scholarly journals The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status

2019 ◽  
Vol 12 ◽  
pp. 175628481882256 ◽  
Author(s):  
Mayur Garg ◽  
Simon G. Royce ◽  
Chris Tikellis ◽  
Claire Shallue ◽  
Pavel Sluka ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Intestinal Resection ◽  
Staining Intensity ◽  
Oral Vitamin ◽  
Vitamin D Intake ◽  
Histological Score ◽  
Inflammatory Bowel ◽  
Protein Staining

Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD). Methods: Colonoscopic biopsies and intestinal resection specimens from the terminal ileum, ascending and sigmoid colon, from patients with and without IBD, were analyzed for VDR mRNA quantification by polymerase chain reaction, and protein localization and semi-quantification by immunohistochemistry. The relationship between VDR and intestinal inflammation, serum 25(OH)D and oral vitamin D intake was elicited. Results: A total of 725 biopsies from 20 patients with Crohn’s disease (CD), 15 with ulcerative colitis (UC) and 14 non-IBD controls who underwent colonoscopy were studied. VDR gene expression and protein staining intensity was similar across all three groups, and across the intestinal segments. Sigmoid colon VDR mRNA expression inversely correlated with faecal calprotectin ( r = −0.64, p = 0.026) and histological score ( r = −0.67, p = 0.006) in UC, and histological score ( r = −0.58, p = 0.019) in patients with CD. VDR staining intensity was higher in quiescent than diseased segments. No relationship with serum 25(OH)D or oral vitamin D intake was noted. Immunohistochemical staining of 28 intestinal resection specimens from 15 patients (5 each with CD, UC and non-IBD controls) showed diffuse VDR staining in the mucosa, submucosa and circular muscle. Conclusions: VDR transcript expression and protein staining intensity are inversely related to inflammation in IBD, but unrelated to serum 25(OH)D, and similar to non-IBD controls. Strategies to upregulate intestinal VDR, potentially translating to modulation of disease activity, require investigation.

Evaluation of Vitamin D Levels and Colonic Expression of the Vitamin D Receptor in Puerto Ricans With Inflammatory Bowel Disease

2015 ◽  
Vol 110 ◽  
pp. S836
Author(s):  
Priscilla M. Medero-Rodriguez ◽  
Yamilka Abreu-Delgado ◽  
Raymond A. Isidro ◽  
Alexandra Gonzalez ◽  
Gil Diaz ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bowel Disease ◽  
Puerto Ricans ◽  
Vitamin D Levels ◽  
Inflammatory Bowel

Association of Vitamin D Receptor Gene Polymorphisms with Inflammatory Bowel Disease

2006 ◽  
Vol 101 ◽  
pp. S435-S436
Author(s):  
Nosratollah Naderi ◽  
Alma Farnood ◽  
Manijeh Habibi ◽  
Faramarz Derakhshan ◽  
Zahra Motahari ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Bowel Disease ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Inflammatory Bowel ◽  
Receptor Gene Polymorphisms

scholarly journals EFFICACY OF HIGH AND LOW DOSE ORAL VITAMIN D REPLACEMENT THERAPY IN INFLAMMATORY BOWEL DISEASE (IBD): SINGLE CENTRE COHORT: Table 1

Gut ◽  
2013 ◽  
Vol 62 (Suppl 2) ◽  
pp. A2.1-A2 ◽  
Author(s):  
H J Hiew ◽  
M Naghibi ◽  
J Wu ◽  
J Saunders ◽  
F Cummings ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Replacement Therapy ◽  
Bowel Disease ◽  
Low Dose ◽  
Single Centre ◽  
Oral Vitamin ◽  
Dose Oral ◽  
Inflammatory Bowel

scholarly journals Role of TaqI-Genetic Polymorphism of Vitamin D Receptor Gene in Bone Metabolism in Children with Inflammatory Bowel Disease

2017 ◽  
Vol 8 (3) ◽  
pp. 111-119
Author(s):  
Tatiana V Gabrusskaia ◽  
Michail M Kostik ◽  
Yulia A Nasyhova ◽  
Maria O Revnova ◽  
Diana A Kuzmina
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bone Metabolism ◽  
Vitamin D Receptor ◽  
Linear Growth ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Vdr Gene ◽  
Inflammatory Bowel

Evaluation of bone mineralization and bone metabolism in children with inflammatory bowel disease (IBD) in accordance with TaqI-polymorphic genotypes of vitamin D receptor (VDR) has been performed in this study. 83 children (38 girls and 54 boys) with IBD (60 with Crohn’s disease, 23 with ulcerative colitis) have been included in the study. Mean age was 13.0 years (11.0; 15.5). All patients have active phase of the disease. Bone mineral density (BMD) of lumbar spine (DEXA) have been assessed in all children. Level of serum osteocalcin (OC) as a marker of osteosynthesis, C-terminal telopeptides (CTT) as a marker of osteoresorbtion, parathyroid hormone (PTH), serum calcium, phosphorus, alkaline phosphatase and 25(OH) vitamin D was measured to evaluate bone metabolism. Molecular-genetic tests: analysis of TaqI (rs731236) polymorphism of vitamin D receptor gene (VDR) was perfomed by polymerase chain reaction with following restriction analysis. Association between molecular markers of VDR gene and bone metabolism and mineralization disturbances have been found. TT genotype of VDR gene was associated with tendency to decrease of linear growth velocity, low linear growth, decrease in osteosynthesis and increase of osteoresorbtion in this group of children. TT-genotype of TaqI-polymorphism of VDR gene can be assessed as a risk factor of bone metabolism disturbances in children with both Crohn’s disease and ulcerative colitis. C allele seems to have protective role in this group.

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