Myorelaxant Effect of Essential Oil of Rhizome of Alpinia calcarata Rosc. on Rat Duodenal Smooth Muscle
2007 ◽
Vol 2
(7)
◽
pp. 1934578X0700200
◽
Keyword(s):
Analysis of the essential oil from the rhizome of Alpinia calcarata Rosc. (ACREO) by a combination of GC and GC-MS revealed the presence of 1,8-cineole (42.2%), endo-fenchyl acetate (14.7%), camphene (7.6%), β-pinene (6.9%), α-terpineol (5.3%) and camphor (5.0%). Twenty-three compounds were identified in the oil. ACREO showed dose dependent myorelaxant activity in rat duodenum. The dose response curves of acetylcholine (ACh) and CaCl2 were shifted by ACREO to the right with increases in EC50 values and decreases in Vmax. These findings suggest that ACREO is a non-competitive antagonist of ACh and calcium.
1975 ◽
Vol 229
(6)
◽
pp. 1635-1640
◽
1991 ◽
Vol 69
(6)
◽
pp. 805-811
◽
1981 ◽
Vol 241
(4)
◽
pp. H557-H563
◽
2005 ◽
Vol 98
(5)
◽
pp. 1603-1606
◽
Keyword(s):
1985 ◽
Vol 58
(2)
◽
pp. 625-634
◽
Keyword(s):
1989 ◽
Vol 257
(4)
◽
pp. R695-R699
◽
Keyword(s):
1983 ◽
Vol 61
(6)
◽
pp. 572-580
◽