Polyvinylidene Fluoride as a Suture Material: Evaluation of Comet Tail-Like Infiltrate and Foreign Body Granuloma

2015 ◽  
Vol 55 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
Andreas Lambertz ◽  
Kai Michael Schröder ◽  
Dominik Stefan Schöb ◽  
Marcel Binnebösel ◽  
Michael Anurov ◽  
...  
Keyword(s):  
Foreign Body ◽  
Polyvinylidene Fluoride ◽  
Foreign Body Reaction ◽  
Suture Material ◽  
Foreign Body Granuloma ◽  
Male Rats ◽  
Comet Tail ◽  
Suture Materials ◽  
Tissue Integration

Background: Biocompatibility and tissue integration of a surgical suture are decisive factors for wound healing and therefore for the success of sutures. The optimal suture material is still under discussion. Polyvinylidene fluoride (PVDF) is described to have superior properties of biocompatibility and is therefore frequently used as a mesh component. Only little information is available about its use as a suture material. The aim of this study was to evaluate the biocompatibility of PVDF as a suture material in comparison to 5 different established sutures in a rat model. Methods: In 30 male rats, a monofilamental PVDF suture (Resopren®) and 5 established control suture materials [polyester (Miralene®), polytetrafluoroethylene (Gore®), poliglecaprone (Monocryl®), polydioxanone (Monoplus®), polyglactin 910 (Vicryl®), USP size 3-0] were placed in the subcutaneous layer of the abdominal wall without knot or tension. After 3, 7 or 21 days, the abdominal walls were explanted for histopathological and immunohistochemical investigation with special regard to the size and quality of foreign body granuloma and the length of the comet tail-like infiltrate (CTI). Results: The PVDF sutures showed the smallest size of foreign body granuloma (60 ± 14 µm) and the smallest CTI length (343 ± 60 µm) of all polymers after 21 days. Only PVDF (Resopren) and polydioxanone (Monoplus) showed a significant collagen I/III ratio increase between days 3 and 21 (p = 0.009 and p = 0.016). The quality of foreign body reaction regarding inflammation, proliferation and fibrotic remodeling was similar between all suture materials. Conclusions: Our data indicate that monofilamental PVDF sutures show a favorable foreign body reaction with small granuloma sizes and CTI length in comparison to established sutures. Its use as a suture material in general surgery could therefore be extended in the future. To reinforce these findings, further clinical studies need to be conducted.

The reaction of the soft tissues of the anterior abdominal wall to various suture material

1982 ◽  
Vol 63 (4) ◽  
pp. 72-74
Author(s):  
V. P. Nefedov ◽  
R. M. Ramazanov
Keyword(s):  
Foreign Body ◽  
Abdominal Wall ◽  
Soft Tissues ◽  
Suture Material ◽  
Anterior Abdominal Wall ◽  
The Body ◽  
Reactive Changes ◽  
Healing Processes

The healing processes of sutured wounds of soft tissues in most cases depend on the type and quality of the suture material. Any kind of suture material in the tissues of the body is a foreign body that causes various reactive changes from the tissues. The nature of these changes, all other things being equal, is mainly determined by the type of suture material, its thickness and the method of sterilization of the tissues on which the sutures are applied, the trauma of surgery, the infection of the wound and the irritating effect of the threads on the tissues.

Plastic Deformation of Polyvinylidene Fluoride and Polypropylene Suture Materials Used for Hernia Repair

2013 ◽  
Vol 641-642 ◽  
pp. 456-459
Author(s):  
Ying Chu Wang ◽  
Pei Hua Zhang
Keyword(s):  
Experimental Data ◽  
Plastic Deformation ◽  
Polyvinylidene Fluoride ◽  
Suture Material ◽  
Element Model ◽  
Creep Model ◽  
Suitable Model ◽  
Suture Materials ◽  
Creep Curves ◽  
Materials Used

This paper studied the irreversible plastic deformation of PVDF monofilament. The four-element creep model was applied to obtain the theoretical creep curves with experimental data using nonlinear regression. The results were compared to the commonly used material PP monofilament. The results showed that four-element model was a suitable model to describe the creep behavior of PVDF monofilament. PVDF monofilament exhibited reduced irreversible plastic deformation under different stresses and elongation rates. It was more stable and recoverable. PVDF could be an advantageous alternative suture material to the traditional suture materials.

Foreign body reaction to suture material mimicking malignant microcalcifications in the breast.

1994 ◽  
Vol 162 (3) ◽  
pp. 729-729 ◽  
Author(s):  
V L Schiller ◽  
C Bos ◽  
R J Brenner ◽  
R R Turner
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Suture Material

Absorbale or Nonabsorbable Suture Materials for Closure of the Dura Mater?

Neurosurgery ◽  
1981 ◽  
Vol 9 (4) ◽  
pp. 407-413 ◽  
Author(s):  
Bertil Vãllfors ◽  
Hans-Arne Hansson ◽  
Joel Svensson
Keyword(s):  
Foreign Body ◽  
Dura Mater ◽  
Polyglycolic Acid ◽  
Vascular Supply ◽  
Foreign Material ◽  
Suture Materials ◽  
Brain Surface ◽  
Foreign Body Reactions ◽  
The Brain

Abstract This study was undertaken to determine which suture material would give the best results for closure of the dura mater. Because there is no need for the suture to remain longer than until healing has occurred and as remaining foreign material will predispose to foreign body reactions and infection. it was consideered important to test new absorbable materials like polyglactin 910 (Vicryl) and polyglycolic acid (Dexon) for closure of the dura mater. The reactions from these materials were compared to those of silk and polyester (Ethibond) in doge 60 days after the suture of dural incisions. The quality of healing with respect to the smoothness of the subdural surface, the presence of adhesions between sutures and the brain surface, the degree of absorption of the material, and reactions around the sutures were evaluated. Vicryl gave the best results. Providing a smooth subdural surface without adhesions. It was almost totally absorbed when healing was completed, in contrast to Dexon and the other materials. The cellular reaction around Vicryl was slight. Silk, Ethibond, and Dexon protruded from the subdural surface and adhesions to the arachnoid were common. When the dura mater was removed. these adhesions tore off the leptomeninges with their vascular supply to the cortex. The results of these experiments seem to justify the recommendation of Vicryl for suturing of the dura mater. Such an absorbable material decreases the risk of foreign body reactions, and infections will be more easily combated because of the absence of foreign material. The lack of subdural adhesions is an advantage if reoperation in necessary.

scholarly journals Bletilla striata polysaccharide cryogel scaffold for spatial control of foreign-body reaction

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jiaxi Chen ◽  
Huiqun Zhou ◽  
Daping Xie ◽  
Yiming Niu
Keyword(s):  
Foreign Body ◽  
Pore Size ◽  
Foreign Body Reaction ◽  
Inflammatory Cells ◽  
Host Tissue ◽  
Bletilla Striata ◽  
Pore Sizes ◽  
Tissue Integration

Abstract Background Implantation of a biomaterial may induce the foreign-body reaction to the host tissue that determines the outcome of the integration and the biological performance of the implants. The foreign-body reaction can be modulated by control of the material properties of the implants. Methods First, we synthesized methacrylated Bletilla striata Polysaccharide (BSP-MA) and constructed a series of open porous cryogels utilizing this material via the freezing-thawing treatment of solvent-precursors systems. Second, Pore size and modulus were measured to characterize the properties of BSP cryogels. Live/dead staining of cells and CCK-8 were performed to test the cytocompatibility of the scaffolds. In addition, the Real-Time qPCR experiments were carried for the tests. Finally, the BSP scaffolds were implanted subcutaneously to verify the foreign-body reaction between host tissue and materials. Results Our data demonstrated that cryogels with different pore sizes and modulus can be fabricated by just adjusting the concentration. Besides, the cryogels showed well cytocompatibility in the in vitro experiments and exhibited upregulated expression levels of pro-inflammation-related genes (Tnfa and Il1b) with the increase of pore size. In vivo experiments further proved that with the increase of pore size, more immune cells infiltrated into the inner zone of materials. The foreign-body reaction and the distribution of immune-regulatory cells could be modulated by tuning the material microstructure. Conclusions Collectively, our findings revealed Bletilla striata polysaccharide cryogel scaffold with different pore sizes can spatially control foreign-body reaction. The microstructure of cryogels could differentially guide the distribution of inflammatory cells, affect the formation of blood vessels and fibrous capsules, which eventually influence the material-tissue integration. This work demonstrates a practical strategy to regulate foreign body reaction and promote the performance of medical devices.

scholarly journals Implantable Drug Delivery Systems and Foreign Body Reaction: Traversing the Current Clinical Landscape

2021 ◽  
Vol 8 (12) ◽  
pp. 205
Author(s):  
Alexey Fayzullin ◽  
Alesia Bakulina ◽  
Karen Mikaelyan ◽  
Anatoly Shekhter ◽  
Anna Guller
Keyword(s):  
Drug Delivery ◽  
Foreign Body ◽  
Drug Delivery Systems ◽  
Foreign Body Reaction ◽  
Delivery Systems ◽  
Treatment Schedule ◽  
Tissue Integration ◽  
Transport Barriers ◽  
Drug Eluting ◽  
Implantable Drug Delivery Systems

Precise delivery of therapeutics to the target structures is essential for treatment efficiency and safety. Drug administration via conventional routes requires overcoming multiple transport barriers to achieve and maintain the local drug concentration and commonly results in unwanted off-target effects. Patients’ compliance with the treatment schedule remains another challenge. Implantable drug delivery systems (IDDSs) provide a way to solve these problems. IDDSs are bioengineering devices surgically placed inside the patient’s tissues to avoid first-pass metabolism and reduce the systemic toxicity of the drug by eluting the therapeutic payload in the vicinity of the target tissues. IDDSs present an impressive example of successful translation of the research and engineering findings to the patient’s bedside. It is envisaged that the IDDS technologies will grow exponentially in the coming years. However, to pave the way for this progress, it is essential to learn lessons from the past and present of IDDSs clinical applications. The efficiency and safety of the drug-eluting implants depend on the interactions between the device and the hosting tissues. In this review, we address this need and analyze the clinical landscape of the FDA-approved IDDSs applications in the context of the foreign body reaction, a key aspect of implant–tissue integration.

A peritoneal defect covered by intraperitoneal mesh prosthesis effects an increased and distinctive foreign body reaction in a minipig model

2020 ◽  
Vol 35 (6) ◽  
pp. 732-739
Author(s):  
Roman Marius Eickhoff ◽  
Andreas Kroh ◽  
Simon Eickhoff ◽  
Daniel Heise ◽  
Marius Julian Helmedag ◽  
...  
Keyword(s):  
Foreign Body ◽  
Polyvinylidene Fluoride ◽  
Foreign Body Reaction ◽  
Minimal Invasive ◽  
Mesh Placement ◽  
Mesh Prosthesis ◽  
Onlay Mesh ◽  
Intraperitoneal Onlay Mesh Technique ◽  
Hydrogel Coating

Background The incidence of incisional hernia is with up to 30% one of the frequent long-term complication after laparotomy. After establishing minimal invasive operations, the laparoscopic intraperitoneal onlay mesh technique (lap. IPOM) was first described in 1993. Little is known about the foreign body reaction of IPOM-meshes, which covered a defect of the parietal peritoneum. This is becoming more important, since IPOM procedure with peritoneal-sac resection and hernia port closing (IPOM plus) is more frequently used. Methods In 18 female minipigs, two out of three Polyvinylidene-fluoride (PVDF) -meshes (I: standard IPOM; II: IPOM with modified structure [bigger pores]; III: IPOM with the same structure as IPOM II + degradable hydrogel-coating) were placed in a laparoscopic IPOM procedure. Before mesh placement, a 2x2cm peritoneal defect was created. After 30 days, animals were euthanized, adhesions were evaluated by re-laparoscopy and mesh samples were explanted for histological and immunohistochemichal investigations. Results All animals recovered after implantation and had no complications during the follow-up period. Analysing foreign body reaction, the IPOM II mesh had a significant smaller inner granuloma, compared to the other meshes (IPOM II: 8.4 µm ± 1.3 vs. IPOM I 9.1 µm ± 1.3, p < 0.001). The degradable hydrogel coating does not prevent adhesions measured by Diamond score (p = 0.46). A peritoneal defect covered by a standard or modified IPOM mesh was a significant factor for increasing foreign body granuloma, the amount of CD3+ lymphocytes, CD68+ macrophages and decrease of pore size. Conclusion A peritoneal defect covered by IPOM prostheses leads to an increased foreign body reaction compared to intact peritoneum. Whenever feasible, a peritoneal defect should be closed accurately before placing an IPOM-mesh to avoid an excessive foreign body reaction and therefore inferior biomaterial properties of the prosthesis.

scholarly journals Improvement of the Electronic—Neuronal Interface by Natural Deposition of ECM

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1378
Author(s):  
Tobias Weigel ◽  
Julian Brennecke ◽  
Jan Hansmann
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Carbon Nanofiber ◽  
Human Fibroblasts ◽  
Porous Electrode ◽  
Modified Electrodes ◽  
Dermal Fibroblasts ◽  
Microscopy Imaging ◽  
Tissue Integration ◽  
A Minor

The foreign body reaction to neuronal electrode implants limits potential applications as well as the therapeutic period. Developments in the basic electrode design might improve the tissue compatibility and thereby reduce the foreign body reaction. In this work, the approach of embedding 3D carbon nanofiber electrodes in extracellular matrix (ECM) synthesized by human fibroblasts for a compatible connection to neuronal cells was investigated. Porous electrode material was manufactured by solution coelectrospinning of polyacrylonitrile and polyamide as a fibrous porogen. Moreover, NaCl represented an additional particulate porogen. To achieve the required conductivity for an electrical interface, meshes were carbonized. Through the application of two different porogens, the electrodes’ flexibility and porosity was improved. Human dermal fibroblasts were cultured on the electrode surface for ECM generation and removed afterwards. Scanning electron microscopy imaging revealed a nano fibrous ECM network covering the carbon fibers. The collagen amount of the ECM coating was quantified by hydroxyproline-assays. The modification with the natural protein coating on the electrode functionality resulted in a minor increase of the electrical capacity, which slightly improved the already outstanding electrical interface properties. Increased cell numbers of SH-SY5Y cell line on ECM-modified electrodes demonstrated an improved cell adhesion. During cell differentiation, the natural ECM enhanced the formation of neurites regarding length and branching. The conducted experiments indicated the prevention of direct cell-electrode contacts by the modification, which might help to shield temporary the electrode from immunological cells to reduce the foreign body reaction and improve the electrodes’ tissue integration.

AN ANALYSIS OF PARTIAL WIDTH FLEXOR TENDON GRAFT PREPARATION ON PORCINE MODELS: THE OPTIMAL SPLIT?

Hand Surgery ◽  
2010 ◽  
Vol 15 (02) ◽  
pp. 99-102
Author(s):  
Toby Colegate-Stone ◽  
Richard Allom ◽  
Adel Tavakkolizadeh ◽  
John Compson
Keyword(s):  
Suture Material ◽  
Flexor Tendon ◽  
Tendon Graft ◽  
Partial Width ◽  
Suture Materials ◽  
Average Force ◽  
Handling Characteristics ◽  
Tendon Grafts ◽  
Flexor Tendon Graft

Partial width tendon grafts are commonly used in upper limb reconstructive surgery. Different techniques are described to harvest the graft including a "cheese wire" technique to split the tendon along its fibres with a filament. However no study has looked at the best material for this purpose. Fresh flexor tendons from pigs' trotters were used to analyse the splitting qualities of 11 different suture materials. The qualities assessed were: whether the suture material was successful in splitting the tendon, the average force required to split the tendon and the resulting quality of the spilt tendon graft. Whilst wire sutures produced a high quality of graft, they were awkward to use as they necessitated handling with a holder due to the higher forces required to split the tendon. Fibrewire provided the best result with respect to graft quality and ease of method as it combined the cutting strength of wire with the handling characteristics of a braided suture.

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