Homicidal Paraquat Poisoning Following Ligature Strangulation

Rohan Ruwanpura; Chathura Nandasiri

doi:10.1177/1925362119891704

Homicidal Paraquat Poisoning Following Ligature Strangulation

Academic Forensic Pathology ◽

10.1177/1925362119891704 ◽

2019 ◽

Vol 9 (3-4) ◽

pp. 212-216

Author(s):

Rohan Ruwanpura ◽

Chathura Nandasiri

Keyword(s):

Fibrosing Alveolitis ◽

Paraquat Poisoning

We report a case of homicidal paraquat poisoning preceded by attempted manual strangulation. The poison had been forcibly ingested when the victim was unconscious due to pressure on the neck. The victim survived for ten days and died due to development of fibrosing alveolitis. The autopsy showed classic features of proliferative stages of paraquat poisoning and healing signs of ligature strangulation.

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Exposure to antidepressants and the risk of cryptogenic fibrosing alveolitis: a case-control study

European Respiratory Journal ◽

10.1034/j.1399-3003.2000.016003409.x ◽

2000 ◽

Vol 16 (3) ◽

pp. 409 ◽

Cited By ~ 9

Author(s):

R. Hubbard ◽

A. Venn ◽

J. Britton

Keyword(s):

Case Control Study ◽

Case Control ◽

Fibrosing Alveolitis ◽

Cryptogenic Fibrosing Alveolitis ◽

Control Study

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Risk of cryptogenic fibrosing alveolitis in metal workers

The Lancet ◽

10.1016/s0140-6736(99)05417-3 ◽

2000 ◽

Vol 355 (9197) ◽

pp. 466-467 ◽

Cited By ~ 6

Author(s):

R Hubbard

Keyword(s):

Fibrosing Alveolitis ◽

Metal Workers ◽

Cryptogenic Fibrosing Alveolitis

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High-Resolution CT in Paraquat Poisoning of the Lung: Role of Prognosis Prediction

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1998.38.6.1027 ◽

1998 ◽

Vol 38 (6) ◽

pp. 1027

Author(s):

Kyoung Suk Kim ◽

Young Tong Kim ◽

Eun Joo Kwon ◽

Choung Sik Choi ◽

Han Heag Im ◽

...

Keyword(s):

High Resolution ◽

Prognosis Prediction ◽

High Resolution Ct ◽

Paraquat Poisoning

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PARAQUAT POISONING IS NOT NECESSARILY FATAL

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1977.tb114643.x ◽

1977 ◽

Vol 2 (17) ◽

pp. 564-565 ◽

Cited By ~ 5

Author(s):

Peter D. Thomas ◽

Dale Thomas ◽

Yuk‐Luen Chan ◽

Anthony R. Clarkson

Keyword(s):

Paraquat Poisoning

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NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis

Annals of the Rheumatic Diseases ◽

10.1136/ard.2010.131243 ◽

2010 ◽

Vol 70 (4) ◽

pp. 668-674 ◽

Cited By ~ 65

Author(s):

P Dieudé ◽

M Guedj ◽

J Wipff ◽

B Ruiz ◽

G Riemekasten ◽

...

Keyword(s):

Innate Immunity ◽

Systemic Sclerosis ◽

Potential Role ◽

Additive Model ◽

Nucleotide Polymorphisms ◽

Fibrosing Alveolitis ◽

Single Nucleotide ◽

Risk Alleles ◽

Caucasian Origin

BackgroundRecent evidence has highlighted a potential role of interleukin 1β (IL-1β) in systemic sclerosis (SSc). NLRP1 provides a scaffold for the assembly of the inflammasome that promotes the processing and maturation of pro-IL-1β. In addition, NLRP1 variants were found to confer susceptibility to autoimmune disorders.ObjectiveTo study a possible association of the NLRP1 rs6502867, rs2670660 and rs8182352, rs12150220 and rs4790797 with SSc in the European Caucasian population.MethodsNLRP1 single nucleotide polymorphisms were genotyped in 3227 individuals comprising a discovery set (870 SSc patients and 962 controls) and a replication set including individuals from Germany (532 SSc patients and 324 controls) and Italy (527 SSc patients and 301 controls), all individuals being of European Caucasian origin.ResultsConditional analyses revealed a significant association for the NLRP1 rs8182352 variant with both anti-topoisomerase-positive and SSc-related fibrosing alveolitis (FA) subsets under an additive model: p=0.0042, OR 1.23 (95% CI 1.07 to 1.41) and p=0.0065 OR 1.19 (95% CI 1.05 to 1.36), respectively. Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.ConclusionsOur results establish NLRP1 as a new genetic susceptibility factor for SSc-related pulmonary fibrosis and anti-topoisomerase-positive SSc phenotypes. This provides new insights into the pathogenesis of SSc, underlining the potential role of innate immunity in particular in the FA-positive SSc subphenotype, which represents a severe subset of the disease.

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