Myonephropathic Metabolic Syndrome After Bilateral Aortoiliac Bypass: A Pathogenic Role of Cholesterol Microemboli

1998 ◽  
Vol 32 (5) ◽  
pp. 513-517
Author(s):  
Hirofumi Fujii ◽  
Yoshiaki Ueda ◽  
Takanori Oka ◽  
Takashi Miyamoto ◽  
Hideki Kawaguchi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Pathogenic Role

Toll-like Receptor as a Molecular Link between Metabolic Syndrome and Inflammation: A Review

2019 ◽  
Vol 20 (12) ◽  
pp. 1264-1280 ◽  
Author(s):  
Sok Kuan Wong ◽  
Kok-Yong Chin ◽  
Soelaiman Ima-Nirwana
Keyword(s):  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Signal Propagation ◽  
Supporting Evidence ◽  
Toll Like Receptor ◽  
Pathogenic Role ◽  
Regulatory Circuits ◽  
Pro Inflammatory Cytokines

Metabolic Syndrome (MetS) involves a cluster of five conditions, i.e. obesity, hyperglycaemia, hypertension, hypertriglyceridemia and low High-Density Lipoprotein (HDL) cholesterol. All components of MetS share an underlying chronic inflammatory aetiology, manifested by increased levels of pro-inflammatory cytokines. The pathogenic role of inflammation in the development of MetS suggested that toll-like receptor (TLR) activation may trigger MetS. This review summarises the supporting evidence on the interactions between MetS and TLR activation, bridged by the elevation of TLR ligands during MetS. The regulatory circuits mediated by TLR activation, which modulates signal propagation, leading to the state of chronic inflammation, are also discussed. Taken together, TLR activation could be the molecular basis in the development of MetS-induced inflammation.

Glucocorticoid-induced metabolic syndrome: establishing the role of AgRP

2018 ◽  
Author(s):  
Charlotte Sefton ◽  
Erika Harno ◽  
Alison Davies ◽  
Tiffany-Jayne Allen ◽  
Jonathan R Wray ◽  
...  
Keyword(s):  
Metabolic Syndrome

The role of omentin in inflammation and metabolic syndrome risk assessment in women with PCO-S

2019 ◽  
Author(s):  
Iwona Zieleń-Zynek ◽  
Joanna Kowalska ◽  
Nowak Justyna ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Risk Assessment ◽  
Metabolic Syndrome

The pathogenic role of surfactant protein B in formation of bronchopulmonary pathology in children

2017 ◽  
pp. 66-71
Author(s):  
O. Yablon ◽  
◽  
N. Zaichko ◽  
O. Mazulov ◽  
Z.I. Rossokha ◽  
...  
Keyword(s):  
Surfactant Protein ◽  
Pathogenic Role ◽  
Surfactant Protein B ◽  
Protein B

Pathogenic role of CCL2/MCP-1 in scleroderma

10.2741/2875 ◽  
2008 ◽  
Vol 13 (13) ◽  
pp. 2686 ◽  
Author(s):  
Toshiyuki Yamamoto
Keyword(s):  
Pathogenic Role

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

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