Associations of depression status and hopelessness with breast cancer: A 24-year follow-up study

2016 ◽  
Vol 22 (10) ◽  
pp. 1322-1331 ◽  
Author(s):  
Amanda M Mitchell ◽  
Patrick Pössel ◽  
Benjamin W Van Voorhees ◽  
William W Eaton

This study extended the literature by examining whether three profiles of depression predicted breast cancer status. In 1076 women of the Baltimore Epidemiologic Catchment Area study, depression status and hopelessness were measured at baseline and breast cancer status was ascertained 24 years later. Double depression, but not major depression or dysthymia, was associated with breast cancer. Hopelessness predicted fewer new cases of breast cancer. When double depression and hopelessness were simultaneously entered as predictors, the regression weights of both predictors increased. The role of severe and extended duration depression as well as possible explanations for unexpected findings are discussed.

2010 ◽  
Vol 62 (2) ◽  
pp. 249-256
Author(s):  
Rabi Abu ◽  
M. Markicevic ◽  
Tijana Vujasinovic ◽  
Silvana Lukic ◽  
Ljiljana Stamatovic ◽  
...  

In our study we investigated the role of the estrogen receptor (ER), progesterone receptor (PR) and clinicohistological parameters in breast cancer patients treated with tamoxifen during the early (2.5 years) vs. late (2.5-5 years) follow-up. The negative status of both ER and PR and tumors equal to or bigger than 2 cm defined the phenotypes and consequently the groups of patients with the worst clinical course of the disease: ER-negative PR-negative, ER-negative pT2 and PR-negative pT2. These high-risk subgroups were related to early follow-up indicating de novo resistance. It is relevant to point out that examined predictive indicators did not show significant importance in the late follow-up study.


2004 ◽  
Vol 34 (2) ◽  
pp. 211-219 ◽  
Author(s):  
S. L. LARSON ◽  
M. R. CLARK ◽  
W. W. EATON

Background. The co-occurrence of affective distress and back pain is well documented but the relationship between them is less certain. This study examines the relationship between lifetime occurrence of depressive disorder and incident back pain reported over a 13-year period.Method. The Baltimore Epidemiologic Catchment Area Study is a prospective study of a household-residing cohort, selected probabilistically from East Baltimore in 1981. Between 1982–3 (wave 2) and again between 1993–6 (wave 3), a follow-up study of the original cohort was conducted. Questions on depressive disorder and back pain were drawn from the Diagnostic Interview Schedule. Logistic regression analyses were used to evaluate whether depressive disorder acts as a risk factor for incident back pain.Results. In cross-sectional analyses, lifetime occurrence of depressive disorder was a significant correlate of lifetime prevalence of back pain at wave 1 (OR=1·6, P=0·01). During the 13-year follow-up, across three data collection points, there was an increase in the risk for incident back pain when depressive disorder was present at baseline (OR=1·9, 95% CI 1·03, 3·4). However, during the short-term follow-up period of 1 year, between baseline and wave 2, depressive disorder at baseline was unrelated to first-ever reports of back pain. Lifetime depressive disorder in both waves 1 (baseline) and 2 (1 year later) was associated with a more than three times greater risk for a first-ever report of back pain during the 12 to 13 year follow-up period, in comparison to those who did not have depressive disorder at waves 1 or 2 (OR=3·4, 95% CI 1·4, 7·8). Back pain at wave 1 was not significantly associated with an increased risk for depression in the longitudinal analysis (OR=0·8, 95% CI 0·5, 1·4).Conclusions. Depressive disorder appears to be a risk factor for incident back pain independent of other characteristics often associated with back pain. Back pain is not a short-term consequence of depressive disorder but emerges over periods longer than 1 year. Moreover, in this study the alternative pathway of back pain as a risk factor for depressive disorder could not be supported.


2021 ◽  
pp. 1-16
Author(s):  
Michelle Teodoro Alves ◽  
Ricardo Simões ◽  
Rodrigo Mendonça Cardoso Pestana ◽  
Angélica Navarro de Oliveira ◽  
Heloísa Helena Marques Oliveira ◽  
...  

2014 ◽  
Vol 22 (9) ◽  
pp. 917-925 ◽  
Author(s):  
Rebecca S. Hock ◽  
Hochang Benjamin Lee ◽  
O. Joseph Bienvenu ◽  
Gerald Nestadt ◽  
Jack F. Samuels ◽  
...  

Author(s):  
Rodrigo M.C. Pestana ◽  
Rita C.F. Duarte ◽  
Michelle T. Alves ◽  
Angélica N. de Oliveira ◽  
Heloísa H.M. Oliveira ◽  
...  

Author(s):  
Camilla Toulmin

This book describes the choices open to farming families in the Sahelian village of Kala, in central Mali. Life in this drought-prone region is harsh and full of risk to health, crops, and livestock, yet there are also opportunities open to the hard-working, audacious and lucky, bringing considerable returns if the timing is right. Three inter-related themes underlie the analysis of production and investment decisions faced by households; the role of risk, the long timeframe within which decisions are made, and the close links between economic performance and household size and organisation. Climatic variability and demographic uncertainty lie at the heart of domestic structures; the extreme vulnerability faced by single individuals means people cluster in large kin-based groups, pooling risks and providing protection. The very limited development of labour markets means that households rely almost entirely on their own members for their workforce, and generating the capital needed for investing in ploughs, wells, carts and livestock must stem from a good year’s grain surplus and migration earnings. Based on field-research over the period 1980-82, this study illustrates a successful response to making ends meet in a land abundant region, despite high risks of drought. A follow-up study of this village was published in 2020: Land, Investment, and Migration. Thirty-five years of village life in Mali (OUP).


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