Serum lncRNA TINCR Serve as a Novel Biomarker for Predicting the Prognosis in Triple-Negative Breast Cancer

Background: Tissue differentiation-inducing non-protein coding RNA (TINCR) has been shown to play a crucial role in pathogenesis of various types of human cancer including breast cancer (BC). The purpose of this study was to determine the potential prognostic value of serum lncRNA TINCR in BC. Methods: Quantitative reverse transcription PCR (qRT-PCR) was performed to detect serum lncRNA TINCR levels in 72 triple-negative BC (TNBC) patients, 105 non-TNBC patients, 60 benign breast disease patients and 86 healthy subjects. Results: The results showed that serum lncRNA TINCR level was significantly increased in BC, especially in TNBC. High circulating lncRNA TINCR was significantly correlated with worse clinicopathological features and clinical outcome of TNBC. Multivariate analysis revealed that serum lncRNA TINCR was an independent prognostic factor for overall survival of TNBC. However, little association was found between serum lncRNA TINCR and the prognosis of non-TNBC. Conclusions: Taken together, our findings demonstrate that serum lncRNA TINCR might be a useful novel and non-invasive biomarker for the prognosis prediction of TNBC.

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Association Between Benign Breast Disease in African American and White American Women and Subsequent Triple-Negative Breast Cancer

JAMA Oncology ◽

10.1001/jamaoncol.2016.5598 ◽

2017 ◽

Vol 3 (8) ◽

pp. 1102 ◽

Cited By ~ 7

Author(s):

Lisa A. Newman ◽

Azadeh Stark ◽

Dhanajay Chitale ◽

Margaret Pepe ◽

Gary Longton ◽

...

Keyword(s):

Breast Cancer ◽

African American ◽

Triple Negative Breast Cancer ◽

Benign Breast Disease ◽

Triple Negative ◽

Breast Disease ◽

American Women ◽

White American ◽

White American Women

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Prognostic value of clinicopathological features in a large cohort of triple negative breast cancer

10.26226/morressier.5b4709826f4cb30010951acc ◽

2018 ◽

Author(s):

Maschenka Balkenhol ◽

Suzanne Mol

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Prognostic Value ◽

Triple Negative ◽

Clinicopathological Features ◽

Large Cohort

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Benign Breast Disease: Toward Molecular Prediction of Breast Cancer Risk

10.21236/ada552165 ◽

2009 ◽

Author(s):

Lynn C. Hartmann

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Benign Breast Disease ◽

Breast Disease

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Percutaneous Progesterone Use and Risk of Breast Cancer: Results from a French Cohort Study of Premenopausal Women with Benign Breast Disease

Cancer Detection and Prevention ◽

10.1046/j.1525-1500.1999.99032.x ◽

1999 ◽

Vol 23 (4) ◽

pp. 290-296 ◽

Cited By ~ 7

Author(s):

Plu-Bureau ◽

Le ◽

Thalabard ◽

Sitruk-Ware ◽

Mauvais-Jarvis

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Benign Breast Disease ◽

Premenopausal Women ◽

Breast Disease ◽

French Cohort

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Correction to: Association between lifestyle, menstrual/reproductive history, and histological factors and risk of breast cancer in women biopsied for benign breast disease

Breast Cancer Research and Treatment ◽

10.1007/s10549-018-4780-4 ◽

2018 ◽

Vol 170 (1) ◽

pp. 203-203

Author(s):

Rhonda Arthur ◽

Yihong Wang ◽

Kenny Ye ◽

Andrew G. Glass ◽

Mindy Ginsberg ◽

...

Keyword(s):

Breast Cancer ◽

Benign Breast Disease ◽

Breast Disease ◽

Reproductive History ◽

Histological Factors

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Probability of women with benign breast disease (BBD) of getting breast cancer (BCA) as determined by salivary carcinoembryonic antigen (CEA): A novel approach

Journal of Steroid Biochemistry ◽

10.1016/0022-4731(87)91185-x ◽

1987 ◽

Vol 28 ◽

pp. 30

Author(s):

E.M. Gimenez-Q ◽

M.L. Givner ◽

B.J. Steele

Keyword(s):

Breast Cancer ◽

Carcinoembryonic Antigen ◽

Benign Breast Disease ◽

Breast Disease ◽

Novel Approach

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Serum levels of oxidative stress marker malondialdehyde in breast cancer patients in relation to pathohistological factors, estrogen receptors, menopausal status, and age

Journal of Health Sciences ◽

10.17532/jhsci.2018.263 ◽

2018 ◽

Vol 8 (3) ◽

pp. 154-161

Author(s):

Jasmina Gubaljevic ◽

Nahida Srabović ◽

Adlija Jevrić-Čaušević ◽

Adaleta Softić ◽

Adi Rifatbegović ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Lymph Nodes ◽

Cancer Patients ◽

Benign Breast Disease ◽

Menopausal Status ◽

Serum Levels ◽

Breast Disease ◽

Breast Cancer Patients ◽

Node Metastases

Introduction: The aim of this study was to determine the serum levels of malondialdehyde (MDA) in patients with invasive breast cancer in relation to its serum levels in patients with benign breast disease, and to investigate correlation between MDA serum levels with pathohistological prognostic factors (tumor size, lymph node involvement, and histologic grade [HG]), estrogen receptor (ER) status, and with breast cancer patient’s age and menopausal status. Methods: A total of 43 with well-documented invasive breast cancer were included in this study: 27 with positive axillary’s lymph nodes, and 16 with negative axillary’s lymph nodes, and 39 patients with findings of benign breast diseases. MDA determination in serum of breast cancer and benign breast disease patients was performed by the fluorimetric method, immunohistochemical staining was performed for ER, and routine pathohistological examination was conducted for pathohistological factors. Results: MDA serum levels in breast cancer patients were significantly higher than MDA serum levels in benign breast disease patients (p = 0.042). No statistically significant difference between MDA serum levels in breast cancer patients with and without lymph node metastases was found (p = 0.238). No statistically significant correlations between MDA serum levels and tumor size (p = 0.256), HG (p = 0.124), or number of positive lymph nodes (0.113) were found. A statistically significant correlation between serum MDA levels and ages of breast cancer patients with lymph node metastases was found (p = 0.006). Conclusion: Obtained results support the importance of MDA in the carcinogenesis of breast cancer. According to our findings, serum level of MDA could not be a useful prognostic factor in breast cancer.

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