Mechanistic models to predict thrust force and torque in bone drilling: An in-vitro study validated with robot-assisted surgical drilling parameters

2021 ◽  
pp. 095440892110259
Author(s):  
Varatharajan Prasannavenkadesan ◽  
Ponnusamy Pandithevan
Keyword(s):  
Mechanistic Model ◽  
Preliminary Investigation ◽  
Cutting Parameters ◽  
Mechanistic Models ◽  
Drill Bit ◽  
Bone Drilling ◽  
Robot Assisted ◽  
Line Field ◽  
Thrust Forces

Compression plates are widely used in orthopaedic surgeries for internal fixation of fractured femurs. To fix the plate and thus to provide compression to a fracture, the self-tapping bone screws are tightened through predrilled pilot holes of smaller diameter. Preliminary investigation showed that the holes drilled with the inappropriate cutting parameters cause mechanical and thermal damages to the local host bone, which further lead to loosening of internal fixations. In this paper, the mechanistic models to predict the thrust forces and torques during bone drilling were developed, using a 3.20 mm diameter drill bit. As a procedure, the cutting action was investigated at three different regions of the drill point, namely cutting lips, secondary cutting edges and indentation zone. The models employed the analytical approach to account for the drill-bit geometry and cutting parameters, and an empirical approach to account for the material and friction properties. To complete the procedure, calibration experiments were conducted on bovine cortical femurs with two different spindle speeds (1000 and 3000 r/min) and feeds (0.03 and 0.06 mm/rev), and then the specific normal and friction coefficients were determined. The developed mechanistic models were validated with different ranges of parameters (500–3500 r/min speeds, and 0.02–0.07 mm/rev feeds) those commonly involved in manual and robot-assisted surgery. The validation study revealed that the thrust forces predicted using the mechanistic models showed a maximum error of only 5.80%. However, the torques predicted from the mechanistic model found with more error than the thrust forces. The predominant reasons for this under-prediction might because of the extrapolation used to determine the specific cutting pressures, slip-line field applied to the indentation zone instead of compressive fracture, and chip clogging involved during the bone drilling as demonstrated in earlier studies. Despite the deviations, the developed mechanistic models satisfactorily follow the trends of the thrust forces and torques experienced during bone drilling. The outcomes can be used to practice the bone drilling procedure and monitor the effect of process parameters on thrust forces and torques in the in-silico environment before performing actual surgery.

Optimization of Drill Bits for Bone Drilling Procedure

2018 ◽  
Author(s):  
Jianbo Sui ◽  
Naohiko Sugita
Keyword(s):  
Genetic Algorithm ◽  
Mechanistic Model ◽  
Drill Bit ◽  
Bone Drilling ◽  
Drill Bits ◽  
Wide Range ◽  
Drilling Conditions

The paper presents a methodology to optimize drill bits to realize safe drilling of bone materials for many surgeries like orthopedics and neurosurgery. First, a mechanistic model is introduced to relate drilling forces to main drill bit geometry parameters. Then a genetic algorithm is developed to optimize drill bit geometry parameters by minimization of drilling forces based on the mechanistic model. Finally prototypes of drill bits with optimized geometry parameters are produced and drilling experiments are conducted to verify the advantages of these new drill bits. The results show that by comparison with normal drill bit, the average drilling forces are reduced to more than 50% by drill bits with optimized geometry parameters under a wide range of drilling conditions.

scholarly journals In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Edward A. K. Smith ◽  
N. T. Henthorn ◽  
J. W. Warmenhoven ◽  
S. P. Ingram ◽  
A. H. Aitkenhead ◽  
...  
Keyword(s):  
Dna Damage ◽  
Phenomenological Models ◽  
Mechanistic Model ◽  
Treatment Plan ◽  
Mechanistic Models ◽  
Relative Distribution ◽  
Proof Of Concept ◽  
Change Analysis ◽  
Dna Damage And Repair

AbstractThere is strong in vitro cell survival evidence that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors such as linear energy transfer (LET) and dose. This is coupled with the growing in vivo evidence, from post-treatment image change analysis, of a variable RBE. Despite this, a constant RBE of 1.1 is still applied as a standard in proton therapy. However, there is a building clinical interest in incorporating a variable RBE. Recently, correlations summarising Monte Carlo-based mechanistic models of DNA damage and repair with absorbed dose and LET have been published as the Manchester mechanistic (MM) model. These correlations offer an alternative path to variable RBE compared to the more standard phenomenological models. In this proof of concept work, these correlations have been extended to acquire RBE-weighted dose distributions and calculated, along with other RBE models, on a treatment plan. The phenomenological and mechanistic models for RBE have been shown to produce comparable results with some differences in magnitude and relative distribution. The mechanistic model found a large RBE for misrepair, which phenomenological models are unable to do. The potential of the MM model to predict multiple endpoints presents a clear advantage over phenomenological models.

scholarly journals The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wuyang Huang ◽  
Ky Young Cho ◽  
Di Meng ◽  
W. Allan Walker
Keyword(s):  
Lactic Acid ◽  
Mechanistic Model ◽  
Transcriptomic Analysis ◽  
Dependent Manner ◽  
Protective Effects ◽  
Very Preterm Infants ◽  
Anti Inflammatory ◽  
The Impact

AbstractAn excessive intestinal inflammatory response may have a role in the pathogenesis of necrotizing enterocolitis (NEC) in very preterm infants. Indole-3-lactic acid (ILA) of breastmilk tryptophan was identified as the anti-inflammatory metabolite involved in probiotic conditioned media from Bifidobacteria longum subsp infantis. This study aimed to explore the molecular endocytic pathways involved in the protective ILA effect against inflammation. H4 cells, Caco-2 cells, C57BL/6 pup and adult mice were used to compare the anti-inflammatory mechanisms between immature and mature enterocytes in vitro and in vivo. The results show that ILA has pleiotropic protective effects on immature enterocytes including anti-inflammatory, anti-viral, and developmental regulatory potentials in a region-dependent and an age-dependent manner. Quantitative transcriptomic analysis revealed a new mechanistic model in which STAT1 pathways play an important role in IL-1β-induced inflammation and ILA has a regulatory effect on STAT1 pathways. These studies were validated by real-time RT-qPCR and STAT1 inhibitor experiments. Different protective reactions of ILA between immature and mature enterocytes indicated that ILA’s effects are developmentally regulated. These findings may be helpful in preventing NEC for premature infants.

scholarly journals Simulating the Effects of Intensifying Silviculture on Desired Species Yields across a Broad Environmental Gradient

Forests ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 755
Author(s):  
Eric B. Searle ◽  
F. Wayne Bell ◽  
Guy R. Larocque ◽  
Mathieu Fortin ◽  
Jennifer Dacosta ◽  
...  
Keyword(s):  
Climate Change ◽  
Forest Management ◽  
Planning Process ◽  
Mechanistic Model ◽  
Natural Disturbance ◽  
Fine Tuning ◽  
Mechanistic Models ◽  
Paradigm Shifts ◽  
Ecological Processes ◽  
Forest Modelling

In the past two decades, forest management has undergone major paradigm shifts that are challenging the current forest modelling architecture. New silvicultural systems, guidelines for natural disturbance emulation, a desire to enhance structural complexity, major advances in successional theory, and climate change have all highlighted the limitations of current empirical models in covering this range of conditions. Mechanistic models, which focus on modelling underlying ecological processes rather than specific forest conditions, have the potential to meet these new paradigm shifts in a consistent framework, thereby streamlining the planning process. Here we use the NEBIE (a silvicultural intervention scale that classifies management intensities as natural, extensive, basic, intensive, and elite) plot network, from across Ontario, Canada, to examine the applicability of a mechanistic model, ZELIG-CFS (a version of the ZELIG tree growth model developed by the Canadian Forest Service), to simulate yields and species compositions. As silvicultural intensity increased, overall yield generally increased. Species compositions met the desired outcomes when specific silvicultural treatments were implemented and otherwise generally moved from more shade-intolerant to more shade-tolerant species through time. Our results indicated that a mechanistic model can simulate complex stands across a range of forest types and silvicultural systems while accounting for climate change. Finally, we highlight the need to improve the modelling of regeneration processes in ZELIG-CFS to better represent regeneration dynamics in plantations. While fine-tuning is needed, mechanistic models present an option to incorporate adaptive complexity into modelling forest management outcomes.

scholarly journals Application of the 1-µsec pulsed-dye laser to the treatment of experimental cerebral vasospasm

1991 ◽  
Vol 75 (2) ◽  
pp. 271-276 ◽  
Author(s):  
Atsushi Teramura ◽  
Robert Macfarlane ◽  
Christopher J. Owen ◽  
Ralph de la Torre ◽  
Kenton W. Gregory ◽  
...  
Keyword(s):  
Cerebral Vasospasm ◽  
Basilar Artery ◽  
Laser Energy ◽  
Autologous Blood ◽  
Preliminary Investigation ◽  
Dye Laser ◽  
Pulsed Dye Laser ◽  
Content Type

✓ Laser energy of 480 nm was applied in 1-µsec pulses varying between 2.2 and 10 mJ to in vitro and in vivo models of cerebral vasospasm. First, the pulsed-dye laser was applied intravascularly via a 320-µm fiber to basilar artery segments from six dogs. The segments were mounted in a vessel-perfusion apparatus and constricted to, on average, 70% of resting diameter by superfusion with dog hemolysate. Immediate increase in basilar artery diameter occurred to a mean of 83% of control. In a second model, the basilar artery was exposed transclivally in the rabbit. In three normal animals, superfusion of the artery with rabbit hemolysate resulted in a reduction of mean vessel diameter to 81% of control. Following extravascular application of the laser, vessels returned to an average of 106% of the resting state. In six rabbits, the basilar artery was constricted by two intracisternal injections of autologous blood, 3 days apart. Two to 4 days after the second injection, the basilar artery was exposed. Extravascular laser treatment from a quartz fiber placed perpendicular to the vessel adventitia resulted in an immediate 53% average increase in caliber to an estimated 107% of control. No reconstriction was observed over a period of up to 5 hours. Morphologically, damage to the arterial wall was slight. This preliminary investigation suggests that the 1-µsec pulsed-dye laser may be of benefit in the treatment of cerebral vasospasm.

Stray Electrical Currents in Laparoscopic Instruments Used in da Vinci® Robot-Assisted Surgery: An In Vitro Study

2011 ◽  
Vol 25 (9) ◽  
pp. 1513-1517 ◽  
Author(s):  
Carlos E. Mendez-Probst ◽  
George Vilos ◽  
Andrew Fuller ◽  
Alfonso Fernandez ◽  
Paul Borg ◽  
...  
Keyword(s):  
Da Vinci ◽  
In Vitro Study ◽  
Vitro Study ◽  
Robot Assisted ◽  
Electrical Currents ◽  
Laparoscopic Instruments ◽  
Robot Assisted Surgery
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