Re: Howard et al. Does a delay in surgery for distal radial fractures affect patient outcome? J Hand Surg Eur. Epub ahead of print 2020. DOI: 10.1177/1753193420941319

Radiation therapy remains an important component of lymphoma treatment. It has evolved with improvements in technology and a better understanding of how to successfully integrate it into lymphoma treatment. There are specific clinical presentations where omission of radiation therapy could adversely affect patient outcome and should not be overlooked. Radiation therapy may serve an important role as primary treatment, as a component of combined modality therapy, as adjuvant therapy to maximize local control, and as an important component of salvage therapy for relapsed or primary refractory lymphoma and in the successful palliation of lymphoma. This review identifies those clinical presentations where the use of radiation therapy should not be overlooked or should at least be considered.

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Does Conversion of a Laparoscopic Colectomy Adversely Affect Patient Outcome?

Diseases of the Colon & Rectum ◽

10.1007/s10350-004-0692-4 ◽

2004 ◽

Vol 47 (10) ◽

pp. 1680-1685 ◽

Cited By ~ 96

Author(s):

Sergio Casillas ◽

Conor P. Delaney ◽

Anthony J. Senagore ◽

Karen Brady ◽

Victor W. Fazio

Keyword(s):

Patient Outcome ◽

Laparoscopic Colectomy ◽

Affect Patient Outcome

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Transcutaneous biopsy of adrenocortical carcinoma is rarely helpful in diagnosis, potentially harmful, but does not affect patient outcome

Acta Endocrinologica ◽

10.1530/eje-13-1033 ◽

2014 ◽

Vol 170 (6) ◽

pp. 829-835 ◽

Cited By ~ 32

Author(s):

Andrew R Williams ◽

Gary D Hammer ◽

Tobias Else

Keyword(s):

Patient Outcome ◽

Overall Survival ◽

Adrenocortical Carcinoma ◽

Stage I ◽

Adrenal Biopsy ◽

Significant Difference ◽

Adrenal Masses ◽

Affect Patient Outcome ◽

Rare Malignancy ◽

The University

ContextAdrenocortical carcinoma (ACC) is a rare malignancy with high recurrence and mortality rates. The utility, sensitivity, and effect on patient outcome of transcutaneous adrenal biopsy (TAB) for single, large, adrenal masses are unclear.ObjectiveThis study evaluated the utility, diagnostic sensitivity, and effect on patient outcome of TAB in patients with ACC.Design and settingWe conducted a retrospective review of the electronic medical records of all ACC patients who were evaluated at the University of Michigan Health System from 1991 to 2011. We evaluated the sensitivity of TAB for tumors with the final pathological diagnosis of ACC. We compared the characteristics and survival of patients with stage I–III disease who underwent TAB with those who did not undergo TAB.ResultsA total of 75 ACC patients with TAB were identified. Complications occurred in at least 11% of patients and were mainly associated with bleeding. The maximum sensitivity of the procedure in diagnosing ACC was 70%. For stage I–III patients, baseline characteristics, stage at diagnosis, and adjuvant treatment with mitotane or radiation were not significantly different between the TAB (n=36) and the non-TAB (n=254) groups. There was no significant difference in recurrence-free (P=0.7) or overall survival (P=0.7) between patients who underwent TAB and those who did not.ConclusionsTAB of single, large, adrenal masses is usually unnecessary, exposes patients to risk, but does not affect recurrence-free or overall survival.

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Association Between Polymorphonuclear Leukocyte Cell Percentage in Cerebrospinal Fluid and Outcome of Tuberculous Meningitis Patients in a Tertiary Hospital in Indonesia

Majalah Kedokteran Bandung ◽

10.15395/mkb.v52n4.1563 ◽

2020 ◽

Vol 52 (4) ◽

Author(s):

Amanda Widayanti ◽

Ahmad Rizal Ganiem ◽

Ida Parwati

Keyword(s):

Patient Outcome ◽

Cerebrospinal Fluid ◽

Intracranial Pressure ◽

Medical Record ◽

Functional Decline ◽

Tertiary Hospital ◽

High Morbidity ◽

Patient Medical Record ◽

Cell Percentage ◽

Affect Patient Outcome

Tuberculous (TB) meningitis is the most severe type of extrapulmonary TB with high morbidity and mortality rates. Many factors affect patient outcome, including the intracranial inflammation process. In acute inflammation, recruitment of a high number of polymorphonuclear (PMN) cells can cause edema which may eventually increase the intracranial pressure. This increase in intracranial pressure may lead to functional decline, disability, and even death. This study aimed to explore the association between the PMN percentage in cerebrospinal fluid (CSF) and TB meningitis patient outcome as measured by the Glasgow Outcome Scale at Dr. Hasan Sadikin General Hospital Bandung, which is a tertiary hospital in Indonesia. This was a retrospective cohort study using patient medical record data from 2017. All TB meningitis patients over 18 years old were included. Patients with missing PMN results in medical record were excluded, which led to a total 88 subjects participating in this study. Variables analyzed were PMN percentage in CSF and patient outcome that were categorized as poor, moderate, and good. Analysis were performed using theKruskal-wallis test. An increase in PMN median as the patient outcome declined were observed, but the association between the PMN percentage in CSF and patient outcome was insignificant (p=0.186). Hence, no association between PMN percentage in CSF and TB meningitis patient outcome was identified in this study.

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Copy number of 8q24.3 drives HSF1 expression and patient outcome in cancer: an individual patient data meta-analysis

Human Genomics ◽

10.1186/s40246-019-0241-3 ◽

2019 ◽

Vol 13 (1) ◽

Cited By ~ 1

Author(s):

Nele Brusselaers ◽

Karl Ekwall ◽

Mickael Durand-Dubief

Keyword(s):

Patient Outcome ◽

Copy Number ◽

Meta Analysis ◽

Tumor Stage ◽

The Cancer Genome Atlas ◽

Cancer Prognosis ◽

Anatomical Location ◽

Tumor Patients ◽

Affect Patient Outcome ◽

Global Increase

Abstract Background The heat-shock transcription factor 1 (HSF1) has been linked to cell proliferation and survival in cancer and has been proposed as a biomarker for poor prognosis. Here, we assessed the role of HSF1 expression in relation to copy number alteration (CNA) and cancer prognosis. Methods Using 10,287 cancer genomes from The Cancer Genome Atlas and Cbioportal databases, we assessed the association of HSF1 expression with CNA and cancer prognosis. CNA of 8q24.3 was categorized as diploid (reference), deletion (fewer copies), gain (+ 1 copy) and amplification (≥ + 2 copies). Multivariate logistic regression modeling was used to assess 5-year survival among those with a first cancer diagnosis and complete follow-up data (N = 9568), categorized per anatomical location and histology, assessing interaction with tumor stage, and expressed as odds ratios and 95% confidence intervals. Results We found that only 54.1% of all tumors have a normal predicted 8q24.3 copy number and that 8q24.3 located genes including HSF1 are mainly overexpressed due to increased copies number of 8q24.3 in different cancers. The tumor of patients having respectively gain (+ 1 copy) and amplification (≥ + 2 copies) of 8q24.3 display a global increase of 5-year mortality (odds ratio = 1.98, 95% CI 1.22–3.21) and (OR = 2.19, 1.13–4.26) after full adjustment. For separate cancer types, tumor patients with 8q24.3 deletion showed a marked increase of 5-year mortality in uterine (OR = 4.84, [2.75–8.51]), colorectal (OR = 4.12, [1.15–14.82]), and ovarian (OR = 1.83, [1.39–2.41]) cancers; and decreased mortality in kidney cancer (OR = 0.41, [0.21–0.82]). Gain of 8q24.3 resulted in significant mortality changes in 5-year mortality for cancer of the uterus (OR = 3.67, [2.03–6.66]), lung (OR = 1.76, [1.24–2.51]), colorectal (OR = 1.75, [1.32–2.31]) cancers; and amplification for uterine (OR = 4.58, [1.43–14.65]), prostate (OR = 4.41 [3.41–5.71]), head and neck (OR = 2.68, [2.17–3.30]), and stomach (OR = 0.56, [0.36–0.87]) cancers. Conclusions Here, we show that CNAs of 8q24.3 genes, including HSF1, are tightly linked to 8q24.3 copy number in tumor patients and can affect patient outcome. Our results indicate that the integration of 8q24.3 CNA detection may be a useful predictor for cancer prognosis.

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