Representativeness of the PDOPPS cohort compared to the Australian PD population

Background: The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is an international, prospective study following persons treated by peritoneal dialysis (PD) to identify modifiable practices associated with improvements in PD technique and person survival. The aim of this study was to assess the representativeness of the Australian cohort included in PDOPPS compared to the complete Australian PD population, as reported to the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. Methods: Adults with at least one PD treatment reported to ANZDATA Registry during the census period of PDOPPS Phase I (November 2014 to April 2018) were compared to the Australian PDOPPS cohort. The primary outcomes were the representativeness of centres and persons. Secondary outcomes explored the association of person characteristics with consent to study participation. Results: After data linkage, 511 PDOPPS participants were compared to 5616 Australians treated with PD. Within centres eligible for PDOPPS, selected centres were similar to other Australian centres. The PDOPPS participants’ cohort tended to include older persons, more males, a higher proportion of Caucasians and more persons with higher socioeconomic advantage compared to the Australian PD population. Differences in distribution across sex and ethnicities between the PDOPPS cohort and the overall PD population were in part due to the selection and consent processes, during which females and non-Caucasians were more likely to not consent to PDOPPS participation. Conclusion: Sampling methods used in PDOPPS allowed for good national representativeness of the included centres. However, representativeness of the unweighted PDOPPS sample was suboptimal in regard to some participant characteristics.

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The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS): Unifying Efforts to Inform Practice and Improve Global Outcomes in Peritoneal Dialysis

Peritoneal Dialysis International ◽

10.3747/pdi.2014.00288 ◽

2016 ◽

Vol 36 (3) ◽

pp. 297-307 ◽

Cited By ~ 45

Author(s):

Jeffrey Perl ◽

Simon J. Davies ◽

Mark Lambie ◽

Ronald L. Pisoni ◽

Keith McCullough ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Practice Patterns ◽

International Study ◽

The United States ◽

Primary Objective ◽

Technique Survival ◽

Related Data ◽

Patient Reported ◽

Dialysis Outcomes ◽

Technique Failure

Background Extending technique survival on peritoneal dialysis (PD) remains a major challenge in optimizing outcomes for PD patients while increasing PD utilization. The primary objective of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is to identify modifiable practices associated with improvements in PD technique and patient survival. In collaboration with the International Society for Peritoneal Dialysis (ISPD), PDOPPS seeks to standardize PD-related data definitions and provide a forum for effective international collaborative clinical research in PD. Methods The PDOPPS is an international prospective cohort study in Australia, Canada, Japan, the United Kingdom (UK), and the United States (US). Each country is enrolling a random sample of incident and prevalent patients from national samples of 20 to 80 sites with at least 20 patients on PD. Enrolled patients will be followed over an initial 3-year study period. Demographic, comorbidity, and treatment-related variables, and patient-reported data, will be collected over the study course. The primary outcome will be all-cause PD technique failure or death; other outcomes will include cause-specific technique failure, hospitalizations, and patient-reported outcomes. Results A high proportion of the targeted number of study sites has been recruited to date in each country. Several ancillary studies have been funded with high momentum toward expansion to new countries and additional participation. Conclusion The PDOPPS is the first large, international study to follow PD patients longitudinally to capture clinical practice. With data collected, the study will serve as an invaluable resource and research platform for the international PD community, and provide a means to understand variation in PD practices and outcomes, to identify optimal practices, and to ultimately improve outcomes for PD patients.

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The Peritoneal Dialysis Outcomes and Practice Patterns Study

Applied Peritoneal Dialysis ◽

10.1007/978-3-030-70897-9_28 ◽

2021 ◽

pp. 395-410

Author(s):

Belinda Stallard ◽

David W. Johnson ◽

Jeffrey Perl ◽

Simon J. Davies

Keyword(s):

Peritoneal Dialysis ◽

Practice Patterns ◽

Dialysis Outcomes

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MO061EARLY PERITONEAL DIALYSIS ATTRITION: PRELIMINARY RESULTS FROM THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS)

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx124.mo061 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii71-iii71 ◽

Cited By ~ 1

Author(s):

Jeffrey Perl ◽

Junhui Zhao ◽

Brian Bieber ◽

Keith McCullough ◽

Yun Li ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Practice Patterns ◽

Preliminary Results ◽

Dialysis Outcomes

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Regional variation in the treatment and prevention of peritoneal dialysis-related infections in the Peritoneal Dialysis Outcomes and Practice Patterns Study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfy204 ◽

2018 ◽

Vol 34 (12) ◽

pp. 2118-2126 ◽

Cited By ~ 14

Author(s):

Neil Boudville ◽

David W Johnson ◽

Junhui Zhao ◽

Brian A Bieber ◽

Ronald L Pisoni ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Infection Prevention ◽

Practice Patterns ◽

Antibiotic Administration ◽

Exit Site ◽

Prevention And Treatment ◽

The Usa ◽

Dialysis Outcomes ◽

The Uk ◽

The Impact

AbstractBackgroundPeritoneal dialysis (PD)-related infections lead to significant morbidity. The International Society for Peritoneal Dialysis (ISPD) guidelines for the prevention and treatment of PD-related infections are based on variable evidence. We describe practice patterns across facilities participating in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).MethodsPDOPPS, a prospective cohort study, enrolled nationally representative samples of PD patients in Australia/New Zealand (ANZ), Canada, Thailand, Japan, the UK and the USA. Data on PD-related infection prevention and treatment practices across facilities were obtained from a survey of medical directors’.ResultsA total of 170 centers, caring for >11 000 patients, were included. The proportion of facilities reporting antibiotic administration at the time of PD catheter insertion was lowest in the USA (63%) and highest in Canada and the UK (100%). Exit-site antimicrobial prophylaxis was variably used across countries, with Japan (4%) and Thailand (28%) having the lowest proportions. Exit-site mupirocin was the predominant exit-site prophylactic strategy in ANZ (56%), Canada (50%) and the UK (47%), while exit-site aminoglycosides were more common in the USA (72%). Empiric Gram-positive peritonitis treatment with vancomycin was most common in the UK (88%) and USA (83%) compared with 10–45% elsewhere. Empiric Gram-negative peritonitis treatment with aminoglycoside therapy was highest in ANZ (72%) and the UK (77%) compared with 10–45% elsewhere.ConclusionsVariation in PD-related infection prevention and treatment strategies exist across countries with limited uptake of ISPD guideline recommendations. Further work will aim to understand the impact these differences have on the wide variation in infection risk between facilities and other clinically relevant PD outcomes.

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Variation in Peritoneal Dialysis–Related Peritonitis Outcomes in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2021.03.022 ◽

2021 ◽

Author(s):

Muthana Al Sahlawi ◽

Junhui Zhao ◽

Keith McCullough ◽

Douglas S. Fuller ◽

Neil Boudville ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Practice Patterns ◽

Dialysis Outcomes

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SP444INTERNATIONAL VARIATIONS IN THE EXPERIENCE OF PATIENTS ON PERITONEAL DIALYSIS (PD) IN THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (PDOPPS)

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfw171.15 ◽

2016 ◽

Vol 31 (suppl_1) ◽

pp. i239-i240

Author(s):

Fredric O Finkelstein ◽

Junhui Zhao ◽

Brian Bieber ◽

S. Vanita Jassal ◽

Hal Morgenstern ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Practice Patterns ◽

Dialysis Outcomes

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Peritoneal Dialysis–Related Infection Rates and Outcomes: Results From the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2019.09.016 ◽

2020 ◽

Vol 76 (1) ◽

pp. 42-53 ◽

Cited By ~ 8

Author(s):

Jeffrey Perl ◽

Douglas S. Fuller ◽

Brian A. Bieber ◽

Neil Boudville ◽

Talerngsak Kanjanabuch ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Practice Patterns ◽

Infection Rates ◽

Dialysis Outcomes

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MON-077 EXPLORING THE STATUS OF PERITONEAL DIALYSIS PRACTICES AND OUTCOMES IN SOUTH KOREA: PARTICIPATION IN THE PERITONEAL DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY

Kidney International Reports ◽

10.1016/j.ekir.2019.05.866 ◽

2019 ◽

Vol 4 (7) ◽

pp. S335-S336

Author(s):

Y.L. Kim ◽

K.H. Oh ◽

S.H. Park ◽

B. Robinson ◽

R. Pisoni ◽

...

Keyword(s):

Peritoneal Dialysis ◽

South Korea ◽

Practice Patterns ◽

The Status ◽

Dialysis Outcomes

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International comparison of peritoneal dialysis prescriptions from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)

Peritoneal Dialysis International ◽

10.1177/0896860819895356 ◽

2020 ◽

Vol 40 (3) ◽

pp. 310-319

Author(s):

Angela Yee-Moon Wang ◽

Junhui Zhao ◽

Brian Bieber ◽

Talerngsak Kanjanabuch ◽

Martin Wilkie ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Practice Patterns ◽

Urine Volume ◽

Japanese Patients ◽

Urea Clearance ◽

Patient Reported ◽

The Us ◽

Dialysis Outcomes ◽

The Uk

Background: We describe peritoneal dialysis (PD) prescription variations among Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) participants on continuous ambulatory PD (CAPD) and automated PD (APD; n = 4657) from Australia/New Zealand (A/NZ), Canada, Japan, Thailand, United Kingdom (UK), and United States (US). Results: CAPD was more commonly used in Thailand and Japan, while APD predominated over CAPD in A/NZ, Canada, the US, and the UK. Total prescribed PD volume normalized to the surface area was the highest in Thailand and the lowest in Japan (for both APD and CAPD) and the UK (for CAPD). PD patients from Thailand had the lowest residual urine volume and residual renal urea clearance, yet achieved the highest dialysis urea clearance. Japanese patients had the lowest dialysis urea clearances for both APD and CAPD. Despite having similar urine volumes to patients in A/NZ, Canada, Japan, and the UK, US CAPD and APD patients used 2.5% and 3.86% glucose PD solutions more frequently, whereas fewer than 25% of these patients used icodextrin. Over half of the patients in A/NZ, Canada, the UK, and Japan used icodextrin, whereas it was hardly used in Thailand. Japan and Thailand were more likely to use 1.5% glucose solutions for their PD prescription. Conclusions: There are considerable international variations in PD modality use and prescription patterns that translate into important differences in achieved dialysis clearances. Ongoing recruitment of additional PDOPPS participants and accrual of follow-up time will allow us to test the associations between specific PD prescription regimens and clinical and patient-reported outcomes.

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