Long term use of Desmopressin for urinary symptoms in multiple sderosis

The benefit of desmopressin (DDAVP) in the treatment of the urinary symptoms of multiple sclerosis has until now only been shown in short crossover studies of up to 6 weeks. We report 19 patient who have used the drug for an average of 2 years and 4 months, 18 of whom confirmed continued dramatic benefit without any obvious change in dosage used or efficacy and with few side effects. Ten of the 19 patienit had also used DDAVP during daytime for special occasions with notable success. This is the first study to suggest that DDAVP is safe and effective in long term use in MS.

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Retinopathy Associated with Adjuvant Interferon in a Patient with Malignant Melanoma: A Case Report and Review of the Literature

Ophthalmology Research An International Journal ◽

10.9734/or/2019/v11i230121 ◽

2019 ◽

pp. 1-7

Author(s):

Mahmut Dogan

Keyword(s):

Multiple Sclerosis ◽

Visual Acuity ◽

Side Effects ◽

Vision Loss ◽

Interferon Treatment ◽

Ocular Toxicity ◽

Review Of The Literature ◽

Immune Mediated ◽

Adjuvant Interferon

Interferons are kinds of proteins with immuneregulatory, antiviral and anti-proliferative functions. Interferons are widely used worldwide for the treatment of many diseases including cancer, hepatit C and immune mediated disease such as multiple sclerosis. Long-term use of interferons have some side effects. However, interferons have ophthalmologic side effects. Ocular toxicity may occur at any time during treatment. There is no association between the dose or duration of interferon treatment and ocular toxicity. Although visual acuity returns to normal in most patients when interferon is discontinued, vision loss may be permanent.

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Long term use of Desmopressin for urinary symptoms in multiple sclerosis

Multiple Sclerosis Journal ◽

10.1191/135245899678846447 ◽

1999 ◽

Vol 5 (6) ◽

pp. 416-417 ◽

Cited By ~ 1

Author(s):

N. Tubridy ◽

R. Addison ◽

F. Schon

Keyword(s):

Multiple Sclerosis ◽

Urinary Symptoms

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The Effect of Ciclosporin versus Azathioprine on the Course of Multiple Sclerosis; Design of a Long-term Follow-up Study and Side Effects

Ciclosporin in Autoimmune Diseases ◽

10.1007/978-3-642-70607-3_12 ◽

1985 ◽

pp. 88-95 ◽

Cited By ~ 2

Author(s):

U. Patzold ◽

D. Dommasch ◽

Sigrid Poser ◽

L. Kappos ◽

J. Haas ◽

...

Keyword(s):

Multiple Sclerosis ◽

Side Effects ◽

Follow Up Study ◽

Long Term Follow Up

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Cutaneous ulcers following hydroxyurea therapy

Phlebologie ◽

10.1055/s-0037-1621559 ◽

2004 ◽

Vol 33 (06) ◽

pp. 202-205 ◽

Cited By ~ 2

Author(s):

K. Hartmann ◽

S. Nagel ◽

T. Erichsen ◽

E. Rabe ◽

K. H. Grips ◽

...

Keyword(s):

Side Effects ◽

Side Effect ◽

Antineoplastic Agent ◽

Limited Time ◽

Myeloproliferative Diseases ◽

Dermatological Side Effects ◽

Chronic Myeloproliferative Diseases ◽

Hydroxyurea Therapy

SummaryHydroxyurea (HU) is usually a well tolerated antineoplastic agent and is commonly used in the treatment of chronic myeloproliferative diseases. Dermatological side effects are frequently seen in patients receiving longterm HU therapy. Cutaneous ulcers have been reported occasionally.We report on four patients with cutaneous ulcers whilst on long-term hydroxyurea therapy for myeloproliferative diseases. In all patients we were able to reduce the dose, or stop HU altogether and their ulcers markedly improved. Our observations suggest that cutaneous ulcers should be considered as possible side effect of long-term HU therapy and healing of the ulcers can be achieved not only by cessation of the HU treatment, but also by reducing the dose of hydroxyurea for a limited time.

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