Multimodal Neuroimaging Using Concurrent EEG/fNIRS for Poststroke Recovery Assessment: An Exploratory Study

2020 ◽  
Vol 34 (12) ◽  
pp. 1099-1110
Author(s):  
Rihui Li ◽  
Sheng Li ◽  
Jinsook Roh ◽  
Chushan Wang ◽  
Yingchun Zhang
Keyword(s):  
Motor Function ◽  
Premotor Cortex ◽  
Cortical Reorganization ◽  
Healthy Controls ◽  
Multimodal Neuroimaging ◽  
Stroke Patients ◽  
Functional Near Infrared Spectroscopy ◽  
Source Imaging ◽  
Eeg Source Imaging ◽  
Function Recovery

Background Persistent motor deficits are very common in poststroke survivors and often lead to disability. Current clinical measures for profiling motor impairment and assessing poststroke recovery are largely subjective and lack precision. Objective A multimodal neuroimaging approach was developed based on concurrent functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) to identify biomarkers associated with motor function recovery and document the poststroke cortical reorganization. Methods EEG and fNIRS data were simultaneously recorded from 9 healthy controls and 18 stroke patients during a hand-clenching task. A novel fNIRS-informed EEG source imaging approach was developed to estimate cortical activity and functional connectivity. Subsequently, graph theory analysis was performed to identify network features for monitoring and predicting motor function recovery during a 4-week intervention. Results The task-evoked strength at ipsilesional primary somatosensory cortex was significantly lower in stroke patients compared with healthy controls ( P < .001). In addition, across the 4-week rehabilitation intervention, the strength at ipsilesional premotor cortex (PMC) ( R = 0.895, P = .006) and the connectivity between bilateral primary motor cortices (M1) ( R = 0.9, P = .007) increased in parallel with the improvement of motor function. Furthermore, a higher baseline strength at ipsilesional PMC was associated with a better motor function recovery ( R = 0.768, P = .007), while a higher baseline connectivity between ipsilesional supplementary motor cortex (SMA)–M1 implied a worse motor function recovery ( R = −0.745, P = .009). Conclusion The proposed multimodal EEG/fNIRS technique demonstrates a preliminary potential for monitoring and predicting poststroke motor recovery. We expect such findings can be further validated in future study.

scholarly journals Electrical stimulation for upper motor function recovery in stroke patients a review

2005 ◽  
Vol 61 (1) ◽  
Author(s):  
I. O. Sorinola
Keyword(s):  
Electrical Stimulation ◽  
Motor Function ◽  
Stroke Recovery ◽  
Stroke Patients ◽  
Function Recovery ◽  
Different Types

The use of electrical stimulation to promote recovery follow-ing pathological disorders dates back to the first discovery of electricalcurrent. However, the evidence for its use for promoting recovery following stroke is not well understood. Different types of research have been undertaken to investigate its effect on stroke recovery with different outcomes. This review is an attempt to highlight what is currently known about the effect of electrical stimulation on motor function recovery after stroke and to point out the areas needing research clarification.

CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage

Science ◽  
2018 ◽  
Vol 360 (6384) ◽  
pp. 50-57 ◽  
Author(s):  
Hiroki Abe ◽  
Susumu Jitsuki ◽  
Waki Nakajima ◽  
Yumi Murata ◽  
Aoi Jitsuki-Takahashi ◽  
...  
Keyword(s):  
Brain Damage ◽  
Motor Function ◽  
Neural Plasticity ◽  
Internal Capsule ◽  
Cortical Reorganization ◽  
Dependent Manner ◽  
Small Compound ◽  
Function Recovery ◽  
Mediator Protein ◽  
Accelerate Rehabilitation

Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization. Edonerpic bound to collapsin-response-mediator-protein 2 (CRMP2) and failed to augment recovery in CRMP2-deficient mice. Edonerpic maleate enhanced motor function recovery from internal capsule hemorrhage in nonhuman primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a clinically potent small compound with which to accelerate rehabilitation after brain damage.

scholarly journals Dynamics of post-stroke hand paresis kinematic pattern during rehabilitation

2019 ◽  
pp. 32-38
Author(s):  
A.E. Khizhnikova ◽  
A.S. Klochkov ◽  
A.M. Kotov–Smolenskiy ◽  
N.A. Suponeva ◽  
M.A. Piradov
Keyword(s):  
Motor Function ◽  
Biomechanical Analysis ◽  
Motor Deficit ◽  
Stroke Patients ◽  
Clinical Indicators ◽  
Motor Functioning ◽  
Post Stroke ◽  
Motor Synergies ◽  
Video Motion Analysis ◽  
Function Recovery

According to the literature data, only 5–20% of post-stroke patients are able to restore the hand motor function completely. Correct goal setting and individual approach to the patient's functional recovery are important. Our study aimed to develop an algorithm of impaired hand motor functioning assessment for post-stroke patients and to determine the principles of the rehabilitation tactics choosing based on the biomechanical analysis. Twenty five patients with hemispheric stroke and 10 healthy volunteers participated in the study. Formal clinical observation scales (Fugl-Meyer Assessment, Ashworth Scale, ARAT) and video motion analysis were used for evaluation of the hand motor function. Patients were divided into 2 groups according to the hand paresis severity (mild/moderate and pronounced/severe). Rehabilitation was carried out in both groups, including mechanotherapy, massage and physical therapy. It was revealed that in the 1st group of patients the motor function recovery in the paretic hand was due to movement performance recovery: biomechanical parameters restoration directly correlated with a decrease in the paresis degree according to the Fugl-Meyer Assessment Scale (r = 0.94; p = 0.01). In the 2nd group of patients, the motor function recovery in the paretic hand was due to motor deficit compensation: according to biomechanical analysis, the pathological motor synergies inversely correlated with a decrease in the paresis degree (r = –0.9; p = 0.03). As a result of the study, an algorithm for selecting the patient management tactics based on the baseline clinical indicators was developed.

scholarly journals Brain Symmetry Index in Healthy and Stroke Patients for Assessment and Prognosis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Andrei Agius Anastasi ◽  
Owen Falzon ◽  
Kenneth Camilleri ◽  
Malcolm Vella ◽  
Richard Muscat
Keyword(s):  
Motor Function ◽  
Visual Cues ◽  
Healthy Controls ◽  
The Novel ◽  
Stroke Patients ◽  
Symmetry Index ◽  
Signal Parameters ◽  
Cortical Stroke ◽  
The Difference

Objective.Quantitative neurophysiological signal parameters are of value in predicting motor recovery after stroke. The novel role of EEG-derived brain symmetry index for motor function prognostication in the subacute phase after stroke is explored.Methods. Ten male stroke patients and ten matched healthy controls were recruited. Motor function was first assessed clinically using the MRC score, its derivative Motricity Index, and the Fugl–Meyer assessment score. EEG was subsequently recorded first with subjects at rest and then during hand grasping motions, triggered by visual cues. Brain symmetry index (BSI) was used to identify the differences in EEG-quantified interhemispheric cortical power asymmetry observable in healthy versus cortical and subcortical stroke patients. Subsequently, any correlation between BSI and motor function was explored.Results. BSI was found to be significantly higher in stroke subjects compared to healthy controls (p=0.023). The difference in BSI was more pronounced in the cortical stroke subgroup (p=0.016). BSI showed only a mild general decrease on repeated monthly recording. Notably, a statistically significant correlation was observed between early BSI and Fugl–Meyer score later in recovery (p<0.050).Conclusions. Brain symmetry index is increased in the subacute poststroke phase and correlates with motor function 1-2 months after stroke.

scholarly journals Acupuncture Enhances Communication between Cortices with Damaged White Matters in Poststroke Motor Impairment

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Xiao Han ◽  
Lijun Bai ◽  
Chuanzhu Sun ◽  
Xuan Niu ◽  
Yanzhe Ning ◽  
...  
Keyword(s):  
Structural Integrity ◽  
Diffusion Tensor ◽  
Premotor Cortex ◽  
Motor Impairment ◽  
Neural Mechanism ◽  
Lower Limbs ◽  
Healthy Controls ◽  
Stroke Patients ◽  
Motor Disability ◽  
Acupuncture Intervention

Stroke is a leading cause of motor disability. Acupuncture is an effective therapeutic strategy for poststroke motor impairment. However, its mechanism is still elusive. Twenty-two stroke patients having a right-hemispheric subcortical infarct and 22 matched healthy controls were recruited to undergo diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) scanning. The resting-state fMRI was implemented before and after needling at GB34 (Yanglingquan). The stroke patients presented a substantially reduced fractional anisotropy value in the right superior longitudinal fasciculus (SLF), corticospinal tract, and corpus callosum. The structural integrity of the frontoparietal part of the SLF (SLF-FP) correlated with the motor scores of lower limbs in stroke patients. This corticocortical association bundle originated from the premotor cortex (PM) and the adjacent supplementary motor area (SMA), known as secondary motor areas, and terminated in the supramarginal gyrus (SMG). After acupuncture intervention, the corresponding functional connectivity between the PM/SMA and SMG was enhanced in stroke patients compared with healthy controls. These findings suggested that the integrity of the SLF is a potential neuroimaging biomarker for motor disability of lower limbs following a stroke. Acupuncture could increase the communication between the cortices connected by the impaired white matter tracts, implying the neural mechanism underlying the acupuncture intervention.

scholarly journals Maladaptive Plasticity for Motor Recovery after Stroke: Mechanisms and Approaches

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Naoyuki Takeuchi ◽  
Shin-Ichi Izumi
Keyword(s):  
Motor Function ◽  
Neural Plasticity ◽  
Motor Pattern ◽  
Movement Pattern ◽  
Competitive Interaction ◽  
Motor Recovery ◽  
Cortical Reorganization ◽  
Stroke Patients ◽  
Compensatory Movement ◽  
Maladaptive Plasticity

Many studies in human and animal models have shown that neural plasticity compensates for the loss of motor function after stroke. However, neural plasticity concerning compensatory movement, activated ipsilateral motor projections and competitive interaction after stroke contributes to maladaptive plasticity, which negatively affects motor recovery. Compensatory movement on the less-affected side helps to perform self-sustaining activity but also creates an inappropriate movement pattern and ultimately limits the normal motor pattern. The activated ipsilateral motor projections after stroke are unable to sufficiently support the disruption of the corticospinal motor projections and induce the abnormal movement linked to poor motor ability. The competitive interaction between both hemispheres induces abnormal interhemispheric inhibition that weakens motor function in stroke patients. Moreover, widespread disinhibition increases the risk of competitive interaction between the hand and the proximal arm, which results in an incomplete motor recovery. To minimize this maladaptive plasticity, rehabilitation programs should be selected according to the motor impairment of stroke patients. Noninvasive brain stimulation might also be useful for correcting maladaptive plasticity after stroke. Here, we review the underlying mechanisms of maladaptive plasticity after stroke and propose rehabilitation approaches for appropriate cortical reorganization.

Sign in / Sign up

Export Citation Format

Share Document