Cystic Encapsulated Papillary Carcinoma in the Male Breast: An Unusual Feature With a Diagnostic Challenge

2021 ◽  
pp. 106689692110187
Author(s):  
Rongying Li ◽  
Karan Saluja ◽  
Brenda Mai ◽  
Michael Covinsky ◽  
Hongxia Sun
Keyword(s):  
Papillary Carcinoma ◽  
Cyst Wall ◽  
Correct Diagnosis ◽  
Nipple Discharge ◽  
Left Breast ◽  
Male Breast ◽  
Unusual Feature ◽  
Breast Mass ◽  
Repeat Biopsy ◽  
Bloody Nipple Discharge

Papillary carcinoma in the male breast is uncommon. Here, we report a case of a large encapsulated papillary carcinoma (EPC) in a 62-year-old male. The patient presented with a left breast mass of 1-year duration and bloody nipple discharge for several days. Mammography and breast ultrasonography showed a large left breast mass. The initial biopsy demonstrated fat necrosis with acute and chronic inflammation only. Due to clinical suspicion, a repeat biopsy was performed and revealed scant fragments of papillary carcinoma in a background of inflammation. The patient underwent left total mastectomy. Grossly, the breast contained a 9.0 cm entirely cystic lesion lined by a hemorrhagic thick fibrotic wall. No solid area was identified in the cyst. The entire cyst wall was examined under microscopy; only a few sections with papillary carcinoma were identified. The lesion was confined to the cyst wall; so, a diagnosis of EPC was made. Compared to the previously reported EPC cases of male breast, the lesion of this case was unusually cystic, which making the diagnosis challenging. Therefore, awareness of this unusual feature, repeat biopsy when the pathology result is discordant, and extensive sampling of the lesion are essential for making the correct diagnosis and guiding patient management.

Large breast lump with bloody nipple discharge: benign intraductal papilloma

2020 ◽  
Vol 13 (11) ◽  
pp. e236818
Author(s):  
Sin Dee Cheah ◽  
Abdul Hadi Imi Sairi
Keyword(s):  
Nipple Discharge ◽  
Large Mass ◽  
Left Breast ◽  
Intraductal Papilloma ◽  
Breast Lump ◽  
Core Needle ◽  
Bloody Nipple Discharge ◽  
Uncommon Presentation ◽  
Large Breast ◽  
Benign Papilloma

A 32-year-old woman presented with a 3 cm×3 cm left breast lump associated with bloody nipple discharge during her early pregnancy. Examination and ultrasonography showed benign features, whereas core needle biopsies revealed a benign papilloma. Six months after her delivery, a 6 cm×6 cm benign papilloma was completely excised via circumareolar incision. The majority of intraductal papillomas are small; however, they can also present as a large mass rarely. We should be wary of a malignant papillary lesion when there is the presence of atypia on core needle biopsy or imaging-histology discordance. A concordant benign papilloma with benign imaging findings is otherwise reassuring. Clinicians need to be aware of this uncommon presentation of large intraductal papilloma as a complete curative excision can be achieved through a cosmetically placed incision.

scholarly journals A CASE OF NONIVASIVE CARCINOMA OF THE MALE BREAST WITH BLOODY NIPPLE DISCHARGE

1998 ◽  
Vol 59 (10) ◽  
pp. 2514-2517
Author(s):  
Teruhisa SAKURAI ◽  
Takaomi SUZUMA ◽  
Shinichiro MIYOSHI ◽  
Hirokazu TANINO ◽  
Shinii MAEBEYA ◽  
...  
Keyword(s):  
Nipple Discharge ◽  
Male Breast ◽  
Bloody Nipple Discharge

Metastatic Prostatic Adenocarcinoma Within a Primary Solid Papillary Carcinoma of the Male Breast

2001 ◽  
Vol 125 (8) ◽  
pp. 1101-1103
Author(s):  
Sunati Sahoo ◽  
Roberta E. Smith ◽  
Joseph L. Potz ◽  
Paul P. Rosen
Keyword(s):  
Breast Carcinoma ◽  
Papillary Carcinoma ◽  
Hormonal Therapy ◽  
Breast Tumor ◽  
Collision Tumor ◽  
Prostatic Adenocarcinoma ◽  
Male Breast ◽  
Breast Mass ◽  
Immunohistochemical Examination ◽  
Solid Papillary Carcinoma

Abstract We report the case of a 78-year-old man who developed a breast mass 12 months after hormonal therapy for palliation of prostatic adenocarcinoma. On histologic and immunohistochemical examination, the breast tumor revealed a unique collision tumor composed of metastatic prostatic adenocarcinoma and solid papillary breast carcinoma.

scholarly journals Papillary carcinoma of the male breast in a comparatively young patient: A case report of a rare entity

2020 ◽  
Vol 8 (5) ◽  
pp. 369-374
Author(s):  
Dr. Dolly Prashant ◽  
◽  
Dr. Viplav Prashant ◽  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Young Patient ◽  
Papillary Carcinoma ◽  
Left Breast ◽  
Male Breast ◽  
Rare Entity ◽  
Papillary Lesions ◽  
Invasive Papillary Carcinoma ◽  
Breast Malignancies

Breast carcinoma in men is rare and intra-cystic papillary carcinoma of male breast is an extremelyrare entity. Papillary lesions of male breast comprise of the spectrum of lesions ranging from benignintraductal papilloma to intraductal papillary carcinoma and invasive papillary carcinoma. It occursmost commonly in the seventh decade of life and accounts for <1% of all breast malignancies. Thepresent case report is of a comparatively younger, 37 years old male who presented with a mass onlower quadrant (retro-areolar region) of the left breast.

scholarly journals A spontaneous unveiling of bilateral DCIS in an elderly male

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Tessa Meyer ◽  
Patrick Borgen ◽  
Kristen Rojas
Keyword(s):  
Breast Cancer ◽  
Male Breast Cancer ◽  
Ductal Carcinoma ◽  
Nipple Discharge ◽  
Incidence Rates ◽  
Male Breast ◽  
Elderly Male ◽  
Brca Mutations ◽  
Cancer Risk Factors ◽  
Bloody Nipple Discharge

Abstract The rarity of male breast cancer continues to limit its study despite increasing incidence rates, particularly within the past decade [Speirs V, Shaaban AM. The rising incidence of male breast cancer. Breast Cancer Res Treat 2009;115:429–30]. Although this trend appears to be substantially documented, male patients with breast cancer have been and continue to be excluded from landmark breast cancer trials. Currently, there are no standardized breast cancer screening protocols in place for men, including those with pathogenic BRCA mutations. As a result, men with breast cancer typically present at a later stage, and on average, 8–10 years later than females [Ruddy KJ, Winer EP. Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship. Ann Oncol 2013;24:1434–43]. As the incidence of disease continues to rise, the need for algorithmic standardization with regards to screening, diagnosing, treating and managing male breast cancer has become imperative. We report the case of a 71-year-old male who presented with spontaneous bloody nipple discharge and was found to have bilateral ductal carcinoma in situ.

scholarly journals Intracystic Papillary Carcinoma in a Male Breast: Thirty Years after Orchiectomy

2017 ◽  
Vol 34 (4) ◽  
pp. 339-343
Author(s):  
Vuka Katić ◽  
Danijela Radojković ◽  
Zoran Radovanović ◽  
Ivan Nagorni ◽  
Andrija Jović ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Nipple Discharge ◽  
Serum Levels ◽  
Breast Conserving Surgery ◽  
Myoepithelial Cells ◽  
Palpable Mass ◽  
Bloody Nipple Discharge ◽  
Intracystic Papillary Carcinoma ◽  
Papillary Lesions ◽  
Cytological Characteristics

Summary Papillary carcinoma of the breast is an extremely rare form of breast carcinoma in males. We report a case of an 83-year-old man who presented with a retroareolar palpable mass, associated with bloody nipple discharge. Cytological characteristics were rare clusters and papillary formations with enlarged hyperchromatic nuclei, surrounded by erythrocytes. Having in mind that a reliable cytological diagnosis of papillary carcinoma cannot be made and that all papillary lesions observed in cytological material should be excised for histological examination, breast conserving surgery (BCS) was performed. Histologically, cystic ducts were lined with atypical papillary formations bridging the duct lumen, but with the absence of both myoepithelial cells and stromal invasion. Prolactin and testosterone serum levels were decreased. Immunohistochemical examination on actin, estrogen and progesteron receptors was negative. The authors have pointed out that the patient had left orchiectomy, induced by tuberculous orchiepididymitis with scrotal fistula, performed thirty years before. Twelve months after breast conserving surgery, the patient is still alive.

Rosai-Dorfman Disease Presenting as a Male Breast Mass

2007 ◽  
Vol 73 (3) ◽  
pp. 294-295 ◽  
Author(s):  
Anton S.N. Dias Perera ◽  
Angela J. Keleher ◽  
Manju Nath
Keyword(s):  
Breast Cancer ◽  
Surgical Resection ◽  
Excisional Biopsy ◽  
Left Breast ◽  
Male Breast ◽  
Breast Mass ◽  
Appropriate Treatment ◽  
Rosai Dorfman Disease ◽  
History Of

A 23-year-old man presented with a 6-week history of a left breast mass. Mammography and ultrasonography confirmed a 1.1 x 0.7-cm mass suggestive of breast cancer. An excisional biopsy revealed Rosai-Dorfman disease of the breast. As illustrated by this case, extranodal Rosai-Dorfman disease can mimic breast cancer. Surgical resection is considered appropriate treatment for this condition.

scholarly journals Ductal Carcinoma In situ of the Male Breast

Breast Care ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. 288-290 ◽  
Author(s):  
Melissa Brents ◽  
John Hancock
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
Nipple Discharge ◽  
Left Breast ◽  
Male Breast ◽  
High Grade

Background: Ductal carcinoma in situ of the male breast is an unusual lesion and most often associated with invasive carcinoma. On rare occasions when the in situ component is present in pure form, histological grade is almost always low to intermediate. Imaging for these patients is difficult as gynecomastia is often present and can mask underlying calcifications or carcinoma. Case Report: We report a case of pure high-grade ductal carcinoma in situ of the male breast in a patient with clear nipple discharge. Breast mammography showed bilateral gynecomastia and benign calcifications. Subsequent breast ultrasound showed dilated ducts of the left breast, and a left breast ductogram showed filling defects suggestive of a papilloma. Excisional biopsy and subsequent mastectomy were consistent with high-grade ductal carcinoma in situ. Conclusion: Male breast cancer is uncommon and, although there is increasing awareness, it is less studied compared to female breast cancer. With a clinical history of nipple discharge of any kind, further evaluation with imaging should be considered. In males with gynecomastia, it is important to remember that ductal carcinoma in situ, even of high grade, is difficult to detect on mammography and may not be associated with suspicious calcifications.

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