scholarly journals An efficient one-pot synthesis and biological evaluation of novel (E)-2-aroyl-4-arylidene-5-oxotetrahydrofuran derivatives

2020 ◽  
pp. 174751982095862
Author(s):  
Hong-Mei Wang ◽  
Xiu-Lian Zhu ◽  
Qin-Hua Chen ◽  
Ming-Wu Ding ◽  
Xiao-Hua Zeng
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Mtt Assay ◽  
Room Temperature ◽  
Biological Evaluation ◽  
Cyclization Reactions ◽  
One Pot ◽  
Hepatocarcinoma Cell ◽  
Synthesis And Biological Evaluation ◽  
Hepatocarcinoma Cell Line

An efficient one-pot base-mediated approach to ( E)-2-aroyl-4-arylidene-5-oxotetrahydro-furans is developed. Nine ( E)-2-aroyl-4-arylidene-5-oxotetrahydrofurans are synthesized in good yields via tandem Passerini and cyclization reactions, starting from Baylis–Hillman acids, aryl glyoxals, and isocyanides at room temperature in the presence of Cs2CO3. In addition, the MTT assay is used to evaluate their cytotoxicities toward the cervical cancer cell lines C-33A, CaSki, and SiHa and the hepatocarcinoma cell line HepG2. The results show that some of the compounds inhibit the proliferation of cancer cells significantly.

New pyrazolyl-dibenzo[b,e][1,4]diazepinones: room temperature one-pot synthesis and biological evaluation

2019 ◽  
Vol 24 (2) ◽  
pp. 355-377 ◽  
Author(s):  
Gaurangkumar C. Brahmbhatt ◽  
Tushar R. Sutariya ◽  
Hiralben D. Atara ◽  
Narsidas J. Parmar ◽  
Vivek K. Gupta ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biological Evaluation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells

2013 ◽  
Vol 23 (24) ◽  
pp. 6721-6727 ◽  
Author(s):  
Jyoti Mareddy ◽  
Suresh Babu Nallapati ◽  
Jayasree Anireddy ◽  
Yumnam Priyadarshini Devi ◽  
Lakshmi Narasu Mangamoori ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Biological Evaluation ◽  
Triazole Derivatives ◽  
New Class ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: Synthesis and Biological Evaluation of KRIBB3 Analogues on a Proliferation of HCT-116 Colorectal Cancer Cells.

ChemInform ◽  
2011 ◽  
Vol 42 (17) ◽  
pp. no-no
Author(s):  
Sangku Lee ◽  
Jae Nyoung Kim ◽  
Ji Hye Min ◽  
Kab Seog Yoon ◽  
Ki Deok Shin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Biological Evaluation ◽  
Colorectal Cancer Cells ◽  
Hct 116 ◽  
Synthesis And Biological Evaluation

ROOM TEMPERATURE SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 2,5-DISUBSTITUTED-1,3,4-OXADIAZOLES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (05) ◽  
pp. 11-15
Author(s):  
R. R Somani ◽  
◽  
P. K Chaskar ◽  
P. M. Patil
Keyword(s):  
Heterocyclic Compounds ◽  
Room Temperature ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
Temperature Synthesis ◽  
Room Temperature Synthesis ◽  
Synthetic Reactions ◽  
Resistant Strains ◽  
Synthesis And Biological Evaluation

One of the principles of green chemistry emphasises on minimisation of environmental and economic impacts by developing synthetic reactions at ambient temperature and pressure.The rise of resistant strains of microorganisms is an issue of regularly expanding seriousness. Therefore, the development of new antimicrobial agents will remain a challenge for chemists. we herein report room temperature synthesis of newer heterocyclic compounds belonging to 1,3,4-oxadiazole scaffold. Their structures were confirmed using various spectroscopic techniques. These compounds were evaluated for antifungal, antibacterial and antitubercular activities.

One Pot Synthesis and Biological Evaluation of Some New Pyridine‐3,5‐dicarbonitrile Derivatives

2018 ◽  
Vol 3 (12) ◽  
pp. 3374-3378 ◽  
Author(s):  
Hitendra Joshi ◽  
Nirav Shah ◽  
Dhiman Sakar ◽  
N. C. Desai ◽  
Krunalsinh A. Jadeja
Keyword(s):  
Biological Evaluation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Synthesis And Biological Evaluation
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