2017 ◽  
Vol 12 (2) ◽  
pp. 025012 ◽  
Author(s):  
Tejinder Kaur ◽  
Senthilguru Kulanthaivel ◽  
Arunachalam Thirugnanam ◽  
Indranil Banerjee ◽  
Krishna Pramanik
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Glycolic Acid ◽  
Bone Tissue Regeneration ◽  
2D And 3D

Enhanced osteogenic differentiation and bone regeneration of poly(lactic-co-glycolic acid) by graphene via activation of PI3K/Akt/GSK-3β/β-catenin signal circuit

2018 ◽  
Vol 6 (5) ◽  
pp. 1147-1158 ◽  
Author(s):  
Xiaowei Wu ◽  
Shang Zheng ◽  
Yuanzhou Ye ◽  
Yuchen Wu ◽  
Kaili Lin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Glycolic Acid ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Autologous Bone ◽  
Potential Strategy ◽  
Gsk 3Β ◽  
Reconstruction Of Bone Defects

The reconstruction of bone defects by guiding autologous bone tissue regeneration with graphene-based biomaterials is a potential strategy in the area of bone tissue engineering.

Preparation of spherical macroporous poly(lactic‐co‐glycolic acid) for bone tissue regeneration

2015 ◽  
Vol 9 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Chunhui Bian ◽  
Huiming Lin ◽  
Xiaofeng Li ◽  
Jie Ma ◽  
Pingping Jiang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Glycolic Acid ◽  
Bone Tissue Regeneration

scholarly journals Local delivery of bone morphogenetic protein-2 from near infrared-responsive hydrogels for bone tissue regeneration

Biomaterials ◽  
2020 ◽  
Vol 241 ◽  
pp. 119909 ◽  
Author(s):  
Silvia Sanchez-Casanova ◽  
Francisco M. Martin-Saavedra ◽  
Clara Escudero-Duch ◽  
Maria I. Falguera Uceda ◽  
Martin Prieto ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Near Infrared ◽  
Local Delivery ◽  
Bone Morphogenetic Protein 2 ◽  
Bone Tissue Regeneration ◽  
Morphogenetic Protein ◽  
Responsive Hydrogels

scholarly journals The Construction of Multi-Incorporated Polylactic Composite Nanofibrous Scaffold for the Potential Applications in Bone Tissue Regeneration

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2402
Author(s):  
Du Nie ◽  
Yi Luo ◽  
Guang Li ◽  
Junhong Jin ◽  
Shenglin Yang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Composite Scaffold ◽  
Nanofibrous Scaffold ◽  
Bone Tissue Regeneration ◽  
Calcium Deposition ◽  
Regeneration Ability ◽  
Bioactive Components ◽  
Bone Mesenchymal Stem Cells ◽  
Potential Applications

To improve the bone regeneration ability of pure polymer, varieties of bioactive components were incorporated to a biomolecular scaffold with different structures. In this study, polysilsesquioxane (POSS), pearl powder and dexamethasone loaded porous carbon nanofibers (DEX@PCNFs) were incorporated into polylactic (PLA) nanofibrous scaffold via electrospinning for the application of bone tissue regeneration. The morphology observation showed that the nanofibers were well formed through electrospinning process. The mineralization test of incubation in simulated body fluid (SBF) revealed that POSS incorporated scaffold obtained faster hydroxyapatite depositing ability than pristine PLA nanofibers. Importantly, benefitting from the bioactive components of pearl powder like bone morphogenetic protein (BMP), bone mesenchymal stem cells (BMSCs) cultured on the composite scaffold presented higher proliferation rate. In addition, by further incorporating with DEX@PCNFs, the alkaline phosphatase (ALP) level and calcium deposition were a little higher based on pearl powder. Consequently, the novel POSS, pearl powder and DEX@PCNFs multi-incorporated PLA nanofibrous scaffold can provide better ability to enhance the biocompatibility and accelerate osteogenic differentiation of BMSCs, which has potential applications in bone tissue regeneration.

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