scholarly journals Benign Umbilical Tumors Resembling Sister Mary Joseph Nodule

2021 ◽  
Vol 15 ◽  
pp. 117955492199502
Author(s):  
Dae-Lyong Ha ◽  
Min-Young Yang ◽  
Jun-Oh Shin ◽  
Hoon-Soo Kim ◽  
Hyun-Chang Ko ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Vascular Pattern ◽  
Characteristic Surface ◽  
Benign Lesions ◽  
Tumor Group ◽  
Common Diagnosis ◽  
Pubmed Search ◽  
Sister Mary Joseph ◽  
Surface Changes

Background: When physicians see an umbilical nodule, most of them instinctively recall the Sister Mary Joseph nodule. Therefore, dermatologists need to recognize umbilical dermatoses that can be mistaken for the Sister Mary Joseph nodules. This study aimed to describe the different kinds of benign umbilical tumors as well as elucidate the factors that can be used to distinguish the Sister Mary Joseph nodule from these tumors. Methods: The “benign umbilical tumor” group included 19 patients, whereas the “Sister Mary Joseph nodule” group comprised 30 patients (2 from our department, 28 from PubMed search). We compared the clinical and dermoscopic findings between 2 groups. Results: In the “benign umbilical tumor” group, the most common diagnosis was dermatofibroma (5/19), followed by keloid (3/19), and soft fibroma (3/19). These tumors had various colors (red, brown to black, and flesh colored) and exhibit characteristic surface changes (eg, verrucous changes in epidermal nevi and verrucae). Conversely, most Sister Mary Joseph nodules have an erythematous color, oozing or ulceration on the surface, and nearby satellite lesions. Furthermore, the dermoscopic findings of Sister Mary Joseph nodules showed a polymorphous vascular pattern and a white or milky-red, amorphous area. Benign lesions showed different dermoscopic patterns: pigment networks with white areas (dermatofibromas), thrombosed capillaries (verrucae), and the “pore sign” (epidermal cysts). Conclusions: Various cutaneous tumors can be mistaken for the Sister Mary Joseph nodule when they develop on the umbilicus; the clinical and dermoscopic differences found in this study may be useful for establishing a differential diagnosis.

Metastases of Urothelium Carcinoma: Differential Diagnosis, Resection, and Survival

2021 ◽  
Author(s):  
Selma Oguzhan ◽  
Stefan Sponholz ◽  
Moritz Schirren ◽  
Mesut Mese ◽  
Joachim Schirren
Keyword(s):  
Differential Diagnosis ◽  
Multimodal Therapy ◽  
Pulmonary Metastases ◽  
Univariate Analysis ◽  
Pulmonary Carcinoma ◽  
Therapy Regimen ◽  
Urothelial Carcinomas ◽  
Common Diagnosis ◽  
Histological Confirmation ◽  
Systemic Therapies

Abstract Background Due to its very aggressive nature and low survival chances, the metastasized urothelium carcinoma poses a challenge in regard to therapy. The gold-standard chemotherapy is platinum based. The therapy options are considered controversial, including new systemic therapies. In this respect, surgical therapies, as already established for pulmonary metastases of other tumor entities play an increasingly important role. The consumption of nicotine is a risk factor not only for urothelium carcinoma but also for a pulmonary carcinoma. Thus, we examined the frequency of a second carcinoma in this cohort. Methods We retrospectively examined patients who had a differential diagnosis of pulmonary metastases, as well as those patients who underwent a surgery due to pulmonary metastases of a urothelium carcinoma between 1999 and 2015. Results A total of 139 patients came to our clinic with the differential diagnosis of pulmonary metastases of a urothelium carcinoma. The most common diagnosis was pulmonary carcinoma (53%). Thirty-one patients underwent surgeries due to pulmonary metastases of a urothelium carcinoma. The median survival was 53 months and the 5-year survival was 51%. With the univariate analysis, only the relapse-free interval of more than 10 months was statistically significant (p < 0.001). Conclusion There is a high coincidence of urothelial carcinoma and lung carcinoma. A histological confirmation should be endeavored. Selected patients undergoing a pulmonary metastasis resection have a survival advantage during the multimodal treatment of pulmonary metastasized urothelial carcinomas. For a definitive recommendation, randomized trials including a uniform multimodal therapy regimen and higher numbers of patients are necessary.

Atypical aspects in testicular tumors and differential diagnosis with benign lesion: Clinical case

1992 ◽  
Vol 59 (2) ◽  
pp. 77-79
Author(s):  
G. Ferro
Keyword(s):  
Differential Diagnosis ◽  
Clinical Case ◽  
Benign Lesion ◽  
Benign Lesions ◽  
Testicular Tumors

The author uses a clinical case to draw attention to some clinical and ultrasonographic aspects of testicular tumors, and in particular typical seminoma in stages I and II. Necrosis is prevalent in seminomas, which makes them difficult to differentiate from benign lesions.

Spiculated Masses

2018 ◽  
Author(s):  
Liva Andrejeva ◽  
Jaime L. Geisel ◽  
Malini Harigopal
Keyword(s):  
Differential Diagnosis ◽  
Tumor Cells ◽  
Clinical Features ◽  
Clinical Management ◽  
Normal Tissue ◽  
Clinical History ◽  
Benign Lesions ◽  
Imaging Protocols ◽  
Malignant Lesions ◽  
Management Recommendations

A spiculated mass is a centrally dense lesion seen on mammography with sharp lines radiating from its margin. The spicules can vary greatly in length, from a few millimeters to several centimeters. In malignant lesions, spicules represent a mixture of tumor cells and fibrosis invading the normal tissue surrounding the lesion. Although a spiculated mass is thought of as a classic finding of malignancy on mammography, ultrasound, and MRI, its differential diagnosis includes benign lesions. However, unless clinical history strongly supports a benign diagnosis, a spiculated mass on any modality typically will require additional workup and biopsy. This chapter reviews the key imaging and clinical features, imaging protocols and pitfalls, differential diagnoses, radiology–pathology correlations, and clinical management recommendations for a spiculated mass. Topics discussed include both malignant and benign masses.

scholarly journals Infantile Myofibroma Presenting as a Large Ulcerative Nodule in a Newborn

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Farooq Shahzad ◽  
Ava G. Chappell ◽  
Chad A. Purnell ◽  
Monica Aldulescu ◽  
Sarah Chamlin
Keyword(s):  
Differential Diagnosis ◽  
Malignant Tumors ◽  
Physical Exam ◽  
Benign Lesions ◽  
Skin Nodule ◽  
The Right ◽  
Infantile Myofibroma

The differential diagnosis of a congenital cutaneous vascular-appearing mass in a newborn is broad and includes both benign and malignant tumors. We report the case of a newborn who presented with an erythematous exophytic skin nodule on the right upper leg. Excision was performed due to ulceration, concern for bleeding, and for diagnosis. Pathology revealed the mass to be an infantile myofibroma. This case highlights the importance of considering a broad differential diagnosis in a newborn with a cutaneous mass. While history, physical exam, and imaging can help diagnose some cases, a biopsy or excision is often needed to distinguish benign lesions from more concerning lesions.

scholarly journals A case report of an intracaval extrathoracic solitary fibrous tumour

2013 ◽  
Vol 95 (4) ◽  
pp. e6-e9 ◽  
Author(s):  
SZ Koh ◽  
HY Tiong ◽  
S Wang ◽  
K Madhavan
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Prognostic Factor ◽  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Vena Cava ◽  
Solitary Fibrous Tumour ◽  
Benign Lesions ◽  
Adverse Prognostic Factor ◽  
Solitary Fibrous Tumours

Solitary fibrous tumours are infrequent neoplasms based in the pleura that are predominantly benign with malignant pathology and behaviour described in 10–36% of cases. Extrathoracic solitary fibrous tumours (ESFTs) have been considered separately to their intrathoracic counterparts and comprise a third of all solitary fibrous tumours. The extrathoracic location was identified as an adverse prognostic factor for local recurrence but not for metastatic disease. So far, there have not been any reports of solitary fibrous tumours demonstrating caval infiltration. We present a case of a benign ESFT infiltrating into the perirenal inferior vena cava. Together with extrauterine leiomyomas, ESFTs should also be considered as a differential diagnosis for the rare benign lesions invading the inferior vena cava.

scholarly journals Etiologies of Pediatric Cervical Lymphadenopathy: A Systematic Review of 2687 Subjects

2019 ◽  
Vol 6 ◽  
pp. 2333794X1986544 ◽  
Author(s):  
Ankita Deosthali ◽  
Katherine Donches ◽  
Michael DelVecchio ◽  
Stephen Aronoff
Keyword(s):  
Systematic Review ◽  
Differential Diagnosis ◽  
Data Extraction ◽  
Meta Analysis ◽  
Case Series ◽  
Cervical Lymphadenopathy ◽  
Granulomatous Disease ◽  
Cross Sectional ◽  
Barr Virus ◽  
Common Diagnosis

Background. Cervical lymphadenopathy in children is common and its etiologies diverse. No systematic review of the differential diagnosis of pediatric cervical lymphadenopathy has been conducted. Objective. To determine the prevalence rate of specific etiologies of pediatric cervical lymphadenopathy. Data Sources. EMBASE, PubMed, and SCOPUS were searched electronically. Bibliographies of select studies were reviewed as well. Study Selection. (1) Any clinical trial, observational study, or cross-sectional case series with 10 or more subjects that included delineation of etiologies and/or associated conditions with lymphadenopathy; (2) subjects aged 0 to 21 years with enlarged lymphoid tissue on body; (3) lymphadenopathy was confirmed by clinical evaluation; and (4) no specific diagnoses were excluded. Data Extraction. Year and location of publication, definition of lymphadenopathy, percentage of lymphadenopathy that was cervical, total number of subjects, gender distribution of subjects, age range of patients, and specific etiologies. Results. Of the 1790 studies, 7 studies that were combined resulted in 2687 subjects that were selected. Nonspecific benign etiology was the most common diagnosis occurring at a rate of 67.8%. Epstein-Barr virus was the next most prevalent (8.86%), followed by malignancy (4.69%) and granulomatous disease (4.06%). The most common malignancy etiology was non-Hodgkin’s lymphoma (46.0%), and the most common granulomatous disease was tuberculosis (73.4%). Conclusions. This systematic review and meta-analysis provides a rate-based differential diagnosis of pediatric cervical lymphadenopathy. Although the most common causes of pediatric cervical lymphadenopathy are nonspecific, the etiologies are diverse. Rates and credible intervals are provided to enable a probability-based diagnostic approach to palpable cervical lymphadenopathy in this age group.

Solitary Pulmonary Nodule

2018 ◽  
Author(s):  
Taine T.V. Pechet ◽  
Olugbenga T Okusanya
Keyword(s):  
Lung Cancer ◽  
Positron Emission Tomography ◽  
Differential Diagnosis ◽  
Cell Lung Cancer ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Emission Tomography ◽  
Common Finding ◽  
Benign Lesions ◽  
Positron Emission

The solitary pulmonary nodule is a common finding that is observed in more than 150,000 persons each year in the United States. Factors influencing probability of malignancy are discussed, including age and environmental factors. Investigative studies are described. Imaging includes chest radiography, computed tomography, and positron emission tomography. Biopsy can be excisional or performed via transthoracic needle or bronchoscopy. The differential diagnosis is broad and can include malignant or benign lesions. Malignant lesions include nonsmall cell lung cancer, small cell lung cancer, pulmonary neuroendocrine tumors, and metastatic malignancies. Benign lesions can include pulmonary hamartoma or inflammatory or infectious nodules. Few, if any, randomized controlled trials exist to direct management. Most clinicians rely on a combination of single-institution studies, a few prospective trials, and clinical acumen to assess a given patient's risk profile to inform decisions on invasive and noninvasive testing. In this review, the tables describe the differential diagnosis of a solitary pulmonary nodule, factors affecting malignant probability of a solitary pulmonary nodule, and the initial assessment of probability of cancer in a solitary pulmonary nodule. This review contains 5 figures, 4 tables, and 73 references. Key Words: bronchoscopy, compute tomography, lung cancer, nodule, positron emission tomography, solitary

Differential diagnosis between metastatic tumors and nonsolid benign lesions of the liver using ferucarbotran-enhanced MR imaging

2010 ◽  
Vol 73 (1) ◽  
pp. 125-130 ◽  
Author(s):  
Hiroki Higashihara ◽  
Takamichi Murakami ◽  
Tonsok Kim ◽  
Masatoshi Hori ◽  
Hiromitsu Onishi ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Benign Lesions ◽  
Metastatic Tumors

scholarly journals CEUS in the differential diagnosis between biliary sludge, benign lesions and malignant lesions

2018 ◽  
Vol 21 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Carla Serra ◽  
Cristina Felicani ◽  
Elena Mazzotta ◽  
Veronica Gabusi ◽  
Valentina Grasso ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Benign Lesions ◽  
Biliary Sludge ◽  
Malignant Lesions

Differential Diagnosis of Spine Tumors: My Favorite Mistake

2019 ◽  
Vol 23 (01) ◽  
pp. 026-035 ◽  
Author(s):  
Domenico Albano ◽  
Carmelo Messina ◽  
Salvatore Gitto ◽  
Olympia Papakonstantinou ◽  
Luca Sconfienza
Keyword(s):  
Differential Diagnosis ◽  
Pulse Sequences ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Imaging Features ◽  
Correct Interpretation ◽  
Benign Lesions ◽  
Contrast Enhanced ◽  
Robust Reliability

AbstractImaging has a pivotal role in the detection and characterization of spine bone tumors (SBTs), especially using magnetic resonance (MR) imaging and computed tomography (CT). Although MR performed with conventional pulse sequences has a robust reliability in the assessment of SBTs, some imaging features of benign lesions and malignancies overlap, making the differential diagnosis challenging. Several imaging tools are now available to perform a correct interpretation of images of SBTs including diffusion-weighted imaging, dynamic contrast-enhanced MR, Dixon sequences, and dual-energy CT. Nevertheless, strengths and weaknesses of imaging modalities should be kept in mind, and it is crucial to be aware of the pitfalls that can be encountered in daily clinical practice when dealing with these lesions. This review provides an overview on the main challenges encountered when dealing with SBTs, providing some tricks of the trade to avoid possible diagnostic traps.

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