Evaluation of the SCKnowIQ Tool and Reproductive CHOICES Intervention Among Young Adults With Sickle Cell Disease or Sickle Cell Trait

Although sickle cell disease has long been viewed as a contraindication to free flap transfer, little data exist evaluating complications of microsurgical procedures in the sickle cell trait patient. Reported is the case of a 55-year-old woman with sickle cell trait who underwent a deep inferior epigastric perforator (DIEP) microvascular free flap following mastectomy. The flap developed signs of venous congestion on postoperative day two but was found to have patent arterial and venous anastomoses upon exploration in the operating room. On near-infrared indocyanine green angiography, poor vascular flow was noted despite patent anastomoses and strong cutaneous arterial Doppler signals. Intrinsic microvascular compromise or sickling remains a risk in the sickle cell trait population as it does for the sickle cell disease population. Just like in sickle cell disease patients, special care should be taken to optimize anticoagulation and minimize ischemia-induced sickling for patients with sickle cell trait undergoing microsurgery.

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Pediatric to Adult Care Transition: Perspectives of Young Adults With Sickle Cell Disease

Journal of Pediatric Psychology ◽

10.1093/jpepsy/jsx088 ◽

2017 ◽

Vol 42 (9) ◽

pp. 1016-1027 ◽

Cited By ~ 8

Author(s):

Jerlym S. Porter ◽

Kimberly M. Wesley ◽

Mimi S. Zhao ◽

Rebecca J. Rupff ◽

Jane S. Hankins

Keyword(s):

Young Adults ◽

Sickle Cell Disease ◽

Sickle Cell ◽

Care Transition ◽

Cell Disease ◽

Adult Care

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A natural history study of adolescents and young adults with sickle cell disease as they transfer to adult care: A need for case management services

Journal of Pediatric Nursing ◽

10.1053/jpdn.2002.30930 ◽

2002 ◽

Vol 17 (1) ◽

pp. 18-27 ◽

Cited By ~ 68

Author(s):

Elizabeth A. Wojciechowski ◽

Anita Hurtig ◽

Louise Dorn

Keyword(s):

Young Adults ◽

Sickle Cell Disease ◽

Natural History ◽

Case Management ◽

Sickle Cell ◽

Adolescents And Young Adults ◽

Cell Disease ◽

Adult Care ◽

Natural History Study ◽

Management Services

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In Reply: Sports and Sickle Cell Trait

PEDIATRICS ◽

10.1542/peds.83.4.650c ◽

1989 ◽

Vol 83 (4) ◽

pp. 650-651

Author(s):

MICHAEL A. NELSON

Keyword(s):

Sickle Cell Disease ◽

Sudden Death ◽

Sickle Cell ◽

Sports Medicine ◽

Sickle Cell Trait ◽

Cell Disease ◽

Variable Expression ◽

Military Recruits ◽

New Information ◽

Athletic Activities

Sickle cell trait was included because, at that time, a great deal of speculation and new information was forthcoming regarding sudden death in military recruits who had sickle cell trait. The members of the Sports Medicine Committee believed that it was important to indicate that, in spite of these new concerns, there were no data to indicate that anyone with sickle cell trait should not be included in any athletic activities. Sickle cell disease was excluded because it is a disease with variable expression and one which is characterized by numerous exacerbations and periods of quiescence.

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PATHOGENESIS OF HYPOSTHENURIA IN PERSONS WITH SICKLE CELL ANEMIA OR THE SICKLE CELL TRAIT

PEDIATRICS ◽

10.1542/peds.26.2.249 ◽

1960 ◽

Vol 26 (2) ◽

pp. 249-254

Author(s):

L. Schlitt ◽

H. G. Keitel

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Sickle Cell Anemia ◽

Renal Damage ◽

Sickle Cell Trait ◽

Urinary Concentration ◽

Cell Disease ◽

Renal Vessels

Hyposthenuria was investigated in subjects with sickle cell trait and in patients with sickle cell anemia. The following were observed: 1) in subjects with sickle cell trait both normal and reduced maxima of urinary concentration are found, whereas all untreated patients with sickle cell anemia over 6 months of age have hyposthenuria; 2) hyposthenuria becomes increasingly more severe with advancing age in both sickle cell anemia and sickle cell trait; 3) in a 6-month-old patient with sickle cell anemia and hyposthenuria, the maxima of urinary concentration returned to normal after two transfusions of normal erythrocytes. Reasons are presented for favoring the hypothesis that hyposthenuria in sickle cell disease is due to renal damage, possibly from intravascular sickling of erythrocytes in renal vessels or from the presence of "free" circulating S-hemoglobin.

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Screening for Sickle Cell Disease: A Hospital Based Study in Eastern Odisha, India

South Asian Journal of Experimental Biology ◽

10.38150/sajeb.2(2).p57-60 ◽

2012 ◽

Vol 2 (2) ◽

pp. 57-60

Author(s):

Jayanti Mishra ◽

Sanghamitra Pati ◽

Mohammad Akhtar Hussain ◽

Niraj Srivastava ◽

Sindhubala Mishra

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Sickle Cell Trait ◽

Cell Disease ◽

Medicine Department ◽

Fetal Haemoglobin ◽

Medical College ◽

Rbc Indices ◽

And Gender ◽

Cell Gene

The highest frequency of sickle cell gene in India is reported in Odisha. The present study was taken up to assess the presence of sickle cell disease among febrile patients of a medical college of eastern Odisha. Patients referred from both pediatric and medicine department to the Hematology section of the department of Pathology, SCB Medical College, Cuttack were subjected to measurement of RBC indices, Sickling test, Haemoglobin Electrophoresis and Fetal Haemoglobin Estimation. Out of total 1000 referred patients 76(7.6%) were found to be positive for sickling. Twoâ€third of sicklingpositive patients had sickle cell trait with electrophoretic AS band. There was a significant association between age and positive sickling (χ2 = 24.357; df = 4, P = <0.0001). No significant association was observed between sickling and gender. Sickle cell positive cases are not uncommon in eastern Odisha. Our study demonstrated sickle cell trait to be more common among screened patients than other forms of sickle cell diseases.

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Heterogeneity of respiratory disease in children and young adults with sickle cell disease

Thorax ◽

10.1136/thoraxjnl-2017-210206 ◽

2017 ◽

Vol 73 (6) ◽

pp. 575-577 ◽

Cited By ~ 6

Author(s):

Alan Lunt ◽

Lucy Mortimer ◽

David Rees ◽

Sue Height ◽

Swee Lay Thein ◽

...

Keyword(s):

Young Adults ◽

Sickle Cell Disease ◽

Lung Disease ◽

Respiratory Disease ◽

Sickle Cell ◽

Elevated Serum ◽

Serum Lactate Dehydrogenase ◽

Cell Disease ◽

Restrictive Lung Disease ◽

Children And Young Adults

To detect and characterise different phenotypes of respiratory disease in children and young adults with sickle cell disease (SCD), 11 lung function and haematological biomarkers were analysed using k-means cluster analysis in a cohort of 114 subjects with SCD aged between 5 and 27 years. Three clusters were detected: cluster 1 had elevated pulmonary capillary blood volume, mixed obstructive/restrictive lung disease, hypoxia and moderately severe anaemia; cluster 2 were older patients with restrictive lung disease; and cluster 3 were younger patients with obstructive lung disease, elevated serum lactate dehydrogenase and bronchodilator reversibility. These results may inform more personalised management strategies to improve outcomes.

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