scholarly journals Pregnancy and myeloproliferative neoplasms : A retrospective monocentric cohort

2017 ◽  
Vol 10 (4) ◽  
pp. 165-169 ◽  
Author(s):  
Mathieu Puyade ◽  
Emilie Cayssials ◽  
Fabrice Pierre ◽  
Olivier Pourrat
Keyword(s):  
Essential Thrombocythemia ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Fetal Death ◽  
Myeloproliferative Neoplasms ◽  
Myelogenous Leukemia ◽  
Intrauterine Fetal Death ◽  
Recurrent Miscarriages ◽  
Fetal Complications ◽  
Placenta Pathology

Background The most frequent myeloproliferative neoplasms are essential thrombocythemia and chronic myelogenous leukemia, which usually manifests with thrombocytosis. Only essential thrombocythemia is associated with morbidity during pregnancy (recurrent miscarriages, intrauterine fetal death, small for gestational age and preeclampsia). The aim of this paper is to describe outcomes of pregnancy in women with myeloproliferative neoplasms seen at a single academic institution. Methods Data were collected retrospectively from 2002 to 2015. Descriptive analyses were performed. Results Eighteen pregnancies in 13 patients and 17 births were identified. One patient had recurrent miscarriages. There were two intrauterine fetal deaths, three small for gestational age linked to vascular placenta pathology and one preeclampsia. All of these mothers harbored JAK2V617F mutation. Two out of three patients with small for gestational age developed a venous thrombosis in the two years following delivery. Conclusion Thrombocytosis associated with myeloproliferative neoplasms should be considered as a risk factor for maternal and fetal complications.

scholarly journals Customized growth charts for twin gestations to optimize identification of small-for-gestational age fetuses at risk of intrauterine fetal death

2013 ◽  
Vol 41 (6) ◽  
pp. 637-642 ◽  
Author(s):  
A. O. Odibo ◽  
A. G. Cahill ◽  
K. R. Goetzinger ◽  
L. M. Harper ◽  
M. G. Tuuli ◽  
...  
Keyword(s):  
At Risk ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Fetal Death ◽  
Intrauterine Fetal Death ◽  
Growth Charts

scholarly journals The risk of intrauterine fetal death in the small-for-gestational-age fetus

2012 ◽  
Vol 207 (4) ◽  
pp. 318.e1-318.e6 ◽  
Author(s):  
Rachel A. Pilliod ◽  
Yvonne W. Cheng ◽  
Jonathan M. Snowden ◽  
Amy E. Doss ◽  
Aaron B. Caughey
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Fetal Death ◽  
Intrauterine Fetal Death

scholarly journals P0150APREECLAMPSIA ABOUT 252 PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Boubchir Akli ◽  
Boubchir Akli ◽  
Brahim Kichou ◽  
MADIOU ALI
Keyword(s):  
Risk Factors ◽  
Adverse Events ◽  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Fetal Death ◽  
Gestational Hypertension ◽  
Adverse Outcomes ◽  
Previous Pregnancy ◽  
Fetal Complications

Abstract Background and Aims The main objective was to estimate the prevalence of pre-eclampsia (PE) in pregnant women in Tizi-ouzou (Algeria). Secondary objectives were to estimate the frequency of PE risk factors, and the incidence of maternal and fetal complications. Methods Our study was observational, prospective and descriptive, including all pregnant women at the prenatal appointment in the 2 maternity units of Tizi-ouzou, between January 2012 and June 2013. PE was diagnosed if gestational hypertension was associated with proteinuria > 300mg/24h, after 20 weeks of gestation. Results We had 252 cases of PE on 3225 pregnant women. The prevalence of PE was 7.8% (CI 95%: 6.9%–8.7%). The most frequent PE risk factors were nulliparity (56%), age >40 years (27%), obesity (26%) and PE in any previous pregnancy (21%). The incidence of maternal adverse events was 28.7% (CI 95%: 23.1%–34.3%), including 5 deaths. The rates of prematurity, small for gestational age infant and fetal death were 58.2%, 49.7% and 6.7%, respectively. Conclusion The prevalence of PE in pregnant women in Tizi-ouzou is around 8%. The incidence of maternal and fetal adverse outcomes remains high. Only earlier diagnosis and closer monitoring could improve the prognosis of our patients, since the treatment of PE remains currently childbirth.

Pathological Study of Stillbirths Placentas at Muhimbili National Hospital, Tanzania

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S22-S23
Author(s):  
A E Malango
Keyword(s):  
Clinical Diagnosis ◽  
Clinical Assessment ◽  
Gestational Age ◽  
Fetal Death ◽  
Consensus Statement ◽  
Cross Sectional Study ◽  
Pathological Examination ◽  
Pathological Study ◽  
Cross Sectional ◽  
Placenta Pathology

Abstract Introduction/Objective Stillbirth is defined as fetal death that occurs at gestational age of ≥28 weeks. In our setting clinical assessment is the only method used to determine cause of stillbirths, with no reported proportion of unknown clinical diagnosis. Studies showed that unknown cause of stillbirths can be reduced by examination of placenta. Causal identification aids in the mourning process and identifying recurrence risks. The study aimed to describe pathological changes in the placentas of stillbirths which have risk to cause fetal death Methods A descriptive cross-sectional study done for the period of 6 months, it involved examination of 80 placentas of stillbirths born at gestational age of ≥ 28 weeks, placentas were fixed in 10% neutral buffered formalin for 8–12 hours. Grossing and interpretation of placenta pathology was according to Amsterdam Placental Workshop Group Consensus Statement. Results Out of 80 stillbirths, 32(40%) had unknown clinical diagnosis. Majority of stillbirth placentas 71(91%) found with either one or combined pathologies with the risk to cause stillbirth. Maternal vascular malperfusion was the commonest pathology and was significantly associated with preterm stillbirths. Maternal floor infarction, a placenta pathology with risk to cause fetal death and high risk of recurrence was among the pathologies found, was seen in 4(5%) of stillbirth placentas. Conclusion Findings in this study clearly indicated the importance of pathological examination of placenta in determining cause of stillbirth. Placenta examination in stillbirths can identify more pathology related to stillbirths than clinical assessment alone.

scholarly journals Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar

2020 ◽  
Vol 13 (1) ◽  
pp. 336-340
Author(s):  
Mohammad Abu-Tineh ◽  
Nancy Kassem ◽  
Mohammad Abdul-Jaber Abdulla ◽  
Omar Mohammad Ismail ◽  
Rola Ghasoub ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Essential Thrombocythemia ◽  
Myeloproliferative Neoplasms ◽  
Pegylated Interferon ◽  
Myelogenous Leukemia ◽  
Hematopoietic Stem ◽  
Pegylated Interferon Alpha ◽  
Pregnant Females ◽  
Increased Risk ◽  
Hemorrhagic Complications

Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, and MPL. All carry an increased risk to transform into acute leukemia or chronic myelogenous leukemia along with thrombosis and hemorrhagic complications. Treatment of such disorders during pregnancy is a challenging footstep, given the high risk of complications for both the mother and the fetus. Here, we report about two pregnant females with ET that has been treated with pegylated interferon alpha with safe and effective outcome.

scholarly journals MPL W515 L/K mutations in myeloproliferative neoplasms

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Sohaila Eldeweny ◽  
Hosny Ibrahim ◽  
Ghada Elsayed ◽  
Mohamed Samra
Keyword(s):  
Bone Marrow ◽  
Polycythemia Vera ◽  
Ethnic Groups ◽  
Essential Thrombocythemia ◽  
Myeloproliferative Neoplasms ◽  
Primary Myelofibrosis ◽  
Myelogenous Leukemia ◽  
Egyptian Population ◽  
Ph Chromosome ◽  
Pathological Variant

Abstract Background Myeloproliferative neoplasms (MPNs) describe a group of diseases involving the bone marrow (BM). Classical MPNs are classified into chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). This classification is based on the presence of Philadelphia (Ph) chromosome (BCR/ABL1). CML is BCR/ABL1-positive while PV, ET, and PMF are negative. JAK2 p. Val617Phe pathological variant is the most associated mutation in BCR/ABL1-negative MPNs. The frequency of JAK2 p. Val617Phe is 90–95% in PV patients, 50–60% in ET, and 40–50% in patients with PMF. Studies on MPL gene led to the revelation of a gain of function pathological variants in JAK2 p. Val617Phe-negative myeloproliferative neoplasms (MPNs). MPL p. W515 L/K pathological variants are the most common across all mutations in MPL gene. The prevalence of these pathological variants over the Egyptian population is not clear enough. In the present study, we aimed to investigate the prevalence of MPL p. W515 L/K pathological variants in the Philadelphia (Ph)-negative MPNs over the Egyptian population. Results We have tested 60 patients with Ph-negative MPNs for MPL p. W515 L/K pathological variants. Median age was 51 (22–73) years. No MPL p. W515 L/K pathological variants were detected among our patients. JAK2 p. Val617Phe in PV and PMF patients showed significantly lower frequency than other studies. Splenomegaly was significantly higher in ET patients compared to other studies. Conclusion MPL p. W515 L/K pathological variants are rare across the Egyptian Ph-negative MPNs, and further studies on a large number are recommended. MPN patients in Egypt are younger compared to different ethnic groups.

Ultrasound Examination in Twin Pregnancy and Late Fetal Death

1997 ◽  
Vol 46 (4) ◽  
pp. 199-207
Author(s):  
H. Rydhstroem ◽  
B. Walles
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Fetal Death ◽  
Perinatal Period ◽  
Second Trimester ◽  
Birth Registry ◽  
National Board ◽  
Biparietal Diameter ◽  
Significant Difference ◽  
Matching Criteria

AbstractObjective. To test the hypothesis that the (case) twin later to succumb in utero has biparietal diameter measurements (by ultrasound) different from those (control) twins surviving the perinatal period.Material and methods. Information from the Medical Birth Registry, National Board of Health and Welfare, Stockholm, was used to identify all births in a defined population in southern Sweden with about 20,000 deliveries each year. In 3,019 twin pregnancies between 1973 and 1989, one or both twins were stillborn in 47 cases (gestational duration ≥28 weeks, birthweight ≥500g.). For each case pregnancy, two control pregnancies were selected, the matching criteria being: same delivery unit, same parity (0, I, II, III+), similar year of delivery (± 1 year) and maternal age (± 5 years). Data on ultrasound examinations were extracted from the original medical records. Screening in early second trimester started at one of the units as early as 1973 and at the latest of 12 units in 1982.Results. There was no obvious difference between cases and controls in intra-pair discordant biparietal diameter (BPD) measured in early second trimester. Nor was there any evident difference in the rate of deviant BPD between cases and controls. In all, 8% of dead male and 24% of dead female fetuses were by definition small-for-gestational age (<-2 standard deviations).Conclusions. No significant difference was seen between cases and controls regarding deviating biparietal diameters. Abdominal diameter may be a better predictor of subsequent fetal death (not analysed in this study), though only about 15% of all dead twins were deemed small-for-gestational age.

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