Letter to the editor on the article “Alteration of redox status by commonly used antimalarial drugs in the north-western region of Nigeria” by Muhammad A et al.

2018 ◽  
Vol 37 (11) ◽  
pp. 1244-1246
Author(s):  
K Szewczyk-Golec ◽  
R Wesołowski ◽  
I Hołyńska-Iwan
Keyword(s):  
Infectious Diseases ◽  
Malaria Infection ◽  
Redox Status ◽  
Antimalarial Drugs ◽  
Western Region ◽  
The North ◽  
Letter To The Editor ◽  
North Western ◽  
Antimalarial Action

Malaria belongs to the most dangerous infectious diseases globally. Every effort to understand the mechanisms involved in Plasmodium spp. malaria infection and the antimalarial action cannot be overestimated. We have read with great interest the recently published article by Muhammad et al. entitled “Alteration of redox status by commonly used antimalarial drugs in the north-western region of Nigeria.” Several questions have arisen about the conducted study that we would like to comment on.

Induction of Haemolysis and DNA Fragmentation in a Normal and Malarial-Infected Blood by Commonly - used Antimalarial Drugs in the North-Western Region of Nigeria

2016 ◽  
Vol 10 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Aliyu Muhammad ◽  
Mohammed Ibrahim ◽  
Ochuko Erukainure ◽  
Nathan Habila ◽  
Aimola Idowu ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Antimalarial Drugs ◽  
Western Region ◽  
Infected Blood ◽  
The North ◽  
North Western

Alteration of redox status by commonly used antimalarial drugs in the north-western region of Nigeria

2016 ◽  
Vol 36 (2) ◽  
pp. 176-183 ◽  
Author(s):  
A Muhammad ◽  
MA Ibrahim ◽  
HA Mohammed ◽  
OL Erukainure ◽  
I Malami ◽  
...  
Keyword(s):  
Reduced Glutathione ◽  
Control Sample ◽  
Redox Status ◽  
Normal Blood ◽  
Western Region ◽  
Healthy Humans ◽  
The North ◽  
Dose Dependent ◽  
North Western ◽  
Apparently Healthy

This study was designed to investigate the alteration of redox status by commonly used antimalarials in Nigeria. Drugs used were artemisinin, artesunate, chloroquine, coartem and quinine at the final concentrations of 0.5–8.0 mg/mL. Blood samples were collected from malarial patients and apparently healthy humans for comparison. Reduced glutathione, catalase, superoxide dismutase (SOD) activities, protein content and lipid peroxidation were determined. All drugs significantly ( p < 0.05) increases the protein level relative to control in normal blood, whereas in the infected, a significant ( p < 0.05) reduction was observed. In normal blood, the antimalarials dose dependently decreased ( p < 0.05) SOD and catalase activities with significant ( p < 0.05) increase in the infected. The level of glutathione in normal blood significantly ( p < 0.05) increases as compared with control, whereas in the infected, similar observation was made except that the levels were less, relative to control sample. Malondialdehyde level significantly ( p < 0.05) increases with increase in drugs concentration even though less than the level in the control with few exceptions. These effects were dose dependent and more pronounced in non-malarial conditions. Commonly used antimalarials might alter the redox status in both healthy and non-healthy subjects thereby inducing oxidative stress.

U-Pb on Zircon and Monazite Geochronology of Granites of the Zhytomyr and Sheremetiv Complexes, the North-Western Region of the Ukrainian Shield

2018 ◽  
Vol 40 (2) ◽  
pp. 63-85 ◽  
Author(s):  
L. Shumlyanskyy ◽  
L. Stepanyuk ◽  
S. Claesson ◽  
K. Rudenko ◽  
A. Bekker
Keyword(s):  
Ukrainian Shield ◽  
Western Region ◽  
The North ◽  
North Western

scholarly journals Hospital training for general practice: views of trainees in the North Western region.

BMJ ◽  
1989 ◽  
Vol 298 (6685) ◽  
pp. 1432-1434 ◽  
Author(s):  
H. Reeve ◽  
A. Bowman
Keyword(s):  
General Practice ◽  
Western Region ◽  
The North ◽  
North Western

scholarly journals Chronicle and mix

2020 ◽  
Vol V (4) ◽  
pp. 214-216
Author(s):  
B. I. Vorotynsky
Keyword(s):  
Mentally Ill ◽  
District Hospital ◽  
The State ◽  
Western Region ◽  
State Council ◽  
Medical Department ◽  
Public Funds ◽  
The North ◽  
District Hospitals ◽  
North Western

- The Ministry of Internal Affairs for the Medical Department is included in the State Council with a presentation on borrowing from the capital of public funds the amounts necessary for the construction of District Hospitals for the mentally ill. These sums will also be used to build the District Hospital in Vilnius, designed for the provinces of the north-western region.

Grey Based Decision Making for Evaluating Sustainable Performance of Indian Marble Industries

2019 ◽  
Vol 8 (2) ◽  
pp. 1-18
Author(s):  
Om Ji Shukla ◽  
Vishnu Jangid ◽  
Gunjan Soni ◽  
Rajesh Kumar
Keyword(s):  
Decision Making ◽  
Environmental Economic ◽  
Social Impact ◽  
Western Region ◽  
Sustainability Criteria ◽  
Sustainable Performance ◽  
The North ◽  
Decision Making Model ◽  
North Western ◽  
Detailed Questionnaire

This article focuses on the environmental, economic and social impact of marble industries in the north-western region of India. It presents a grey-based decision-making model for evaluating the extent of sustainability in three marble processing industries. The goal of this article is twofold. First, to identify the important criteria of sustainable performance in marble sector and second to compare three marble processing firms on the basis of sustainability criteria using grey based decision-making approach. A detailed questionnaire was sent to three marble processing firms and the analysis is done on the basis of the received responses.

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