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2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Esther Herrera-Luis ◽  
Annie Li ◽  
Angel C. Y. Mak ◽  
Javier Perez-Garcia ◽  
Jennifer R. Elhawary ◽  
...  

Abstract Introduction DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, no epigenome-wide association study (EWAS) of lung function has been performed in this population. Here, we aimed to identify DNA methylation patterns associated with lung function in pediatric asthma among Latinos. Results We conducted an EWAS in whole blood from 250 Puerto Rican and 148 Mexican American children and young adults with asthma. A total of five CpGs exceeded the genome-wide significance threshold of p = 1.17 × 10−7 in the combined analyses from Puerto Ricans and Mexican Americans: cg06035600 (MAP3K6, p = 6.13 × 10−8) showed significant association with pre-bronchodilator Tiffeneau–Pinelli index, the probes cg00914963 (TBC1D16, p = 1.04 × 10−7), cg16405908 (MRGPRE, p = 2.05 × 10−8), and cg07428101 (MUC2, p = 5.02 × 10−9) were associated with post-bronchodilator forced vital capacity (FVC), and cg20515679 (KCNJ6) with post-bronchodilator Tiffeneau–Pinelli index (p = 1.13 × 10−8). However, these markers did not show significant associations in publicly available data from Europeans (p > 0.05). A methylation quantitative trait loci analysis revealed that methylation levels at these CpG sites were regulated by genetic variation in Latinos and the Biobank-based Integrative Omics Studies (BIOS) consortium. Additionally, two differentially methylated regions in REXOC and AURKC were associated with pre-bronchodilator Tiffeneau–Pinelli index (adjusted p < 0.05) in Puerto Ricans and Mexican Americans. Moreover, we replicated some of the previous differentially methylated signals associated with lung function in non-Latino populations. Conclusions We replicated previous associations of epigenetic markers with lung function in whole blood and identified novel population-specific associations shared among Latino subgroups.


2022 ◽  
Author(s):  
Manuel Cano ◽  
Camila Gelpi-Acosta

This study examined differences across Latine heritage groups (i.e., Mexican, Puerto Rican, Cuban, Dominican, Central American, South American) in rates of US drug overdose mortality. The study utilized 2015-2019 mortality data from the National Center for Health Statistics for 29,137 Hispanic individuals who died of drug overdose. Using population estimates from the American Community Survey, age-standardized drug overdose mortality rates were calculated by specific Latine heritage and sex, nativity, educational attainment, and geographic region. Standardized rate ratios (SRRs), incidence rate ratios (IRRs) from negative binomial regression models, and 95% Confidence Intervals (CIs) were calculated, and multiple imputation was used for missing Latine heritage group in select models. Drug overdose mortality rates in the Puerto Rican heritage population were more than three times as high as in the Mexican heritage population (IRR 3.61 [95% CI 3.02-4.30] in unadjusted model; IRR 3.70 [95% CI 3.31-4.15] in model adjusting for age, sex, nativity, educational attainment, and region; SRR 3.23 [95% CI, 3.15-3.32] in age-standardized model with missing Hispanic heritage imputed). Higher age-standardized rates of drug overdose mortality were observed in males than females across all Latine groups, yet the magnitude of the sex differential varied by Latine heritage. The relationship between drug overdose mortality and nativity differed by Latine heritage; in all groups except Puerto Rican, overdose mortality rates were significantly higher in the US-born than those not US-born. In contrast, overdose mortality rates were significantly lower in US-born Puerto Ricans than in Puerto Ricans who were not US-born (e.g., born in Puerto Rico; SRR, 0.84 [95% CI 0.80-0.88]). The relationship between drug overdose mortality and educational attainment (for ages 25+) also varied between Latine groups. The diverse subgroups comprising the US Latine population vary not only in rates of drug overdose mortality, but also in demographic risk factors for fatal drug overdose.


2021 ◽  
pp. 089826432110641
Author(s):  
Kaipeng Wang ◽  
Anao Zhang ◽  
Adolfo G. Cuevas ◽  
Carson M. De Fries ◽  
Ladson Hinton ◽  
...  

Objectives To examine the association between post-traumatic stress and depression and whether such an association differs by level of loneliness among older Puerto Ricans. Methods Data were collected from 304 Puerto Ricans aged 60 and above living in the Greater Boston area who responded to questionnaires. We used ordinary least squares regression to examine the association between post-traumatic stress, loneliness, and depressive symptoms. Results Post-traumatic stress was significantly associated with higher levels of depression. The association between post-traumatic stress and depression was stronger for those experiencing a higher degree of loneliness. Discussion In working with older Puerto Ricans experiencing post-traumatic stress, it is important for mental health professionals to incorporate the assessment of loneliness and to prevent and reduce comorbid depression by addressing loneliness through improving social skills, enhancing social support, and reducing maladaptive social cognition.


Significance The Board has now argued the case for federal endorsement of this latest version of the plan before the judge overseeing the process. The process has taken four years to reach this point, but a further delay is possible. Impacts Puerto Ricans will continue to leave the island given the ongoing uncertainties related to education, employment and healthcare. Despite some interest earlier this year, Congress is expected to make little progress on the island’s constitutional status in 2022. With 5 million Puerto Ricans registered to vote on the mainland, island issues will feature in some 2022 midterm elections.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 410-410
Author(s):  
Kaipeng Wang ◽  
Adolfo Cuevas ◽  
Anao Zhang ◽  
Carson de Fries ◽  
Ladson Hinton ◽  
...  

Abstract Puerto Ricans have a significantly higher prevalence of post-traumatic stress disorder (PTSD) than other racial and ethnic groups. PTSD can lead to co-morbid depression, which exacerbates the risk for compromised mental and physical health among older adults. Loneliness, a robust indicator of poor social support, is likely to worsen the dysphoric symptoms of PTSD and increase the risks of depression. However, few studies have focused on the moderating role of loneliness on the association between post-traumatic stress and depression. This study examines the association between post-traumatic stress and depression and whether such an association differs by loneliness among older Puerto Ricans. Data were collected from 304 Puerto Ricans aged 60-81 living in the Greater Boston area who responded to questionnaires in a survey. We used ordinary least squares regression to examine the association between post-traumatic stress, loneliness, and depression. We found that post-traumatic stress was significantly associated with higher levels of depression; however, the association was contingent on experiences of loneliness. The association between post-traumatic stress and depression was stronger for those experiencing a higher degree of loneliness. Findings underscored the role that loneliness plays in exacerbating the risk of developing co-morbid PTSD and depression among older Puerto Ricans. In working with older Puerto Ricans experiencing post-traumatic stress, it is important for mental health professionals to incorporate the assessment of loneliness and to prevent and reduce co-morbid depression by addressing loneliness through improving social skills, enhancing social support, and reducing maladaptive social cognition.


2021 ◽  
pp. 100998
Author(s):  
Mao-Mei Liu ◽  
Michael Crowe ◽  
Edward Telles ◽  
Ivonne Z. Jiménez-Velázquez ◽  
William Dow

2021 ◽  
pp. 1-17
Author(s):  
Karenjot Kaur ◽  
Kimberly J. Arcoleo ◽  
Denise Serebrisky ◽  
Deepa Rastogi ◽  
Flavio F. Marsiglia ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258324
Author(s):  
Daniel K. Cooper ◽  
Mayra Bámaca-Colbert ◽  
Eric K. Layland ◽  
Emily G. Simpson ◽  
Benjamin L. Bayly

Background Puerto Ricans and Mexican immigrants are often exposed to multiple types of adversity across their lifetime (e.g., maltreatment, household dysfunction, discrimination) and this exposure can increase the risk for adult mental health problems. Purpose The objective of this study was to (a) identify subgroups of individuals exposed to unique combinations of childhood adversity and lifetime discrimination among Puerto Ricans and Mexican immigrants, and (b) compare the prevalence of mental health problems across different risk profiles. Method We used existing data from the HCHS/SOL Sociocultural Ancillary Study. Participants included Puerto Rican (N = 402) and Mexican adults (N = 1351) born outside but living in the continental U.S. Findings Through latent profile analysis, we selected a three-profile solution for Puerto Ricans: (a) Low Exposure (low on all adversity items; 58% of sample), (b) Adverse Childhood Experiences (ACEs) Only (high on ACEs items, average or lower than average on discrimination items; 32%), and (c) Dual Exposure (high on all adversity items; 10%). For Mexicans, we selected a four-profile solution: (a) Low Exposure (52%), (b) ACEs Only (24%), (c) Maltreatment and Discrimination (15%), and (d) Dual Exposure (9%). For Mexicans, we found that the Dual Exposure and the Maltreatment and Discrimination profiles had the highest levels of mental health problems. For Puerto Ricans, the Dual Exposure and ACEs Only profiles had the highest levels of mental health problems, suggesting that Puerto Ricans may be more vulnerable to the effects of childhood adversities as compared to Mexican immigrants. Results from our study indicate that different patterns of adversity exposure are linked to different levels of mental health outcomes, and therefore, may require different intervention dosage. Understanding which groups of individuals are at highest and lowest risk for mental health problems is critical for developing effective, tailored interventions to prevent the negative effects of childhood adversity and discrimination for Latinxs.


Author(s):  
Gillian M. Belbin ◽  
Stephanie Rutledge ◽  
Tetyana Dodatko ◽  
Sinead Cullina ◽  
Michael C. Turchin ◽  
...  

2021 ◽  

To expand the lens of what is considered an environmental issue in Latinx studies, this overview includes a hemispheric approach even if the focus remains on US Latinx populations, primarily because Latinx and Indigenous peoples across the Americas draw on centuries of knowledge tied to caretaking of the land and that environmental ethic continues to be evidenced in many ways. We can measure high Latinx participation in mainstream environmentalism, look to the many grassroots movements that respond to local, national, and transnational environmental justice concerns, and recognize how Latinxs have redefined the very ideas of “nature” and what counts as an environmental issue. We also read across disciplines, including ecocritical scholarship that shows how writers contribute to the development of a sense of place and connect readers to an environmental ethic; research on politics and policymaking reveals both the negative impacts of environmental and economic policies on Latinx groups as well as the consistently pro-environmental attitudes Latinxs demonstrate in surveys. Revisionist and recuperative histories bring our attention to activists and actions that broaden our awareness of what counts as an environmental issue, such as the reckoning the Alianza Federal de Mercedes brought in the 1960s for the restoration of land grants in New Mexico. Gender studies approaches show that women are leading environmental movements in Latinx communities (as they do around the world). We see that, for many Latinxs, displacement and place-making play a large role in mediating relationships with nature—this is evident as much through literary analysis as it is through critical geography studies. Finally, we look at the topic of environmental justice, which is large enough that we pulled themes such as food justice and green space access out for development in their own sections while attending to different notions of environmental justice and the different kinds of environmental harms experienced by activists and environmental defenders in the United States and throughout Latin American and the Caribbean. In the United States, Latinx environmental activism was highly visible in the 1960s when the United Farm Workers campaigns gained national prominence; however, a land-based and environmental ethic among people of Mexican descent is evident much earlier than even the 19th century when Mexican territory was ceded to the United States. While much has been written about Mexican Americans’ relationships to the environment, emerging research seeks to uncover environmental attitudes and issues that impact other Latinx groups. Puerto Ricans, for example, are the second-largest Latinx group in the United States, and Puerto Ricans on the island developed a robust environmental movement though anti-colonial mobilizations in the 1960s. Further, recent migrants to the US mainland bring an awareness of the impacts of neoliberal globalization, extraction economies, and development driven environmental degradation that is especially acute, from hurricanes that displace people from their homes in the Caribbean to droughts, floods, and rising sea levels that impact Guatemala, El Salvador, Honduras, and other countries across Latin America. For many, those very issues, including increased violence as a result of environmental and economic conflicts, drove their migration. This work serves as a starting point for researchers interested in environmental issues in Latinx studies, and more comparative research on environmental issues across the hemisphere remains to be done.


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