Temporospatial Characterization of Brain Oscillations (TSCBO) Associated with Subprocesses of Verbal Working Memory in Schizophrenia

2008 ◽  
Vol 39 (4) ◽  
pp. 194-202 ◽  
Author(s):  
Massoud Stephane ◽  
Nuri F. Ince ◽  
Arthur Leuthold ◽  
Giuseppe Pellizzer ◽  
Ahmed H. Tewfik ◽  
...  
Keyword(s):  
Working Memory ◽  
Brain Activity ◽  
Spatial Location ◽  
Verbal Working Memory ◽  
Primacy Effect ◽  
Brain Oscillations ◽  
Parietal Lobes ◽  
Occipital Lobes ◽  
Encode Phase

The studies of the neural correlates of verbal working memory in schizophrenia are somewhat inconsistent. This could be related to experimental paradigms that engage differentially working memory components or methodological limitations in terms of characterization of brain activity. Magnetoencephalographic recordings were obtained on 10 schizophrenia patients and 11 healthy controls while performing a modified Sternberg paradigm to investigate subprocesses of verbal working memory. A new method for temporospatial characterization of brain oscillations was applied to whole head recordings and a 1–48 Hz frequency range. Patients differed from controls in event-related synchronization/desynchronization (ERS/ERD) patterns during the encode phase, the mid-maintain phase, and the end of the maintain phase. During the encode phase, patients did not show 1–4 Hz ERS in the left anterior frontal and left parietal lobes. In the mid-maintain phase, the left anterior frontal and left parietal lobes 1–4 Hz ERS, and the bilateral occipital lobes 8–32 Hz ERS were not observed in patients. At the end of the maintain phase, patients did not exhibit 12–48 Hz ERD in the left frontal and parietal lobes. The behavioral data showed reduced primacy effect In schizophrenia, the encode and maintain subprocesses were associated with less ERS and less ERD, respectively. These ERS/ERD abnormalities had specificity in terms of frequency and spatial location. Less ERD reflects reduced complexity of the neural activity, while reduced ERS reflects failure of the neural systems to resume idle state. The impaired primacy effect appears related to specific ERS/ERD patterns in the encode and maintain phases.

214 – Temporospatial characterization of brain oscillations associated with subprocesses of verbal working memory in schizophrenia

2008 ◽  
Vol 98 ◽  
pp. 121-122
Author(s):  
M. Stephane ◽  
N.F. Ince ◽  
A. Leuthold ◽  
G. Pellizzer ◽  
A. Twefk ◽  
...  
Keyword(s):  
Working Memory ◽  
Verbal Working Memory ◽  
Brain Oscillations

Effects of Aquatic Motor Intervention on Verbal Working Memory and Brain Activity-A Pilot Study

2018 ◽  
Vol 12 (2) ◽  
pp. 90-99 ◽  
Author(s):  
Michal Nissim ◽  
Ronit Ram-Tsur ◽  
Joseph Glicksohn ◽  
Michal Zion ◽  
Zemira Mevarech ◽  
...  
Keyword(s):  
Working Memory ◽  
Pilot Study ◽  
Brain Activity ◽  
Verbal Working Memory

scholarly journals Brain activity is contingent on neuropsychological function in an fMRI study of Verbal Working Memory in Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Xenia Kobeleva ◽  
Judith Machts ◽  
Maria Veit ◽  
Stefan Vielhaber ◽  
Susanne Petri ◽  
...  
Keyword(s):  
Working Memory ◽  
Amyotrophic Lateral Sclerosis ◽  
Functional Neuroimaging ◽  
Current Knowledge ◽  
Brain Activity ◽  
Reaction Times ◽  
Verbal Working Memory ◽  
Research Field ◽  
Fmri Study ◽  
Lateral Sclerosis

AbstractAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that causes progressive degeneration of neurons in motor and non-motor regions, affecting multiple cognitive domains. In order to contribute to the growing research field that employs structural and functional neuroimaging to investigate the effect of ALS on different working memory components, we conducted a functional magnetic resonance imaging (fMRI) study exploring the localization and intensity of alterations in neural activity. Being the first study to specifically address verbal working memory via fMRI in the context of ALS, we employed the verbal n-back task with 0-back and 2-back conditions. Despite ALS patients showing unimpaired accuracies and reaction times, there was significantly increased brain activity of frontotemporal and parietal regions in the 2-back minus 0-back contrast in patients compared to controls. This increased brain activity was largely associated with a better neuropsychological performance within the ALS group, suggesting a compensatory effect. This study therefore adds to the current knowledge on neural correlates of working memory in ALS and contributes to a more nuanced understanding of hyperactivity during cognitive processes in fMRI studies of ALS.

Modality-specific processing streams in verbal working memory: evidence from spatio-temporal patterns of brain activity

1997 ◽  
Vol 6 (2) ◽  
pp. 95-113 ◽  
Author(s):  
Daniel S Ruchkin ◽  
Rita S Berndt ◽  
Ray Johnson ◽  
Walter Ritter ◽  
Jordan Grafman ◽  
...  
Keyword(s):  
Working Memory ◽  
Brain Activity ◽  
Temporal Patterns ◽  
Verbal Working Memory ◽  
Spatio Temporal

Verbal and spatial working memory performance among HIV-infected adults

2002 ◽  
Vol 8 (4) ◽  
pp. 532-538 ◽  
Author(s):  
CHARLES H. HINKIN ◽  
DAVID J. HARDY ◽  
KAREN I. MASON ◽  
STEVEN A. CASTELLON ◽  
MONA N. LAM ◽  
...  
Keyword(s):  
Working Memory ◽  
Mixed Model ◽  
Spatial Working Memory ◽  
Memory Performance ◽  
Memory Task ◽  
Executive Dysfunction ◽  
Spatial Location ◽  
Verbal Working Memory ◽  
Memory Condition ◽  
Percent Accuracy

Subtypes of working memory performance were examined in a cohort of 50 HIV-infected adults and 23 uninfected controls using an n-back paradigm (2-back) in which alphabetic stimuli were quasi-randomly presented to a quadrant of a computer monitor. In the verbal working memory condition, participants determined whether each successive letter matched the letter that appeared two previously in the series, regardless of spatial location. In the spatial working memory condition, participants determined whether each letter matched the spatial location of the letter that had appeared two previously, regardless of letter identity. The dependent variable was percent accuracy in each condition. Results of mixed model ANOVA revealed that the HIV-infected participants performed significantly worse than controls on both the verbal and spatial working memory tasks. A significant main effect for working memory condition was also present with both participant groups performing better on the spatial working memory task. These results, the first study of HIV-infected adults to directly compare verbal versus spatial working memory performance using the identical test stimuli across task conditions, suggests that HIV infection is associated with a decrement in working memory efficiency that is equally apparent for both verbal and spatial processing. These findings implicate central executive dysfunction as a likely substrate and provide the basis for hypothesizing that decline in working memory may contribute to other HIV-associated neuropsychological deficits. (JINS, 2002, 8, 532–538.)

scholarly journals Nicotinic Versus Muscarinic Blockade Alters Verbal Working Memory-Related Brain Activity in Older Women

2008 ◽  
Vol 16 (4) ◽  
pp. 272-282 ◽  
Author(s):  
Julie A. Dumas ◽  
Andrew J. Saykin ◽  
Brenna C. McDonald ◽  
Thomas W. McAllister ◽  
Mary L. Hynes ◽  
...  
Keyword(s):  
Working Memory ◽  
Older Women ◽  
Brain Activity ◽  
Verbal Working Memory

Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory.

2005 ◽  
Vol 19 (4) ◽  
pp. 509-519 ◽  
Author(s):  
Jill M. Goldstein ◽  
Matthew Jerram ◽  
Russell Poldrack ◽  
Robert Anagnoson ◽  
Hans C. Breiter ◽  
...  
Keyword(s):  
Working Memory ◽  
Sex Differences ◽  
Brain Activity ◽  
Verbal Working Memory ◽  
Prefrontal Cortical

scholarly journals The Effects of Working Memory Training on Brain Activity

2021 ◽  
Vol 11 (2) ◽  
pp. 155
Author(s):  
Edward Nęcka ◽  
Aleksandra Gruszka ◽  
Adam Hampshire ◽  
Justyna Sarzyńska-Wawer ◽  
Andreea-Elena Anicai ◽  
...  
Keyword(s):  
Neural Network ◽  
Working Memory ◽  
Brain Activity ◽  
High Accuracy ◽  
Stop Signal Task ◽  
Memory Training ◽  
Control Group ◽  
Parietal Lobes ◽  
Improved Performance ◽  
Back Task

This study aimed to investigate if two weeks of working memory (WM) training on a progressive N-back task can generate changes in the activity of the underlying WM neural network. Forty-six healthy volunteers (23 training and 23 controls) were asked to perform the N-back task during three fMRI scanning sessions: (1) before training, (2) after the half of training sessions, and (3) at the end. Between the scanning sessions, the experimental group underwent a 10-session training of working memory with the use of an adaptive version of the N-back task, while the control group did not train anything. The N-back task in the scanning sessions was relatively easy (n = 2) in order to ensure high accuracy and a lack of between-group differences at the behavioral level. Such training-induced differences in neural efficiency were expected. Behavioral analyses revealed improved performance of both groups on the N-back task. However, these improvements resulted from the test-retest effect, not the training outside scanner. Performance on the non-trained stop-signal task did not demonstrate any transfer effect. Imaging analysis showed changes in activation in several significant clusters, with overlapping regions of interest in the frontal and parietal lobes. However, patterns of between-session changes of activation did not show any effect of training. The only finding that can be linked with training consists in strengthening the correlation between task performance accuracy and activation of the parietal regions of the neural network subserving working memory (left superior parietal lobule and right supramarginal gyrus posterior). These results suggest that the effects of WM training consist in learning that, in order to ensure high accuracy in the criterion task, activation of the parietal regions implicated in working memory updating must rise.

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