Book reviews : Management of severe malaria Second Edition. Published by the World Health Organization, Geneva 2000. Paperback 70 pp. Price $13.50 ISBN 92-4-154523-2

2001 ◽  
Vol 121 (2) ◽  
pp. 128-128
Author(s):  
David Donaldson

Richard B. Fisher, Edward Jenner 1749-823.London: André Deutsch, 1991. Pp. 361, £20.00. ISBN 0 233 98681 2 In the summer of 1796, Joseph Banks, long-serving President of the Royal Society, turned down Jenner’s Inquiry on what he called the variolae vaccinae as ‘inadequate’ for publication in the Philosophical Transactions . Barely two years later a revised version, with several additions to the originally very few experimental cowpox inoculations, was published privately. The blurb’s claim that Jenner thus ‘freed mankind from "the spotted plague", smallpox’, seems an exaggerated tribute which ignores the hard work of successive later generations to provide a safe, theoretical basis for Jenner’s empiricism, and also the enormous technical and financial resources invested by the World Health Organization in the prolonged global campaign which finally achieved eradication of smallpox nearly 200 years later. Even within Edward Jenner’s own lifetime, the story of the progress of ‘vaccination’ as opposed to ‘variolation’ was a complex one, not helped by his failure to realize the need for periodic re-vaccination.


2011 ◽  
Vol 10 (1) ◽  
Author(s):  
Josh Hanson ◽  
Sophia WK Lam ◽  
Sanjib Mohanty ◽  
Shamshul Alam ◽  
Md Mahtab Uddin Hasan ◽  
...  

Author(s):  
Eliford Kitabi ◽  
Timothy J Bensman ◽  
Justin C Earp ◽  
Dakshina M Chilukuri ◽  
Heidi Smith ◽  
...  

Abstract For treatment of severe malaria, the World Health Organization recommends 3 mg/kg intravenous artesunate in pediatric patients weighing less than 20 kg. Here we describe the Food and Drug Administration’s rationale for selecting 2.4 mg/kg in pediatric patients weighing less than 20 kg based on literature review and independent analyses.


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