Perioperative Management of Bleeding and Transfusion for Lung Transplantation

2019 ◽  
Vol 24 (1) ◽  
pp. 74-83 ◽  
Author(s):  
Joseph J. Pena ◽  
Brandi A. Bottiger ◽  
Andrea N. Miltiades
Keyword(s):  
Lung Transplantation ◽  
Point Of Care ◽  
Factor Vii ◽  
Current Evidence ◽  
Blood Product Transfusion ◽  
Long Term Outcomes ◽  
Transfusion Requirements ◽  
Coagulation Testing ◽  
Short And Long Term

Perioperative allogeneic blood product transfusion is common in lung transplantation and has various implications on the short- and long-term outcomes of lung recipients. This review summarizes the effect of transfusion on outcomes including primary graft dysfunction, chronic lung allograft dysfunction, and all-cause mortality. We outline known risk factors for increased transfusion requirement in lung transplantation and present current evidence regarding the effect of hemostatic agents including antifibrinolytics, recombinant factor VII, and prothrombin complex concentrates. Finally, we highlight the roles of point-of-care coagulation testing and goal-directed transfusion strategies in reducing transfusion requirements in lung transplantation.

scholarly journals Current Status of Distal Embolization in Femoropopliteal Endovascular Interventions

2018 ◽  
Vol 52 (6) ◽  
pp. 440-447 ◽  
Author(s):  
Alessandro Cannavale ◽  
Mariangela Santoni ◽  
Marianna Gazzetti ◽  
Carlo Catalano ◽  
Fabrizio Fanelli
Keyword(s):  
Management Strategies ◽  
Major Amputation ◽  
Current Status ◽  
Current Evidence ◽  
Long Term Outcomes ◽  
Distal Embolization ◽  
Endovascular Interventions ◽  
Atherosclerotic Lesions ◽  
Short And Long Term

The application of advanced endovascular techniques in very complex femoropopliteal atherosclerotic lesions has shown to expose patients to a higher risk of distal embolization (DE). This complication can affect both the short- and long-term outcomes, leading to worsening ischemia, early minor/major amputation, and longer hospital stay. Recently, there has been an increasing body of evidence on pathophysiology and clinical–radiological management of DE that however has not been systematically addressed by guidelines. The aim of this review was to analyze the current evidence outlining definition and classification, risk assessment, prevention, and management strategies of DE in femoropopliteal endovascular interventions.

Short- and Long-term Outcomes After Lung Transplantation From Circulatory-Dead Donors

2017 ◽  
Vol 101 (11) ◽  
pp. 2691-2694 ◽  
Author(s):  
David Ruttens ◽  
An Martens ◽  
Sofie Ordies ◽  
Stijn E. Verleden ◽  
Arne P. Neyrinck ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Long Term Outcomes ◽  
Short And Long Term

Acute Postoperative Pain

2017 ◽  
Author(s):  
Kelly Zach ◽  
Julio A. Gonzalez-Sotomayor
Keyword(s):  
Postoperative Pain ◽  
Patient Characteristics ◽  
Current Evidence ◽  
Long Term Outcomes ◽  
Acute Postoperative Pain ◽  
Analgesic Regimen ◽  
Potential Benefits ◽  
Short And Long Term ◽  
Selection Of

Inadequate management of acute postoperative pain increases morbidity and mortality. Poorly controlled pain results in delayed hospital discharge and may lead to the development of chronic pain. Current evidence supports the implementation of a multimodal analgesic regimen, where different pharmacologic and nonpharmacologic interventions are used. The selection of the different components of this multimodal analgesic approach should consider their potential benefits and limitations, as well as the unique patient characteristics and the surgical procedure. It is the responsibility of the perioperative health care provider to formulate an optimal pain management strategy to ultimately enhance patient satisfaction and improve short- and long-term outcomes.

scholarly journals Recovery from AKI and Short- and Long-Term Outcomes after Lung Transplantation

2012 ◽  
Vol 8 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Edgard Wehbe ◽  
Andra E. Duncan ◽  
Gohar Dar ◽  
Marie Budev ◽  
Brian Stephany
Keyword(s):  
Lung Transplantation ◽  
Long Term Outcomes ◽  
Short And Long Term

scholarly journals Treatment of MIS-C in Children and Adolescents

2022 ◽  
Author(s):  
Sanaa Mahmoud ◽  
Mostafa El-Kalliny ◽  
Alyaa Kotby ◽  
Mona El-Ganzoury ◽  
Eman Fouda ◽  
...  
Keyword(s):  
Management Strategies ◽  
Biologic Agents ◽  
Current Evidence ◽  
Long Term Outcomes ◽  
Thrombotic Risk ◽  
Future Studies ◽  
Management Plans ◽  
Short And Long Term ◽  
Inflammatory Syndrome

Abstract Purpose of Review Different treatment approaches have been described for the management of COVID-19-related multisystem inflammatory syndrome in children (MIS-C), the pathogenesis of which has not yet been fully elucidated. Here, we comprehensively review and summarize the recommendations and management strategies that have been published to date. Recent Findings MIS-C patients are treated with different regimens, mostly revolving around the use of immunomodulatory medications, including IVIG and glucocorticoids as first-tier therapy. Refractoriness to IVIG and glucocorticoids warrants a step-up of immunomodulatory therapy to biologic agents such as anakinra, tocilizumab, and infliximab. Summary We review the current evidence regarding the use of monotherapy versus combination therapy, as well as the current recommendations for assessing thrombotic risk and administering antiplatelet and anticoagulant therapy. We anticipate that future studies will provide evidence for management plans that maximize short- and long-term outcomes.

scholarly journals Short and Long Term Outcomes for Scleroderma Related Lung Transplantation

2021 ◽  
Vol 40 (4) ◽  
pp. S368-S369
Author(s):  
E.M. Schumer ◽  
S. Saddoughi ◽  
C. Kennedy ◽  
V. Khullar ◽  
A. Pochettino ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Long Term Outcomes ◽  
Short And Long Term
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