CA 125 in Benign Gynecological Conditions

1998 ◽  
Vol 13 (4) ◽  
pp. 231-237 ◽  
Author(s):  
H. Meden ◽  
A. Fattahi-Meibodi
Keyword(s):  
Tumor Marker ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Cirrhosis Of The Liver ◽  
Ca 125 ◽  
Ovarian Cysts ◽  
Gynecological Tumors ◽  
Ovarian Abscess

The tumor marker CA 125 was initially thought to be specific for ovarian malignancies. Subsequently it was found to be raised in a variety of benign conditions, including pregnancy, pelvic inflammatory disease, tuberculosis and cirrhosis of the liver. With respect to gynecological tumors, CA 125 may be elevated in benign ovarian cysts, tubo-ovarian abscess, endometriosis, hyperstimulation syndrome, ectopic pregnancy and fibroids. These results demonstrate that CA 125 is a marker of non-specific peritoneal conditions.

scholarly journals Very High CA125 due to Non-neoplastic Lesion of Ovary

2014 ◽  
Vol 7 (2) ◽  
pp. 52-54
Author(s):  
KDB Bista
Keyword(s):  
Tumor Marker ◽  
Pelvic Inflammatory Disease ◽  
Young Woman ◽  
Inflammatory Disease ◽  
Abdominal Tuberculosis ◽  
Ca 125 ◽  
Ovarian Malignancy ◽  
Obstetrics And Gynaecology ◽  
Neoplastic Lesion ◽  
Very High

High CA-125 levels have been strongly associated with ovarian malignancy. But due to nonspecific nature of this tumor marker it has been found to be raised to high levels above 1000u/Ml even in some non neoplastic conditions which have to be kept in mind. A young woman was found to have very high Ca125 levels of 3500u/Ml after rupture of endometrioma. Endometrioma, pelvic inflammatory disease, abdominal tuberculosis are some of the nonneoplastic conditions associated with very high levels of Ca125. DOI: http://www.dx.doi.org/10.3126/njog.v7i2.11146   Nepal Journal of Obstetrics and Gynaecology / Vol 7 / No. 2 / Issue 14 / July-Dec, 2012 / 52-54

scholarly journals ECTOPIC PREGNANCY

2011 ◽  
Vol 18 (01) ◽  
pp. 24-27
Author(s):  
AFROZA ABBAS ◽  
H. AKRAM
Keyword(s):  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
International Studies ◽  
Reproductive Health Care ◽  
Nulliparous Women ◽  
Causative Factors ◽  
Contraceptive Utilization ◽  
Labour Room ◽  
Timely Referral

Objective: To find out the causative factors for rising rate of ectopic pregnancy in young women at periphery. Design: Descriptive study. Place and Duration of Study: Maula Bakhsh Teaching Hospital ( Obstetrical and gynaecological unit) Sargodha , from January 2008 – December 2008. Patients and Methods: All patients who were presented in labour room emergency and gynaecological out patients department with confirmed diagnosis of ectopic pregnancy on USG were included in the study. A pre-formed proforma was used to record the details about the demographic features, pre-existing risk factors for ectopic pregnancy, clinical features at presentation and management. Results: Frequency of ectopic pregnancy was too high in our study compared to international studies. Majority of patients were young and nullipara. Leading risk factor is pelvic inflammatory disease due to septic induced abortion. 92% of patients had acute presentation. Conclusions: Rising rate of ectopic pregnancy was found in young, nulliparous women secondary to pelvic inflammatory disease. The frequency can be reduced by awareness of reproductive health care, liberal contraceptive utilization, acceptable adequate planned family. Early diagnosis and timely referral may be helpful in treating the patients prior to tubal rupture with decreased morbidity and mortality.

scholarly journals Ten years transmission of the new variant of Chlamydia trachomatis in Sweden: prevalence of infections and associated complications

2017 ◽  
Vol 94 (2) ◽  
pp. 100-104 ◽  
Author(s):  
Jenny Dahlberg ◽  
Ronza Hadad ◽  
Karin Elfving ◽  
Inger Larsson ◽  
Jenny Isaksson ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Complication Rates ◽  
Becton Dickinson ◽  
Specific Pcr ◽  
Single Target ◽  
New Variant ◽  
Low Prevalence

ObjectivesIn 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. It has a deletion in the plasmid resulting in failed detection by the single target systems from Abbott and Roche used at that time, whereas the third system used, from Becton Dickinson (BD), detects nvCT. The proportion of nvCT was initially up to 65% in counties using Abbott/Roche systems. This study analysed the proportion of nvCT from 2007 to 2015 in four selected counties and its impact on chlamydia-associated complications.MethodsC. trachomatis-positive specimens collected from 2007 to 2015 were analysed by a specific PCR to identify nvCT cases. Genotyping was performed by multilocus sequence typing (MLST) and ompA sequencing. Ectopic pregnancy and pelvic inflammatory disease records were extracted from the national registers.ResultsIn total, 5101 C. trachomatis-positive samples were analysed. The nvCT proportion significantly decreased in the two counties using Roche systems, from 56% in 2007 to 6.5% in 2015 (p<0.001). In the two counties using BD systems, a decrease was also seen, from 19% in 2007 to 5.2% in 2015 (p<0.001). Fifteen nvCT cases from 2015 and 102 cases from 2006 to 2009 had identical MLST profiles. Counties using Roche/Abbott systems showed higher mean rates of ectopic pregnancy and pelvic inflammatory disease compared with counties using BD systems.ConclusionsThe nvCT proportion has decreased in all counties and converged to a low prevalence irrespective of previous rates. Genotyping showed that nvCT is clonal and genetically stable. Failing detection only marginally affected complication rates.

Pelvic inflammatory disease

2020 ◽  
pp. 536-549
Author(s):  
Gillian Dean ◽  
Jonathan Ross
Keyword(s):  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Severe Disease ◽  
Lower Abdominal Pain ◽  
Asymptomatic Infection ◽  
Public Understanding ◽  
Transmitted Infection ◽  
Delay In Diagnosis ◽  
Sexually Transmitted

Pelvic inflammatory disease is a sexually transmitted infection of the female upper genital tract. Rates of pelvic inflammatory disease have fallen in many countries over the last 10 years, at least in part due to increased screening for chlamydial infection. The clinical spectrum ranges from asymptomatic infection through to severe disease requiring hospitalization. Due to the non-specific nature of the condition, diagnosis can be challenging. All sexually active women presenting with acute lower abdominal pain should have a pregnancy test to rule out ectopic pregnancy. Treatment must be initiated as soon as the diagnosis is suspected and include antibiotics covering a broad spectrum of pathogens. Delay in diagnosis increases the risk of adverse sequelae including ectopic pregnancy and infertility. It is recommended that current and recent sexual partners receive empirical treatment, regardless of symptoms or microbiological results, and refrain from sexual contact until completion of therapy. Through better public understanding of the symptoms of pelvic inflammatory disease, women seeking earlier medical attention may reduce the risk of reproductive damage.

scholarly journals Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients

2019 ◽  
Vol 69 (9) ◽  
pp. 1517-1525 ◽  
Author(s):  
Casper D J den Heijer ◽  
Christian J P A Hoebe ◽  
Johanna H M Driessen ◽  
Petra Wolffs ◽  
Ingrid V F van den Broek ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Reproductive Health ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Antibiotic Use ◽  
Female Infertility ◽  
Dependent Manner ◽  
Increased Risk ◽  
Ct Test

Abstract Background We evaluated the risk of pelvic inflammatory disease (PID), ectopic pregnancy, and infertility in women with a previous Chlamydia trachomatis (CT) diagnosis compared with women who tested negative for CT and CT untested women, considering both targeted and incidental (ie, prescribed for another indication) use of CT-effective antibiotics. Methods This was a retrospective study of women aged 12–25 years at start of follow-up within the Clinical Practice Research Datalink GOLD database linked to index of multiple deprivation quintiles, 2000–2013. CT test status and antibiotic use were determined in a time-dependent manner. Risk of PID, ectopic pregnancy, or female infertility were evaluated using of Cox proportional hazard models. Results We studied 857 324 women, contributing 6 457 060 person-years. Compared with women who tested CT-negative, women who tested CT-positive had an increased risk of PID (adjusted hazard ratio [aHR], 2.36; 95% confidence interval [CI], 2.01–2.79), ectopic pregnancy (aHR, 1.87; 95% CI, 1.38–2.54), and infertility (aHR, 1.85; 95% CI, 1.27–2.68). The PID risk was higher for women with 2 or more positive CT tests than those with 1 positive test. PID risk increased with the number of previous antibiotic prescriptions, regardless of CT test status. Conclusions We showed an association between CT-positive tests and 3 adverse reproductive health outcomes. Moreover, this risk increased with repeat CT infections. CT-effective antibiotic use showed no decreased risks of subsequent PID regardless of CT history. Our results confirm the reproductive health burden of CT, which requires adequate public health interventions.

scholarly journals Clinico-Ultrasonographic Profile of Ectopic Pregnancy in Western Nepal

2018 ◽  
Vol 8 (1) ◽  
pp. 2-6
Author(s):  
Sangeeta Devi Gurung ◽  
Prakash Sharma
Keyword(s):  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Radiological Finding ◽  
Previous History ◽  
First Trimester ◽  
Reproductive Age ◽  
Age Group ◽  
Type Iii ◽  
Reproductive Age Group

Introduction: Ectopic pregnancy (EP) is one of the major complications in first trimester pregnancy, resulting in increased maternal morbidity and mortality. It accounts for 1.3-2.4% of all pregnancies. Previously, though laparoscopy was considered as the gold standard for diagnosis of ectopic pregnancy, due to availability of high resolution ultrasound, it has become the first line investigation for the diagnosis of ectopic pregnancy.Methods: It is a prospective study conducted in Manipal Teaching Hospital, Pokhara, from January 2015 till December 2017. All the cases diagnosed with ectopic pregnancy were included in the study.  Ultrasonological and intraoperative findings were recorded. Data was analyzed using SPSS (VERSION 16).Results: Twenty six patients were diagnosed with ectopic pregnancies. The incidence was 0.35%. It was most common among the reproductive age group between 20-40 years with mean age of 30.50 years. Pelvic inflammatory disease (n=10, 38.5%) was considered as risk factor. Radiological finding of Type III ectopic pregnancy (n=21, 80.8%) was the most common type.Conclusion: Ectopic pregnancy is common among reproductive age group with previous history of pelvic inflammatory disease. Type III is the most common type.

scholarly journals Chlamydia Public Health Programs and the Epidemiology of Pelvic Inflammatory Disease and Ectopic Pregnancy

2012 ◽  
Vol 207 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Michael L. Rekart ◽  
Mark Gilbert ◽  
Rafael Meza ◽  
Paul H. Kim ◽  
Michael Chang ◽  
...  
Keyword(s):  
Public Health ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Health Programs ◽  
Public Health Programs

Miscellaneous topics in gynaecology

2016 ◽  
Author(s):  
Stergios K. Doumouchtsis ◽  
S. Arulkumaran ◽  
Maya Basu ◽  
Claudine Domoney ◽  
Stergios K. Doumouchtsis ◽  
...  
Keyword(s):  
Sexual Assault ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Urinary Retention ◽  
Genital Herpes ◽  
Inflammatory Disease ◽  
Emergency Surgery ◽  
Medical Management ◽  
Prophylactic Antibiotics

This chapter outlines miscellaneous topics in gynaecology, such as urinary retention, sexual assault (including incidence, risks, examination, and management), and pharmacotherapeutics in gynaecology (drugs used in the treatment of pelvic inflammatory disease (PID), prophylactic antibiotics for emergency surgery, genital herpes, menorrhagia and dysmenorrhoea, and medical management of ectopic pregnancy and miscarriage).

Pelvic Inflammatory Disease and Tubo-Ovarian Abscess

2016 ◽  
Author(s):  
John Holst
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Intrauterine Device ◽  
White Blood Cells ◽  
Health Department ◽  
Immunocompetent Patient ◽  
Local Health ◽  
Hiv Patients ◽  
Gastrointestinal Complaints ◽  
Ovarian Abscess

Pelvic inflammatory disease (PID) consists of inflammation in various parts of the upper genital tract and includes endometritis, salpingitis, tubo-ovarian abscess (TOA), and/or pelvic peritonitis. Overt acute PID patients typically present as ill-appearing with pain, fever, chills, purulent vaginal discharge, nausea, vomiting, and elevated white blood cells. “Silent” PID presents with dyspareunia, irregular bleeding, and urinary and gastrointestinal complaints. Bacterial vaginosis (BV) and associated microorganisms are present in acute PID patients. PID coverage is focused on a polymicrobial infection. HIV patients typically have more severe symptoms and are more likely to have a TOA than an immunocompetent patient, but HIV alone does not mandate hospital admission nor does parenteral therapy improve outcomes compared to non-HIV patients. Gonorrhea and chlamydia cases must be reported to the local health department; it is not mandatory for PID patients to remove an intrauterine device at the time of diagnosis.

Sign in / Sign up

Export Citation Format

Share Document