Attention and Executive Disorders in Neurofibromatosis 1: Comparison Between NF1 With ADHD Symptomatology (NF1 + ADHD) and ADHD Per Se

Objective: To compare children with Neurofibromatosis type 1 and associated ADHD symptomatology (NF1 + ADHD) with children having received a diagnosis of ADHD without NF1. The idea was that performance differences in tasks of attention between these two groups would be attributable not to the ADHD symptomatology, but to NF1 alone. Method: One group of children with NF1 + ADHD ( N = 32), one group of children with ADHD ( N = 31), and one group of healthy controls ( N = 40) participated in a set of computerized tasks assessing intensive, selective, and executive aspects of attention. Results: Differences were found between the two groups of patients in respect of several aspects of attention. Children with NF1 + ADHD did not always perform worse than children with ADHD. Several double dissociations can be established between the two groups of patients. Conclusion: ADHD symptomatology in NF1 does not contribute to all attention deficits, and ADHD cannot account for all attention impairments in NF1.

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Attention Deficit Predicts Intellectual Functioning in Children with Neurofibromatosis Type 1

International Journal of Pediatrics ◽

10.1155/2019/9493837 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Magdalena Heimgärtner ◽

Sofia Granström ◽

Karin Haas-Lude ◽

Robert A. Leark ◽

Victor-Felix Mautner ◽

...

Keyword(s):

Risk Factor ◽

Neurofibromatosis Type 1 ◽

Attention Deficit ◽

Neurofibromatosis Type ◽

Intellectual Functioning ◽

Attention Problems ◽

Full Scale ◽

Intelligence Test ◽

Attention Deficits

Aims. Attention deficit hyperactivity disorder (ADHD) is one of the most frequent neurocognitive impairments in neurofibromatosis type 1 (NF1) and a well-known risk factor for intellectual dysfunction in general. Since NF1 is per se associated with intellectual difficulties, this comorbidity may be crucial for the cognitive development of affected patients. In our study, we investigated if attention deficits are associated with intellectual functioning in NF1 and if children with NF1 plus ADHD differ in their intellectual and attention profiles from children affected by NF1-only or ADHD only. Methods. 111 children aged between 6 and 12 years (53 NF1 plus ADHD, 28 NF1-only, 30 ADHD-only) performed the German version of the intelligence test WISC-IV and a continuous performance test (T.O.V.A.) to assess attention functions. Parents completed questionnaires about everyday attention and executive functions (Conners 3®, BRIEF). Results. Children with NF1 plus ADHD showed significantly lower intelligence test scores (full-scale IQ: 89.39 [1.40]) than patients with NF1-only (full-scale IQ: 101.14 [1.98]; p<.001), and intellectual functioning correlated significantly with attention performance in NF1 (p<.001). As compared to NF1-only, attention, and executive functioning were impaired on several dimensions (T.O.V.A., Conners 3® and BRIEF) in NF1 plus ADHD. ADHD-only was associated with significantly higher problem scores regarding hyperactivity/impulsivity and inattention (Conners 3®). NF1-only was associated with inattentiveness when compared to the normative sample of the T.O.V.A. Conclusion. NF1 is associated with variable attention problems. Severe attention deficits appear to be a risk factor for intellectual dysfunction in NF1, more than NF1 without attention deficit. NF1 plus ADHD presents a specific cognitive profile, which differs from that of NF1 and from neurotypical ADHD.

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Analysis of an alternatively spliced exon of the neurofibromatosis type 1 gene in cultured melanocytes from patients with neurofibromatosis 1

Archives of Dermatological Research ◽

10.1007/bf00373420 ◽

1995 ◽

Vol 287 (5) ◽

pp. 413-416 ◽

Cited By ~ 3

Author(s):

Ingrid Eisenbarth ◽

Sven Hoffmeyer ◽

Dieter Kaufmann ◽

G�nter Assum ◽

Winfrid Krone

Keyword(s):

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Neurofibromatosis 1 ◽

Alternatively Spliced

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The HMG-CoA Reductase Inhibitor Lovastatin Reverses the Learning and Attention Deficits in a Mouse Model of Neurofibromatosis Type 1

Current Biology ◽

10.1016/j.cub.2005.09.043 ◽

2005 ◽

Vol 15 (21) ◽

pp. 1961-1967 ◽

Cited By ~ 253

Author(s):

Weidong Li ◽

Yijun Cui ◽

Steven A. Kushner ◽

Robert A.M. Brown ◽

J. David Jentsch ◽

...

Keyword(s):

Mouse Model ◽

Neurofibromatosis Type 1 ◽

Reductase Inhibitor ◽

Neurofibromatosis Type ◽

Attention Deficits ◽

Hmg Coa Reductase ◽

Hmg Coa Reductase Inhibitor ◽

Coa Reductase

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PHALANGES DEFORMITY ASSOCIATED WITH NEUROFIBROMATOSIS-1: A CASE REPORT

Hand Surgery ◽

10.1142/s0218810412720367 ◽

2012 ◽

Vol 17 (03) ◽

pp. 379-381

Author(s):

Hiroyoshi Hagiwara ◽

Suguru Hagiwara ◽

Takashi Ajiki ◽

Yuichi Hoshino

Keyword(s):

Case Report ◽

Neurofibromatosis Type 1 ◽

Ring Finger ◽

Neurofibromatosis Type ◽

Neurofibromatosis 1

We present a case of phalangeal deformity in a 17-year-old boy. The deformity was caused by a neurofibroma associated with neurofibromatosis type 1, affecting the left ring finger. The mass was surgically resected. Recurrence had not occurred at three-year follow-up.

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Conflict processing in juvenile patients with neurofibromatosis type 1 (NF1) and healthy controls – Two pathways to success

NeuroImage Clinical ◽

10.1016/j.nicl.2017.02.014 ◽

2017 ◽

Vol 14 ◽

pp. 499-505 ◽

Cited By ~ 9

Author(s):

Annet Bluschke ◽

Maja von der Hagen ◽

Katharina Papenhagen ◽

Veit Roessner ◽

Christian Beste

Keyword(s):

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Healthy Controls ◽

Conflict Processing

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Abnormal late visual responses and alpha oscillations in neurofibromatosis type 1: a link to visual and attention deficits

Journal of Neurodevelopmental Disorders ◽

10.1186/1866-1955-6-4 ◽

2014 ◽

Vol 6 (1) ◽

Cited By ~ 8

Author(s):

Maria J Ribeiro ◽

Otília C d’Almeida ◽

Fabiana Ramos ◽

Jorge Saraiva ◽

Eduardo D Silva ◽

...

Keyword(s):

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Attention Deficits ◽

Visual Responses ◽

Alpha Oscillations

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Multiple Neurofibromas with Hypertrichosis in a Filipino Patient with Neurofibromatosis 1

Acta Medica Philippina ◽

10.47895/amp.v53i2.196 ◽

2019 ◽

Vol 53 (2) ◽

Author(s):

Leah Antoinette M. Caro-Chang ◽

Maria Franchesca S. Quinio ◽

Georgina C. Pastorfide

Keyword(s):

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

The Philippines ◽

Neurofibromatosis 1 ◽

First Report ◽

Lisch Nodules ◽

Cutaneous Neurofibromas

This is a case of an 11-year-old male who presented with multiple neurofibromas with hypertrichosis. Classic cutaneous neurofibromas, café-au-lait macules, axillary freckling, Lisch nodules, and scoliosis were also present fulfilling a diagnosis of Neurofibromatosis type 1. This is the first report of multiple neurofibromas with hypertrichosis in the Philippines. Hypertrichosis overlying a neurofibroma is rarely reported and the mechanism remains to be elucidated.

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Visuospatial but Not Verbal Working Memory Deficits in Adult Patients With Neurofibromatosis Type 1

Frontiers in Psychology ◽

10.3389/fpsyg.2021.751384 ◽

2021 ◽

Vol 12 ◽

Author(s):

Hanlu Tang ◽

Qiong Wu ◽

Shiwei Li ◽

Yehong Fang ◽

Zhijun Yang ◽

...

Keyword(s):

Working Memory ◽

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Cognitive Status ◽

Adult Patients ◽

Healthy Controls ◽

Significant Difference ◽

Existing Data ◽

Back Task

Background: Cognitive dysfunction is one of the main symptoms of neurofibromatosis type 1 (NF1). As an important cognitive function, working memory (WM) has rarely been systematically analyzed in NF1 by isolating the particular domain of WM, and existing data involving WM in adult patients with NF1 are insufficient. This study aimed to investigate the characteristics of different types of WM in NF1 from the perspective of the adult population.Method: We comprehensively analyzed WM in both verbal and visuospatial WM domains by using the N-back task (including the verbal N-back task and the visuospatial N-back task) in 31 adults with NF1 and 34 healthy controls matched for age, gender, education levels, and general cognitive status. The accuracy and reaction times (RTs) in the N-back task were entered into mixed-design ANOVA.Results: Compared with healthy controls, adults with NF1 presented significantly lower mean accuracy and longer RTs in the visuospatial N-back task. However, no significant difference was found between the NF1 group and healthy controls in the verbal N-back task.Conclusions: The present study suggested that adults with NF1 might have deficits in visuospatial WM. We did not find evidence for verbal WM deficits in adult patients with NF1. Our findings supplement and refine the existing data on WM in the context of NF1.

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Neurofibromatosis-1 and Pregnancy: Case report

Hellenic Journal of Obstetrics and Gynecology ◽

10.33574/hjog.1543 ◽

2018 ◽

Vol 17 (2) ◽

pp. 35-40

Author(s):

K Kalmantis ◽

A Petsa ◽

G Daskalakis ◽

E Alexopoulos ◽

E Korovesi ◽

...

Keyword(s):

Case Report ◽

Neurofibromatosis Type 1 ◽

Placenta Previa ◽

Genetic Diseases ◽

Neurofibromatosis Type ◽

Normal Pregnancy ◽

Neurofibromatosis 1 ◽

Rare Case Report ◽

Male Neonate

Introduction: Neurofibromatosis type-1 (NF-1) is one of the most common genetic diseases following an autosomal dominant inheritance pattern. Maternal and fetal complications have been reported. Purpose: To present a very interesting and rare case report regarding neurofibromatosis – 1 (NF-1) in pregnancy and to create a complete review concerning this genetic disease. Materials and Methods: Articles were identified through electronic databases; no date or language restrictions were placed; relevant citations were hand searched. The search was conducted using the following terms: neurofibromatosis, neurofibromatosis type-1, pregnancy. Case presentation: We present a case of a 36-year-old nulliparous pregnant woman affected by NF-1. She presented with café-au-lait spots and cutaneous/subcutaneous neurofibromas, progressively increasing in size and number. The unique obstetric complication was placenta previa, diagnosed in the second trimester. A caesarean section was performed on the 36th week. A healthy male neonate unaffected by NF-1 was born. Both post-operative period and puerperium were uneventful. Conclusions: This case report highlights the fact that a normal pregnancy outcome can occur in pregnant women with NF-1 and proper counselling should be in place so that informed decisions can be made by future parents.

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