scholarly journals Bioactive Clerodane Diterpenes from Roots of Carex Distachya

2010 ◽  
Vol 5 (10) ◽  
pp. 1934578X1000501
Author(s):  
Antonio Fiorentino ◽  
Brigida D'Abrosca ◽  
Severina Pacifico ◽  
Angelina Izzo ◽  
Grazia D'Angelo ◽  
...  
Keyword(s):  
Mediterranean Basin ◽  
Chemical Characterization ◽  
Shoot Elongation ◽  
2D Nmr ◽  
Herbaceous Species ◽  
2D Nmr Spectroscopy ◽  
Perennial Plant ◽  
Clerodane Diterpenes ◽  
The Mediterranean Basin

Two new clerodane diterpenes were isolated from roots of Carex distachya Desf., a perennial plant widely distributed in the coastal area of the Mediterranean basin. Chemical characterization of the metabolites was carried out mainly by 1D and 2D NMR spectroscopy. The isolated compounds influenced either positively or negatively the plant growth (root and shoot elongation) of three coexisting herbaceous species.

scholarly journals Phytochemical Investigation of the Australian Lichens Ramalina glaucescens and Xanthoria parietina

2009 ◽  
Vol 4 (7) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Daniel A. Dias ◽  
Sylvia Urban
Keyword(s):  
Antibacterial Properties ◽  
Usnic Acid ◽  
2D Nmr ◽  
Antibacterial Activities ◽  
2D Nmr Spectroscopy ◽  
Full Characterization ◽  
Phytochemical Investigation ◽  
Xanthoria Parietina ◽  
Shift Assignment

Phytochemical investigation of the Australian lichen, Ramalina glaucescens resulted in the isolation of a new halogenated depside, 5-chlorosekikaic acid 5, together with (+)-usnic acid 1, sekikaic acid 2, atranorin 6 and parietin 7, the latter of which was isolated from the associated (co-occurring) lichen, X. parietina. Compound 5 is suspected to be an artifact of the isolation procedure. All structures were assigned using spectroscopic methods and mass spectrometry. In addition to the full characterization of 5, this report represents the first application of 2D NMR spectroscopy to complete the unequivocal chemical shift assignment for compounds 2 and 7. Compounds 1-2 and 5-7 all displayed varying degrees of antitumor activity (ranging from an IC50 of 15 μM to >44 μM) with compounds 1, 2 and 5 also displaying antibacterial properties. Of these, (+)-usnic acid 1 displayed the most significant antitumor and antibacterial activities.

scholarly journals Proposed Research for Innovative Solutions for Chickpeas and Beans in a Climate Change Scenario: The Mediterranean Basin

2020 ◽  
Vol 12 (4) ◽  
pp. 1315
Author(s):  
Federico Martinelli ◽  
Francisco Javier Ollero ◽  
Antonio Giovino ◽  
Anna Perrone ◽  
Abdelkader Bekki ◽  
...  
Keyword(s):  
Climate Change ◽  
Mediterranean Basin ◽  
Field Experiments ◽  
Molecular Networks ◽  
Change Scenario ◽  
Environmental Constraint ◽  
The Mediterranean ◽  
Near Future ◽  
The Mediterranean Basin

In order to gain insight into the complex molecular networks driving legume adaptation caused by climate change, it is necessary to deeply characterize the existing germplasm in response to the environmental constraint predicted to worsen in the near future: drought. In this study, we propose to perform a three-year deep agronomic characterization of local genotypes of selected legumes in abiotic stressing conditions through controlled and field experiments conducted in several countries of the Mediterranean basin (Italy, Spain, Algeria, Tunisia, Turkey, Lebanon, and Croatia). These phenotypic analyses will be integrated with a multi-omic approach aiming at identifying the key players involved in the modulation of the analyzed traits that includes the analysis of the plant methylome, transcriptome, and proteome. Following this approach, we propose to deliver epigenomic markers linked with rapid adaptation mechanisms in response to drought. Besides, new genetic variability by breeding could be created in stressing conditions and produce the basis for the obtainment of more productive cultivars in worsening environments. The epigenetic marks identified in “omic” activities will be validated in molecular marker-assisted selection in F2–F4 populations. Finally, specific rhizobia strains for the best evaluated genotypes will be identified in order to enhance symbiotic nitrogen fixation in drought stress conditions with selected cultivars.

Synthesis of a Mycobacterium tuberculosis Tetra-acylated Sulfolipid Analogue and Characterization of the Chiral Acyl Chains Using Anisotropic NAD 2D-NMR Spectroscopy

2013 ◽  
Vol 78 (15) ◽  
pp. 7648-7657 ◽  
Author(s):  
Aurélie Lemétais ◽  
Yann Bourdreux ◽  
Philippe Lesot ◽  
Jonathan Farjon ◽  
Jean-Marie Beau
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Nmr Spectroscopy ◽  
2D Nmr ◽  
2D Nmr Spectroscopy ◽  
Acyl Chains

scholarly journals Synthesis and characterization of allyl- and vinyl-substituted 1,2-bis(tetrazolo)ethanes as polymeric precursors

2016 ◽  
Vol 71 (12) ◽  
pp. 1199-1209
Author(s):  
Vera A. Hartdegen ◽  
Maximilian S. Hofmayer ◽  
Konstantin Karaghiosoff ◽  
Thomas M. Klapötke
Keyword(s):  
Allyl Bromide ◽  
2D Nmr ◽  
Synthesis And Characterization ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
2D Nmr Spectroscopy ◽  
X Ray ◽  
Physical Stimuli ◽  
Thermal Stability Of

AbstractOn the basis of 1,2-bis(5-tetrazolo)ethane (BTE) the corresponding twofold vinyl and allyl N-substituted derivatives were synthesized using 1,2-dibromoethane and allyl bromide, respectively. The compounds were obtained as two different constitutional isomers. Both species were analyzed using NMR and IR spectroscopy, elemental analysis, as well as mass spectrometry. In the case of the diallyl bistetrazoles, the two isomers were characterized using 2D NMR spectroscopy. The synthesis of the divinyl compounds gave crystals of the 2,2′-N-substituted isomer, which were analyzed by single-crystal X-ray diffraction. The thermal stability of the compounds was determined using differential scanning calorimetry (DSC) and gave decomposition temperatures around 190°C and 230°C. For the investigation of the inherent energetic potential, sensitivities toward physical stimuli and detonation parameters were determined. The compounds turned out to be insensitive toward friction and impact and possess moderate energetic properties.

scholarly journals Characterization of the Structure of 2-(4-methyl-2 Phenyl-4, 5-dihydrooxazol-4-ylmethyl)-isoindole-1, 3-dione by 1D, COSY and HSQC 2D NMR Spectroscopy

2021 ◽  
pp. 30-37
Author(s):  
Khadim Dioukhane ◽  
Younas Aouine ◽  
Asmae Nakkabi ◽  
Salaheddine Boukhssas ◽  
Hassane Faraj ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
2D Nmr ◽  
The Other ◽  
Two Dimensional ◽  
Hsqc Spectrum ◽  
2D Nmr Spectroscopy ◽  
Perfect Correlation ◽  
Dione Derivative ◽  
The One

The identity of the 2-(4-Methyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl)-isoindole-1,3-dione, previously synthesized in our laboratory, was proven without doubt by means of 1D and 2D NMR spectroscopy. Two-dimensional NMR spectroscopy played a major role. The analysis of the 2D-COSY spectrum of isoindoline-1,3-dione derivative shows a perfect correlation between neighboring protons. Thus, a correlation was noted between the protons of the phthalimide, H(8) and H(9) on the one hand and H(8') and H(9') on the other hand. The analysis of the 2D-HSQC spectrum of the studied compound indicates a faultless correlation between protons and adjacent carbons, and no correlation in the case of all quaternary carbons.

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