Central nervous system vasculitis in systemic lupus erythematosus: a case series report in a tertiary referral centre

Lupus ◽  
2017 ◽  
Vol 26 (13) ◽  
pp. 1440-1447 ◽  
Author(s):  
M Rodrigues ◽  
O Galego ◽  
C Costa ◽  
D Jesus ◽  
P Carvalho ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Lupus Erythematosus ◽  
Past History ◽  
Case Series ◽  
Resonance Imaging ◽  
Cns Vasculitis ◽  
Magnetic Resonance Imaging Mri

Central nervous system (CNS) vasculitis (CNS) in systemic erythematosus lupus (SLE) is a rare and challenging diagnosis. We report four cases of CNS vasculitis that occurred 5 to 16 years after the diagnosis of SLE. Magnetic resonance imaging (MRI) detected different features suggestive of CNS vasculitis: enhancement and thickening of the vascular wall, vascular stenosis, ischemic brain lesions and intracerebral haemorrhage unlikely to correspond to other mimic aetiologies. Three patients received combination therapy with glucocorticoids (GC) and cyclophosphamide (CYC). Intravenous human immunoglobulin (IVIG) was administered when the patient had a past history of serious adverse event to CYC or high infectious risk. All patients showed imagiological improvement, at least partially, 5 to 23 days after starting treatment. We discuss the management of CNS in SLE including the role of magnetic resonance imaging (MRI).

scholarly journals Magnetic Resonance Imaging in the evaluation of Vasculopathy in the Morning Glory Anomaly.

2021 ◽  
Author(s):  
gordon heller
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Pediatric Patients ◽  
Case Series ◽  
Morning Glory ◽  
Resonance Imaging ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri

Abstract Morning Glory Anomaly is rare but its fundoscopic findings are well documented in the ophthalmologic literature. It is sporadic, without sexual predisposition and usually unilateral. Furthermore, it is associated with numerous central nervous system anomalies, including vasculopathy of the central nervous system. This case series reports four pediatric patients over a three year period in which ophthalmologic evaluation identified Morning Glory Anomaly. Magnetic Resonance Imaging (MRI) and Magnetic Resonance Angiography (MRA) were subsequently obtained to assess for associated intracranial vascular anomalies. This report is of significance as it demonstrates the spectrum of intracranial vasculopathy in this rare entity.

scholarly journals Acute Disseminated Encephalomyelitis: Current Perspectives

Children ◽  
2020 ◽  
Vol 7 (11) ◽  
pp. 210
Author(s):  
Renata Barbosa Paolilo ◽  
Kumaran Deiva ◽  
Rinze Neuteboom ◽  
Kevin Rostásy ◽  
Ming Lim
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Acute Disseminated Encephalomyelitis ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Immune Mediated ◽  
Magnetic Resonance Imaging Mri

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated central nervous system (CNS) disorder, characterized by polyfocal symptoms, encephalopathy and typical magnetic resonance imaging (MRI) findings, that especially affects young children. Advances in understanding CNS neuroimmune disorders as well as the association of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) with both monophasic and recurrent forms of ADEM have led to new insights into its definition, management and outcome. In this review, we aim to provide an update based on current epidemiologic, clinical, radiological and immunopathological aspects and clinical outcome of ADEM.

Imaging of CNS Fungal Infections: Review Article

2021 ◽  
Vol 104 (5) ◽  
pp. 872-885
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Fungal Infections ◽  
Imaging Features ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Fungal infections of the central nervous system (CNS) are usually identified in immunocompromised patients but rare in immunocompetent hosts. The clinical and imaging manifestations are mainly influenced by types of fungal pathogen and immune status of the patients. The CNS fungal infections can develop through hematogenous dissemination from primary site of infection, cerebrospinal fluid seeding, or direct extension from adjacent sources of infection. Fungal infections can result in meningitis, meningoencephalitis, cerebritis, granuloma, or abscess formation, which imaging findings are often non-specific and difficult to distinguish from bacterial or tuberculous infection, non-infectious inflammatory disease, or even intracranial neoplasm. Vascular complications including vasculitis, cerebral infarction, or mycotic aneurysm are commonly present due to angioinvasion of fungal hyphae. In addition, some characteristic imaging features of fungal infections can be identified by computed tomography (CT) or magnetic resonance imaging (MRI), such as intracavitary projections in fungal abscesses and gelatinous pseudocysts in cryptococcosis that could help suggest the diagnosis. Recognizing the imaging findings of common intracranial fungal infections combined with appropriate clinical setting is crucial for allowing early diagnosis and leading to early specific treatment. The present article reviewed common imaging findings of CNS fungal infections and distinct imaging features of specific pathogens. Keywords: Fungal infection, Brain abscess, Cryptococcosis, Central nervous system (CNS), Computed tomography (CT), Diffusion weighted imaging (DWI), Magnetic resonance imaging (MRI)

scholarly journals Anti-myelin oligodendrocyte glycoprotein antibodies: Magnetic resonance imaging findings in a case series and a literature review

2017 ◽  
Vol 31 (1) ◽  
pp. 69-82 ◽  
Author(s):  
Cellina Michaela ◽  
Fetoni Vincenza ◽  
Ciocca Matteo ◽  
Pirovano Marta ◽  
Oliva Giancarlo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Optic Neuritis ◽  
Case Series ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Demyelinating Diseases ◽  
Imaging Features ◽  
Resonance Imaging

Myelin oligodendrocyte glycoprotein is a protein exclusively expressed on the surface of oligodendrocytes and myelin in the central nervous system. Antibodies against myelin oligodendrocyte glycoprotein were initially detected in children with demyelinating syndromes, and more recently reported in a broad spectrum of central nervous system demyelinating diseases in adults, including neuromyelitis optica spectrum disorders and bilateral optic neuritis. Patients with myelin oligodendrocyte glycoprotein antibody-associated demyelination appear to have unique clinical and radiological features. To the best of our knowledge a series of Italian patients with optic neuritis and positivity to myelin oligodendrocyte glycoprotein antibodies has not yet been reported and the paper on myelin oligodendrocyte glycoprotein antibodies are more focused on clinical features, diagnosis and outcome than on the radiological appearance, so we want to retrospectively report magnetic resonance imaging features of a group of eight patients, who came to our Ophthalmologic Emergency Department for optic neuritis and were found seropositive for myelin oligodendrocyte glycoprotein antibodies, comparing our data with the findings described in the literature.

scholarly journals Magnetic Resonance Imaging Lesions in the Central Nervous System of a Dog with Canine Monocytic Ehrlichiosis

2011 ◽  
Vol 2011 ◽  
pp. 1-5
Author(s):  
Linda G. Lang ◽  
John F. Griffin ◽  
Jonathan M. Levine ◽  
Edward B. Breitschwerdt
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Cervical Spinal Cord ◽  
Resonance Imaging ◽  
Csf Analysis ◽  
Elevated Protein ◽  
Canine Monocytic Ehrlichiosis ◽  
Magnetic Resonance Imaging Mri

A ten-year-old neutered male dog was examined for tetraparesis, vestibular dysfunction, ataxia, and vertebral column hyperesthesia of 10 days duration. On magnetic resonance imaging (MRI), there were multifocal, punctate, T2-hyperintense lesions in the brain and cervical spinal cord and intracranial leptomeningeal contrast enhancement. Cerebrospinal fluid (CSF) analysis revealed a predominantly mononuclear pleocytosis and mildly elevated protein.Ehrlichia caniswas diagnosed by serum immunofluorescent antibody (IFA) testing. The dog improved with administration of doxycycline. This report describes MRI central nervous system findings in a dog with ehrlichiosis.

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