Exogenous Administration of Substance P Enhances Wound Healing in a Novel Skin-Injury Model

2005 ◽  
Vol 230 (4) ◽  
pp. 271-280 ◽  
Author(s):  
Angel V. Delgado ◽  
Albert T. McManus ◽  
James P. Chambers
Keyword(s):  
Wound Healing ◽  
Nervous System ◽  
Soft Tissue ◽  
Substance P ◽  
Wound Repair ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Inflammatory Cells ◽  
Target Cells

Soft tissue injury accounts for approximately 44% of all wounds in both the military and civilian populations. Following injury to soft tissue, Substance P (SP) and other neuropeptides are released by cutaneous neurons and modulate the function of immunocompetent and inflammatory cells, as well as epithelial and endothelial cells. The interaction between these components of the nervous system and multiple target cells affecting cutaneous repair is of increasing interest. In this report, we describe the effects of SP on wound repair in a novel, laser-induced, skin-wound model. Gross and histologic examination of laser-induced injury revealed that exogenously administered SP affects wound healing via neurite outgrowth, in addition to adhesion molecule and neurokinin-1 receptor involvement in vivo. All SP effects were decreased by pretreatment with Spantide II, an SP antagonist. The elucidation of SP-mediating mechanisms is crucial to firmly establishing the involvement and interaction of the peripheral nervous system and the immune system in cutaneous repair. Findings presented here suggest that SP participates in the complex network of mediators involved in cutaneous inflammation and wound healing.

Healing effects of curcumin nanoparticles in deep tissue injury mouse model.

2020 ◽  
Vol 18 ◽  
Author(s):  
Zirui Zhang ◽  
Shangcong Han ◽  
Panpan Liu ◽  
Xu Yang ◽  
Jing Han ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mrna Expression ◽  
Tissue Injury ◽  
Inflammatory Cells ◽  
Pcr Analysis ◽  
Protective Effects ◽  
Deep Tissue ◽  
Deep Tissue Injury

Background: Chronic inflammation and lack of angiogenesis are the important pathological mechanisms in deep tissue injury (DTI). Curcumin is a well-known anti-inflammatory and antioxidant agent. However, curcumin is unstable under acidic and alkaline conditions, and can be rapidly metabolized and excreted in the bile, which shortens its bioactivity and efficacy. Objective: This study aimed to prepare curcumin-loaded poly (lactic-co-glycolic acid) nanoparticles (CPNPs) and to elucidate the protective effects and underlying mechanisms of wound healing in DTI models. Methods: CPNPs were evaluated for particle size, biocompatibility, in vitro drug release and their effect on in vivo wound healing. Results : The results of in vivo wound closure analysis revealed that CPNP treatments significantly improved wound contraction rates (p<0.01) at a faster rate than other three treatment groups. H&E staining revealed that CPNP treatments resulted in complete epithelialization and thick granulation tissue formation, whereas control groups resulted in a lack of compact epithelialization and persistence of inflammatory cells within the wound sites. Quantitative real-time PCR analysis showed that treatment with CPNPs suppressed IL-6 and TNF-α mRNA expression, and up-regulated TGF-β, VEGF-A and IL-10 mRNA expression. Western blot analysis showed up-regulated protein expression of TGF-β, VEGF-A and phosphorylatedSTAT3. Conclusion: Our results showed that CPNPs enhanced wound healing in DTI models, through modulation of the JAK2/STAT3 signalling pathway and subsequent upregulation of pro-healing factors.

In Vivo Analysis of Microcirculation following Closed Soft-Tissue Injury

2000 ◽  
Vol 82 (12) ◽  
pp. 69
Author(s):  
Klaus-D. Schaser ◽  
Brigitte Vollmar ◽  
Michael D. Menger ◽  
Lioba Schewior ◽  
Stefan N. Kroppenstedt ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
In Vivo Analysis

In Vivo Analysis of Microcirculation following Closed Soft-Tissue Injury

2000 ◽  
Vol 82 (12) ◽  
pp. 20
Author(s):  
Klaus-D. Schaser ◽  
Brigitte Vollmar ◽  
Michael D. Menger ◽  
Lioba Schewior ◽  
Stefan N. Kroppenstedt ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
In Vivo Analysis

In Vivo Analysis of Microcirculation following Closed Soft-Tissue Injury

2000 ◽  
Vol 82 (2) ◽  
pp. 72
Author(s):  
Klaus-D. Schaser ◽  
Brigitte Vollmar ◽  
Michael D. Menger ◽  
Lioba Schewior ◽  
Stefan N. Kroppenstedt ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
In Vivo Analysis

scholarly journals On the Importance of 3D, Geometrically Accurate, and Subject-Specific Finite Element Analysis for Evaluation of in-Vivo Soft Tissue Loads

2016 ◽  
Author(s):  
Kevin Mattheus Moerman ◽  
Marc van Vijven ◽  
Leandro R. Solis ◽  
Eline E. van Haaften ◽  
Arjan C.Y. Loenen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Pressure Ulcers ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Internal Tissue ◽  
Element Analysis ◽  
Cord Injury ◽  
Subject Specific ◽  
Load Evaluation

Pressure ulcers are a type of local soft tissue injury due to sustainedmechanical loading and remain a common issue in patient care. People withspinal cord injury (SCI) are especially at risk of pressure ulcers due toimpaired mobility and sensory perception. The development of load improvingsupport structures relies on realistic tissue load evaluation e.g. usingfinite element analysis (FEA). FEA requires realistic subject-specificmechanical properties and geometries. This study focuses on the effect ofgeometry. MRI is used for the creation of geometrically accurate models ofthe human buttock for three able-bodied volunteers and three volunteerswith SCI. The effect of geometry on observed internal tissue deformationsfor each subject is studied by comparing FEA findings for equivalentloading conditions. The large variations found between subjects confirmsthe importance of subject-specific FEA.

scholarly journals IFATS Collection: Human Adipose-Derived Stem Cells Seeded on a Silk Fibroin-Chitosan Scaffold Enhance Wound Repair in a Murine Soft Tissue Injury Model

Stem Cells ◽  
2009 ◽  
Vol 27 (1) ◽  
pp. 250-258 ◽  
Author(s):  
Andrew M. Altman ◽  
Yasheng Yan ◽  
Nadine Matthias ◽  
Xiaowen Bai ◽  
Carmen Rios ◽  
...  
Keyword(s):  
Stem Cells ◽  
Soft Tissue ◽  
Silk Fibroin ◽  
Wound Repair ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Adipose Derived Stem Cells ◽  
Chitosan Scaffold ◽  
Injury Model

scholarly journals In vivo effects of Pain Relieving Plaster on closed soft tissue injury in rabbit ears

2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Yong-Zhi Wang ◽  
Chun-Yu Guo ◽  
Hong-Gang Zhong ◽  
Wan-Nian Zhang ◽  
De-Long Wang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
In Vivo Effects ◽  
Rabbit Ears

scholarly journals Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Claire E. Olingy ◽  
Cheryl L. San Emeterio ◽  
Molly E. Ogle ◽  
Jack R. Krieger ◽  
Anthony C. Bruce ◽  
...  
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Classical Monocytes

scholarly journals A Review of Therapeutic Ultrasound: Biophysical Effects

2001 ◽  
Vol 81 (7) ◽  
pp. 1351-1358 ◽  
Author(s):  
Kerry G Baker ◽  
Valma J Robertson ◽  
Francis A Duck
Keyword(s):  
Soft Tissue ◽  
Clinical Effect ◽  
Physical Therapists ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Therapeutic Ultrasound ◽  
Scientific Basis ◽  
Effectiveness Studies ◽  
Biophysical Effects

Abstract Almost 2 decades ago, it was pointed out that physical therapists tended to overlook the tenuous nature of the scientific basis for the use of therapeutic ultrasound. The purpose of this review is to examine the literature regarding the biophysical effects of therapeutic ultrasound to determine whether these effects may be considered sufficient to provide a reason (biological rationale) for the use of insonation for the treatment of people with pain and soft tissue injury. This review does not discuss articles that examined the clinical usefulness of ultrasound (see article by Robertson and Baker titled “A Review of Therapeutic Ultrasound: Effectiveness Studies” in this issue). The frequently described biophysical effects of ultrasound either do not occur in vivo under therapeutic conditions or have not been proven to have a clinical effect under these conditions. This review reveals that there is currently insufficient biophysical evidence to provide a scientific foundation for the clinical use of therapeutic ultrasound for the treatment of people with pain and soft tissue injury.

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