scholarly journals Cruzain Inhibitory Activity of Leaf Essential Oils of Neotropical Lauraceae and Essential Oil Components

2007 ◽  
Vol 2 (12) ◽  
pp. 1934578X0700201 ◽  
Author(s):  
William N. Setzer ◽  
Sean L. Stokes ◽  
Ashley F. Penton ◽  
Sayaka Takaku ◽  
William A. Haber ◽  
...  
Keyword(s):  
Costa Rica ◽  
Essential Oil ◽  
Essential Oils ◽  
Cysteine Protease ◽  
Inhibitory Activity ◽  
Synergistic Effects ◽  
Germacrene D ◽  
Inhibitory Activities ◽  
Oil Components ◽  
Increased Activity

The leaf essential oils of twenty-three species of Lauraceae from Monteverde, Costa Rica, have been screened for inhibition of the cysteine protease cruzain. Of these, nine showed promising cruzain inhibitory activity (IC50 < 100 μg/mL), six showed marginal activity (IC50, 100–500 μg/mL), and eight were inactive (IC50 > 500 μg/mL). The cruzain inhibitory activities of the essential oils can be attributed to active sesquiterpenoid components as well as synergistic effects between two or more components. The sesquiterpenes α-copaene, β-caryophyllene, α-humulene, and germacrene D are active (IC50 ~5–30 μg/mL) alone, but also show increased activity in combination with other essential oil components.

scholarly journals Cruzain Inhibitory Activity of the Leaf Essential Oil from an Undescribed Species of Eugenia from Monteverde, Costa Rica

2007 ◽  
Vol 2 (12) ◽  
pp. 1934578X0700201 ◽  
Author(s):  
Sean L. Stokes ◽  
Ramona A. Cole ◽  
Mariana P. Rangelova ◽  
William A. Haber ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Essential Oil ◽  
Trypanosoma Cruzi ◽  
Cysteine Protease ◽  
Inhibitory Activity ◽  
Undescribed Species ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil

The leaf essential oil of Eugenia sp. nov. “San Bosco” inhibits cruzain, a cysteine protease from Trypanosoma cruzi, the parasitic protozoan responsible for Chagas disease, with an IC50 of 36.4 μg/mL. Eugenia “San Bosco” leaf oil is dominated by the sesquiterpene hydrocarbons zingiberene (24.7%) and germacrene D (11.1%), and these two compounds (IC50 = 8.6 and 21.2 μg/mL, respectively) are likely responsible for the cruzain inhibitory activity observed in the essential oil.

scholarly journals Chemical Compositions of the Bark Essential Oils of Croton Monteverdensis and Croton Niveus from Monteverde, Costa Rica

2006 ◽  
Vol 1 (7) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Chemical Compositions ◽  
Medicinal Uses ◽  
Oil Components

The essential oils of the barks of Croton monteverdensis Huft and C. niveus Jacq. (Euphorbiaceae) from Monteverde, Costa Rica, were isolated by hydrodistillation in yields of 0.03% and 0.10%, respectively. The chemical composition of the oils was determined by GC–MS. The most abundant essential oil components of C. monteverdensis were α-pinene (17.1%), β-pinene (10.5%), and linalool (8.3%), while C. niveus bark oil was made up largely of α-pinene (14.4%), 1,8-cineole (11.6%), and borneol (8.5%). The major components account for the fragrances and are consistent with the traditional medicinal uses of these plants.

scholarly journals Analysis of the Leaf Essential Oil of Stauranthus perforatus from Monteverde, Costa Rica

2006 ◽  
Vol 1 (3) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Jennifer M. Schmidt ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Germacrene D ◽  
Leaf Essential Oil ◽  
Oil Components

The leaf essential oil of Stauranthus perforatus Leibm. (Rutaceae) from Monteverde, Costa Rica, was isolated by hydrodistillation and the chemical composition determined by GC–MS. The most abundant essential oil components were α-pinene, germacrene D, and α-cadinol.

scholarly journals Chemical Constituents of the Essential Oil from Aerial Parts and Fruit of Anisosciadium Orientale

2012 ◽  
Vol 7 (1) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Vahid Rowshan ◽  
Ahmad Hatami ◽  
Atefeh Bahmanzadegan ◽  
Mahnaz Yazdani
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Chemical Constituents ◽  
Aerial Parts ◽  
Germacrene D ◽  
Geranyl Butyrate ◽  
Oil Components ◽  
Fruit Oil

The essential oils from aerial parts and fruits of Anisosciadium orientale DC. growing wild in Iran were obtained by hydrodistillation and analyzed by GC and GC/MS. Seventy-one compounds were identified in the fruit oil and fifteen in the oil from the aerial parts. The main oil components of the fruits and aerial parts were myristicin (33.5%-33.7%), α-terpinolene (22%-25.8%) and limonene (19.5%-19.7%). Some compounds, such as geranyl butyrate and germacrene-D, were only detected in the fruit oil.

scholarly journals Essential Oil Compositions and Cytotoxic Activities of Dendropanax capillaris, Oreopanax Nubigenus, and Schefflera Rodrigueziana from Monteverde, Costa Rica

2009 ◽  
Vol 4 (2) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Justin D. Richmond ◽  
Brittany R. Agius ◽  
Brenda S. Wright ◽  
William A. Haber ◽  
Debra M. Moriarity ◽  
...  
Keyword(s):  
Costa Rica ◽  
Essential Oil ◽  
Essential Oils ◽  
In Vitro Cytotoxicity ◽  
Cytotoxic Activities ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D ◽  
Leaf Oil ◽  
High Concentrations

The leaf essential oils of Dendropanax capillaris, Oreopanax nubigenus and Schefflera rodrigueziana (Araliaceae) were isolated by hydrodistillation and analyzed by GC-MS. The leaf oil of Dendropanax capillaris was composed of only four compounds, β-pinene (25.3%), δ-3-carene (44.7%), daucene (17.1%), and dauca-5,8-diene (12.9%). Oreopanax nubigenus leaf oil was dominated by the sesquiterpene hydrocarbons germacrene D (70.1%) and β-caryophyllene (11.8%), while Schefflera rodrigueziana leaf oil was made up entirely of sesquiterpene hydrocarbons, mostly germacrene D (27.6%), β-cubebene (27.2%), β-caryophyllene (12.2%), α-cubebene (11.1%), and α-copaene (10.8%). Both O. nubigenus and S. rodrigueziana leaf oils showed notable in-vitro cytotoxicity on MDA-MB-231 cells, which may be attributable to the relatively high concentrations of germacrene D and β-caryophyllene in those oils.

scholarly journals Chemical Composition and Cytotoxic Activity of the Leaf Essential Oil of Ocotea tonduzii from Monteverde, Costa Rica

2007 ◽  
Vol 2 (7) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Anita Bansal ◽  
Debra M. Moriarity ◽  
Sayaka Takaku ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activities ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Oil Components ◽  
Mcf 7

The leaf essential oil of Ocotea tonduzii from Monteverde, Costa Rica has been obtained by hydrodistillation and analyzed by GC-MS. The principal constituents of O. tonduzii leaf oil were the monoterpenes α-pinene (41.4%) and pinene (25.1%) and the sesquiterpenes α-humulene (6.9%), β-caryophyllene (5.8%), and germacrene D (3.8%). O. tonduzii leaf oil was notably cytotoxic on MCF-7, MDA-MB-231, MDA-MB-468, and UACC-257 cells in vitro. The major essential oil components showed cytotoxic activities comparable to doxorubicin ( LC50, 20–70 μg/mL).

scholarly journals Composition of Essential Oils Isolated from the Needles of Pinus uncinata and P. uliginosa Grown in Poland

2015 ◽  
Vol 10 (2) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Radosław Bonikowski ◽  
Konrad Celiński ◽  
Aleksandra Wojnicka-Półtorak ◽  
Tomasz Maliński
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Bornyl Acetate ◽  
Peat Bog ◽  
Pinus Uncinata ◽  
Mountain Pine ◽  
Germacrene D ◽  
Similar Content ◽  
Oil Components ◽  
Retention Indexes

The compositions of mountain pine (Pinus uncinata) and peat-bog pine (P. uliginosa) needle essential oils were investigated. Enantiomeric compositions of selected monoterpene hydrocarbons were also examined. Respectively, fifty-three and seventy-six components of the essential oils were identified using GC-MS and retention indexes. The main group of essential oil components of mountain pine needles were monoterpenes, and bornyl acetate constituted approximately 30% (46.3g/100g) of the oil. In peat-bog pine essential oil, monoterpenes and sesquiterpenes exhibited a similar content (ca. 40%). Bornyl acetate and a-pinene were the main constituents of both essential oils. In the essential oil of P. uncinata needles, limonene, camphene, myrcene and ( E)-β-caryophyllene were also noticeable, while in the essential oil of P. uliginosa needles, Δ-car-3-ene, ( E)-β-caryophyllene, germacrene D, δ-cadinene, germacrene D 4-ol and α-cadinol were present in notable quantities. In both essential oils, borneol propionate, isobutyrate, 2-methylbutyrate and isovalerate were detected. Their presence was confirmed by synthesis and analysis of the standards; retention indexes on a non-polar column are published herein.

scholarly journals Cytotoxic Leaf Essential Oils from Neotropical Lauraceae: Synergistic Effects of Essential Oil Components

2007 ◽  
Vol 2 (12) ◽  
pp. 1934578X0700201 ◽  
Author(s):  
Brenda S. Wright ◽  
Anita Bansal ◽  
Debra M. Moriarity ◽  
Sayaka Takaku ◽  
William N. Setzer
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Cytotoxic Activity ◽  
Volatile Compounds ◽  
Synergistic Effects ◽  
The Other ◽  
Cytotoxic Activities ◽  
Oil Components ◽  
Mcf 7

The leaf essential oils of Beilschmiedia sp. nov. “chancho blanco”, Cinnamomum costaricanum, Ocotea meziana, Ocotea sp. nov. “los llanos” and Ocotea sp. nov. “small leaf” showed notable in-vitro cytotoxic activity on MCF-7 cells. In order to examine possible synergistic effects of essential oil components, cytotoxic activities of 1:1 binary mixtures of a number of volatile compounds were determined. Notable synergistic cytotoxic enhancement was observed for mixtures of various compounds with citral, citronellal, and artemisia ketone. The cytotoxic activity of α-humulene, on the other hand, was antagonized by pinenes, thujene, and camphene. Likewise, camphene and terpinen-4-ol reduced the activity of β-caryophyllene.

scholarly journals The Volatile Phytochemistry of Seven Native American Aromatic Medicinal Plants

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1061
Author(s):  
Sims K. Lawson ◽  
Prabodh Satyal ◽  
William N. Setzer
Keyword(s):  
Native American ◽  
Medicinal Plants ◽  
Essential Oil ◽  
Essential Oils ◽  
Palmitic Acid ◽  
Methyl Salicylate ◽  
Chromatographic Techniques ◽  
Germacrene D ◽  
First Time ◽  
Gaultheria Procumbens

As part of our evaluation of essential oils derived from Native American medicinal plants, we have obtained the essential oils of Agastache foeniculum (Pursch) Kuntze (Lamiaceae), Gaultheria procumbens L. (Ericaceae), Heliopsis helianthoides (L.) Sweet (Asteraceae), Liatris spicata (L.) Willd. (Asteraceae), Pycnanthemum incanum (L.) Michx. (Lamiaceae), Smallanthus uvedalia (L.) Mack. ex Mack. (Asteraceae), and Verbena hastata L. (Verbenaceae) by hydrodistillation. The essential oils were analyzed by gas chromatographic techniques. The essential oil of A. foeniculum was dominated by estragole (88–93%), while methyl salicylate (91%) dominated the G. procumbens essential oil. Germacrene D was the major component in H. helianthoides (42%) and L. spicata (24%). 1,8-Cineole (31%) and α-terpineol (17%) were the main compounds in P. incanum essential oil. The essential oil of S. uvedalia showed α-pinene (24%), perillene (15%), and β-caryophyllene (17%) as major components. Verbena hastata essential oil was rich in 1-octen-3-ol (up to 29%) and palmitic acid (up to 22%). Four of these essential oils, H. helianthoides, L. spicata, P. incanum, and V. hastata, are reported for the first time. Additionally, the enantiomeric distributions of several terpenoid components have been determined.

scholarly journals Chemical composition and antifungal activity of essential oils from four Asteraceae plants grown in Egypt

2018 ◽  
Vol 73 (7-8) ◽  
pp. 313-318 ◽  
Author(s):  
Rose Vanessa Bandeira Reidel ◽  
Simona Nardoni ◽  
Francesca Mancianti ◽  
Claudia Anedda ◽  
Abd El-Nasser G. El Gendy ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Antifungal Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Inhibitory Activity ◽  
First Time

Abstract The objective of the present paper was the assessment of the chemical composition of the essential oils from four Asteraceae species with a considerable food, medicinal, and agricultural value, collected in Egypt, together with their in vitro inhibitory activity against molds and yeasts. The essential oil of Launaea cornuta flowers was also evaluated for the first time, but because of its very low yield (<0.01%), no antifungal test was performed.

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