Botulinum Toxin A Injection for Treatment of Chronic Skin Ulcer: A Case Series and Literature Review

Chronic skin ulcer (CSU) often combines with a variety of refractory factors that respond poorly to routine treatments. Botulinum toxin A (BTX-A) can be injected subcutaneously to improve the local blood supply, to reduce pain, and to promote wound healing. At present, few reports have mentioned BTX-A injection for chronic skin ulcer treatment. We observed the effect of four cases that used BTX-A to treat CSU and provided a brief review of the literature. Four cases of CSUs with 4 different causes were treated with BTX-A injection (4 U/cm2). The specific operation is as follows: local, multipoint, cyclic, equidistant, and subcutaneous injections with a depth of 6 to 8 mm. The ulcer area was significantly reduced. Subsequently, the ulcer healed within 20 to 48 days. Botulinum toxin A is recommended as an important treatment for chronic skin ulcer that can improve healing of skin ulcers with various etiologies.

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Botulinum toxin A injection into corrugator muscle for frontally localised chronic daily headache or chronic tension-type headache

The Journal of Laryngology & Otology ◽

10.1017/s0022215108003198 ◽

2008 ◽

Vol 123 (4) ◽

pp. 412-417 ◽

Cited By ~ 19

Author(s):

J A de Ru ◽

J Buwalda

Keyword(s):

Botulinum Toxin ◽

Botulinum Toxin A ◽

Botulinum Toxin Injection ◽

Botulinum Toxin Type A ◽

Effective Means ◽

Case Series ◽

Botulinum Toxin Type ◽

Toxin A ◽

Tertiary Referral Centre ◽

Corrugator Supercilii

AbstractObjective:To describe our results with botulinum toxin type A injection for headache in carefully selected patients, and to present the rationale behind this therapy.Setting:Tertiary referral centre.Patients and methods:This article describes a case series of 10 consecutive patients with frontally localised headache, whose pain worsened when pressure was applied at the orbital rim near the supratrochlear nerve. The patients received a local anaesthetic nerve block with Xylocaine 2 per cent at this site. If this reduced the pain, they were then offered treatment with botulinum toxin.Intervention:Injection with 12.5 IU of botulinum toxin A into the corrugator supercilii muscle on both sides (a total of 25 IU).Main outcome measure:Pain severity scoring by the patients, ranging from zero (no pain) to 10 (severe pain) on a verbal scale.Results:Following injection, all patients had less pain for approximately two months. This treatment did not appear to have lasting side effects.Conclusion:Xylocaine injection is a good predictor of the effectiveness of botulinum toxin injection into the corrugator muscle as treatment of frontally localised headache. We hypothesise that this pain is caused by entrapment of the supratrochlearis nerve in the corrugator muscle. Furthermore, we found botulinum toxin injection to be a safe and effective means of achieving pain relief in this patient group.

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Treatment of Depression with Botulinum Toxin A: A Case Series

Dermatologic Surgery ◽

10.1111/j.1524-4725.2006.32136.x ◽

2006 ◽

Vol 32 (5) ◽

pp. 645-650 ◽

Cited By ~ 29

Author(s):

ERIC FINZI ◽

ERIKA WASSERMAN

Keyword(s):

Botulinum Toxin ◽

Botulinum Toxin A ◽

Case Series ◽

Toxin A ◽

Treatment Of Depression

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Poster 332 Ultrasound-guided Injections for Low Back Pain: Botulinum Toxin-A and Platelet-rich Plasma: Case Series

PM&R ◽

10.1016/j.pmrj.2011.08.360 ◽

2011 ◽

Vol 3 ◽

pp. S288-S288

Author(s):

Gordon D. Ko ◽

Annie Hum

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Botulinum Toxin ◽

Platelet Rich Plasma ◽

Botulinum Toxin A ◽

Case Series ◽

Low Back ◽

Ultrasound Guided ◽

Toxin A

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Dangers of counterfeit botulinum toxin: a brief review of the literature

Journal of Aesthetic Nursing ◽

10.12968/joan.2012.1.5.254 ◽

2012 ◽

Vol 1 (5) ◽

pp. 254-257

Author(s):

Karen Svolkinas

Keyword(s):

Botulinum Toxin ◽

Botulinum Toxin A ◽

Review Of The Literature ◽

Toxin A

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Botulinum Toxin A for the Treatment of a Child with SUNCT Syndrome

Pain Research and Management ◽

10.1155/2016/8016065 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 12

Author(s):

Yi Zhang ◽

Haifeng Zhang ◽

Ya-Jun Lian ◽

Yun-Qing Ma ◽

Nan-Chang Xie ◽

...

Keyword(s):

Botulinum Toxin ◽

Botulinum Toxin A ◽

First Episode ◽

Toxin A ◽

Temporal Area ◽

Subcutaneous Injections ◽

Sunct Syndrome ◽

Therapeutic Benefits ◽

Inflammatory Drugs

Background.Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) syndrome is an unusual cause of headache, mainly described in older adults, and is rare in children. Pain attacks may be severe, frequent, and prolonged. The therapeutic benefits of many drugs are disappointing.Patient and Methods.A 12-year-old boy suffered severe headache and toothache for 20 days. As treatment with nonsteroidal anti-inflammatory drugs, anticonvulsants, and steroids proved ineffective, he was treated with ipsilateral multisite subcutaneous injections of botulinum toxin A 70 U around the orbit, the temporal area, and the upper gum.Results.The pain had reduced in frequency and severity by the fourth day after treatment and had completely disappeared after 7 days. There were no side effects or recurrence during a subsequent 17-month follow-up period.Conclusion.Botulinum toxin A can be used to treat the first episode of SUNCT in children over the age of 12 years.

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