Building a legacy? Ambivalent impacts of a malaria vaccine clinical trial

2018 ◽  
Vol 23 (4) ◽  
pp. 413-425
Author(s):  
Sandalia Genus
Keyword(s):  
Clinical Trial ◽  
Medical Research ◽  
Malaria Vaccine ◽  
Research Centre ◽  
Global Health Research ◽  
Vaccine Clinical Trial ◽  
North Eastern ◽  
Trial Staff ◽  
Lasting Change

This article examines infrastructure and technology assembled to support a malaria vaccine clinical trial, conducted between 2009 and 2014. It draws on ethnographic fieldwork at a medical research centre in north-eastern Tanzania, with additional data from interviews with researchers, vaccine scientists and trial funders. The infrastructure and technology were conceived of as enabling the development of a vaccine and facilitating future medical research and health care provision in Tanzania. However, after the clinical trial ended, these material remains were decaying, repurposed or lacked long-term sustainability without continued research funding. For trial staff in Tanzania, this led to expressions of affect, including disappointment, ambivalence and frustration as expectations for the future were foreclosed. The author argues that the material remains of the clinical trial had varied impacts and, furthermore, ambivalence is an embedded part of clinical trials due to their time constraints and lack of local rooting. The end of this clinical trial exposes the limitations of global health research in bringing about lasting change to low-resource settings. This article highlights the need to consider the life of material objects after research concludes.

scholarly journals Impact of RTS,S/AS02A and RTS,S/AS01B on Genotypes of P. falciparum in Adults Participating in a Malaria Vaccine Clinical Trial

PLoS ONE ◽  
2009 ◽  
Vol 4 (11) ◽  
pp. e7849 ◽  
Author(s):  
John N. Waitumbi ◽  
Samuel B. Anyona ◽  
Carol W. Hunja ◽  
Carolyne M. Kifude ◽  
Mark E. Polhemus ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Malaria Vaccine ◽  
Vaccine Clinical Trial

scholarly journals Harmonization study between three laboratories for expression of malaria vaccine clinical trial IgG antibody ELISA data in µg/mL

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Geneviève M. Labbé ◽  
Kazutoyo Miura ◽  
Sarah E. Silk ◽  
Wenjuan Gu ◽  
James E. Moon ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Malaria Vaccine ◽  
Igg Antibody ◽  
Vaccine Clinical Trial ◽  
Antibody Elisa ◽  
Elisa Data

scholarly journals Applying a framework to assess the impact of cardiovascular outcomes improvement research

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mitchell N. Sarkies ◽  
Suzanne Robinson ◽  
Tom Briffa ◽  
Stephen J. Duffy ◽  
Mark Nelson ◽  
...  
Keyword(s):  
Medical Research ◽  
Research Impact ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Cardiovascular Outcomes ◽  
Research Centre ◽  
Patient Reported ◽  
The Impact ◽  
Research Domain

Abstract Background Health and medical research funding agencies are increasingly interested in measuring the impact of funded research. We present a research impact case study for the first four years of an Australian National Health and Medical Research Council funded Centre of Research Excellence in Cardiovascular Outcomes Improvement (2016–2020). The primary aim of this paper was to explore the application of a research impact matrix to assess the impact of cardiovascular outcomes improvement research. Methods We applied a research impact matrix developed from a systematic review of existing methodological frameworks used to measure research impact. This impact matrix was used as a bespoke tool to identify and understand various research impacts over different time frames. Data sources included a review of existing internal documentation from the research centre and publicly available information sources, informal iterative discussions with 10 centre investigators, and confirmation of information from centre grant and scholarship recipients. Results By July 2019, the impact on the short-term research domain category included over 41 direct publications, which were cited over 87 times (median journal impact factor of 2.84). There were over 61 conference presentations, seven PhD candidacies, five new academic collaborations, and six new database linkages conducted. The impact on the mid-term research domain category involved contributions towards the development of a national cardiac registry, cardiovascular guidelines, application for a Medicare Benefits Schedule reimbursement item number, introduction of patient-reported outcome measures into several databases, and the establishment of nine new industry collaborations. Evidence of long-term impacts were described as the development and use of contemporary management for aortic stenosis, a cardiovascular risk prediction model and prevention targets in several data registries, and the establishment of cost-effectiveness for stenting compared to surgery. Conclusions We considered the research impact matrix a feasible tool to identify evidence of academic and policy impact in the short- to midterm; however, we experienced challenges in capturing long-term impacts. Cost containment and broader economic impacts represented another difficult area of impact to measure.

Computer Analyses in Preventive Health Research

1967 ◽  
Vol 06 (01) ◽  
pp. 8-14 ◽  
Author(s):  
M. F. Collen
Keyword(s):  
Medical Research ◽  
Preventive Medicine ◽  
Health Research ◽  
Large Scale ◽  
Preventive Health ◽  
New Era ◽  
Large Numbers ◽  
Normal Test ◽  
Computer Analyses

The utilization of an automated multitest laboratory as a data acquisition center and of a computer for trie data processing and analysis permits large scale preventive medical research previously not feasible. Normal test values are easily generated for the particular population studied. Long-term epidemiological research on large numbers of persons becomes practical. It is our belief that the advent of automation and computers has introduced a new era of preventive medicine.

Sign in / Sign up

Export Citation Format

Share Document