Subjective social status is indirectly associated with short-term smoking cessation through nicotine withdrawal symptoms

This study used data collected from a smoking cessation program ( N = 146) to evaluate whether subjective social status was indirectly associated with smoking cessation through nicotine withdrawal symptoms. Findings indicated that subjective social status was indirectly associated with smoking cessation through withdrawal symptoms, specifically through anger and anxiety symptoms. People with lower subjective social status reported more withdrawal symptoms, particularly symptoms related to anger and anxiety, shortly after a quit attempt, and as such, were less likely to achieve smoking abstinence. Findings from this study provide insight into why socioeconomically disadvantaged adults are less likely to remain abstinent after a quit attempt.

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Evaluation of smokers with and without asthma in terms of smoking cessation outcome, nicotine withdrawal symptoms, and craving: Findings from a self-guided quit attempt

Addictive Behaviors ◽

10.1016/j.addbeh.2016.07.021 ◽

2016 ◽

Vol 63 ◽

pp. 149-154 ◽

Cited By ~ 4

Author(s):

Alison C. McLeish ◽

Samantha G. Farris ◽

Adrienne L. Johnson ◽

Jonathan A. Bernstein ◽

Michael J. Zvolensky

Keyword(s):

Smoking Cessation ◽

Nicotine Withdrawal ◽

Withdrawal Symptoms ◽

Quit Attempt ◽

Smoking Cessation Outcome

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Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1707047115 ◽

2018 ◽

Vol 115 (16) ◽

pp. 4282-4287 ◽

Cited By ~ 15

Author(s):

Julia K. Brynildsen ◽

Bridgin G. Lee ◽

Isaac J. Perron ◽

Sunghee Jin ◽

Sangwon F. Kim ◽

...

Keyword(s):

United States ◽

Smoking Cessation ◽

The United States ◽

Nicotine Withdrawal ◽

Withdrawal Symptoms ◽

Ampk Activation ◽

Ampk Signaling ◽

Amp Activated Protein Kinase ◽

Multiple Health ◽

Withdrawal Signs

Cigarette smoking is the leading cause of preventable disease and death in the United States, with more persons dying from nicotine addiction than any other preventable cause of death. Even though smoking cessation incurs multiple health benefits, the abstinence rate remains low with current medications. Here we show that the AMP-activated protein kinase (AMPK) pathway in the hippocampus is activated following chronic nicotine use, an effect that is rapidly reversed by nicotine withdrawal. Increasing pAMPK levels and, consequently, downstream AMPK signaling pharmacologically attenuate anxiety-like behavior following nicotine withdrawal. We show that metformin, a known AMPK activator in the periphery, reduces withdrawal symptoms through a mechanism dependent on the presence of the AMPKα subunits within the hippocampus. This study provides evidence of a direct effect of AMPK modulation on nicotine withdrawal symptoms and suggests central AMPK activation as a therapeutic target for smoking cessation.

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Prospective evaluation of the effects of anxiety sensitivity and state anxiety in predicting acute nicotine withdrawal symptoms during smoking cessation.

Psychology of Addictive Behaviors ◽

10.1037/a0024133 ◽

2012 ◽

Vol 26 (2) ◽

pp. 289-297 ◽

Cited By ~ 33

Author(s):

Kirsten A. Johnson ◽

Sherry Stewart ◽

David Rosenfield ◽

Dan Steeves ◽

Michael J. Zvolensky

Keyword(s):

Smoking Cessation ◽

Anxiety Sensitivity ◽

State Anxiety ◽

Nicotine Withdrawal ◽

Withdrawal Symptoms ◽

Prospective Evaluation

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Effects of nicotine dose and administration method on withdrawal symptoms and side effects during short-term smoking abstinence.

Experimental and Clinical Psychopharmacology ◽

10.1037/1064-1297.5.1.54 ◽

1997 ◽

Vol 5 (1) ◽

pp. 54-64 ◽

Cited By ~ 24

Author(s):

Scott J. Leischow ◽

Suzanne N. Valente ◽

Anabel L. Hill ◽

Pamela S. Otte ◽

Mikel Aickin ◽

...

Keyword(s):

Side Effects ◽

Withdrawal Symptoms ◽

Smoking Abstinence ◽

Short Term ◽

Administration Method

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Exenatide Adjunct to Nicotine Patch Facilitates Smoking Cessation and May Reduce Post-Cessation Weight Gain: a Pilot Randomized Controlled Trial

Nicotine & Tobacco Research ◽

10.1093/ntr/ntab066 ◽

2021 ◽

Author(s):

Luba Yammine ◽

Charles E Green ◽

Thomas R Kosten ◽

Constanza de Dios ◽

Robert Suchting ◽

...

Keyword(s):

Smoking Cessation ◽

Body Weight ◽

Weight Gain ◽

Extended Release ◽

Nicotine Patch ◽

Withdrawal Symptoms ◽

Secondary Outcome ◽

Smoking Abstinence ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1

Abstract Introduction Approved pharmacological treatments for smoking cessation are modestly effective, underscoring the need for improved pharmacotherapies. Glucagon-like peptide-1 receptor (GLP-1R) agonists attenuate the rewarding effects of nicotine in preclinical studies. We examined the efficacy of extended-release exenatide, a GLP-1R agonist, combined with nicotine replacement therapy (NRT, patch) for smoking cessation, craving and withdrawal symptoms, with post-cessation body weight as secondary outcome. Methods Eighty-four prediabetic and/or overweight smokers were randomized (1:1) to once-weekly placebo or exenatide, 2 mg, subcutaneously. All participants received NRT (21 mg) and brief smoking cessation counseling. Seven-day point prevalence abstinence (expired CO level ≤5 ppm), craving, withdrawal and post-cessation body weight were assessed following 6 weeks of treatment. A Bayesian approach for analyzing generalized linear models yielded posterior probabilities (PP) to quantify the evidence favoring hypothesized effects of treatment on the study outcomes. Results Exenatide increased the risk for smoking abstinence compared to placebo (46.3% and 26.8%, respectively), (RR = 1.70; 95% credible interval = [0.96, 3.27]; PP = 96.5%). Exenatide reduced end-of-treatment craving in the overall sample and withdrawal among abstainers. Post-cessation body weight was 5.6 pounds lower in the exenatide group compared to placebo (PP=97.4%). Adverse events were reported in 9.5% and 2.3% of participants in the exenatide and placebo groups, respectively. Conclusions Exenatide, in combination with the NRT improved smoking abstinence, reduced craving and withdrawal symptoms, and decreased weight gain among abstainers. Findings suggest that the GLP-1R agonist strategy is worthy of further research in larger, longer duration studies. Implications Despite considerable progress in tobacco control, cigarette smoking remains the leading cause of preventable disease, disability, and death. In this pilot study, we showed that extended-release exenatide, a glucagon-like peptide-1 receptor agonist, added to the nicotine patch, improved abstinence and mitigated post-cessation body weight gain compared to patch alone. Further research is needed to confirm these initial positive results.

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Effectiveness of Nicotine Withdrawal Symptoms Management Program Using LINE Application to Increase Self-Efficacy for Industrial Workers

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2021.12.13025 ◽

2021 ◽

Vol 104 (12) ◽

pp. 1920-1929

Keyword(s):

Smoking Cessation ◽

Self Efficacy ◽

Nicotine Withdrawal ◽

Management Program ◽

Withdrawal Symptoms ◽

Control Group ◽

Industrial Workers ◽

Exhaled Carbon Monoxide ◽

Cigarette Craving ◽

Withdrawal Management

Background: Smoking is a risk factor for chronic diseases. A combination of tobacco use with occupational hazards among industrial workers could increase the risk of occupational disease and injury. Nicotine is known to be highly addictive. It is difficult not only to maintain the decrease in smoking but also to continue quitting tobacco use. Moreover, nicotine withdrawal can be challenging and lead to failure in the smoking cessation process. Self-efficacy theory has been used recently for the development of effective smoking cessation programs. Objective: To develop an online nicotine withdrawal symptoms management program based on self-efficacy theory and examine its effectiveness. Materials and Methods: A quasi-experimental design with a control group pretest-posttest design was used. The sample consisted of male employees working in a consumer product manufacturing industry in Bangkok. An intervention group (n=28) received an online nicotine withdrawal symptoms management program via LINE application based on self-efficacy theory for one month. In comparison, participants in the control group (n=29) received a conventional smoking cessation program. The effectiveness of the intervention on nicotine withdrawal symptoms, cigarette craving, self-efficacy perception of nicotine withdrawal management, cigarette rolls per day, nicotine dependence level, exhaled carbon monoxide level, and smoking cessation behavior the first and fourth week were examined using a repeated-measures analysis of variance. Results: At one-month follow-up, there were significant differences between the two groups on nicotine withdrawal symptoms score, cigarette craving level, self-efficacy perception of nicotine withdrawal management, cigarette rolls per day, nicotine addiction level, exhaled carbon monoxide level, and smoking cessation behaviors (p<0.001). In addition, there was a significant difference in the self-reported nicotine withdrawal symptoms score in terms of irritability, anger, anxiety, concentration deficit, depression, and insomnia (p<0.001) between groups, between times, and between times and groups (p<0.001). Conclusion: Nicotine withdrawal symptoms management program using LINE application is effective in encouraging smoking cessation. Keywords: Smoking cessation; Nicotine withdrawal symptoms; LINE application; Industrial workers

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Patterns of E-cigarette Use and Subsequent Cigarette Smoking Cessation Over 2 Years (2013/2014–2015/2016) in the Population Assessment of Tobacco and Health Study

Nicotine & Tobacco Research ◽

10.1093/ntr/ntaa182 ◽

2020 ◽

Cited By ~ 3

Author(s):

Allison M Glasser ◽

Mahathi Vojjala ◽

Jennifer Cantrell ◽

David T Levy ◽

Daniel P Giovenco ◽

...

Keyword(s):

Smoking Cessation ◽

Cigarette Smoking ◽

The United States ◽

Adjusted Relative Risk ◽

Cigarette Use ◽

Short Term ◽

Population Assessment ◽

Quit Attempt ◽

Quit Smoking

Abstract Introduction Understanding the population impact of e-cigarettes requires determining their effect on cigarette smoking cessation. Methods Using the US Population Assessment of Tobacco and Health cohort, we examined smoking cessation among adult current cigarette smokers at Wave 1 with follow-up data at Waves 2 and 3 (n = 9724). Results By Wave 3 (2015/2016), 17.3% of smokers had quit smoking. Smokers using e-cigarettes daily or who increased to daily use over the three waves were two to four times more likely to have quit in the short term (<1 year) and long term (1+ years) compared with never e-cigarette users (p < .001). E-cigarette use in the last quit attempt was associated with a higher likelihood of short-term (<1 year) quitting at Wave 3 (adjusted relative risk ratio: 1.33; 95% confidence interval: 1.04, 1.71) compared with smokers who did not use an e-cigarette in their last quit attempt. Noncurrent (no use in any wave) e-cigarette users and users who were unstable in use frequency were 33% and 47% less likely to quit in the short-term, respectively (p < .001). Flavored (vs nonflavored) and using a rechargeable (vs disposable) e-cigarette device was associated with an increased likelihood of both short- and long-term quitting. Conclusion Smoking cessation was more likely among frequent e-cigarette users, users of e-cigarettes in last quit attempt, and users of flavored and rechargeable devices. Less frequent, unstable, past, or never e-cigarette users were less likely to quit smoking. Monitoring the relationship between patterns of e-cigarette and cigarette use is complex but critical for gauging the potential of e-cigarettes as a harm reduction tool. Implications This study suggests that consistent and frequent e-cigarette use over time is associated with cigarette smoking cessation among adults in the United States. In addition, findings suggest that flavored e-cigarette use and use of rechargeable e-cigarette devices can facilitate smoking cessation. These results underscore the importance of carefully defining and characterizing e-cigarette exposure patterns, potential confounders, and use of e-cigarettes to quit smoking, as well as variations in length of the smoking cessation.

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