scholarly journals Chemical Composition and Cytotoxic Activity of the Leaf Essential Oil of Ocotea tonduzii from Monteverde, Costa Rica

2007 ◽  
Vol 2 (7) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Anita Bansal ◽  
Debra M. Moriarity ◽  
Sayaka Takaku ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activities ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Oil Components ◽  
Mcf 7

The leaf essential oil of Ocotea tonduzii from Monteverde, Costa Rica has been obtained by hydrodistillation and analyzed by GC-MS. The principal constituents of O. tonduzii leaf oil were the monoterpenes α-pinene (41.4%) and pinene (25.1%) and the sesquiterpenes α-humulene (6.9%), β-caryophyllene (5.8%), and germacrene D (3.8%). O. tonduzii leaf oil was notably cytotoxic on MCF-7, MDA-MB-231, MDA-MB-468, and UACC-257 cells in vitro. The major essential oil components showed cytotoxic activities comparable to doxorubicin ( LC50, 20–70 μg/mL).

scholarly journals Analysis of the Leaf Essential Oil of Stauranthus perforatus from Monteverde, Costa Rica

2006 ◽  
Vol 1 (3) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Jennifer M. Schmidt ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Germacrene D ◽  
Leaf Essential Oil ◽  
Oil Components

The leaf essential oil of Stauranthus perforatus Leibm. (Rutaceae) from Monteverde, Costa Rica, was isolated by hydrodistillation and the chemical composition determined by GC–MS. The most abundant essential oil components were α-pinene, germacrene D, and α-cadinol.

scholarly journals Essential Oil Compositions and Cytotoxic Activities of Dendropanax capillaris, Oreopanax Nubigenus, and Schefflera Rodrigueziana from Monteverde, Costa Rica

2009 ◽  
Vol 4 (2) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Justin D. Richmond ◽  
Brittany R. Agius ◽  
Brenda S. Wright ◽  
William A. Haber ◽  
Debra M. Moriarity ◽  
...  
Keyword(s):  
Costa Rica ◽  
Essential Oil ◽  
Essential Oils ◽  
In Vitro Cytotoxicity ◽  
Cytotoxic Activities ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D ◽  
Leaf Oil ◽  
High Concentrations

The leaf essential oils of Dendropanax capillaris, Oreopanax nubigenus and Schefflera rodrigueziana (Araliaceae) were isolated by hydrodistillation and analyzed by GC-MS. The leaf oil of Dendropanax capillaris was composed of only four compounds, β-pinene (25.3%), δ-3-carene (44.7%), daucene (17.1%), and dauca-5,8-diene (12.9%). Oreopanax nubigenus leaf oil was dominated by the sesquiterpene hydrocarbons germacrene D (70.1%) and β-caryophyllene (11.8%), while Schefflera rodrigueziana leaf oil was made up entirely of sesquiterpene hydrocarbons, mostly germacrene D (27.6%), β-cubebene (27.2%), β-caryophyllene (12.2%), α-cubebene (11.1%), and α-copaene (10.8%). Both O. nubigenus and S. rodrigueziana leaf oils showed notable in-vitro cytotoxicity on MDA-MB-231 cells, which may be attributable to the relatively high concentrations of germacrene D and β-caryophyllene in those oils.

scholarly journals Chemical Composition of the Leaf Essential Oil of Casimiroa Edulis La Llave & Lex. (Rutaceae) from Monteverde, Costa Rica

2009 ◽  
Vol 4 (3) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Sarah L. Miller ◽  
William A. Haber ◽  
William N. Setzer
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Traditional Use ◽  
Sesquiterpene Hydrocarbons ◽  
Germacrene D ◽  
Casimiroa Edulis ◽  
Leaf Oil ◽  
Leaf Essential Oil

The leaf essential oil of Casimiroa edulis (Rutaceae), collected from Monteverde, Costa Rica, has been obtained by hydrodistillation and analyzed by GC-MS. The leaf oil was dominated by sesquiterpene hydrocarbons, predominately germacrene D (16-22%) and ( E)-caryophyllene (16-17%), consistent with the traditional use of this plant as a sedative, sleep inducer and hypotensive.

scholarly journals Composition and in-vitro CytotoxicActivities of the Leaf Essential Oil of Beilschmiedia erythrophloia from Taiwan

2013 ◽  
Vol 8 (1) ◽  
pp. 1934578X1300800
Author(s):  
Yu-Chang Su ◽  
Chen-Lung Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cytotoxic Activities ◽  
Anticancer Activities ◽  
Leaf Essential Oil ◽  
Main Components ◽  
Type Apparatus

This study investigated the chemical composition and in-vitro cytotoxic activities of the essential oil isolated from the leaf of Beilschmiedia erythrophloia. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Fifty-five compounds were identified, representing 100% of the oil. The main components identified were β-caryophyllene (22.6%), α-humulene (21.9%), terpinen-4-ol (5.3%), cis-β-ocimene (5.1%), sabinene (5.0%) and limonene (4.5%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells.

scholarly journals Leaf Essential Oil Composition of Five Species of Beilschmiedia from Monteverde, Costa Rica

2007 ◽  
Vol 2 (1) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
William N. Setzer ◽  
William A. Haber
Keyword(s):  
Costa Rica ◽  
Essential Oil ◽  
Carbonyl Compounds ◽  
Essential Oil Composition ◽  
Chemical Compositions ◽  
Oil Composition ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Cis And Trans

The leaf essential oils of five species of Beilschmiedia from Monteverde, Costa Rica (Beilschmiedia alloiophylla, B. brenesii, B. costaricensis, B. tilaranensis, and an undescribed Beilschmiedia species “chancho blanco”) have been obtained by hydrodistillation and analyzed by GC-MS in order to discern the differences and similarities between the volatile chemical compositions of these species. The principal constituents of B. alloiophylla leaf oil were germacrene D (18.9%), cis- and trans-β-ocimene (18.8% and 9.3%, respectively), α-pinene (11.8%), and bicyclogermacrene (9.1%). The leaf oil of B. brenesii was composed largely of the sesquiterpenes germacrene D (19.3%), β-caryophyllene (13.4%), α-copaene (9.0%), α-humulene (8.1%), and δ-cadinene (5.8%), and the carbonyl compounds 2-undecanone (12.8%), trans-2-hexenal (8.8%), and 2-tridecanone (3.8%). α-Bisabolol (72.1%) dominated the leaf oil of B. costaricensis, while B. tilaranensis had germacrene D (54.9%), β-caryophyllene (14.8%), and δ-cadinene (5.1%) as major components. Beilschmiedia “chancho blanco” leaf oil was composed largely of β-caryophyllene (16.6%), bicyclogermacrene (14.1%), and α-pinene (12.1%).

scholarly journals Leaf Essential Oil of Manekia naranjoana (Piperaceae) from Costa Rica and its Cytotoxic Activity

2011 ◽  
Vol 6 (1) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Carlos Chaverri ◽  
Cecilia Díaz ◽  
José F. Cicció
Keyword(s):  
Costa Rica ◽  
Chemical Composition ◽  
Essential Oil ◽  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Tumor Cell Lines ◽  
Capillary Gc ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Low Toxicity

The chemical composition of the leaf oil of Manekia naranjoana (C. DC.) Callejas (Piperaceae) from Costa Rica was analyzed by capillary GC/FID and GC/MS. Fifty-five compounds were identified. Major compounds from the leaf oil were β-pinene (30.6%), α-pinene (18.8%), limonene (13.7%), and β-caryophyllene (6.1%). The oil presented very low toxicity to tumor and non-tumor cell lines, even though it contains components, such as α- and β-pinene, limonene and others, which have been shown to be cytotoxic. This is the first report of the chemical composition of the essential oil obtained from this species.

scholarly journals Chemical Composition, Antimicrobial, and Cytotoxic Activities of the Essential Oil of Otostegia fruticosa subsp. schimperi from Yemen

2017 ◽  
Vol 12 (6) ◽  
pp. 1934578X1701200
Author(s):  
Nasser A. Awadh Ali ◽  
Ebtesam Hasan Alhamzy ◽  
Bhuwan K. Chhetri ◽  
Noura S. Dosoky ◽  
William N. Setzer
Keyword(s):  
Mass Spectrometry ◽  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Gas Chromatography ◽  
Essential Oil ◽  
Gas Chromatography Mass Spectrometry ◽  
Cytotoxic Activities ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Mcf 7

The leaf essential oil of Otostegia fruticosa subsp. schimperi (Lamiaceae) was obtained by hydrodistillation and analyzed by gas chromatography – mass spectrometry (GC-MS). The major components in the leaf oil were τ-cadinol (9.3%), β-caryophyllene (8.8%), and bornyl formate (5.2%) as well as two unidentified diterpenoids (12.7% and 9.4%, respectively). The leaf oil was screened for antibacterial ( Bacillus cereus, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), antifungal ( Aspergillus niger, Candida albicans, and Botrytis cinerea), and cytotoxic (MCF-7 and MDA-MB-231) activity. The oil did not show antimicrobial or antifungal activity, but it showed very good cytotoxicity against MCF-7 (IC50 = 55.1 μg/mL) and MDA-MB-231 (IC50 = 70.3 μg/mL) cell lines.

scholarly journals Composition and in vitro Anticancer Activities of the Leaf Essential Oil of Neolitsea variabillima from Taiwan

2013 ◽  
Vol 8 (4) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Yu-Chang Su ◽  
Kuan-Ping Hsu ◽  
Eugene I-Chen Wang ◽  
Chen-Lung Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Anticancer Activities ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Main Components ◽  
Type Apparatus

This study investigated the chemical composition and in vitro anticancer activities of the essential oil isolated from the leaf of Neolitsea variabillima. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Sixty-seven compounds were identified, representing 100% of the oil. The main components identified were trans-β-ocimene (13.4%), α-cadinol (10.5%), terpinen-4-ol (9.3%), τ-cadinol (9.2%), β-caryophyllene (8.8%), and sabinene (6.7%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells. The presence of β-caryophyllene, τ-cadinol, and α-cadinol significantly contributed to the anticancer activities of N. variabillima leaf oil.

scholarly journals Chemical Composition and Anti-mildew Activities of Essential Oils from Different Parts of Michelia compressa var. formosana

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000
Author(s):  
Yu-Chang Su ◽  
Kuang-Ping Hsu ◽  
Eugene I-Chen Wang ◽  
Chen-Lung Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Main Constituent ◽  
Germacrene D ◽  
Leaf Oil ◽  
Essential Oil Yield ◽  
Different Parts ◽  
Type Apparatus

In this study, anti-mildew activities of the essential oils of the leaves, wood, twigs, flowers, and their constituents from Michelia compressa var. formosana were evaluated in vitro against 7 mildew fungi. The main compounds responsible for the anti-mildew activities were isolated and identified. The essential oils from the fresh leaves, wood, twigs, and flowers of M. compressa var. formosana were isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. The essential oil yield from the flowers was the highest, and the oils obtained from the 4 parts of the tree were composed mainly of sesquiterpenoids. The leaf oil consisted primarily of α-cadinol (18.9%) and germacrene D (18.5%); the twig oil's main constituent was α-cadinol (19.1%); the wood oil's major components were α-cadinol (25.7%) and β-eudesmol (20.2%); and the flower oil contained α-cadinol (11.4%). Comparing the anti-mildew activities of the oils suggested that wood oil was the most effective. Further fractionation of the wood oil produced α-cadinol, β-eudesmol, τ-cadinol, and elemol. The 4 compounds exhibit very strong anti-mildew activities, and these in descending order are α-cadinol, elemol, β-eudesmol, and τ-cadinol. For the anti-mildew activities of the wood oil, the active source compounds were determined to be α-cadinol, elemol, β-eudesmol, and τ-cadinol.

Anticancer Activity and Chemical Composition of Leaf Essential Oil from Solidago canadensis L. in China

2011 ◽  
Vol 347-353 ◽  
pp. 1584-1589 ◽  
Author(s):  
De Qiang Li ◽  
Sheng Hao Pan ◽  
Xi Wu Zhu ◽  
Lin Tan ◽  
Yue Fen Cao
Keyword(s):  
Essential Oil ◽  
Leaf Tissue ◽  
Bornyl Acetate ◽  
Cytotoxic Activities ◽  
Solidago Canadensis ◽  
Germacrene D ◽  
Leaf Oil ◽  
Leaf Essential Oil ◽  
Effect Level ◽  
Main Components

The essential oil was obtained at yield of 0.30% by hydrodistillation from fresh leaf tissue of Solidago canadensis L. collected from Zhejiang Province, China. GC and GC/MS analysis identified 46 components, representing 94.6% of the leaf oil. The main components were (-)germacrene D (28.4%), bornyl acetate (9.2%), D-Limonene (5.0%). The essential oil was tested for cytotoxic activities against three tumor cell lines. The inhibitory concentrations of the essential oil at 50% effect level (IC50) were 68.1 μg/ml for SMMC-7721, 71.4 μg/ml for SGC-7901, and 156.9 μg/ml for Hala, respectively.

Sign in / Sign up

Export Citation Format

Share Document