Disease activity patterns in juvenile systemic lupus erythematosus and its relation to early aggressive treatment

Lupus ◽  
2010 ◽  
Vol 19 (13) ◽  
pp. 1550-1556 ◽  
Author(s):  
MH Otten ◽  
K. Cransberg ◽  
MAJ van Rossum ◽  
JW Groothoff ◽  
JE Kist-van Holthe ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Activity Patterns ◽  
Aggressive Treatment ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus

scholarly journals High Disease Activity: An Independent Factor for Reduced Immunogenicity of the Pandemic Influenza A Vaccine in Patients With Juvenile Systemic Lupus Erythematosus

2013 ◽  
Vol 65 (7) ◽  
pp. 1121-1127 ◽  
Author(s):  
Lucia M. A. Campos ◽  
Clovis A. Silva ◽  
Nadia E. Aikawa ◽  
Adriana A. Jesus ◽  
Julio C. B. Moraes ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Pandemic Influenza ◽  
Lupus Erythematosus ◽  
Influenza A ◽  
High Disease Activity ◽  
Independent Factor ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus

Myelitis in systemic lupus erythematosus: clinical characteristics and effect in accrual damage. A single-center experience

Lupus ◽  
2016 ◽  
Vol 26 (3) ◽  
pp. 248-254 ◽  
Author(s):  
L Quintanilla-González ◽  
Y Atisha-Fregoso ◽  
L Llorente ◽  
H Fragoso-Loyo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Clinical Characteristics ◽  
Control Group ◽  
Aggressive Treatment ◽  
Systemic Lupus ◽  
Neurologic Sequelae ◽  
One Year

Objective The purpose of this study was to describe the clinical characteristics of acute transverse myelitis, including the time of their presentation, and to evaluate their effect on accrual damage in patients with systemic lupus erythematosus (SLE). Methods Patients with SLE who were hospitalized because of incident, noninfectious myelitis at our institute between January 1997 and December 2013 were identified. As a control group, we selected for each of the patients in the study group one SLE patient hospitalized at the closest date to the case due to other severe non-neuropsychiatric (NP) SLE manifestation, with no history of NP manifestations or noninfectious disease. Clinical characteristics, laboratory results, treatment, disease activity (SLEDAI-2K), and damage (SLICC/ACR-DI) were collected from medical charts at the index hospitalization and one year after hospitalization. Results Demographics and SLE characteristics, including age at SLE diagnosis and time since SLE diagnosis to hospitalization, were comparable in patients with myelitis and controls. At hospitalization, disease activity and cumulative damage were similar in both groups. Patients with myelitis received more aggressive treatment than controls. One year after hospitalization, two of the 15 patients who completed follow-up had symptom improvement without neurologic sequelae, and 13 of them had some improvement of symptoms with neurologic sequelae. Four patients died in the myelitis group, three of them of infectious diseases, and one of alveolar hemorrhage. No patient died because of myelopathy and in the control group no patient died, although three were lost during the follow-up. Disease activity and treatment did not differ between both groups. However, cumulative damage was higher among the patients with myelitis than controls (1.9 ± 0.9 vs 0.75 ± 0.9; p = 0.003). Conclusion Patients with myelitis have clinical characteristics similar to those observed in non-NP SLE and receive more aggressive treatment. Furthermore, myelitis is associated with a significant increase in accrual damage compared with severe non-NP manifestations.

Inflammatory cervicovaginal cytology is associated with disease activity in juvenile systemic lupus erythematosus

Lupus ◽  
2007 ◽  
Vol 16 (6) ◽  
pp. 430-435 ◽  
Author(s):  
M.V. Febronio ◽  
R.M.R. Pereira ◽  
E. Bonfa ◽  
A.D. Takiuti ◽  
E.A.G. Pereyra ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus

Natural Killer and Natural Killer T Cells in Juvenile Systemic Lupus Erythematosus: Relation to Disease Activity and Progression

2019 ◽  
Vol 67 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Asmaa M. Zahran ◽  
Mona H. Abdel-Rahim ◽  
Khalid I. Elsayh ◽  
Manal M. Hassanien ◽  
Safaa A. Mahran ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
Disease Activity ◽  
Natural Killer ◽  
Lupus Erythematosus ◽  
Natural Killer T Cells ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus ◽  
Killer T Cells ◽  
Natural Killer T
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