scholarly journals External Quality Assessment in the Evaluation of Laboratory Performance of Faecal Culture

2017 ◽  
Vol 10 ◽  
pp. 117863611769125
Author(s):  
Salla J Kiiskinen ◽  
Tarja Ojanen ◽  
Yvonne Björkman ◽  
Harri Laitinen ◽  
Anja Siitonen
Keyword(s):  
Public Health ◽  
Quality Control ◽  
External Quality Assessment ◽  
False Negative ◽  
The Other ◽  
Epidemiological Surveillance ◽  
External Quality Control ◽  
External Quality ◽  
Faecal Culture

In Finland, all laboratories carrying out diagnostics of infectious diseases in humans are approved by the Regional State Administrative Agencies and are obligated to participate in External Quality Assurance rounds. Performance in these rounds is thought to reflect the quality of laboratory work. In the 6-year study period, 17 Finnish laboratories received 48 simulated faecal specimens for the culturing of diarrhoeal pathogens, yielding altogether 586 faecal culture External Quality Control specimens and 581 reports. The results were correct in 92% of all reports and in 67% of all specimens. False-negative Salmonella results were given for 2 of the 18 specimens, one with biochemically atypical Salmonella strain and the other with a low count of Salmonella cells. False-negative Shigella report was given for 6 of the 7 specimens in some participating laboratory. Detection of all common faecal pathogens is especially relevant to patient safety, public health, and epidemiological surveillance.

Thromboelastography/-metry and external quality control

2010 ◽  
Vol 30 (02) ◽  
pp. 91-95 ◽  
Author(s):  
M. Schwaiger ◽  
C. Jámbor ◽  
A. Dick
Keyword(s):  
Quality Control ◽  
Plasma Sample ◽  
Fibrinogen Level ◽  
External Quality Assessment ◽  
External Quality Control ◽  
External Quality ◽  
Acute Bleeding ◽  
Pilot Survey ◽  
Formation Kinetics ◽  
Α Angle

SummaryThromboelastography/thromboelastometry (TEG→/ROTEM→) is widely used in near-patient setting, especially in perioperative and intensive care medicine for the management of acute bleeding. Until now a comprehensive quality management especially an external quality control of TEG→/ROTEM→ results is not established. Here we report about our results of a pilot survey performed in 2008 and 2009 integrated in the External Quality Assessment Schemes (EQAS) performed by INSTAND. According to this first EQAS data ROTEM→ results can be controlled in external quality schemes using lyophilized plasma samples. The clot firmness (A20) and clot formation kinetics characterized by the α-angle showed very good reproducibility both between the participants and between different surveys. Variations for CT and CFT were considerably higher especially in the plasma sample with reduced fibrinogen level. Regular participation in an external quality assurance will help to confirm this beneficial technology in emergency settings.

The Preparation of Control Blood for External Quality Assessment Programs in Oral Anticoagulant Control

1978 ◽  
Vol 39 (01) ◽  
pp. 210-214 ◽  
Author(s):  
C A van Dijk-Wierda ◽  
L P van Halem-Visser ◽  
R van der Hoeff-van Halem ◽  
E A Loeliger
Keyword(s):  
Quality Control ◽  
The Netherlands ◽  
Quality Assessment ◽  
Oral Anticoagulant ◽  
External Quality Assessment ◽  
External Quality Control ◽  
External Quality ◽  
Blood Samples ◽  
Anticoagulant Agents

SummaryA method is described for the preparation of blood samples differing in coagulability, now used for external quality control in The Netherlands by laboratories employing thrombotest for the assessment of oral anticoagulant agents.

scholarly journals External quality control of chemical-analytical units of refractory enterprises in 2016

2017 ◽  
Vol 117 ◽  
pp. 238-243
Author(s):  
E. A. Bondarenko ◽  
V. V. Varganov ◽  
N. N. Konchinko
Keyword(s):  
Quality Control ◽  
Chemical Analysis ◽  
Refractory Plant ◽  
External Quality Control ◽  
External Quality ◽  
Analysis Methods ◽  
Central Factory ◽  
Refinery Plant

External quality control of the chemical-analytical departments of the central factory laboratories was carried out: PJSC Krasnoarmeysky Dinas Factory, PJSC Chasovoyarsk Refractory Plant, PJSC Velikoanadol Refinery Plant. During the chemical analysis of samples of refractories of the listed enterprises, the analysis methods, equipment and materials described in DSTU 3305(3, 4, 5)—96 (GOST 2642.(3, 4, 5)—97) — gravimetric (SiO2), complexometric (Al2O3), photometric (Fe2O3). As a result of the work carried out, conclusions were drawn up in which the quality of the work of the chemical analytical units of the central factory laboratories of the PJSC “Krasnoarmeysky Dinas Factory”, PJSC “Chasovoyarsk Refractory Plant”, and PJSC “VELIKOANADOL REFRACTORY PLANT” was considered satisfactory.

scholarly journals Benchmark for Evaluating the Quality of DNA Sequencing: Proposal from an International External Quality Assessment Scheme

2006 ◽  
Vol 52 (4) ◽  
pp. 728-736 ◽  
Author(s):  
Simon J Patton ◽  
Andrew J Wallace ◽  
Rob Elles
Keyword(s):  
Dna Sequencing ◽  
Quality Assessment ◽  
Clinical Laboratory ◽  
External Quality Assessment ◽  
Sequence Data ◽  
False Negative ◽  
Read Length ◽  
External Quality ◽  
External Quality Assessment Scheme

Abstract Background: In the past 15 years, clinical laboratory science has been transformed by the use of technologies that cross the traditional boundaries between laboratory disciplines. However, during this period, issues of quality have not always been given adequate attention. The European Molecular Genetics Quality Network (EMQN) has developed a novel external quality assessment scheme for evaluation of DNA sequencing. We report the results of an international survey of the quality of DNA sequencing among 64 laboratories from 21 countries. Methods: Current practice for DNA sequence analysis was established by use of an online questionnaire. Participating laboratories were provided with 4 DNA samples of validated genotype. Evaluation of the results included assessing the quality of sequence data, variant genotypes, and mutation nomenclature. To accommodate variations in mutation nomenclature, variants indicated by participants were scored for compliance with 3 acceptable marking schemes. Results: A total of 346 genotypes were analyzed. Of these, 19 (5%) genotyping errors were made. Of these, 10 (53%) were false-negative and 9 (47%) were false-positive results. A further 27 (8%) errors were made in naming mutations. Results were analyzed for 3 indicators of data quality: PHRED quality scores, Quality Read Length, and Quality Read Overlap. Most laboratories produced results of acceptable diagnostic quality as judged by these indicators. The results were used to calculate a consensus benchmark for DNA sequencing against which individual laboratories could rank their performance. Conclusions: We propose that the consensus benchmark can be used as a baseline against which the aggregate and individual laboratory standard of DNA sequencing may be tracked from year to year.

scholarly journals The Implications of Assaying External Quality Control Sera under ‘Special Conditions’

1984 ◽  
Vol 21 (1) ◽  
pp. 64-68 ◽  
Author(s):  
R M Rowan ◽  
M F Laker ◽  
K G M M Alberti
Keyword(s):  
Quality Control ◽  
Internal Control ◽  
The Other ◽  
Calibration Standard ◽  
External Quality Control ◽  
External Quality ◽  
Identical Series

Two identical series of Wellcome quality control specimens were analysed by different procedures. One series was entered into the laboratory in the same way as patients' specimens while the other was analysed under special favourable conditions. This involved assaying the samples in replicate in different batches, omitting transcription errors and outliers, and placing the sample in a position following a calibration standard or an internal control. It was found that a significantly higher position in overall league ranking was achieved by assaying the control under ‘special conditions’.

scholarly journals Internal audit key quality components

Revizor ◽  
2021 ◽  
Vol 24 (94) ◽  
pp. 59-65
Author(s):  
Svetlana Jamandilović
Keyword(s):  
Quality Control ◽  
Internal Audit ◽  
External Quality Control ◽  
External Quality ◽  
Internal Auditors ◽  
Level Of Confidence ◽  
High Level

The services provided by internal auditors are based on a high level of confidence in the quality of their work. Continuous internal and periodic external quality control of internal audit activities are of key importance for maintaining confidence in the work of internal auditors.

Comparison of three commercial assays for the measurement of 17α-hydroxyprogesterone (17α-OHPR): limitations of the quality control system

2004 ◽  
Vol 42 (4) ◽  
Author(s):  
Ursula Meier ◽  
Claudia Schnabel ◽  
Dagmar Kunz ◽  
Reinhard Driesch ◽  
Axel M. Gressner
Keyword(s):  
Quality Control ◽  
Moving Average ◽  
External Quality Control ◽  
Acth Stimulation ◽  
Hydroxylase Deficiency ◽  
External Quality ◽  
Stimulation Tests ◽  
21 Hydroxylase Deficiency

AbstractThe measurement of 17α-hydroxyprogesterone (17α-OHPR) is of value for the diagnosis and management of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. In the central laboratory from 2000 to 2002, we observed, using the assay from the manufacturer DSL, an elevation of the moving average of 17α-OHPR concentrations and a number of adrenocorticotropic hormone (ACTH) stimulation tests despite the lack of any changes to the internal and external quality control, of which the criteria were continuously fulfilled. We studied a population of n=49 patients for the measurement of 17α-OHPR, with and without extraction, to evaluate the quality of different commercially available radioimmunoassays. The internal and external quality controls were successful in determining 17α-OHPR. An excellent measurement and correlation of 17α-OHPR was expressed with the assay from the manufacturer IBL without extraction and from the manufacturer DSL with extraction. The quantitative determination of 17α-OHPR requires adequate specificity and accuracy of the 17α-OHPR radioimmunoassays. The results show that internal and external quality control systems are not sufficient to resolve analytical problems described in this study.

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